Biomedical Research Education & Training
Faculty Member

Smith, Jeffrey R., M.D., Ph.D.
Associate Professor of Medicine
Associate Professor of Cancer Biology

Lab Url: N/A

Phone Number: 615-936-2171

Email Address: jeffrey.smith@vanderbilt.edu

Smith, Jeffrey's picture
Academic history
A.B., Harvard University
M.D., Ph.D., University of Texas Southwestern Medical Center
N/AN/AN/AN/A

Office Address   Mailing Address

535 Light Hall

Division of Genetic Medicine 529 Light Hall 37232-0275


Research Keywords
gene, genetic, genome, genomic, polymorphism, mutation, SNP, mutant, pedigree, family, familial, hereditary, heritability, population, cancer, prostate, breast, zebrafish, statistic, bioinformatic, computational, personalized medicine, risk, predisposition, GWAS,Cancer,Chromosome,Genetics,Genome,Genomics,Human Genetics,Malignancy,Molecular medicine,Mutation,Polymorphism,Recombination,Stem cells,Transcription factor,Transformation

Research Specialty
Genetics and genomics of cancer

Research Description
Our research group investigates genetic predisposition to cancer, with parallel goals of elucidating causality and contributing to personalized medicine. We apply state-of-the-art genomics technology and custom bioinformatics in large-scale projects of breast and prostate cancer. We have also contributed genomics tools for the zebrafish model organism.

The breast cancer project is a collaborative study with Dr. William Dupont to determine genetic causes of breast cancer within the Nashville Breast Cohort (NBC) and additional breast cancer study populations. The NBC is a cohort of 8000 women with benign forms of breast disease who have been followed for over two decades for the development of invasive breast cancer. The cohort enables investigation of genetic, epidemiologic, and pathologic factors in the progression of premalignant breast lesions to invasive breast cancer.

Our prostate cancer project investigates genetic causes of familial prostate cancer. Prostate cancer has the largest heritable risk of all common cancers, but relatively little is known about the underlying genetic etiology. The study population is comprised of 1000 prostate cancer cases with a family history the disease, and 1000 controls without any personal or family history of prostate cancer (comparing those in the extremes of the distribution of genetic load for prostate cancer).

A third project has developed genetic mapping resources for the zebrafish vertebrate model organism. We identified 1.2 million SNPs, developed a high-resolution genetic map, and characterized the diversity and ancestry of common strains. As an example of the utility of the resource, we demonstrated that sex determination in zebrafish is a complex trait, not involving sex chromosomes.

Clinical Interests
Prostate and Breast Cancer Genetics

Publications
Breyer, JP, Dorset, DC, Clark, TA, Bradley, KM, Wahlfors, TA, McReynolds, KM, Maynard, WH, Chang, SS, Cookson, MS, Smith, JA, Schleutker, J, Dupont, WD, Smith, JR. An Expressed Retrogene of the Master Embryonic Stem Cell Gene POU5F1 Is Associated with Prostate Cancer Susceptibility. Am J Hum Genet, 94(3), 395-404, 2014

Chung, C, Solus, J, Oeser, A, Li, C, Raggi, P, Smith, J, Stein, C. Genetic variation and coronary atherosclerosis in patients with systemic lupus erythematosus. Lupus, 2014

Gray, RS, Wilm, TP, Smith, J, Bagnat, M, Dale, RM, Topczewski, J, Johnson, SL, Solnica-Krezel, L. Loss of col8a1a function during zebrafish embryogenesis results in congenital vertebral malformations. Dev Biol, 386(1), 72-85, 2014

Kodaman, N, Aldrich, MC, Smith, JR, Signorello, LB, Bradley, K, Breyer, J, Cohen, SS, Long, J, Cai, Q, Giles, J, Bush, WS, Blot, WJ, Matthews, CE, Williams, SM. A small number of candidate gene SNPs reveal continental ancestry in African Americans. Ann Hum Genet, 77(1), 56-66, 2013

