Biomedical Research Education & Training
Faculty Member

Oates, John A., M.D.
Professor of Medicine
Thomas F. Frist Sr. Chair in Medicine
Professor of Pharmacology

Lab Url: http://www.mc.vanderbilt.edu/medschool/IBR/IBR_JohnOates.php

Phone Number: (615) 343-4847

Email Address: john.oates@vanderbilt.edu

Oates, John's picture
Academic history
B.S., Wake Forest College
M.D., Bowman Gray School of Medicine
, New York Hospital-cornell Medical Center
, National Institutes of Health
, National Institutes of Health
, Karolinska Institute

Office Address   Mailing Address

536 RRB

514-A RRB 2200 Pierce Ave 37232 6602


Research Keywords
Aspirin, cyclooxygenases, Alzheimer's disease, Subarachnoid hemorrhage Translational research

Clinical Research Keywords
aspirin, subarachnoid hemorrhage, cyclooxygenase in cancer, platelet function

Research Specialty
Aspirin as an antiplatelet drug for cardioprotection. New therapies for subarachnoid hemorrhage Lipid modification of Amyloid Beta in Alzheimer's disease Platelets in the pathophysiology and treatment of cardiovascular disease.

Research Description
Our research has focused on the participation of the oxygenated metabolites of arachidonic acid (eicosanoids) in the pathophysiology and treatment of human diseases. One pathway of arachidonic acid oxygenation leads to the formation of prostaglandins and related molecules; the initial step in their formation is catalyzed by one of the two cyclooxygenase enzymes, which are inhibited by aspirin and the nonsteroidal anti-inflammatory drugs. One of these enzymes, cyclooxygenase-2 (COX-2), is an inducible enzyme, the biosynthesis of which is stimulated by growth factors, cytokines, and endotoxin, and is inhibited by glucocorticoids.
We are investigating the mechanisms for interindividual variation in the effects of aspirin as an antiplatelet drug employed as a cardioprotective agent. This research is based on our discovery that the irrreversible inhibition of the platelet cycloxygenase-1 is regulated by the redox status of the enzyme. Also under study are the changes in the platelet proteome associated with loss of aspirin's effect on continued administration.
We have found that the delayed vasospasm that can cause severe neurological deficits in subarachnoid hemorrhage is temporally associated with and hypothetically caused by lipid peroxidation resulting from hemoglobin radicals. Our research has identified agents that can inhibit such hemoprotein lcatalyzed ipid peroxidation in vitro and in vivo. We are now investigating a series of hemprotein reductants to determine the compounds most potent in reducing hemoprotein catalyzed lipid peroxidation with the aim of developing a treatment strategy for not only subarachnoid hemorrhage, but also other diseases in which hemoprotein catalyzed lipid peroxidation contributes to the pathophysiology including rhabdomyolysis, myocardial infarction, sickle cell disease, and malaria.
Work on Alzheimer's disease addresses a highly reactive keto-aldehyde product of the cyclooxygenases called levuglandin. We discovered that levuglandins can greatly accelerate the oligomerization of amyloid beta and that the oligomers so formed are neurotoxic. Moreover, we have developed mass spectrometric methods for measuring protein adducts of the levuglandins, and find that they are increased by 12 fold in the brains of patients who died of Alzheimer's disease. W are now working with scavengers of the levuglandins that prevent their reaction with proteins to determine their effects in transgenic mouse models of Alzheimer's disease. Other work addresses mechanisms for decreasing amyloid beta biosynthesis by enhancing cleavage of its precursor protein by the alpha -secretase enzyme.


Clinical Research Description
The participation of the cyclooxygenase enzyme in evolution of highly malignant cancers. Mechanisms determining resistance to aspirin. Methods for assessing activation of platelets in humans. Translational research in subarachnoid hemorrhage.

Publications
Adler, DH, Cogan, JD, Phillips, JA, Schnetz-Boutaud, N, Milne, GL, Iverson, T, Stein, JA, Brenner, DA, Morrow, JD, Boutaud, O, Oates, JA. Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction. J Clin Invest, 118(6), 2121-31, 2008 PMCID:2350426

Babaev, VR, Chew, JD, Ding, L, Davis, S, Breyer, MD, Breyer, RM, Oates, JA, Fazio, S, Linton, MF. Macrophage EP4 deficiency increases apoptosis and suppresses early atherosclerosis. Cell Metab, 8(6), 492-501, 2008 PMCID:2614698

Bala, M, Chin, CN, Logan, AT, Amin, T, Marnett, LJ, Boutaud, O, Oates, JA. Acetylation of prostaglandin H2 synthases by aspirin is inhibited by redox cycling of the peroxidase. Biochem Pharmacol, 75(7), 1472-81, 2008 PMCID:2693035

Jackson, AL, Oates, JA. A patient with adult erythermalgia: evidence suggesting an autoimmune etiology. Am J Med Sci, 335(4), 320-2, 2008

Roberts, LJ, Oates, JA, Linton, MF, Fazio, S, Meador, BP, Gross, MD, Shyr, Y, Morrow, JD. The relationship between dose of vitamin E and suppression of oxidative stress in humans. Free Radic Biol Med, 43(10), 1388-93, 2007 PMCID:2072864

