Biomedical Research Education & Training
Faculty Member

Zent, Roy, M.D., Ph.D.
Professor of Medicine
Professor of Cell and Developmental Biology
Thomas F. Frist Sr. Chair in Medicine
Professor of Cancer Biology

Lab Url: N/A

Phone Number: 322-4632

Email Address:

Zent, Roy's picture
Academic history
M.D., University of Witwatersrand, South Africa
M.MED., University of Cape Town, South Africa
Ph.D., University of Toronto, Canada
Postdoc., The Scripps Research Institute, CA, USA
Research Scientist, University of California, San Diego

Office Address   Mailing Address


C-3210 MCN 2372

Research Keywords
Integrin biology, Kidney, Signal transduction, Branching morphogenesis,Kidney,Mouse,Developmental biology,Kidney,Receptor,Renal biology

Research Description
The laboratory works on the basic role of integrins in epithelial cell biology. We utilize the kidney as a model system and perform biochemical techniques, cell biology and transgenic mice to understand the basic mechanisms whereby integrin-ECM interactions modify cell function. In addition, in collaboration with Dr. Charles Sanders, we perform structural functions on integrins utilizing NMR.

Cleghorn, WM, Branch, KM, Kook, S, Arnette, C, Bulus, N, Zent, R, Kaverina, I, Gurevich, EV, Weaver, AM, Gurevich, VV. Arrestins regulate cell spreading and motility via focal adhesion dynamics. Mol Biol Cell, 26(4), 622-35, 2015

Gangadhariah, MH, Luther, JM, Garcia, V, Paueksakon, P, Zhang, MZ, Hayward, SW, Love, HD, Falck, JR, Manthati, VL, Imig, JD, Schwartzman, ML, Zent, R, Capdevila, JH, Pozzi, A. Hypertension is a major contributor to 20-hydroxyeicosatetraenoic acid-mediated kidney injury in diabetic nephropathy. J Am Soc Nephrol, 26(3), 597-610, 2015

Karak??se, E, Geiger, T, Flynn, K, Lorenz-Baath, K, Zent, R, Mann, M, F??ssler, R. The focal adhesion protein PINCH-1 associates with EPLIN at integrin adhesion sites. J Cell Sci, 128(5), 1023-33, 2015

Keller, B, M??hlenkamp, M, Deuschle, E, Siegfried, A, M??ssner, S, Schade, J, Griesinger, T, Katava, N, Braunsdorf, C, Fehrenbacher, B, Jim??nez-Soto, LF, Schaller, M, Haas, R, Genth, H, Retta, SF, Meyer, H, B??ttcher, RT, Zent, R, Sch??tz, M, Autenrieth, IB, Bohn, E. Yersinia enterocolitica exploits different pathways to accomplish adhesion and toxin injection into host cells. Cell Microbiol, 17(8), 1179-204, 2015

Neelisetty, S, Alford, C, Reynolds, K, Woodbury, L, Nlandu-Khodo, S, Yang, H, Fogo, AB, Hao, CM, Harris, RC, Zent, R, Gewin, L. Renal fibrosis is not reduced by blocking transforming growth factor-?? signaling in matrix-producing interstitial cells. Kidney Int, 88(3), 503-14, 2015

Wang, H, Chen, X, Su, Y, Paueksakon, P, Hu, W, Zhang, MZ, Harris, RC, Blackwell, TS, Zent, R, Pozzi, A. p47(phox) contributes to albuminuria and kidney fibrosis in mice. Kidney Int, 87(5), 948-62, 2015

Yazlovitskaya, EM, Tseng, HY, Viquez, O, Tu, T, Mernaugh, G, McKee, KK, Riggins, K, Quaranta, V, Pathak, A, Carter, BD, Yurchenco, P, Sonnenberg, A, B??ttcher, RT, Pozzi, A, Zent, R. Integrin ??3??1 regulates kidney collecting duct development via TRAF6-dependent K63-linked polyubiquitination of Akt. Mol Biol Cell, 26(10), 1857-74, 2015

Yi, Y, Polosukhina, D, Love, HD, Hembd, A, Pickup, M, Moses, HL, Lovvorn, HN, Zent, R, Clark, PE. A Murine Model of K-ras and ??-Catenin Induced Renal Tumors Expresses High Levels of E2F1 and Resembles Human Wilms Tumor. J Urol, 2015