Breyer, JP, Avritt, TG, McReynolds, KM, Dupont, WD, Smith, JR. Confirmation of the HOXB13 G84E germline mutation in familial prostate cancer. Cancer Epidemiol Biomarkers Prev, 21(8), 1348-53, 2012

Edwards, TL, Velez Edwards, DR, Villegas, R, Cohen, SS, Buchowski, MS, Fowke, JH, Schlundt, D, Long, J, Long, JR, Cai, Q, Zheng, W, Shu, XO, Hargreaves, MK, Smith, J, Jeffrey, S, Williams, SM, Signorello, LB, Blot, WJ, Matthews, CE. HTR1B, ADIPOR1, PPARGC1A, and CYP19A1 and obesity in a cohort of Caucasians and African Americans: an evaluation of gene-environment interactions and candidate genes. Am J Epidemiol, 175(1), 11-21, 2012

Higginbotham, KS, Breyer, JP, McReynolds, KM, Bradley, KM, Schuyler, PA, Plummer, WD, Freudenthal, ME, Trentham-Dietz, A, Newcomb, PA, Parl, FF, Sanders, ME, Page, DL, Egan, KM, Dupont, WD, Smith, JR. A multistage genetic association study identifies breast cancer risk loci at 10q25 and 16q24. Cancer Epidemiol Biomarkers Prev, 21(9), 1565-73, 2012

Bradley, KM, Breyer, JP, Melville, DB, Broman, KW, Knapik, EW, Smith, JR. An SNP-Based Linkage Map for Zebrafish Reveals Sex Determination Loci. G3 (Bethesda), 1(1), 3-9, 2011

Cohen, SS, Gammon, MD, North, KE, Millikan, RC, Lange, EM, Williams, SM, Zheng, W, Cai, Q, Long, J, Smith, JR, Signorello, LB, Blot, WJ, Matthews, CE. ADIPOQ, ADIPOR1, and ADIPOR2 Polymorphisms in Relation to Serum Adiponectin Levels and BMI in Black and White Women. Obesity (Silver Spring), 2011

Crooke, PS, Justenhoven, C, Brauch, H, , , Dawling, S, Roodi, N, Higginbotham, KS, Plummer, WD, Schuyler, PA, Sanders, ME, Page, DL, Smith, JR, Dupont, WD, Parl, FF. Estrogen metabolism and exposure in a genotypic-phenotypic model for breast cancer risk prediction. Cancer Epidemiol Biomarkers Prev, 20(7), 1502-15, 2011

Higginbotham, KS, Breyer, JP, Bradley, KM, Schuyler, PA, Plummer, WD, Freudenthal, ME, Trentham-Dietz, A, Newcomb, PA, Sanders, ME, Page, DL, Parl, FF, Egan, KM, Dupont, WD, Smith, JR. A Multistage Association Study Identifies a Breast Cancer Genetic Locus at NCOA7. Cancer Res, 71(11), 3881-3888, 2011

Melville, DB, Montero-Balaguer, M, Levic, DS, Bradley, K, Smith, JR, Hatzopoulos, AK, Knapik, EW. The feelgood mutation in zebrafish dysregulates COPII-dependent secretion of select extracellular matrix proteins in skeletal morphogenesis. Dis Model Mech, 4(6), 763-76, 2011

Signorello, LB, Shi, J, Cai, Q, Zheng, W, Williams, SM, Long, J, Cohen, SS, Li, G, Hollis, BW, Smith, JR, Blot, WJ. Common variation in vitamin D pathway genes predicts circulating 25-hydroxyvitamin D Levels among African Americans. PLoS One, 6(12), e28623, 2011

Dupont, WD, Breyer, JP, Bradley, KM, Schuyler, PA, Plummer, WD, Sanders, ME, Page, DL, Smith, JR. Protein phosphatase 2A subunit gene haplotypes and proliferative breast disease modify breast cancer risk. Cancer, 116(1), 8-19, 2010 PMCID:2793011