Boutaud, O, Montine, TJ, Chang, L, Klein, WL, Oates, JA. PGH-derived levuglandin adducts increase the neurotoxicity of amyloid beta1-42. J Neurochem, 96(4), 917-23, 2006 PMCID:1621054

Davies, SS, Brantley, EJ, Voziyan, PA, Amarnath, V, Zagol-Ikapitte, I, Boutaud, O, Hudson, BG, Oates, JA, Roberts, LJ. Pyridoxamine analogues scavenge lipid-derived gamma-ketoaldehydes and protect against H2O2-mediated cytotoxicity. Biochemistry, 45(51), 15756-67, 2006 PMCID:2597444

Boutaud, O, Andreasson, KI, Zagol-Ikapitte, I, Oates, JA. Cyclooxygenase-dependent lipid-modification of brain proteins. Brain Pathol, 15(2), 139-42, 2005

Burleigh, ME, Babaev, VR, Patel, MB, Crews, BC, Remmel, RP, Morrow, JD, Oates, JA, Marnett, LJ, Fazio, S, Linton, MF. Inhibition of cyclooxygenase with indomethacin phenethylamide reduces atherosclerosis in apoE-null mice. Biochem Pharmacol, 70(3), 334-42, 2005

Burleigh, ME, Babaev, VR, Yancey, PG, Major, AS, McCaleb, JL, Oates, JA, Morrow, JD, Fazio, S, Linton, MF. Cyclooxygenase-2 promotes early atherosclerotic lesion formation in ApoE-deficient and C57BL/6 mice. J Mol Cell Cardiol, 39(3), 443-52, 2005

McAdam, BF, Byrne, D, Morrow, JD, Oates, JA. Contribution of cyclooxygenase-2 to elevated biosynthesis of thromboxane A2 and prostacyclin in cigarette smokers. Circulation, 112(7), 1024-9, 2005

Smith, LH, Petrie, MS, Morrow, JD, Oates, JA, Vaughan, DE. The sterol response element binding protein regulates cyclooxygenase-2 gene expression in endothelial cells. J Lipid Res, 46(5), 862-71, 2005

Zagol-Ikapitte, I, Masterson, TS, Amarnath, V, Montine, TJ, Andreasson, KI, Boutaud, O, Oates, JA. Prostaglandin H(2)-derived adducts of proteins correlate with Alzheimer''s disease severity. J Neurochem, 94(4), 1140-5, 2005

Brame, CJ, Boutaud, O, Davies, SS, Yang, T, Oates, JA, Roden, D, Roberts, LJ. Modification of proteins by isoketal-containing oxidized phospholipids. J Biol Chem, 279(14), 13447-51, 2004

Murphey, LJ, Williams, MK, Sanchez, SC, Byrne, LM, Csiki, I, Oates, JA, Johnson, DH, Morrow, JD. Quantification of the major urinary metabolite of PGE2 by a liquid chromatographic/mass spectrometric assay: determination of cyclooxygenase-specific PGE2 synthesis in healthy humans and those with lung cancer. Anal Biochem, 334(2), 266-75, 2004

Zagol-Ikapitte, I, Bernoud-Hubac, N, Amarnath, V, Roberts, LJ, Boutaud, O, Oates, JA. Characterization of bis(levuglandinyl) urea derivatives as products of the reaction between prostaglandin H2 and arginine. Biochemistry, 43(18), 5503-10, 2004

Aronoff, DM, Boutaud, O, Marnett, LJ, Oates, JA. Inhibition of prostaglandin H2 synthases by salicylate is dependent on the oxidative state of the enzymes. J Pharmacol Exp Ther, 304(2), 589-95, 2003

Boutaud, O, Dixon, DA, Oates, JA, Sawaoka, H. Tristetraprolin binds to the COX-2 mRNA 3' untranslated region in cancer cells. Adv Exp Med Biol, 525, 157-60, 2003

Boutaud, O, Li, J, Zagol, I, Shipp, EA, Davies, SS, Roberts, LJ, Oates, JA. Levuglandinyl adducts of proteins are formed via a prostaglandin H2 synthase-dependent pathway after platelet activation. J Biol Chem, 278(19), 16926-8, 2003

Sawaoka, H, Dixon, DA, Oates, JA, Boutaud, O. Tristetraprolin binds to the 3'-untranslated region of cyclooxygenase-2 mRNA. A polyadenylation variant in a cancer cell line lacks the binding site. J Biol Chem, 278(16), 13928-35, 2003

Tang, YW, Johnson, JE, Browning, PJ, Cruz-Gervis, RA, Davis, A, Graham, BS, Brigham, KL, Oates, JA, Loyd, JE, Stecenko, AA. Herpesvirus DNA is consistently detected in lungs of patients with idiopathic pulmonary fibrosis. J Clin Microbiol, 41(6), 2633-40, 2003 PMCID:156536

Boutaud, O, Aronoff, DM, Richardson, JH, Marnett, LJ, Oates, JA. Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H(2) synthases. Proc Natl Acad Sci U S A, 99(10), 7130-5, 2002 PMCID:124540

Boutaud, O, Ou, JJ, Chaurand, P, Caprioli, RM, Montine, TJ, Oates, JA. Prostaglandin H2 (PGH2) accelerates formation of amyloid beta1-42 oligomers. J Neurochem, 82(4), 1003-6, 2002

