Vanderbilt University School of Medicine

Fowke, Jay H. , Ph.D., MPH
Associate Professor of Medicine
Associate Professor of Urologic Surgery

Lab Url: N/A

Phone Number: 615-936-2903


Fowke, Jay's picture

Office Address   Mailing Address

Institute of Medicine and Public Health 12th floor 37232-8300

Research Keywords
cancer epidemiology molecular epidemiology nutritional epidemiology cancer screening racial disparities,Cancer

Research Specialty
Epidemiology of prostate, breast, and colorectal cancers.

Research Description
We use epidemiologic methods to investigate the the causes of cancer. This includes several investigations to understand the relationship between diet or obesity affects the risk of breast or prostate cancer. Genetic markers of susceptibility to these cancers are also investigated. Addtionally, we have started work to understand racial disparities in cancer risk, including the possibility that differences in cancer screening practices by race affect disease outcomes.

Barocas, DA, Grubb, R, Black, A, Penson, DF, Fowke, JH, Andriole, G, Crawford, ED. Association between race and follow-up diagnostic care after a positive prostate cancer screening test in the Prostate, Lung, Colorectal, and Ovarian cancer screening trial. Cancer, , , 2013.

Dallal, CM, Stone, RA, Cauley, JA, Ness, RB, Vogel, VG, Fentiman, IS, Fowke, JH, Krogh, V, Loft, S, Meilahn, EN, Muti, P, Olsen, A, Overvad, K, Sieri, S, Tj??nneland, A, Ursin, G, Wellejus, A, Taioli, E. Urinary estrogen metabolites and breast cancer: a combined analysis of individual level data. Int J Biol Markers, 28(1), e3-e16, 2013.

Fesinmeyer, MD, North, KE, Lim, U, B????kov??, P, Crawford, DC, Haessler, J, Gross, MD, Fowke, JH, Goodloe, R, Love, SA, Graff, M, Carlson, CS, Kuller, LH, Matise, TC, Hong, CP, Henderson, BE, Allen, M, Rohde, RR, Mayo, P, Schnetz-Boutaud, N, Monroe, KR, Ritchie, MD, Prentice, RL, Kolonel, LN, Manson, JE, Pankow, J, Hindorff, LA, Franceschini, N, Wilkens, LR, Haiman, CA, Le Marchand, L, Peters, U. Effects of smoking on the genetic risk of obesity: the population architecture using genomics and epidemiology study. BMC Med Genet, 14, 6, 2013.

Fowke, JH, Motley, S, Dai, Q, Concepcion, R, Barocas, DA. Association between biomarkers of obesity and risk of high-grade prostatic intraepithelial neoplasia and prostate cancer--evidence of effect modification by prostate size. Cancer Lett, 328(2), 345-52, 2013.

Fowke, JH, Phillips, S, Koyama, T, Byerly, S, Concepcion, R, Motley, SS, Clark, PE. Association between physical activity, lower urinary tract symptoms (LUTS) and prostate volume. BJU Int, 111(1), 122-8, 2013.

Graff, M, Gordon-Larsen, P, Lim, U, Fowke, JH, Love, SA, Fesinmeyer, M, Wilkens, LR, Vertilus, S, Ritchie, MD, Prentice, RL, Pankow, J, Monroe, K, Manson, JE, Le Marchand, L, Kuller, LH, Kolonel, LN, Hong, CP, Henderson, BE, Haessler, J, Gross, MD, Goodloe, R, Franceschini, N, Carlson, CS, Buyske, S, Buzkov??, P, Hindorff, LA, Matise, TC, Crawford, DC, Haiman, CA, Peters, U, North, KE. The Influence of Obesity-Related Single Nucleotide Polymorphisms on BMI Across the Life Course: The PAGE Study. Diabetes, 62(5), 1763-7, 2013.

Barocas, DA, Gray, DT, Fowke, JH, Mercaldo, ND, Blume, JD, Chang, SS, Cookson, MS, Smith, JA, Penson, DF. Racial variation in the quality of surgical care for prostate cancer. J Urol, 188(4), 1279-85, 2012.