Bryan, L, Ibrahim, T, Zent, R, Fischer, MJ. The kidney research predicament. J Am Soc Nephrol, 25(5), 898-903, 2014

Byron, A, Randles, MJ, Humphries, JD, Mironov, A, Hamidi, H, Harris, S, Mathieson, PW, Saleem, MA, Satchell, SC, Zent, R, Humphries, MJ, Lennon, R. Glomerular cell cross-talk influences composition and assembly of extracellular matrix. J Am Soc Nephrol, 25(5), 953-66, 2014

Lennon, R, Byron, A, Humphries, JD, Randles, MJ, Carisey, A, Murphy, S, Knight, D, Brenchley, PE, Zent, R, Humphries, MJ. Global analysis reveals the complexity of the human glomerular extracellular matrix. J Am Soc Nephrol, 25(5), 939-51, 2014

Miller, CG, Pozzi, A, Zent, R, Schwarzbauer, JE. Effects of high glucose on integrin activity and fibronectin matrix assembly by mesangial cells. Mol Biol Cell, 25(16), 2342-50, 2014

Plosa, EJ, Young, LR, Gulleman, PM, Polosukhin, VV, Zaynagetdinov, R, Benjamin, JT, Im, AM, van der Meer, R, Gleaves, LA, Bulus, N, Han, W, Prince, LS, Blackwell, TS, Zent, R. Epithelial ??1 integrin is required for lung branching morphogenesis and alveolarization. Development, 141(24), 4751-62, 2014

Skrypnyk, N, Chen, X, Hu, W, Su, Y, Mont, S, Yang, S, Gangadhariah, M, Wei, S, Falck, JR, Jat, JL, Zent, R, Capdevila, JH, Pozzi, A. PPAR?? activation can help prevent and treat non-small cell lung cancer. Cancer Res, 74(2), 621-31, 2014

Lee, K, Boyd, KL, Parekh, DV, Kehl-Fie, TE, Baldwin, HS, Brakebusch, C, Skaar, EP, Boothby, M, Zent, R. Cdc42 Promotes Host Defenses against Fatal Infection. Infect Immun, 81(8), 2714-23, 2013

Moik, D, B??ttcher, A, Makhina, T, Grashoff, C, Bulus, N, Zent, R, F??ssler, R. Mutations in the Paxillin-binding Site of Integrin-linked Kinase (ILK) Destabilize the Pseudokinase Domain and Cause Embryonic Lethality in Mice. J Biol Chem, 288(26), 18863-71, 2013

Natarajan, C, Hata, AN, Hamm, HE, Zent, R, Breyer, RM. Extracellular loop II modulates GTP sensitivity of the prostaglandin EP3 receptor. Mol Pharmacol, 83(1), 206-16, 2013

Pozzi, A, Zent, R. Integrins in kidney disease. J Am Soc Nephrol, 24(7), 1034-9, 2013

Bartlett, CS, Boyd, KL, Harris, RC, Zent, R, Breyer, RM. EP1 disruption attenuates end-organ damage in a mouse model of hypertension. Hypertension, 60(5), 1184-91, 2012

Borza, CM, Su, Y, Chen, X, Yu, L, Mont, S, Chetyrkin, S, Voziyan, P, Hudson, BG, Billings, PC, Jo, H, Bennett, JS, Degrado, WF, Eckes, B, Zent, R, Pozzi, A. Inhibition of integrin I?2I?1 ameliorates glomerular injury. J Am Soc Nephrol, 23(6), 1027-38, 2012 PMCID:3386947

Bulus, N, Feral, C, Pozzi, A, Zent, R. CD98 Increases Renal Epithelial Cell Proliferation by Activating MAPKs. PLoS One, 7(6), e40026, 2012 PMCID:3386947

Gewin, L, Vadivelu, S, Neelisetty, S, Srichai, MB, Paueksakon, P, Pozzi, A, Harris, RC, Zent, R. Deleting the TGF-?? receptor attenuates acute proximal tubule injury. J Am Soc Nephrol, 23(12), 2001-11, 2012

Gewin, L, Zent, R. How Does TGF-I? Mediate Tubulointerstitial Fibrosis. Semin Nephrol, 32(3), 228-35, 2012