Burleigh, ME, Babaev, VR, Oates, JA, Harris, RC, Gautam, S, Riendeau, D, Marnett, LJ, Morrow, JD, Fazio, S, Linton, MF. Cyclooxygenase-2 promotes early atherosclerotic lesion formation in LDL receptor-deficient mice. Circulation, 105(15), 1816-23, 2002

Cox, B, Murphey, LJ, Zackert, WE, Chinery, R, Graves-Deal, R, Boutaud, O, Oates, JA, Coffey, RJ, Morrow, JD. Human colorectal cancer cells efficiently conjugate the cyclopentenone prostaglandin, prostaglandin J(2), to glutathione. Biochim Biophys Acta, 1584(1), 37-45, 2002

Nakayama T, Soma M, Watanabe Y, Hasimu B, Sato M, Aoi N, Kosuge K, Kanmatsuse K, Kokubun S, Morrow JD, Oates JA. Splicing mutation of the prostacyclin synthase gene in a family associates with hypertension. Biochem biophys res Commun, 297(5), 1135-9, 2002

Sheller J, Dworski R, Hagaman D, Oates J, Murray J. The prostaglandin E agonist, misoprostol, inhibits airway IL-5 production in atopic asthmatics. Prostaglandins Other Lipid Mediat, 70(1-2), 185-93, 2002

Smith, LH, Boutaud, O, Breyer, M, Morrow, JD, Oates, JA, Vaughan, DE. Cyclooxygenase-2-dependent prostacyclin formation is regulated by low density lipoprotein cholesterol in vitro. Arterioscler Thromb Vasc Biol, 22(6), 983-8, 2002

Boutaud, O, Brame, CJ, Chaurand, P, Li, J, Rowlinson, SW, Crews, BC, Ji, C, Marnett, LJ, Caprioli, RM, Roberts, LJ, Oates, JA. Characterization of the lysyl adducts of prostaglandin H-synthases that are derived from oxygenation of arachidonic acid. Biochemistry, 40(23), 6948-55, 2001

Boutaud, O, Li, J, Chaurand, P, Brame, CJ, Marnett, LJ, Roberts, LJ, Oates, JA. Oxygenation of arachidonic acid by cyclooxygenases generates reactive intermediates that form adducts with proteins. Adv Exp Med Biol, 500, 133-7, 2001

Hartert, TV, Dworski, RT, Mellen, BG, Oates, JA, Murray, JJ, Sheller, JR. Prostaglandin E(2) decreases allergen-stimulated release of prostaglandin D(2) in airways of subjects with asthma. Am J Respir Crit Care Med, 162(2 Pt 1), 637-40, 2000

Murphey, LJ, Hachey, DL, Oates, JA, Morrow, JD, Brown, NJ. Metabolism of bradykinin In vivo in humans: identification of BK1-5 as a stable plasma peptide metabolite. J Pharmacol Exp Ther, 294(1), 263-9, 2000

Sheller JR, Mitchell D, Meyrick B, Oates J, Breyer R. EP2 receptor mediates bronchodilation by PGE2 in mice. J Appl Physiol, 88, 2214-2218, 2000

Tellioglu T, Oates JA, Biaggioni I. Muchausen's syndrome presenting as a baroreflex failure. N Engl J Med, 343(8), 581, 2000

Boutaud, O, Brame, CJ, Salomon, RG, Roberts, LJ, Oates, JA. Characterization of the lysyl adducts formed from prostaglandin H2 via the levuglandin pathway. Biochemistry, 38(29), 9389-96, 1999

Boutaud, Olivier, Brame, Cynthia J., Salomon, Robert G., Roberts II, Jackson, and Oates, John A. Characterization of the lysyl adducts formed from prostaglandin H2 via the levuglanding pathway. Biochemistry, 38(29), 9389-9396, 1999

Chinery, R, Coffey, RJ, Graves-Deal, R, Kirkland, SC, Sanchez, SC, Zackert, WE, Oates, JA, Morrow, JD. Prostaglandin J2 and 15-deoxy-delta12,14-prostaglandin J2 induce proliferation of cyclooxygenase-depleted colorectal cancer cells. Cancer Res, 59(11), 2739-46, 1999

Chinery, Rebecca, Coffey, Robert J., Graves-Deal Ramona, Kirkland, Susan C., Sanchez, Stephanie E., Zackert, William, E., Oates, John, Morrow, Jason D. Prostaglandin J2 and 15-deoxy-delta 12, 14- prostaglandin J2 induce proliferation of cyclooxygenase-depleted colorectal cancer cells. Cancer Res , 59(11), 2739-46, 1999

Dworski, R, Murray, JJ, Roberts, LJ, Oates, JA, Morrow, JD, Fisher, L, Sheller, JR. Allergen-induced synthesis of F(2)-isoprostanes in atopic asthmatics. Evidence for oxidant stress. Am J Respir Crit Care Med, 160(6), 1947-51, 1999