Signorello, LB, Williams, SM, Zheng, W, Smith, JR, Long, J, Cai, Q, Hargreaves, MK, Hollis, BW, Blot, WJ. Blood vitamin d levels in relation to genetic estimation of African ancestry. Cancer Epidemiol Biomarkers Prev, 19(9), 2325-31, 2010

Breyer, JP, McReynolds, KM, Yaspan, BL, Bradley, KM, Dupont, WD, Smith, JR. Genetic variants and prostate cancer risk: candidate replication and exploration of viral restriction genes. Cancer Epidemiol Biomarkers Prev, 18(7), 2137-44, 2009

Breyer, JP, Sanders, ME, Airey, DC, Cai, Q, Yaspan, BL, Schuyler, PA, Dai, Q, Boulos, F, Olivares, MG, Bradley, KM, Gao, YT, Page, DL, Dupont, WD, Zheng, W, Smith, JR. Heritable variation of ERBB2 and breast cancer risk. Cancer Epidemiol Biomarkers Prev, 18(4), 1252-8, 2009 PMCID:2730036

Gudmundsson, J, Sulem, P, Gudbjartsson, DF, Blondal, T, Gylfason, A, Agnarsson, BA, Benediktsdottir, KR, Magnusdottir, DN, Orlygsdottir, G, Jakobsdottir, M, Stacey, SN, Sigurdsson, A, Wahlfors, T, Tammela, T, Breyer, JP, McReynolds, KM, Bradley, KM, Saez, B, Godino, J, Navarrete, S, Fuertes, F, Murillo, L, Polo, E, Aben, KK, van Oort, IM, Suarez, BK, Helfand, BT, Kan, D, Zanon, C, Frigge, ML, Kristjansson, K, Gulcher, JR, Einarsson, GV, Jonsson, E, Catalona, WJ, Mayordomo, JI, Kiemeney, LA, Smith, JR, Schleutker, J, Barkardottir, RB, Kong, A, Thorsteinsdottir, U, Rafnar, T, Stefansson, K. Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility. Nat Genet, 41(10), 1122-6, 2009

Love, HD, Booton, SE, Boone, BE, Breyer, JP, Koyama, T, Revelo, MP, Shappell, SB, Smith, JR, Hayward, SW. Androgen regulated genes in human prostate xenografts in mice: relation to BPH and prostate cancer. PLoS One, 4(12), e8384, 2009 PMCID:2793011

Cai, Q, Kataoka, N, Li, C, Wen, W, Smith, JR, Gao, YT, Shu, XO, Zheng, W. Haplotype analyses of CYP19A1 gene variants and breast cancer risk: results from the Shanghai Breast Cancer Study. Cancer Epidemiol Biomarkers Prev, 17(1), 27-32, 2008 PMCID:2633134

Ciarleglio, CM, Ryckman, KK, Servick, SV, Hida, A, Robbins, S, Wells, N, Hicks, J, Larson, SA, Wiedermann, JP, Carver, K, Hamilton, N, Kidd, KK, Kidd, JR, Smith, JR, Friedlaender, J, McMahon, DG, Williams, SM, Summar, ML, Johnson, CH. Genetic Differences in Human Circadian Clock Genes among Worldwide Populations. J Biol Rhythms, 23(4), 330-40, 2008 PMCID:2579796