Lu, Z, Van Horn, WD, Chen, J, Mathew, S, Zent, R, Sanders, CR. Bicelles at low concentrations. Mol Pharm, 9(4), 752-61, 2012

Mathew, S, Lu, Z, Palamuttam, RJ, Mernaugh, G, Hadziselimovic, A, Chen, J, Bulus, N, Gewin, LS, Voehler, M, Meves, A, Ballestrem, C, F??ssler, R, Pozzi, A, Sanders, CR, Zent, R. ??1 integrin NPXY motifs regulate kidney collecting-duct development and maintenance by induced-fit interactions with cytosolic proteins. Mol Cell Biol, 32(20), 4080-91, 2012

Plosa, EJ, Gooding, KA, Zent, R, Prince, LS. Nonmuscle myosin II regulation of lung epithelial morphology. Dev Dyn, 241(11), 1770-81, 2012

Pozzi, A, Zent, R. Hold tight or you''ll fall off: CD151 helps podocytes stick in high-pressure situations. J Clin Invest, 122(1), 13-6, 2012

Praekelt, U, Kopp, PM, Rehm, K, Linder, S, Bate, N, Patel, B, Debrand, E, Manso, AM, Ross, RS, Conti, F, Zhang, MZ, Harris, RC, Zent, R, Critchley, DR, Monkley, SJ. New isoform-specific monoclonal antibodies reveal different sub-cellular localisations for talin1 and talin2. Eur J Cell Biol, 91(3), 180-91, 2012

Shi, M, Pedchenko, V, Greer, BH, Van Horn, WD, Santoro, SA, Sanders, CR, Hudson, BG, Eichman, BF, Zent, R, Pozzi, A. Enhancing integrin ??1 inserted (I) domain affinity to ligand potentiates integrin ??1??1-mediated down-regulation of collagen synthesis. J Biol Chem, 287(42), 35139-52, 2012

Yu, L, Su, Y, Paueksakon, P, Cheng, H, Chen, X, Wang, H, Harris, RC, Zent, R, Pozzi, A. Integrin I?1/Akita double-knockout mice on a Balb/c background develop advanced features of human diabetic nephropathy. Kidney Int, 81(11), 1086-97, 2012

Zent, R, Harris, R. The mammalian kidney. Exp Cell Res, 318(9), v, 2012

Zent, R, Pozzi, A. Connecting the segments. J Am Soc Nephrol, 23(10), 1603-5, 2012

Clark, PE, Polosukhina, D, Love, H, Correa, H, Coffin, C, Perlman, EJ, de Caestecker, M, Moses, HL, Zent, R. I?-Catenin and K-RAS synergize to form primitive renal epithelial tumors with features of epithelial Wilms'' tumors. Am J Pathol, 179(6), 3045-55, 2011

Mathew, S, Chen, X, Pozzi, A, Zent, R. Integrins in renal development. Pediatr Nephrol, 2011

Pozzi, A, Zent, R. Extracellular matrix receptors in branched organs. Curr Opin Cell Biol, 2011

Pozzi, A, Zent, R. TGF-I? Sequestration by Mesangial Cell Integrin I?vI?8 A Novel Mechanism of Glomerular Endothelial Cell Regulation. Am J Pathol, 178(2), 485-9, 2011

Borza, CM, Chen, X, Mathew, S, Mont, S, Sanders, CR, Zent, R, Pozzi, A. Integrin {alpha}1{beta}1 promotes caveolin-1 dephosphorylation by activating T cell protein-tyrosine phosphatase. J Biol Chem, 285(51), 40114-24, 2010

Chen, X, Whiting, C, Borza, C, Hu, W, Mont, S, Bulus, N, Zhang, MZ, Harris, RC, Zent, R, Pozzi, A. Integrin alpha1beta1 regulates epidermal growth factor receptor activation by controlling peroxisome proliferator-activated receptor gamma-dependent caveolin-1 expression. Mol Cell Biol, 30(12), 3048-58, 2010

Clark, PE, Polosukhina, DA, Gyabaah, K, Moses, HL, Thorburn, A, Zent, R. TRAIL and interferon-alpha act synergistically to induce renal cell carcinoma apoptosis. J Urol, 184(3), 1166-74, 2010