Goldstein, RE, O'Neill, JA, Holcomb, GW, Morgan, WM, Neblett, WW, Oates, JA, Brown, N, Nadeau, J, Smith, B, Page, DL, Abumrad, NN, Scott, HW. Clinical experience over 48 years with pheochromocytoma. Ann Surg, 229(6), 755-64; discussion 764-6, 1999 PMCID:1420821

Kennedy, CR, Zhang, Y, Brandon, S, Guan, Y, Coffee, K, Funk, CD, Magnuson, MA, Oates, JA, Breyer, MD, Breyer, RM. Salt-sensitive hypertension and reduced fertility in mice lacking the prostaglandin EP2 receptor. Nat Med, 5(2), 217-20, 1999

Kennedy, Christopher RJ., Zhang, Yahua, Brandon, Suzanne, Guan, Youfei, Coffee, Keith, Funk, Colin D., Magnuson, Mark A., Oates, John, Breyer, Matthew D., and Breyer, Richard M. Salt-sensitive hypertension and reduced fertility in mice lacking the prostaglandin EP2 receptor. Nat Med, 52(2), 217-20, 1999

Morrow, JD, Oates, JA, Roberts, LJ, Zackert, WE, Mitchell, TA, Lazarus, G, Guzzo, C. Increased formation of thromboxane in vivo in humans with mastocytosis. J Invest Dermatol, 113(1), 93-7, 1999

Morrow, JD, Zackert, WE, Yang, JP, Kurhts, EH, Callewaert, D, Dworski, R, Kanai, K, Taber, D, Moore, K, Oates, JA, Roberts, LJ. Quantification of the major urinary metabolite of 15-F2t-isoprostane (8-iso-PGF2alpha) by a stable isotope dilution mass spectrometric assay. Anal Biochem, 269(2), 326-31, 1999

Denney, WD, Kemp, WE, Anthony, LB, Oates, JA, Byrd, BF. Echocardiographic and biochemical evaluation of the development and progression of carcinoid heart disease. J Am Coll Cardiol, 32(4), 1017-22, 1998

Dworski, RT, Funk, CD, Oates, JA, Sheller, JR. Prednisone increases PGH-synthase 2 in atopic humans in vivo. Am J Respir Crit Care Med, 155(1), 351-7, 1997

Roberts, LJ, Moore, KP, Zackert, WE, Oates, JA, Morrow, JD. Identification of the major urinary metabolite of the F2-isoprostane 8-iso-prostaglandin F2alpha in humans. J Biol Chem, 271(34), 20617-20, 1996

Anthony, LB, May, ME, Oates, JA. Case report: lanreotide in the management of hypercalcemia of malignancy. Am J Med Sci, 309(6), 312-4, 1995

Morrow, J.D., Frei, B., Longmire, A.W., Gaziano, J.M., Lynch, S.M., Shyr, Y., Strauss, W.E., Oates, J.A., Roberts, L.J., II. Increase in circulating products of lipid peroxidation (F2-isoprostanes) in smokers: Smoking as a cause of oxidative damage. N Engl J Med , 332(18), 1198-03, 1995

Morrow, JD, Frei, B, Longmire, AW, Gaziano, JM, Lynch, SM, Shyr, Y, Strauss, WE, Oates, JA, Roberts, LJ. Increase in circulating products of lipid peroxidation (F2-isoprostanes) in smokers. Smoking as a cause of oxidative damage. N Engl J Med, 332(18), 1198-203, 1995

Morrow, JD, Guzzo, C, Lazarus, G, Oates, JA, Roberts, LJ. Improved diagnosis of mastocytosis by measurement of the major urinary metabolite of prostaglandin D2. J Invest Dermatol, 104(6), 937-40, 1995

Murray, JJ, Mullins, MD, Knapp, HR, Keller, SL, Serafin, WE, Roberts, LJ, Struthers, BJ, Oates, JA. Regulation of the Immune Response by Eicosanoids: Pharmacology and Clinical Effects of Prostaglandin E in Aspirin-Sensitive Syndromes. Am J Ther, 2(10), 739-748, 1995

Oates, JA. Introduction: Misoprostol and Eicosanoid Symposium. Am J Ther, 2(9), 591-594, 1995

Dworski, R., Fitzgerald, G.A., Oates, J.A., Sheller, J.R. Effect of oral prednisone on airway inflammatory mediators in atopic asthma. Am J Repir Crit Care Med, 149, 953-959, 1994

Morrow, JD, Awad, JA, Oates, JA, Roberts, LJ. Identification of skin as a major site of prostaglandin D2 release following oral administration of niacin in humans. J Invest Dermatol, 98(5), 812-5, 1992

Legrand, AB, Lawson, JA, Meyrick, BO, Blair, IA, Oates, JA. Substitution of 15-hydroxyeicosatetraenoic acid in the phosphoinositide signaling pathway. J Biol Chem, 266(12), 7570-7, 1991

Morrow, JD, Prakash, C, Awad, JA, Duckworth, TA, Zackert, WE, Blair, IA, Oates, JA, Roberts, LJ. Quantification of the major urinary metabolite of prostaglandin D2 by a stable isotope dilution mass spectrometric assay. Anal Biochem, 193(1), 142-8, 1991