Buchowski, MS, Matthews, CE, Cohen, SS, Signorello, LB, Fowke, JH, Hargreaves, MK, Schlundt, DG, Blot, WJ. Evaluation of a questionnaire to assess sedentary and active behaviors in the Southern Community Cohort Study. J Phys Act Health, 9(6), 765-75, 2012.

Cohen, SS, Fowke, JH, Cai, Q, Buchowski, MS, Signorello, LB, Hargreaves, MK, Zheng, W, Blot, WJ, Matthews, CE. Differences in the association between serum leptin levels and body mass index in black and white women: a report from the Southern Community Cohort Study. Ann Nutr Metab, 60(2), 90-7, 2012.

Edwards, TL, Velez Edwards, DR, Villegas, R, Cohen, SS, Buchowski, MS, Fowke, JH, Schlundt, D, Long, J, Long, JR, Cai, Q, Zheng, W, Shu, XO, Hargreaves, MK, Smith, J, Jeffrey, S, Williams, SM, Signorello, LB, Blot, WJ, Matthews, CE. HTR1B, ADIPOR1, PPARGC1A, and CYP19A1 and obesity in a cohort of Caucasians and African Americans: an evaluation of gene-environment interactions and candidate genes. Am J Epidemiol, 175(1), 11-21, 2012.

Fesinmeyer, MD, North, KE, Ritchie, MD, Lim, U, Franceschini, N, Wilkens, LR, Gross, MD, B????kov??, P, Glenn, K, Quibrera, PM, Fern??ndez-Rhodes, L, Li, Q, Fowke, JH, Li, R, Carlson, CS, Prentice, RL, Kuller, LH, Manson, JE, Matise, TC, Cole, SA, Chen, CT, Howard, BV, Kolonel, LN, Henderson, BE, Monroe, KR, Crawford, DC, Hindorff, LA, Buyske, S, Haiman, CA, Le Marchand, L, Peters, U. Genetic Risk Factors for BMI and Obesity in an Ethnically Diverse Population: Results From the Population Architecture Using Genomics and Epidemiology (PAGE) Study. Obesity (Silver Spring), , , 2012.

Fowke, JH, Motley, SS, Concepcion, RS, Penson, DF, Barocas, DA. Obesity, body composition, and prostate cancer. BMC Cancer, 12, 23, 2012.

Barocas, DA, Motley, S, Cookson, MS, Chang, SS, Penson, DF, Dai, Q, Milne, G, Roberts, LJ, Morrow, J, Concepcion, RS, Smith, JA, Fowke, JH. Oxidative stress measured by urine F2-isoprostane level is associated with prostate cancer. J Urol, 185(6), 2102-7, 2011.

Cohen, SS, Gammon, MD, Signorello, LB, North, KE, Lange, EM, Fowke, JH, Hargreaves, MK, Cai, Q, Zheng, W, Blot, WJ, Matthews, CE. Serum adiponectin in relation to body mass index and other correlates in black and white women. Ann Epidemiol, 21(2), 86-94, 2011.

Dai, Q, Motley, SS, Smith, JA, Concepcion, R, Barocas, D, Byerly, S, Fowke, JH. Blood magnesium, and the interaction with calcium, on the risk of high-grade prostate cancer. PLoS One, 6(4), e18237, 2011.

Epplein, M, Signorello, LB, Zheng, W, Cai, Q, Hargreaves, MK, Michel, A, Pawlita, M, Fowke, JH, Correa, P, Blot, WJ. Helicobacter pylori prevalence and circulating micronutrient levels in a low-income United States population. Cancer Prev Res (Phila), 4(6), 871-8, 2011.

Fowke, JH, Gao, YT, Chow, WH, Cai, Q, Shu, XO, Li, HL, Ji, BT, Rothman, N, Yang, G, Chung, FL, Zheng, W. Urinary isothiocyanate levels and lung cancer risk among non-smoking women: a prospective investigation. Lung Cancer, 73(1), 18-24, 2011.

