Biomedical Research Education & Training
Faculty Member

Winder, Danny G., Ph.D.
Professor of Molecular Physiology and Biophysics
Professor of Psychiatry

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Phone Number: (615) 322-1144

Email Address:

Winder, Danny's picture
Academic history
Postdoc, Columbia Univ. Coll. of Physicians & Surgeons
B.S., North Georgia College
Ph.D., Emory University

Office Address   Mailing Address

750a Robinson Res Bldg (MRBI)

702 Light Hall 37232-0615

Research Keywords
neuroscience, glutamate, LTP, synaptic transmission, synapse, long-term potentiation, memory, addiction, signal transduction, electrophysiology, nucleus accumbens, bed nucleus of the stria terminalis,Neuroscience,Signal transduction

Research Specialty
Synaptic mechanisms in addiction and anxiety

Research Description
Glutamatergic synaptic transmission is the primary means of fast excitatory neural communication in the brain. Modulation of this transmission serves an important role in brain function. For example, long-term potentiation (LTP), a persistent modification of synaptic transmission elicited by bursts of synaptic activity has been postulated to play roles in memory storage. LTP is an appealing candidate for a cellular substrate for memory storage in part because, like memory, it is a lasting change to a transient stimulus. Another brain function that involves a similar lasting change in response to a transient stimulus is the transition from recreational drug use to addiction. Thus, research in my lab is directed toward determining how synaptic transmission is modulated by stress and substances of abuse, and the signal transduction cascades utilized. To accomplish this, we employ a variety of electrophysiological and biochemical techniques in brain slices. Through the use of regulatable systems to overexpress transgenes that interfere with regulation of transmission in key brain regions, studies are also planned to address the roles of modulation of glutamatergic transmission in processes such as addiction and anxiety.

Wills, TA, Klug, JR, Silberman, Y, Baucum, AJ, Weitlauf, C, Colbran, RJ, Delpire, E, Winder, DG. GluN2B subunit deletion reveals key role in acute and chronic ethanol sensitivity of glutamate synapses in bed nucleus of the stria terminalis. Proc Natl Acad Sci U S A, 109(5), E278-87, 2012

Conrad, KL, Louderback, KM, Gessner, CP, Winder, DG. Stress-induced alterations in anxiety-like behavior and adaptations in plasticity in the bed nucleus of the stria terminalis. Physiol Behav, 104(2), 248-56, 2011

Gosnell, HB, Silberman, Y, Grueter, BA, Duvoisin, RM, Raber, J, Winder, DG. mGluR8 modulates excitatory transmission in the bed nucleus of the stria terminalis in a stress-dependent manner. Neuropsychopharmacology, 36(8), 1599-607, 2011

Gustin, RM, Shonesy, BC, Robinson, SL, Rentz, TJ, Baucum, AJ, Jalan-Sakrikar, N, Winder, DG, Stanwood, GD, Colbran, RJ. Loss of Thr286 phosphorylation disrupts synaptic CaMKIII? targeting, NMDAR activity and behavior in pre-adolescent mice. Mol Cell Neurosci, 47(4), 286-92, 2011

Lindsley, CW, Bates, BS, Menon, UN, Jadhav, SB, Kane, AS, Jones, CK, Rodriguez, AL, Conn, PJ, Olsen, CM, Winder, DG, Emmitte, KA. (3-Cyano-5-fluorophenyl)biaryl negative allosteric modulators of mGlu(5): Discovery of a new tool compound with activity in the OSS mouse model of addiction. ACS Chem Neurosci, 2(8), 471-482, 2011

Nobis, WP, Kash, TL, Silberman, Y, Winder, DG. I?-Adrenergic receptors enhance excitatory transmission in the bed nucleus of the stria terminalis through a corticotrophin-releasing factor receptor-dependent and cocaine-regulated mechanism. Biol Psychiatry, 69(11), 1083-90, 2011

McElligott, ZA, Klug, JR, Nobis, WP, Patel, S, Grueter, BA, Kash, TL, Winder, DG. Distinct forms of Gq-receptor-dependent plasticity of excitatory transmission in the BNST are differentially affected by stress. Proc Natl Acad Sci U S A, 107(5), 2271-6, 2010 PMCID:2836642