Gudmundsson, J, Sulem, P, Rafnar, T, Bergthorsson, JT, Manolescu, A, Gudbjartsson, D, Agnarsson, BA, Sigurdsson, A, Benediktsdottir, KR, Blondal, T, Jakobsdottir, M, Stacey, SN, Kostic, J, Kristinsson, KT, Birgisdottir, B, Ghosh, S, Magnusdottir, DN, Thorlacius, S, Thorleifsson, G, Zheng, SL, Sun, J, Chang, BL, Elmore, JB, Breyer, JP, McReynolds, KM, Bradley, KM, Yaspan, BL, Wiklund, F, Stattin, P, Lindstr??m, S, Adami, HO, McDonnell, SK, Schaid, DJ, Cunningham, JM, Wang, L, Cerhan, JR, St Sauver, JL, Isaacs, SD, Wiley, KE, Partin, AW, Walsh, PC, Polo, S, Ruiz-Echarri, M, Navarrete, S, Fuertes, F, Saez, B, Godino, J, Weijerman, PC, Swinkels, DW, Aben, KK, Witjes, JA, Suarez, BK, Helfand, BT, Frigge, ML, Kristjansson, K, Ober, C, Jonsson, E, Einarsson, GV, Xu, J, Gronberg, H, Smith, JR, Thibodeau, SN, Isaacs, WB, Catalona, WJ, Mayordomo, JI, Kiemeney, LA, Barkardottir, RB, Gulcher, JR, Thorsteinsdottir, U, Kong, A, Stefansson, K. Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer. Nat Genet, 40(3), 281-3, 2008

Yaspan, BL, McReynolds, KM, Elmore, JB, Breyer, JP, Bradley, KM, Smith, JR. A haplotype at chromosome Xq27.2 confers susceptibility to prostate cancer. Hum Genet, 123(4), 379-86, 2008

Ye, C, Gao, YT, Wen, W, Breyer, JP, Shu, XO, Smith, JR, Zheng, W, Cai, Q. Association of mitochondrial DNA displacement loop (CA)n dinucleotide repeat polymorphism with breast cancer risk and survival among Chinese women. Cancer Epidemiol Biomarkers Prev, 17(8), 2117-22, 2008 PMCID:2643086

Bradley, KM, Elmore, JB, Breyer, JP, Yaspan, BL, Jessen, JR, Knapik, EW, Smith, JR. A major zebrafish polymorphism resource for genetic mapping. Genome Biol, 8(4), R55, 2007 PMCID:1896001

Yaspan, BL, Breyer, JP, Cai, Q, Dai, Q, Elmore, JB, Amundson, I, Bradley, KM, Shu, XO, Gao, YT, Dupont, WD, Zheng, W, Smith, JR. Haplotype analysis of CYP11A1 identifies promoter variants associated with breast cancer risk. Cancer Res, 67(12), 5673-82, 2007

Baffoe-Bonnie*, AB, Smith*, JR, Stephan, DA, Schleutker, J, Carpten, JD, Kainu, T, Gillanders, EM, Matikainen, M, Teslovich, TM, Tammela, T, Sood, R, Balshem, AM, Scarborough, SD, Xu, J, Isaacs, WB, Trent, JM, Kallioniemi, OP, Bailey-Wilson, JE. A major locus for hereditary prostate cancer in Finland: localization by linkage disequilibrium of a haplotype in the HPCX region. Hum Genet, 117(4), 307-16, 2005

Boyapati, SM, Shu, XO, Ruan, ZX, Cai, Q, Smith, JR, Wen, W, Gao, YT, Zheng, W. Polymorphisms in ER-alpha gene interact with estrogen receptor status in breast cancer survival. Clin Cancer Res, 11(3), 1093-8, 2005

Owens, SE, Broman, KW, Wiltshire, T, Elmore, JB, Bradley, KM, Smith, JR, Southard-Smith, EM. Genome-wide linkage identifies novel modifier loci of aganglionosis in the Sox10Dom model of Hirschsprung disease. Hum Mol Genet, 14(11), 1549-58, 2005

Wen, W, Gao, YT, Shu, XO, Yu, H, Cai, Q, Smith, JR, Zheng, W. Insulin-like growth factor-I gene polymorphism and breast cancer risk in Chinese women. Int J Cancer, 113(2), 307-11, 2005

Adegoke, OJ, Shu, XO, Gao, YT, Cai, Q, Breyer, J, Smith, J, Zheng, W. Genetic polymorphisms in uridine diphospho-glucuronosyltransferase 1A1 (UGT1A1) and risk of breast cancer. Breast Cancer Res Treat, 85(3), 239-45, 2004