Gewin, L, Bulus, N, Mernaugh, G, Moeckel, G, Harris, RC, Moses, HL, Pozzi, A, Zent, R. TGF-beta receptor deletion in the renal collecting system exacerbates fibrosis. J Am Soc Nephrol, 21(8), 1334-43, 2010

He, W, Wang, Y, Zhang, MZ, You, L, Davis, LS, Fan, H, Yang, HC, Fogo, AB, Zent, R, Harris, RC, Breyer, MD, Hao, CM. Sirt1 activation protects the mouse renal medulla from oxidative injury. J Clin Invest, 120(4), 1056-68, 2010 PMCID:2846063

Pozzi, A, Zent, R. ZO-1 and ZONAB interact to regulate proximal tubular cell differentiation. J Am Soc Nephrol, 21(3), 388-90, 2010 PMCID:2846063

Pozzi, A, Zent, R. Regulation of endothelial cell functions by basement membrane- and arachidonic acid-derived products. Wiley Interdiscip Rev Syst Biol Med, 1(2), 254-72, 2010

Riggins, KS, Mernaugh, G, Su, Y, Quaranta, V, Koshikawa, N, Seiki, M, Pozzi, A, Zent, R. MT1-MMP-mediated basement membrane remodeling modulates renal development. Exp Cell Res, 316(17), 2993-3005, 2010

Smeeton, J, Zhang, X, Bulus, N, Mernaugh, G, Lange, A, Karner, CM, Carroll, TJ, F??ssler, R, Pozzi, A, Rosenblum, ND, Zent, R. Integrin-linked kinase regulates p38 MAPK-dependent cell cycle arrest in ureteric bud development. Development, 137(19), 3233-43, 2010

Wang, SE, Yu, Y, Criswell, TL, Debusk, LM, Lin, PC, Zent, R, Johnson, DH, Ren, X, Arteaga, CL. Oncogenic mutations regulate tumor microenvironment through induction of growth factors and angiogenic mediators. Oncogene, 2010

Yamashita, H, Tripathi, M, Harris, MP, Liu, S, Weidow, B, Zent, R, Quaranta, V. The role of a recombinant fragment of laminin-332 in integrin alpha3beta1-dependent cell binding, spreading and migration. Biomaterials, 31(19), 5110-21, 2010

Benjamin, JT, Gaston, DC, Halloran, BA, Schnapp, LM, Zent, R, Prince, LS. The role of integrin alpha8beta1 in fetal lung morphogenesis and injury. Dev Biol, 335(2), 407-17, 2009 PMCID:2846063

Cheng, H, Fan, X, Guan, Y, Moeckel, GW, Zent, R, Harris, RC. Distinct roles for basal and induced COX-2 in podocyte injury. J Am Soc Nephrol, 20(9), 1953-62, 2009 PMCID:2846063

Lange, A, Wickstr??m, SA, Jakobson, M, Zent, R, Sainio, K, F??ssler, R. Integrin-linked kinase is an adaptor with essential functions during mouse development. Nature, 461(7266), 1002-6, 2009 PMCID:2846063

Moser M, Legate KR, Zent R, Fassler R.. The tail of integrins, talin, and kindlins.. Science, 15(324), 895-9, 2009

Moser, M, Legate, KR, Zent, R, F??ssler, R. The tail of integrins, talin, and kindlins. Science, 324(5929), 895-9, 2009 PMCID:2846063

Nystr??m, A, Shaik, ZP, Gullberg, D, Krieg, T, Eckes, B, Zent, R, Pozzi, A, Iozzo, RV. Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity. Blood, 114(23), 4897-906, 2009 PMCID:2846063

Pozzi, A, Voziyan, PA, Hudson, BG, Zent, R. Regulation of matrix synthesis, remodeling and accumulation in glomerulosclerosis. Curr Pharm Des, 15(12), 1318-33, 2009

Pozzi, A, Zent, R, Chetyrkin, S, Borza, C, Bulus, N, Chuang, P, Chen, D, Hudson, B, Voziyan, P. Modification of collagen IV by glucose or methylglyoxal alters distinct mesangial cell functions. J Am Soc Nephrol, 20(10), 2119-25, 2009 PMCID:2846063

Wang, SE, Xiang, B, Zent, R, Quaranta, V, Pozzi, A, Arteaga, CL. Transforming growth factor beta induces clustering of HER2 and integrins by activating Src-focal adhesion kinase and receptor association to the cytoskeleton. Cancer Res, 69(2), 475-82, 2009 PMCID:2629389