Morrow, JD, Prakash, C, Duckworth, TA, Zackert, WE, Blair, IA, Oates, JA, Roberts, LJ. A stable isotope dilution mass spectrometric assay for the major urinary metabolite of PGD2. Adv Prostaglandin Thromboxane Leukot Res, 21A, 315-8, 1991

Mosqueda-Garcia, R, Oates, JA, Appalsamy, M, Robertson, D. Administration of carbamazepine in the nucleus of the solitary tract inhibits the antihypertensive effect of clonidine. Eur J Pharmacol, 197(2-3), 213-6, 1991

Roberts, LJ, Oates, JA. Biochemical diagnosis of systemic mast cell disorders. J Invest Dermatol, 96(3), 19S-24S; discussion 24S-25S, 1991

Roberts, LJ, Oates, JA. Biochemical diagnosis of systemic mast cell disorders. J Invest Dermatol, 96(3 Suppl), 19S-24S; discussion 24S-25S; 60S-65S, 1991

Murray, JJ, Nowak, J, Oates, JA, FitzGerald, GA. Platelet-vessel wall interactions in individuals who smoke cigarettes. Adv Exp Med Biol, 273, 189-98, 1990

Sebaldt, RJ, Sheller, JR, Oates, JA, Roberts, LJ, FitzGerald, GA. Inhibition of eicosanoid biosynthesis by glucocorticoids in humans. Proc Natl Acad Sci U S A, 87(18), 6974-8, 1990 PMCID:54664

Smith, S, Anthony, L, Roberts, LJ, Oates, JA, Pincus, T. Resolution of musculoskeletal symptoms in the carcinoid syndrome after treatment with the somatostatin analog octreotide. Ann Intern Med, 112(1), 66-8, 1990

Brash, AR, Yokoyama, C, Oates, JA, Yamamoto, S. Mechanistic studies of the dioxygenase and leukotriene synthase activities of the porcine leukocyte 12S-lipoxygenase. Arch Biochem Biophys, 273(2), 414-22, 1989

Dworski, R, Sheller, JR, Wickersham, NE, Oates, JA, Brigham, KL, Roberts, LJ, Fitzgerald, GA. Allergen-stimulated release of mediators into sheep bronchoalveolar lavage fluid. Effect of cyclooxygenase inhibition. Am Rev Respir Dis, 139(1), 46-51, 1989

Oates, JA. Aspirin in the prevention of catastrophes of the coronary circulation. Adv Prostaglandin Thromboxane Leukot Res, 19, 57-63, 1989

Oates, JA. The Jeremiah Metzger lecture. Participation of eicosanoids in the syndromes of myocardial ischemia. Trans Am Clin Climatol Assoc, 101, 154-60, 1989 PMCID:2376512

Brigham, KL, Serafin, W, Zadoff, A, Blair, I, Meyrick, B, Oates, JA. Prostaglandin E2 attenuation of sheep lung responses to endotoxin. J Appl Physiol, 64(6), 2568-74, 1988

Bruch, JS, Stein, RS, Oates, JA. Hypertension complicating essential thrombocythemia. Am J Med Sci, 295(5), 466-8, 1988

FitzGerald, GA, Oates, JA, Nowak, J. Cigarette smoking and hemostatic function. Am Heart J, 115(1 Pt 2), 267-71, 1988

Oates, JA. Antagonism of antihypertensive drug therapy by nonsteroidal anti-inflammatory drugs. Hypertension, 11(3 Pt 2), II4-6, 1988

Oates, JA, FitzGerald, GA, Branch, RA, Jackson, EK, Knapp, HR, Roberts, LJ. Clinical implications of prostaglandin and thromboxane A2 formation (2). N Engl J Med, 319(12), 761-7, 1988

Oates, JA, FitzGerald, GA, Branch, RA, Jackson, EK, Knapp, HR, Roberts, LJ. Clinical implications of prostaglandin and thromboxane A2 formation (1). N Engl J Med, 319(11), 689-98, 1988

Parris, WC, Oates, JA, Kambam, J, Shmerling, R, Sawyers, JF. Pre-treatment with somatostatin in the anaesthetic management of a patient with carcinoid syndrome. Can J Anaesth, 35(4), 413-6, 1988

Brash, AR, Oates, JA, Yokoyama, C, Yamamoto, S. Mechanism of transformation of 15(S)-hydroperoxyeicosatetraenoic acid to 15-series leukotrienes by purified porcine leukocyte 12-lipoxygenase. Adv Prostaglandin Thromboxane Leukot Res, 17A, 75-7, 1987

Nowak, J, Murray, JJ, FitzGerald, GA, Wehr, CJ, Hammon, JW, Oates, JA. Eicosanoids and sudden cardiac death. Adv Prostaglandin Thromboxane Leukot Res, 17A, 20-4, 1987

Scott, HW, Parris, WC, Sandidge, PC, Oates, JA, Roberts, LJ. Hazards in operative management of patients with systemic mastocytosis. Ann Surg, 197(5), 507-14, 1983 PMCID:1353019

Scott, HW, Dean, RH, Lea, JW, Waterhouse, G, Sussman, C, Robertson, D, Oates, JA. Surgical experience with retrogastric and retropancreatic pheochromocytomas. Surgery, 92(5), 853-65, 1982