Cantrell, VA, Owens, SE, Chandler, RL, Airey, DC, Bradley, KM, Smith, JR, Southard-Smith, EM. Interactions between Sox10 and EdnrB modulate penetrance and severity of aganglionosis in the Sox10Dom mouse model of Hirschsprung disease. Hum Mol Genet, 13(19), 2289-301, 2004

Zheng, W, Gao, YT, Shu, XO, Wen, W, Cai, Q, Dai, Q, Smith, JR. Population-based case-control study of CYP11A gene polymorphism and breast cancer risk. Cancer Epidemiol Biomarkers Prev, 13(5), 709-14, 2004

Cai, Q, Gao, YT, Wen, W, Shu, XO, Jin, F, Smith, JR, Zheng, W. Association of breast cancer risk with a GT dinucleotide repeat polymorphism upstream of the estrogen receptor-alpha gene. Cancer Res, 63(18), 5727-30, 2003

Carpten, J, Nupponen, N, Isaacs, S, Sood, R, Robbins, C, Xu, J, Faruque, M, Moses, T, Ewing, C, Gillanders, E, Hu, P, Bujnovszky, P, Makalowska, I, Baffoe-Bonnie, A, Faith, D, Smith, J, Stephan, D, Wiley, K, Brownstein, M, Gildea, D, Kelly, B, Jenkins, R, Hostetter, G, Matikainen, M, Schleutker, J, Klinger, K, Connors, T, Xiang, Y, Wang, Z, De Marzo, A, Papadopoulos, N, Kallioniemi, OP, Burk, R, Meyers, D, Gronberg, H, Meltzer, P, Silverman, R, Bailey-Wilson, J, Walsh, P, Isaacs, W, Trent, J. Germline mutations in the ribonuclease L gene in families showing linkage with HPC1. Nat Genet, 30(2), 181-4, 2002

Ho, GY, Knapp, M, Freije, D, Nelson, WG, Smith, JR, Carpten, JD, Bailey-Wilson, JE, Beaty, TH, Petersen, G, Xu, J, Kamensky, V, Walsh, PC, Isaacs, WB. Transmission/disequilibrium tests of androgen receptor and glutathione S-transferase pi variants in prostate cancer families. Int J Cancer, 98(6), 938-42, 2002

Smith, J., Collins, F., and Gelehrter, T. Molecular Genetics of Common Disease. In: The Genetic Basis of Common Diseases, Second Edition, edited by King, Rotter, and Motulsky. (Oxford Univesity Press), 2002

Stephan, DA, Howell, GR, Teslovich, TM, Coffey, AJ, Smith, L, Bailey-Wilson, JE, Malechek, L, Gildea, D, Smith, JR, Gillanders, EM, Schleutker, J, Hu, P, Steingruber, HE, Dhami, P, Robbins, CM, Makalowska, I, Carpten, JD, Sood, R, Mumm, S, Reinbold, R, Bonner, TI, Baffoe-Bonnie, A, Bubendorf, L, Heiskanen, M, Kallioneimi, OP, Baxevanis, AD, Joseph, SS, Zucchi, I, Burk, RD, Isaacs, W, Ross, MT, Trent, JM. Physical and transcript map of the hereditary prostate cancer region at xq27. Genomics, 79(1), 41-50, 2002

Xu, J, Zheng, SL, Chang, B, Smith, JR, Carpten, JD, Stine, OC, Isaacs, SD, Wiley, KE, Henning, L, Ewing, C, Bujnovszky, P, Bleeker, ER, Walsh, PC, Trent, JM, Meyers, DA, Isaacs, WB. Linkage of prostate cancer susceptibility loci to chromosome 1. Hum Genet, 108(4), 335-45, 2001