Fowke, JH, Motley, SS, Barocas, DA, Cookson, MS, Concepcion, R, Byerly, S, Smith, JA. The associations between statin use and prostate cancer screening, prostate size, high-grade prostatic intraepithelial neoplasia (PIN), and prostate cancer. Cancer Causes Control, 22(3), 417-26, 2011.

Fowke, JH, Munro, H, Signorello, LB, Blot, WJ, Penson, DF, , . Association between socioeconomic status (SES) and lower urinary tract symptom (LUTS) severity among black and white men. J Gen Intern Med, 26(11), 1305-10, 2011.

Penson, DF, Munro, HM, Signorello, LB, Blot, WJ, Fowke, JH, , . Obesity, physical activity and lower urinary tract symptoms: results from the Southern Community Cohort Study. J Urol, 186(6), 2316-22, 2011.

Fowke, JH. Head and neck cancer: a case for inhibition by isothiocyanates and indoles from cruciferous vegetables. Eur J Cancer Prev, 16(4), 348-56, 2007.

Fowke, JH, Motley, SS, Cookson, MS, Concepcion, R, Chang, SS, Wills, ML, Smith, JA. The association between body size, prostate volume and prostate-specific antigen. Prostate Cancer Prostatic Dis, 10(2), 137-42, 2007.

Fowke, JH, Motley, SS, Wills, M, Cookson, MS, Concepcion, RS, Eckstein, CW, Chang, SS, Smith, JA. Prostate volume modifies the association between obesity and prostate cancer or high-grade prostatic intraepithelial neoplasia. Cancer Causes Control, 18(4), 375-84, 2007.

M'Koma, AE, Blum, DL, Norris, JL, Koyama, T, Billheimer, D, Motley, S, Ghiassi, M, Ferdowsi, N, Bhowmick, I, Chang, SS, Fowke, JH, Caprioli, RM, Bhowmick, NA. Detection of pre-neoplastic and neoplastic prostate disease by MALDI profiling of urine. Biochem Biophys Res Commun, 353(3), 829-34, 2007. PMCID:2562600

Canter, JA, Kallianpur, AR, Fowke, JH. Re: North American white mitochondrial haplogroups in prostate and renal cancer. J Urol, 176(5), 2308-9; author reply 2309, 2006.

Fowke, JH, Morrow, JD, Motley, S, Bostick, RM, Ness, RM. Brassica vegetable consumption reduces urinary F2-isoprostane levels independent of micronutrient intake. Carcinogenesis, 27(10), 2096-102, 2006.

Fowke, JH, Signorello, LB, Chang, SS, Matthews, CE, Buchowski, MS, Cookson, MS, Ukoli, FM, Blot, WJ. Effects of obesity and height on prostate-specific antigen (PSA) and percentage of free PSA levels among African-American and Caucasian men. Cancer, 107(10), 2361-7, 2006.

Fowke, JH, Signorello, LB, Underwood, W, Ukoli, FA, Blot, WJ. Obesity and prostate cancer screening among African-American and Caucasian men. Prostate, 66(13), 1371-80, 2006.

Teas, J, Cunningham, JE, Fowke, JH, Nitcheva, D, Kanwat, CP, Boulware, RJ, Sepkovic, DW, Hurley, TG, Hebert, JR. Urinary estrogen metabolites, prostate specific antigen, and body mass index among African-American men in South Carolina. Cancer Detect Prev, 29(6), 494-500, 2005.

Fowke, JH, Schlundt, D, Gong, Y, Jin, F, Shu, XO, Wen, W, Liu, DK, Gao, YT, Zheng, W. Impact of season of food frequency questionnaire administration on dietary reporting. Ann Epidemiol, 14(10), 778-85, 2004.

Fowke, JH, Schlundt, D, Signorello, LB, Ukoli, FA, Blot, WJ. Prostate cancer screening between low-income African-American and Caucasian men. Urol Oncol, 23(5), 333-40, 2004.