Zhang, X, Mernaugh, G, Yang, DH, Gewin, L, Srichai, MB, Harris, RC, Iturregui, JM, Nelson, RD, Kohan, DE, Abrahamson, D, F??ssler, R, Yurchenco, P, Pozzi, A, Zent, R. beta1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting duct structural integrity. Development, 136(19), 3357-66, 2009 PMCID:2846063

Abair, TD, Bulus, N, Borza, C, Sundaramoorthy, M, Zent, R, Pozzi, A. Functional Analysis of the cytoplasmic domain of the integrin {alpha}1 subunit in endothelial cells. Blood, 2008 PMCID:2569176

Abair, TD, Sundaramoorthy, M, Chen, D, Heino, J, Ivaska, J, Hudson, BG, Sanders, CR, Pozzi, A, Zent, R. Cross-talk between integrins alpha1beta1 and alpha2beta1 in renal epithelial cells. Exp Cell Res, 314(19), 3593-604, 2008 PMCID:2729514

Borza, CM, Borza, DB, Pedchenko, V, Saleem, MA, Mathieson, PW, Sado, Y, Hudson, HM, Pozzi, A, Saus, J, Abrahamson, DR, Zent, R, Hudson, BG. Human podocytes adhere to the KRGDS motif of the alpha3alpha4alpha5 collagen IV network. J Am Soc Nephrol, 19(4), 677-84, 2008 PMCID:2390958

Erdogan, M, Pozzi, A, Bhowmick, N, Moses, HL, Zent, R. Transforming growth factor-beta (TGF-beta) and TGF-beta-associated kinase 1 are required for R-Ras-mediated transformation of mammary epithelial cells. Cancer Res, 68(15), 6224-31, 2008

Macias-Perez, I, Borza, C, Chen, X, Yan, X, Ibanez, R, Mernaugh, G, Matrisian, LM, Zent, R, Pozzi, A. Loss of integrin alpha1beta1 ameliorates Kras-induced lung cancer. Cancer Res, 68(15), 6127-35, 2008

Macias-Perez, IM, Zent, R, Carmosino, M, Breyer, MD, Breyer, RM, Pozzi, A. Mouse EP3 alpha, beta, and gamma receptor variants reduce tumor cell proliferation and tumorigenesis in vivo. J Biol Chem, 283(18), 12538-45, 2008 PMCID:2335350

Maginnis, MS, Mainou, BA, Derdowski, A, Johnson, EM, Zent, R, Dermody, TS. NPXY motifs in the beta1 integrin cytoplasmic tail are required for functional reovirus entry. J Virol, 82(7), 3181-91, 2008 PMCID:2268482

Montanez, E, Ussar, S, Schifferer, M, B??sl, M, Zent, R, Moser, M, F??ssler, R. Kindlin-2 controls bidirectional signaling of integrins. Genes Dev, 22(10), 1325-30, 2008 PMCID:2377186

Pozzi, A, Jarad, G, Moeckel, GW, Coffa, S, Zhang, X, Gewin, L, Eremina, V, Hudson, BG, Borza, DB, Harris, RC, Holzman, LB, Phillips, CL, Fassler, R, Quaggin, SE, Miner, JH, Zent, R. Beta1 integrin expression by podocytes is required to maintain glomerular structural integrity. Dev Biol, 316(2), 288-301, 2008 PMCID:2396524

Srichai, MB, Hao, C, Davis, L, Golovin, A, Zhao, M, Moeckel, G, Dunn, S, Bulus, N, Harris, RC, Zent, R, Breyer, MD. Apoptosis of the Thick Ascending Limb Results in Acute Kidney Injury. J Am Soc Nephrol, 2008 PMCID:2488270

Chen, X, Abair, TD, Ibanez, MR, Su, Y, Frey, MR, Dise, RS, Polk, DB, Singh, AB, Harris, RC, Zent, R, Pozzi, A. Integrin alpha1beta1 controls reactive oxygen species synthesis by negatively regulating epidermal growth factor receptor-mediated Rac activation. Mol Cell Biol, 27(9), 3313-26, 2007 PMCID:1899972