Bergthorsson, JT, Johannesdottir, G, Arason, A, Benediktsdottir, KR, Agnarsson, BA, Bailey-Wilson, JE, Gillanders, E, Smith, J, Trent, J, Barkardottir, RB. Analysis of HPC1, HPCX, and PCaP in Icelandic hereditary prostate cancer. Hum Genet, 107(4), 372-5, 2000

Berry*, R, Schaid, DJ, Smith*, JR, French, AJ, Schroeder, JJ, McDonnell, SK, Peterson, BJ, Wang, ZY, Carpten, JD, Roberts, SG, Tester, DJ, Blute, ML, Trent, JM, Thibodeau, SN. Linkage analyses at the chromosome 1 loci 1q24-25 (HPC1), 1q42.2-43 (PCAP), and 1p36 (CAPB) in families with hereditary prostate cancer. Am J Hum Genet, 66(2), 539-46, 2000 PMCID:1288107

Carpten, JD, Makalowska, I, Robbins, CM, Scott, N, Sood, R, Connors, TD, Bonner, TI, Smith, JR, Faruque, MU, Stephan, DA, Pinkett, H, Morgenbesser, SD, Su, K, Graham, C, Gregory, SG, Williams, H, McDonald, L, Baxevanis, AD, Klingler, KW, Landes, GM, Trent, JM. A 6-Mb high-resolution physical and transcription map encompassing the hereditary prostate cancer 1 (HPC1) region. Genomics, 64(1), 1-14, 2000

Schleutker*, J, Matikainen, M, Smith*, J, Koivisto, P, Baffoe-Bonnie, A, Kainu, T, Gillanders, E, Sankila, R, Pukkala, E, Carpten, J, Stephan, D, Tammela, T, Brownstein, M, Bailey-Wilson, J, Trent, J, Kallioniemi, OP. A genetic epidemiological study of hereditary prostate cancer (HPC) in Finland: frequent HPCX linkage in families with late-onset disease. Clin Cancer Res, 6(12), 4810-5, 2000

Xu, J. Combined analysis of hereditary prostate cancer linkage to 1q24-25: results from 772 hereditary prostate cancer families from the International Consortium for Prostate Cancer Genetics. Am J Hum Genet, 66(3), 945-57, 2000 PMCID:1288175

Gronberg*, H, Smith*, J, Emanuelsson, M, Jonsson, BA, Bergh, A, Carpten, J, Isaacs, W, Xu, J, Meyers, D, Trent, J, Damber, JE. In Swedish families with hereditary prostate cancer, linkage to the HPC1 locus on chromosome 1q24-25 is restricted to families with early-onset prostate cancer. Am J Hum Genet, 65(1), 134-40, 1999 PMCID:1378083

Xu*, J., Meyers, D., Freije, D., Isaacs, S., Wiley, K., Nusskern, D., Ewing, C., Wilkens, E., Bujnovszky, P., Bova, G., Walsh, P., Isaacs, W., Schleutker*, J., Matikainen*, M., Tammela, T., Visakorpi, T., Kallioniemi, O., Berry*, R., Schaid*, D., French, A., McDonnell, S., Schroeder, J., Blute, M., Thibodeau, S., Gronberg*, H., Emanuelsson, M., Damber, J., Bergh, A., Jonsson, B., Smith*, J., Bailey-Wilson, J., Carpten, J., Stephan, D., Gillanders, E., Amundson, I., Kainu, T., Freas-Lutz, D., Baffoe-Bonnie, A., Van Aucken, A., Sood, R., Collins, F., Brownstein, M., and Trent, J. (1998) Evidence for a Prostate Cancer Susceptibility Locus on the X Chromosome. Nature Genetics, 20, 175-179.