Olsen, CM, Childs, DS, Stanwood, GD, Winder, DG. Operant sensation seeking requires metabotropic glutamate receptor 5 (mGluR5). PLoS One, 5(11), e15085, 2010 PMCID:2994905

Kash, TL, Baucum, AJ, Conrad, KL, Colbran, RJ, Winder, DG. Alcohol exposure alters NMDAR function in the bed nucleus of the stria terminalis. Neuropsychopharmacology, 34(11), 2420-9, 2009 PMCID:2864644

Shields, AD, Wang, Q, Winder, DG. alpha2A-adrenergic receptors heterosynaptically regulate glutamatergic transmission in the bed nucleus of the stria terminalis. Neuroscience, 163(1), 339-51, 2009 PMCID:2744292

Healey, JC, Winder, DG, Kash, TL. Chronic ethanol exposure leads to divergent control of dopaminergic synapses in distinct target regions. Alcohol, 42(3), 179-90, 2008

Kash, TL, Nobis, WP, Matthews, RT, Winder, DG. Dopamine enhances fast excitatory synaptic transmission in the extended amygdala by a CRF-R1-dependent process. J Neurosci, 28(51), 13856-65, 2008 PMCID:2630395

Olsen, CM, Huang, Y, Goodwin, S, Ciobanu, DC, Lu, L, Sutter, TR, Winder, DG. Microarray analysis reveals distinctive signaling between the bed nucleus of the stria terminalis, nucleus accumbens, and dorsal striatum. Physiol Genomics, 32(3), 283-98, 2008

Grueter, BA, McElligott, ZA, Winder, DG. Group I mGluRs and long-term depression: potential roles in addiction. Mol Neurobiol, 36(3), 232-44, 2007

Kash, TL, Matthews, RT, Winder, DG. Alcohol Inhibits NR2B-Containing NMDA Receptors in the Ventral Bed Nucleus of the Stria Terminalis. Neuropsychopharmacology, 2007

McElligott, ZA, Winder, DG. alpha(1)-Adrenergic Receptor-Induced Heterosynaptic Long-Term Depression in the Bed Nucleus of the Stria Terminalis Is Disrupted in Mouse Models of Affective Disorders. Neuropsychopharmacology, 2007

Robison, AJ, Winder, DG, Colbran, RJ, Bartlett, RK. Oxidation of calmodulin alters activation and regulation of CaMKII. Biochem Biophys Res Commun, 356(1), 97-101, 2007 PMCID:1899527

Grueter, BA, Gosnell, HB, Olsen, CM, Schramm-Sapyta, NL, Nekrasova, T, Landreth, GE, Winder, DG. Extracellular-signal regulated kinase 1-dependent metabotropic glutamate receptor 5-induced long-term depression in the bed nucleus of the stria terminalis is disrupted by cocaine administration. J Neurosci, 26(12), 3210-9, 2006

Kash, TL, Winder, DG. Neuropeptide Y and corticotropin-releasing factor bi-directionally modulate inhibitory synaptic transmission in the bed nucleus of the stria terminalis. Neuropharmacology, 51(5), 1013-22, 2006

Olsen, CM, Winder, DG. A method for single-session cocaine self-administration in the mouse. Psychopharmacology (Berl), 2006

Olsen, CM, Winder, DG. A method for single-session cocaine self-administration in the mouse. Psychopharmacology (Berl), 187(1), 13-21, 2006

Vanhoose, AM, Clements, JM, Winder, DG. Novel blockade of protein kinase A-mediated phosphorylation of AMPA receptors. J Neurosci, 26(4), 1138-45, 2006

Egli, RE, Kash, TL, Choo, K, Savchenko, V, Matthews, RT, Blakely, RD, Winder, DG. Norepinephrine modulates glutamatergic transmission in the bed nucleus of the stria terminalis. Neuropsychopharmacology, 30(4), 657-68, 2005

Grueter, BA, Winder, DG. Group II and III metabotropic glutamate receptors suppress excitatory synaptic transmission in the dorsolateral bed nucleus of the stria terminalis. Neuropsychopharmacology, 30(7), 1302-11, 2005