Dwyer, JP, Yates, KM, Sumner, EL, Stone, WJ, Wang, Y, Koury, MJ, Fogo, AB, Zent, R. Chronic myeloid leukemia-associated membranoproliferative glomerulonephritis that responded to imatinib mesylate therapy. Clin Nephrol, 67(3), 176-81, 2007

Erdogan, M, Pozzi, A, Bhowmick, N, Moses, HL, Zent, R. Signaling pathways regulating TC21-induced tumorigenesis. J Biol Chem, 282(38), 27713-20, 2007

Rao, R, Redha, R, Macias-Perez, I, Su, Y, Hao, C, Zent, R, Breyer, MD, Pozzi, A. Prostaglandin E2-EP4 receptor promotes endothelial cell migration via ERK activation and angiogenesis in vivo. J Biol Chem, 282(23), 16959-68, 2007

Voss, B, McLaughlin, JN, Holinstat, M, Zent, R, Hamm, HE. PAR1, but not PAR4, activates human platelets through a Gi/o/phosphoinositide-3 kinase signaling axis. Mol Pharmacol, 71(5), 1399-406, 2007

Zeng, F, Zhang, MZ, Singh, AB, Zent, R, Harris, RC. ErbB4 isoforms selectively regulate growth factor induced Madin-Darby canine kidney cell tubulogenesis. Mol Biol Cell, 18(11), 4446-56, 2007 PMCID:2043549

Zent, R, Pozzi, A. Angiogenesis in diabetic nephropathy. Semin Nephrol, 27(2), 161-71, 2007

Borza, CM, Pozzi, A, Borza, DB, Pedchenko, V, Hellmark, T, Hudson, BG, Zent, R. Integrin {alpha}3beta1, a Novel Receptor for {alpha}3(IV) Noncollagenous Domain and a Trans-dominant Inhibitor for Integrin {alpha}vbeta3. J Biol Chem, 281(30), 20932-9, 2006

Liang, XB, Ma, LJ, Naito, T, Wang, Y, Madaio, M, Zent, R, Pozzi, A, Fogo, AB. Angiotensin type 1 receptor blocker restores podocyte potential to promote glomerular endothelial cell growth. J Am Soc Nephrol, 17(7), 1886-95, 2006

Moeckel, GW, Zhang, L, Chen, X, Rossini, M, Zent, R, Pozzi, A. Role of integrin alpha1beta1 in the regulation of renal medullary osmolyte concentration. Am J Physiol Renal Physiol, 290(1), F223-31, 2006

Nakagawa, K, Holla, VR, Wei, Y, Wang, WH, Gatica, A, Wei, S, Mei, S, Miller, CM, Cha, DR, Price, E, Zent, R, Pozzi, A, Breyer, MD, Guan, Y, Falck, JR, Waterman, MR, Capdevila, JH. Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel. J Clin Invest, 116(6), 1696-702, 2006 PMCID:1459070

Pozzi, A, Coffa, S, Bulus, N, Zhu, W, Chen, D, Chen, X, Mernaugh, G, Su, Y, Cai, S, Singh, A, Brissova, M, Zent, R. H-Ras, R-Ras, and TC21 Differentially Regulate Ureteric Bud Cell Branching Morphogenesis. Mol Biol Cell, 2006 PMCID:1415315

Zent, R, Pozzi, A. Antiangiogenic therapy in diabetic nephropathy. J Am Soc Nephrol, 17(2), 325-7, 2006

Zent, R, Yan, X, Su, Y, Hudson, BG, Borza, DB, Moeckel, GW, Qi, Z, Sado, Y, Breyer, MD, Voziyan, P, Pozzi, A. Glomerular injury is exacerbated in diabetic integrin alpha1-null mice. Kidney Int, 70(3), 460-70, 2006

Cai, S, Bulus, N, Fonseca-Siesser, PM, Chen, D, Hanks, SK, Pozzi, A, Zent, R. CD98 modulates integrin beta1 function in polarized epithelial cells. J Cell Sci, 118(Pt 5), 889-99, 2005

Chen, X, Su, Y, Fingleton, B, Acuff, H, Matrisian, LM, Zent, R, Pozzi, A. Increased plasma MMP9 in integrin alpha1-null mice enhances lung metastasis of colon carcinoma cells. Int J Cancer, 116(1), 52-61, 2005