Fowke, JH, Shu, XO, Dai, Q, Jin, F, Cai, Q, Gao, YT, Zheng, W. Oral contraceptive use and breast cancer risk: modification by NAD(P)H:quinone oxoreductase (NQO1) genetic polymorphisms. Cancer Epidemiol Biomarkers Prev, 13(8), 1308-15, 2004.

Matthews, CE, Fowke, JH, Dai, Q, Leon Bradlow, H, Jin, F, Shu, XO, Gao, YT, Longcope, C, Hebert, JR, Zheng, W. Physical activity, body size, and estrogen metabolism in women. Cancer Causes Control, 15(5), 473-81, 2004.

Fowke, JH, Shu, XO, Dai, Q, Shintani, A, Conaway, CC, Chung, FL, Cai, Q, Gao, YT, Zheng, W. Urinary isothiocyanate excretion, brassica consumption, and gene polymorphisms among women living in Shanghai, China. Cancer Epidemiol Biomarkers Prev, 12(12), 1536-9, 2003.

Fowke, Jay H, Chung, Fung-Lung, Jin, Fan, Qi, Dai, Cai, Qiuyin, Conaway, Cliff, Cheng, Jia-Rong, Shu, Xiao-Ou, Gao, Yu-Tang, Zheng, Wei. Urinary isothiocyanate levels, brassica, and human breast cancer. Cancer Res, 63(14), 3980-6, 2003.

Fowke, Jay H, Qi, Dai, Bradlow, H Leon, Shu, Xiao Ou, Gao, Yu Tang, Cheng, Jin Rong, Jin, Fan, Zheng, Wei. Urinary estrogen metabolites and breast cancer: differential pattern of risk found with pre- versus post-treatment collection. Steroids, 68(1), 65-72, 2003.

Fowke, Jay H, Hebert, James R, Fahey, Jed W. Urinary excretion of dithiocarbamates and self-reported Cruciferous vegetable intake: application of the 'method of triads' to a food-specific biomarker. Public Health Nutr, 5(6), 791-9, 2002.

Fowke, J H, Fahey, J W, Stephenson, K K, Hebert, J R. Using isothiocyanate excretion as a biological marker of Brassica vegetable consumption in epidemiological studies: evaluating the sources of variability. Public Health Nutr, 4(3), 837-46, 2001.

Fowke, J H, Longcope, C, Hebert, J R. Macronutrient intake and estrogen metabolism in healthy postmenopausal women. Breast Cancer Res Treat, 65(1), 1-10, 2001.

Fowke, J H, Longcope, C, Hebert, J R. Brassica vegetable consumption shifts estrogen metabolism in healthy postmenopausal women. Cancer Epidemiol Biomarkers Prev, 9(8), 773-9, 2000.

DeCaprio, A P, Kinney, E A, Fowke, J H. Regioselective binding of 2,5-hexanedione to high-molecular-weight rat neurofilament proteins in vitro. Toxicol Appl Pharmacol, 145(1), 211-7, 1997.

Richardson, R J, Moore, T B, Kayyali, U S, Fowke, J H, Randall, J C. Inhibition of hen brain acetylcholinesterase and neurotoxic esterase by chlorpyrifos in vivo and kinetics of inhibition by chlorpyrifos oxon in vitro: application to assessment of neuropathic risk. Fundam Appl Toxicol, 20(3), 273-9, 1993.

DeCaprio, A P, Fowke, J H. Limited and selective adduction of carboxyl-terminal lysines in the high molecular weight neurofilament proteins by 2,5-hexanedione in vitro. Brain Res, 586(2), 219-28, 1992.

DeCaprio, A P, Spink, D C, Chen, X, Fowke, J H, Zhu, M, Bank, S. Characterization of isothiocyanates, thioureas, and other lysine adduction products in carbon disulfide-treated peptides and protein. Chem Res Toxicol, 5(4), 496-504, 1992.

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