Norman, ED, Egli, RE, Colbran, RJ, Winder, DG. A potassium channel blocker induces a long-lasting enhancement of corticostriatal responses. Neuropharmacology, 48(2), 311-21, 2005

Schramm-Sapyta, NL, Olsen, CM, Winder, DG. Cocaine Self-Administration Reduces Excitatory Responses in the Mouse Nucleus Accumbens Shell. Neuropsychopharmacology, 2005

Weitlauf, C, Honse, Y, Auberson, YP, Mishina, M, Lovinger, DM, Winder, DG. Activation of NR2A-containing NMDA receptors is not obligatory for NMDA receptor-dependent long-term potentiation. J Neurosci, 25(37), 8386-90, 2005

Matthews, Robert T, Coker, Olusegun, Winder, Danny G. A novel mouse brain slice preparation of the hippocampo-accumbens pathway. J Neurosci Methods, 137(1), 49-60, 2004

Schramm-Sapyta, Nicole L., Pratt, Adeola R., Winder, Danny G.. Effects of periadolescent versus adult cocaine exposure on cocaine conditioned place preference and motor sensitization in mice. Psychopharmacology (Berl), 2004

Vanhoose, Amanda M, Ritchie, Marylyn D, Winder, Danny G. Regulation of cAMP levels in area CA1 of hippocampus by Gi/o-coupled receptors is stimulus dependent in mice. Neurosci Lett, 370(1), 80-3, 2004

Weitlauf, Carl, Egli, Regula E, Grueter, Brad A, Winder, Danny G. High-frequency stimulation induces ethanol-sensitive long-term potentiation at glutamatergic synapses in the dorsolateral bed nucleus of the stria terminalis. J Neurosci, 24(25), 5741-7, 2004

Egli, Regula E., Winder, Danny G. Excitable and Synaptic Properties of Neurons of Mouse Bed Nucleus of the Stria Terminalis: Differential Dorsal and Ventral Distribution of Excitable Properties. J Neurophysiol, 2003

Morozov, Alexei, Muzzio, Isabel A, Bourtchouladze, Rusiko, Van-Strien, Niels, Lapidus, Kyle, Yin, DeQi, Winder, Danny G, Adams, J Paige, Sweatt, J David, Kandel, Eric R. Rap1 couples cAMP signaling to a distinct pool of p42/44MAPK regulating excitability, synaptic plasticity, learning, and memory. Neuron, 39, 309-25, 2003

Vanhoose, Amanda M, Winder, Danny G. NMDA and beta1-adrenergic receptors differentially signal phosphorylation of glutamate receptor type 1 in area CA1 of hippocampus. J Neurosci, 23, 5827-34, 2003

Schramm, Nicole L, Egli, Regula E, Winder, Danny G. LTP in the mouse nucleus accumbens is developmentally regulated. Synapse, 45, 213-9, 2002

Vanhoose, Amanda M, Emery, Megan, Jimenez, Lismary, Winder, Danny G. ERK activation by G-protein-coupled receptors in mouse brain is receptor identity-specific. J Biol Chem, 277, 9049-53, 2002

Winder, D.G. and Kandel, E.R. Genetic strategies for the study of hippocampal-based memory storage. In: J.J. Bolhuis (Ed.) Brain Mechanisms of Perception, Learning and Memory: Essays for Gabriel Horn. Oxford University Press.. Oxford, 2002

Winder, Danny G, Egli, Regula E, Schramm, Nicole L, Matthews, Robert T. Synaptic plasticity in drug reward circuitry. Curr Mol Med, 2, 667-76, 2002

Malleret, G., Haditsch, U., Genoux, D., Jones, M., Bliss, T.V.P., Vanhoose, A.M., Weitlauf, C., Kandel, E.R., Winder, D.G. and Mansuy, I.M. Inducible and reversible enhancement of learning, memory storage and long-term potentiation by genetic inhibition of calcineurin. Cell , 104, 675-686, 2001

Winder, D G, Schramm, N L. Plasticity and behavior: new genetic techniques to address multiple forms and functions. Physiol Behav, 73, 763-80, 2001

Winder, D G, Sweatt, J D. Roles of serine/threonine phosphatases in hippocampal synaptic plasticity. Nat Rev Neurosci, 2, 461-74, 2001

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