Chen, X, Su, Y, Fingleton, B, Acuff, H, Matrisian, LM, Zent, R, Pozzi, A. An orthotopic model of lung cancer to analyze primary and metastatic NSCLC growth in integrin alpha1-null mice. Clin Exp Metastasis, 22(2), 185-93, 2005

Mai, W, Chen, D, Ding, T, Kim, I, Park, S, Cho, SY, Chu, JS, Liang, D, Wang, N, Wu, D, Li, S, Zhao, P, Zent, R, Wu, G. Inhibition of Pkhd1 Impairs Tubulomorphogenesis of Cultured IMCD Cells. Mol Biol Cell, 2005 PMCID:1196347

Mernaugh, RL, Yan, H, Chen, D, Edl, J, Hanley, G, Pozzi, A, Zent, R. Production and characterization of mouse ureteric bud cell-specific rat hybridoma antibodies utilizing subtractive immunization and high-throughput screening. J Immunol Methods, 306(1-2), 115-27, 2005

Muraoka-Cook, RS, Shin, I, Yi, JY, Easterly, E, Barcellos-Hoff, MH, Yingling, JM, Zent, R, Arteaga, CL. Activated type I TGFbeta receptor kinase enhances the survival of mammary epithelial cells and accelerates tumor progression. Oncogene, 2005

Pozzi, A, Macias-Perez, I, Abair, T, Wey, S, Su, Y, Zent, R, Falk, JR, Capdevila, JH. Charaterization of 5,6-and 8,9-Epoxyeicosatrienoic acids (5,6- AND 8,9-EET) as potent in vivo angiogenic lipids. J Biol Chem, 2005

Tvorogov, D, Wang, XJ, Zent, R, Carpenter, G. Integrin-dependent PLC-gamma1 phosphorylation mediates fibronectin-dependent adhesion. J Cell Sci, 118(Pt 3), 601-10, 2005

Chen, Dong, Roberts, Richard, Pohl, Martin, Nigam, Sanjay, Kreidberg, Jordan, Wang, Zemin, Heino, Jyrki, Ivaska, Johanna, Coffa, Sergio, Harris, Raymond C., Pozzi, Ambra, Zent, Roy. Differential expression of collagen and laminin binding integrins mediate ureteric bud and inner medullary collecting duct cell tubulogenesis. Am J Physiol Renal Physiol, 2004

Chen, X, Moeckel, G, Morrow, JD, Cosgrove, D, Harris, RC, Fogo, AB, Zent, R, Pozzi, A. Lack of integrin alpha1beta1 leads to severe glomerulosclerosis after glomerular injury. Am J Pathol, 165(2), 617-30, 2004 PMCID:1618576

Fisher, ME, Rossini, M, Simmons, E, Harris, RC, Moeckel, G, Zent, R. A woman with chronic hepatitis C infection and nephrotic syndrome who developed multiple renal lesions after interferon alfa therapy. Am J Kidney Dis, 44(3), 567-73, 2004

Henderson, NC, Collis, EA, Mackinnon, AC, Simpson, KJ, Haslett, C, Zent, R, Ginsberg, M, Sethi, T. CD98hc (SLC3A2) interaction with beta 1 integrins is required for transformation. J Biol Chem, 279(52), 54731-41, 2004

Pedchenko, Vadim, Zent, Roy, Hudson, Billy G.. {alpha}v{beta}3 and {alpha}v{beta}5 Integrins Bind Both the Proximal RGD Site and Non-RGD Motifs within Noncollagenous (NC1) Domain of the {alpha}3 Chain of Type IV Collagen: IMPLICATION FOR THE MECHANISM OF ENDOTHELIAL CELL ADHESION. J Biol Chem, 279(4), 2772-2780, 2004

Singh, Amar B, Tsukada, Toshiaki, Zent, Roy, Harris, Raymond C. Membrane-associated HB-EGF modulates HGF-induced cellular responses in MDCK cells. J Cell Sci, 117(Pt 8), 1365-79, 2004

Hata, Aaron N, Zent, Roy, Breyer, Matthew D, Breyer, Richard M. Expression and molecular pharmacology of the mouse CRTH2 receptor. J Pharmacol Exp Ther, 306(2), 463-70, 2003