Scott, HW, Reynolds, V, Green, N, Page, D, Oates, JA, Robertson, D, Roberts, S. Clinical experience with malignant pheochromocytomas. Surg Gynecol Obstet, 154(6), 801-18, 1982

Dean, RH, Oates, JA, Wilson, JP, Rhamy, RK, Hollifield, JW, Burko, H, Foster, JH. Bilateral renal artery stenosis and renovascular hypertension. Surgery, 81(1), 53-60; discussion 60-2, 1977

Scott, HW, Oates, JA, Nies, AS, Burko, H, Page, DL, Rhamy, RK. Pheochromocytoma: present diagnosis and management. Ann Surg, 183(5), 587-93, 1976 PMCID:1344352

Chang LCT, Splawinski JA, Oates JA, Nies AS. Enhanced renal prostaglandin production in the dog, II: Effects on intra-renal hemodynamics. Circ Res, 36(1), 204-7, 1975

Danon A, Chang LCT, Sweetman BJ, Nies AS, Oates JA. Synthesis of prostaglandins by the rat renal papilla in vitro: Mechanism of stimulation by angiotensin II. Biochimica et Biophys Acta, 388(1), 71-83, 1975

Danon A, Heimberg M, Oates JA. Enrichment of rat tissue lipids with fatty acids that are prostaglandin precursors. Biochimica et Biophys Acta, 388(3), 318-330, 1975

Frolich JC, Wilson TW, Sweetman BJ, Smigel M, Nies AS, Carr K, Watson JT, Oates JA. Urinary Prostaglandins: Identification and origin. J Clin Invest, 55(4), 763-70, 1975

Tannenbaum J, Splawinski JA, Oates JA, Nies AS. Enhanced renal prostaglandin production in the dog, I: Effects on renal function. Cir res, 36(1), 197-203, 1975

Fann WE, Davis JM, Janowsky DS, Kaufmann JS, Cavanaugh JH, Oates JA. Effect of antidepressant and antimanicc drugs on amine uptake in man. J Nerv & Mental Disease, 158(5), 361-368, 1974

Frolich JC, Wilson TW, Smigel M, Oates JA. A competitive protein binding assay specific for prostaglandin E. Biochimica et Biophys Acta, 348(2), 241-48, 1974

Hengstmann JH, Falkner FC, Watson JT, Oates JA. Quantitative determination of guanethidine and other guanido-containg drugs in biological fluids by gas chromatography with flame ionization detection and multiple ion detection. Analytical Chemistry, 46, 35-39, 1974

Bieck PR, Oates JA, Robison GA, Adkins RB. Cyclic AMP in the regulation of gastric secretion in dogs and humans. Am J Physiol, 224(1), 158-64, 1973

Rangno RE, Kaufmann JS, Cavanaugh JH, Island D, Watson JT, Oates JA. Effects of a false neurotransmitter, p-hydroxynorephedrine, on the function of adrenergic neurons in hypertensive patients. J Clin Invest, 52(4), 952-960, 1973

Shand DG, Morgan DH, Oates JA. The release of guanethidine and bethanidine by splenic nerve stimulation: A quantitative evaluation showing dissociation from adrenergic blockade. J Pharmacol Exp Ther, 184(1), 73-80, 1973

Splawinski JA, Nies AS, Sweetman B, Oates JA. The effects of arachidonic acid, prostaglandin E2 and prostaglandin F2α on the longitudinal stomach strip of the rat. J Pharmacol Exp Ther, 187(3), 501-10, 1973

Sweetman BJ, Watson JT, Carr K, Oates JA, Frolich JC . Quantitative vapor-phase analysis of prostaglandin F2α in female human urine. Prostaglandins, 3(3), 385-87, 1973

Watson JT, Pelster DR, Sweetman BJ, Frolich JC, Oates JA. Display-oriented data system for multiple ion detection with gas chromatography-mass spectrometry in quantifying biomedically important compunds. Analytical Chemistry, 45(12), 2071-78, 1973

Fann WE, Davis JM, Janowsky DS, Cavanaugh JH, Kaufmann JS, Griffith JD, Oates JA. Effects of lithium on adrenergic function in man. Clin Pharmacol Ther, 13(1), 71-77, 1972

Fann WE, Davis JM, Janowsky DS, Kaufmann JS, Griffith JD, Oates JA. Effect of iprindole on amine uptake in man. Arch Gen Psychiatry, 26(2), 158-162, 1972

Gerber N, Lynn R, Oates JA. Acute intoxication with 5,5-diphenyl-hydantoin (Dilantin) associated with impairment of biotransformation. Ann Intern Med, 77, 765-771, 1972

Griffith JD, Cavanaugh J, Held J, Oates JA. Dextroamphetamine: Evaluation of psychotominetic properties in man. Arch Gen Psychiatry, 26(2), 97-100, 1972

Klatte EC, Babb OW, Burko H, Foster JH, Rhamy RK, Oates JA. The roentgenographic pre and postoperative assessment of patients with renovascular disease. Am J Roentgenol Radium Ther Nucl Med, 114(4), 696-709, 1972

McAllister RG Jr, Michelakis AM, Oates JA, Foster JH. malignant hypertension due to renal artery stenosis. Greater renin release from the nonstenotic kidney. JAMA, 221(8), 865-68, 1972