Carpten, J., Smith, J., Stephan, D., Isaacs, W., Trent, J. Searching for Prostate Cancer Genes. Science and Medicine, 5, 26-35, 1998

Ghosh, S, Karanjawala, ZE, Hauser, ER, Ally, D, Knapp, JI, Rayman, JB, Musick, A, Tannenbaum, J, Te, C, Shapiro, S, Eldridge, W, Musick, T, Martin, C, Smith, JR, Carpten, JD, Brownstein, MJ, Powell, JI, Whiten, R, Chines, P, Nylund, SJ, Magnuson, VL, Boehnke, M, Collins, FS. Methods for precise sizing, automated binning of alleles, and reduction of error rates in large-scale genotyping using fluorescently labeled dinucleotide markers. FUSION (Finland-U.S. Investigation of NIDDM Genetics) Study Group. Genome Res, 7(2), 165-78, 1997

Gronberg, H, Isaacs, SD, Smith, JR, Carpten, JD, Bova, GS, Freije, D, Xu, J, Meyers, DA, Collins, FS, Trent, JM, Walsh, PC, Isaacs, WB. Characteristics of prostate cancer in families potentially linked to the hereditary prostate cancer 1 (HPC1) locus. JAMA, 278(15), 1251-5, 1997

Gronberg, H, Xu, J, Smith, JR, Carpten, JD, Isaacs, SD, Freije, D, Bova, GS, Danber, JE, Bergh, A, Walsh, PC, Collins, FS, Trent, JM, Meyers, DA, Isaacs, WB. Early age at diagnosis in families providing evidence of linkage to the hereditary prostate cancer locus (HPC1) on chromosome 1. Cancer Res, 57(21), 4707-9, 1997

Brownstein, M., Carpten, J., and Smith, J. Modulation of Nontemplated Nucleotide Addition by Taq DNA Polymerase: Primer Modifications that Facilitate Genotyping. Biotechniques, 20, 1004-1010, 1996

Smith, J., Freije, D., Carpten, J., Gronberg, H., Xu, J., Isaacs, S., Brownstein, M., Bova, G., Guo, H., Bujnovszky, P., Nusskern, D., Damber, J., Bergh, A., Emanuelsson, M., Kallioniemi, O., Walker-Daniels, J., Bailey-Wilson, J., Beaty, T., Meyers, D., Walsh, P., Collins, F., Trent, J., and Isaacs, W. Major Susceptibility Locus for Prostate Cancer on Chromosome 1 Suggested by a Genome-Wide Search. Science, 274(Nov 22), 1371-1374, 1996

Smith, JR, Carpten, JD, Brownstein, MJ, Ghosh, S, Magnuson, VL, Gilbert, DA, Trent, JM, Collins, FS. Approach to genotyping errors caused by nontemplated nucleotide addition by Taq DNA polymerase. Genome Res, 5(3), 312-7, 1995

Smith, JR, Osborne, TF, Goldstein, JL, Brown, MS. Identification of nucleotides responsible for enhancer activity of sterol regulatory element in low density lipoprotein receptor gene. J Biol Chem, 265(4), 2306-10, 1990

Gil, G, Smith, JR, Goldstein, JL, Slaughter, CA, Orth, K, Brown, MS, Osborne, TF. Multiple genes encode nuclear factor 1-like proteins that bind to the promoter for 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Proc Natl Acad Sci U S A, 85(23), 8963-7, 1988 PMCID:282633

Smith, JR, Osborne, TF, Brown, MS, Goldstein, JL, Gil, G. Multiple sterol regulatory elements in promoter for hamster 3-hydroxy-3-methylglutaryl-coenzyme A synthase. J Biol Chem, 263(34), 18480-7, 1988

Gil, G, Smith, JR, Goldstein, JL, Brown, MS. Optional exon in the 5'-untranslated region of 3-hydroxy-3-methylglutaryl coenzyme A synthase gene: conserved sequence and splicing pattern in humans and hamsters. Proc Natl Acad Sci U S A, 84(7), 1863-6, 1987 PMCID:304541


Postdoctoral Position Available
Yes

Postdoctoral Position Details
Postdoctoral position available to qualified applicants in human genomics and cancer genetics. Inquiries welcome.

Updated Date
04/09/2014