Koshikawa, Naohiko, Schenk, Susann, Moeckel, Gilbert, Sharabi, Andrew, Miyazaki, Kaoru, Gardner, Humphrey, Zent, Roy, Quaranta, Vito. Proteolytic processing of laminin-5 by MT1-MMP in tissues and its effects on epithelial cell morphology. FASEB J, 2003

Pozzi, Ambra, Zent, Roy. Integrins: sensors of extracellular matrix and modulators of cell function. Nephron Exp Nephrol, 94(3), e77-84, 2003

Bhowmick, N A, Zent, R, Ghiassi, M, McDonnell, M, Moses, H L. Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38MAPK and epithelial plasticity. J Biol Chem, 276(50), 46707-13, 2001

Fenczik, C A, Zent, R, Dellos, M, Calderwood, D A, Satriano, J, Kelly, C, Ginsberg, M H. Distinct domains of CD98hc regulate integrins and amino acid transport. J Biol Chem, 276(12), 8746-52, 2001

Zent, R, Bush, K T, Pohl, M L, Quaranta, V, Koshikawa, N, Wang, Z, Kreidberg, J A, Sakurai, H, Stuart, R O, Nig?!m, S K. Involvement of laminin binding integrins and laminin-5 in branching morphogenesis of the ureteric bud during kidney development. Dev Biol, 238(2), 289-302, 2001

Zent, R, Fenczik, C A, Calderwood, D A, Liu, S, Dellos, M, Ginsberg, M H. Class- and splice variant-specific association of CD98 with integrin beta cytoplasmic domains. J Biol Chem, 275(7), 5059-64, 2000

Calderwood, D A, Zent, R, Grant, R, Rees, D J, Hynes, R O, Ginsberg, M H. The Talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation. J Biol Chem, 274(40), 28071-4, 1999

Zent, R, Ailenberg, M, Downey, G P, Silverman, M. ROS stimulate reorganization of mesangial cell-collagen gels by tyrosine kinase signaling. Am J Physiol, 276(2 Pt 2), F278-87, 1999

Zent, R, Ailenberg, M, Silverman, M. Tyrosine kinase cell signaling pathways of rat mesangial cells in 3-dimensional cultures: response to fetal bovine serum and platelet-derived growth factor-BB. Exp Cell Res, 240(1), 134-43, 1998

Zent, R, Katz, A, Quaggin, S, Cattran, D, Wade, J, Cardella, C, Zaltzman, J, Fenton, S, Cole, E. Thrombotic microangiopathy in renal transplant recipients treated with cyclosporin A. Clin Nephrol, 47(3), 181-6, 1997

Zent, R, Nagai, R, Cattran, D C. Idiopathic membranous nephropathy in the elderly: a comparative study. Am J Kidney Dis, 29(2), 200-6, 1997

De Villiers, C, Zent, R, Eastman, R W, Swingler, D. A flight of fantasy: false memories in frontal lobe disease. J Neurol Neurosurg Psychiatry, 61(6), 652-3, 1996 PMCID:486667

Zent, R, Ailenberg, M, Waddell, T K, Downey, G P, Silverman, M. Puromycin aminonucleoside inhibits mesangial cell-induced contraction of collagen gels by stimulating production of reactive oxygen species. Kidney Int, 47(3), 811-7, 1995

Bargman, J M, Zent, R, Ellis, P, Auger, M, Wilson, S. Diagnosis of lymphoma in a continuous ambulatory peritoneal dialysis patient by peritoneal fluid cytology. Am J Kidney Dis, 23(5), 747-50, 1994

Katz, A, Zent, R, Bargman, J M. IgG heavy-chain deposition disease. Mod Pathol, 7(8), 874-8, 1994

Zent, R, Myers, J E, Donald, D, Rayner, B L. Continuous ambulatory peritoneal dialysis: an option in the developing world. Perit Dial Int, 14(1), 48-51, 1994

Zent, R, Van Zyl Smit, R, Duffield, M, Cassidy, M J. Crescentic nephritis at Groote Schuur Hospital, South Africa--not a benign disease. Clin Nephrol, 42(1), 22-9, 1994

Morton, L P, Reynolds, L, Zent, R, Rayner, B L. Hearing thresholds in CAPD patients. Adv Perit Dial, 8, 150-2, 1992

Postdoctoral Position Available

Postdoctoral Position Details

Updated Date