Fan WE, Janowsky DS, Davis JM, Oates JA. Chlorpromazine reversal of the antihypertensive action of quanethidine. Lancet, 2(721), 436-437, 1971

Klatte EC, Worrell JA, Foster JH, Phamy RK, Burko H, Michelakis AM, Oates JA. Diagnostic criteria of bilateral renovascular hypertension. Radiology, 101(2), 301-4, 1971

McAllister RG Jr, Van Way CW III, Dayani K, Anderson WJ, Temple E, Michelakis AM, Coppage WS Jr, Oates JA. Malignant hypertension:Effect of therapy on renin and aldosterone. Circ Res Suppl, 28(5), Sppl 2:160-74, 1971

Shand DG, Cavanaugh JH, Oates JA. The fate of SU-13197, a new antiarrhythmic drug, in rat and man. Clin Pharmacol Ther, 12(5), 769-78, 1971

Shand DG, Oates JA. metabolism of propranolol by rat liver microsomes and its inhibition by phenothiazine and tricyclic antidepressant drugs. Biochem pharmacol, 20(7), 1720-23, 1971

Shand DG, Sell CG, Oates JA. Hypertrophic obstructive cardiomyopathy in an infant:Propranolol therapy for 3 years. N Engl J med, 285(15), 843-44, 1971

. Effects on transport of biogenic amines in man. Psychopharmacologica, 22(2), 111-25, 1971

Cavanaugh JH, Griffith JD, Oates JA. Effect of amphetamine on the pressor response to tyramine:Formation of p-hydroxynorephedrine from amphetamine in man. Clin Pharmacol Ther, 11(5), 656-664, 1970

Flegin OT, Morgan DH, Oates JA, Shand DG. The mechanism of the reversal of the effect of quanethidine by amphetamines in cat and man. Br J Pharm, 39, 253P-254P, 1970

Mitchell JR, Cavanaugh JH, Arias L, Oates JA. Guanethidine and related agents: III. Antagonism by drugs which inhibit the norepinephrine pump in man. J Clin Invest, 49(8), 1596-1604, 1970

Mitchell JR, Cavanaugh JH, Dingell JV, Oates JA. Guanethidine and related agents: II. Metabolism by hepatic microsomes and its inhibition by drugs. J Pharmacology & Experimental Therapeutics, 172, 108-114, 1970

Mitchell JR, Oates JA. Guanethidine and related agents:I. Mechanism of the selective blockade of adrenergic neurons and its antagonism by drugs. J Pharmacology & Experimental Therapeutics, 172, 100-107, 1970

Morgan DH, Oates JA, Shand DG. Evidence that quanethidine does not block adrenergic nerves by acting as a false transmitter. Br J pharmacol, 39(1), 186P-187P, 1970

Shand DG, Nuckolls EM, Oates JA. Plasma propranolol levels in adults with observations in four children. Clin Pharmacol Ther, 11, 112-120, 1970

Foster JH, Phamy RK, Oates JA, Klatte EC, Burko HC, Michelakis AM. Renovascular hypertension secondary to atherosclerosis. Am J Med, 46(5), 741-750, 1969

Foster JH, Rhamy RK, Oates JA, Klatte EC, Burko HC, Michelakis AM. Hypertension and fibromuscular dysplasia of the renal arteries. Surgery, 65, 157-181, 1969

Oates JA, Fann WE, Cavanaugh JH. Effect of doxepin on the norepinephrine pump. Psychosomatics, 10(3), 12-13, 1969

Van Way CW, Anderson WJ, Michelaskis AM, Manlove A, Oates JA. The role of renin in coarctation of the aorta. Surg Forum, 20, 207-209, 1969

DesPrez RM, Oates JA. Lack of relationship of febrile response to endotoxin and brain stem 5-hydroxytryptamine. Proc Soc Exp Biol Med, 127, 793-794, 1968

Malmquist J, Oates JA. Effects of adrenergic neuron-blocking quanidine derivatives on mitochondrial metabolism. Biochem Pharmacol, 17(9), 1845-1854, 1968

Pettinger WA, OatesJA. Supersensitivity to tyramine during monoamine oxidase inhibition in man. Clin Pharmacol Therap, 9, 341-344, 1968

Pettinger WA, Soyangco FG, Oates JA. Inhibition of monoamine oxidase in man by furazolidone. Clin Pharmacol Therap, 9, 442-447, 1968

Mitchell JR, Arias L, Oates JA. Antagonism of the antihypertensive action of quanethidine sulfate by desipramine hydrochloride. JAMA, 202(10), 973-976, 1967

Zachariae H, malmquist J, Oates JA, Pettinger W. Studies on mechanism of kinin formation in inflammation. J Physiol, 190, 81-90, 1967

DesPrez R, Helman R, Oates JA. Inhibition of endotoxin fever by reserpine. Proc Soc Exp Biol and Med, 122, 746-749, 1966

Foster JH, Oates JA, Rhamy RK, Klatte EC, Pettinger WA, Burko H, Younger RK, Scott HW Jr. Detection and treatment of patients with renovascular hypertension. Surgery, 60, 240-252, 1966

Foster JH, Pettinger WA, Oates JA, Rhamy RK, Klatte EC, Burko HC, Bolasny BL, Gordon RD, Puyau FA, Younger BS. Malignant hypertension secondary to renal artery stenosis in children. Ann Surgery, 164(4), 700-713, 1966

Oates JA, Pettinger WA, Doctor RB. Evidence for the release of bradykinin in carcinoid syndrome. J Clin Invest, 45(2), 173-178, 1966

Zachariae H, Malmquist J, Oates JA. Kininase in himan polymorphonuclear leukocytes. Life Sciences, 5, 2347-2355, 1966

Zachariae H, Oates JA. Effect of pH on an experimental kinin forming system in rat subcutaneous tissue. J Invest Dermatol, 47, 493-496, 1966

Melmon KL, Sjoerdsma A, Oates JA, Laster L. Treatment of malabsorption and diarrhea of the carcinoid sundrome with methysergide. Gastroenterology, 48(1), 18, 1965

Oates JA, Seligmann AW, Clark MA, Rousseau P, Lee RE. The relative efficacy of quanethidine, methylodopa and pargyline as antihypertensive agents. N Engl J Med, 273(14), 729-734, 1965

Hodge JV, Oates JA, Sjoerdsma A. Reduction of the central effects of tryptophan by a decarboxylase inhibitor. Clin Pharmacol Ther, 5(2), 149-155, 1964

Melmon KL, Rivlin R, Oates JA, Sjoerdsma A. Further studies of plasma tyrosine in patients with altered thyroid function. J Clin Endocrinol and Metab, 24(8), 691-698, 1964

Oates JA, Melmon K, Sjoerdsma A, Gillespie L, Mason DT. Release of a kinin peptide in the carcinoid syndrome. Lancet, 1(1), 514-17, 1964

Oates JA, Nirenberg PA, Jepson JB, Sjoerdsma A, Udenfriend S. Conversation of phenylalamine to phenethylamine in patients with phenylketonuria. Proc Soc Exp Biol Med, 112, 1078, 1963

Gillespie L, Oates JA, Crout JR, Sjoerdsma A. Clinical and chemical studies with α-methyldopa in patients with hypertension. Circulation, 25, 281, 1962

Levine RJ, Oates JA, Vendsalu A, Sjoerdsma A. Studies on the metabolism of aromatic amines in relation to altered thyroid function in man. J Clin Endocrinol Metab, 22, 1242, 1962

Oates JA, Marsh EB, Sjoerdsma A. Studies on histamine in himan urine using a fluorometric method of assay. Clin Chem Acta, 7, 488, 1962

Oates JA, Sjoerdsma A. A unique syndrome associated with secretion of 5-hydroxytryptophan by metastatic gastric carcinoids. Am J Med, 32, 333, 1962

Oates JA, Sjoerdsma A. Metabolism of 5-hydroxy-D-and L-tryptophan in man:Synthesis of serotonin from the D-isomer. Proc Soc Exp Biol Med, 108, 264, 1961

Pisano JJ, Oates JA, Karmen A, Sjoerdsma A, Udenfriend S. Identification of P-hydroxy-α-(methylaminomethyl) benzyl alcohol (synephrine) in human urine. J Biol Chem, 236, 898, 1961

Jepson JB, Lovenberg W, Zaltzman P, Oates JA, Sjoerdsma A, Udenfriend S. Amine metabolism studies in normal and phenylketonuric humans by monoamine oxidase inhibition. Biochem J, 74, 5P, 1960

Oates JA, Gillespie L, Udenfriend S, Sjoerdsma. Amino acid decarboxylase inhibition and blood pressure reduction in man by α-methyldopa. Science, 131, 1890-91, 1960

Oates JA, Sjoerdsma A. Neurologic effects of tryptophan in patients receiving a monoamine oxidase inhibitor. Neurology, 10(12), 1076-78, 1960

Sjoerdsma A, Oates JA, Gillespie L. Quantification of monoamine oxidase inhibition produced by various drugs in man. Proc Soc Exp Biol Med, 103, 485, 1960

Sjoerdsma A, Oates JA, Zaltzman P, Udenfriend S. Serotonin synthesis in carcinoid patients: Its inhibition by α-methyldopa with measurement of associated increases in urinary 5-hydroxytryptophan. New Engl J Med, 263, 585, 1960

Sjoerdsma A, Lovenberg W, Oates JA, Crout JR, Udenfriend S. Alterations in the pattern of amine excretion in man produced by a monamine oxidase inhibitor. Science, 130, 225, 1959

Sjoerdsma A, Oates JA, Zaltzman P, Udenfriend S. Identification and assay of urinary tryptamine: Application as an index of monamine oxidase inhibition in man. JPET, 126:, 217, 1959

Artom C, Lofland HB, Oates JA. In vivo incorporation of diethanolamine into liver lipids. J Biol Chem, 233, 833, 1958


Postdoctoral Position Available
Yes

Postdoctoral Position Details
Post-doctoral position in translational research, oriented to clinical investigation based on mechanistic hypotheses. Areas include optimization of the use of aspirin as a cardioprotective agent, investigation of the function of platelets in cardiovascular disease, basic biology of the platelet, Alzheimer's disease, and development of new therapy for subarachnoid hemorrhage.

Updated Date
03/21/2011