Vanderbilt University School of
U-2206 Medical Center North
U-2206 MCN 2561
Atherosclerosis, Thrombosis, Lipid metabolism,
Biochemistry, Heart, Pathology, Vascular Biology,
Pathology, Apoptosis, Cancer, Cell Biology, Intracellular Traffic, Cholesterol,Pathology,Vascular Biology
Vascular biology and how changes in the vasculature can affect heart disease, stroke, and cancer.
Research in the laboratory is focused on vascular biology and how changes in the vasculature can affect heart disease, stroke, and cancer. The studies correlate microscopy and biochemistry evidence to determine what changes occur and how these changes affect the disease process. Currently, three interrelated studies are ongoing.
In the first, we are trying to learn why in atherosclerosis the lysosomes of macrophages and smooth muscle cells in the artery wall become bloated with cholesterol. To do this, we use cultured macrophages and look at the uptake and processing of cholesterol. The cholesterol is delivered to the cells within modified lipoproteins. This is similar to what occurs in vivo. We compare quantitative microscopic observations on the uptake and fate of the lipoproteins with measures of key biochemical pathways in cholesterol metabolism. In this way we are beginning to dissect why lysosomes cannot clear their cholesterol load. To relate these tissue culture experiments to the disease process, we also compare the appearance of these tissue culture cells to that exhibited by cells during various stages of atherosclerosis. This is also allowing us to investigate the effect this bloating has on progression of the disease. Among our findings, we have shown that lysosomal cholesterol accumulation occurs in two stages. In the initial stage, cholesteryl esters delivered by lipoproteins are broken down in th lysosome but the resulting unesterified cholesterol cannot escape the lysosome. In later stages, and perhaps related to the free cholesterol accumulation, hydrolysis of the cholesteryl esters is inhibited. This produces lysosomes rich in both free and esterified cholesterol.
In the second set of studies, we are exploring how triglycerides can alter intracellular cholesterol metabolism. We have found that triglycerides significantly increase the rate of cholesterol metabolism and cellular clearance of cholesterol. We are now trying to define the mechanisms by which this occurs.
In a new line of investigation in the laboratory, we are investigating how inhibition of cholesterol use can effect cell proliferation. Under conditions where cholesterol is scarce, cell proliferation, such as that seen in tumors, is slowed. The cell can acquire cholesterol exogenously or synthesize it internally. Each pool of cholesterol appears to have a slight different trafficking mechanism within the cells. It is still not clear whether an inhibition of use of one pool can be compensated by use of cholesterol from the other pool. Cholesterol restriction is a potential means of slowing some tumor growth. However, to fully understand the potential, much more knowledge of cholesterol trafficking and utilization within different cell types is required. . . .
Kojima, T, Van Deusen, M, Jerome, WG, Garrett, CG, Sivasankar, MP, Novaleski, CK, Rousseau, B. Quantification of acute vocal fold epithelial surface damage with increasing time and magnitude doses of vibration exposure. PLoS One, 9(3), e91615, 2014.
Baudoin, JP, Jerome, WG, K??bel, C, de Jonge, N. Whole-cell analysis of low-density lipoprotein uptake by macrophages using STEM tomography. PLoS One, 8(1), e55022, 2013.
Cai, Q, Brissova, M, Reinert, RB, Pan, FC, Brahmachary, P, Jeansson, M, Shostak, A, Radhika, A, Poffenberger, G, Quaggin, SE, Jerome, WG, Dumont, DJ, Powers, AC. Enhanced expression of VEGF-A in ?? cells increases endothelial cell number but impairs islet morphogenesis and ?? cell proliferation. Dev Biol, 367(1), 40-54, 2012.
Deng, X, Morris, J, Dressmen, J, Tubb, MR, Tso, P, Jerome, WG, Davidson, WS, Thompson, TB. The Structure of Dimeric Apolipoprotein A-IV and Its Mechanism of Self-Association. Structure, 20(5), 767-79, 2012.
Kirkbride, KC, Hong, NH, French, CL, Clark, ES, Jerome, WG, Weaver, AM. Regulation of late endosomal/lysosomal maturation and trafficking by cortactin affects Golgi morphology. Cytoskeleton (Hoboken), 69(9), 625-43, 2012.
Ooms, LS, Jerome, WG, Dermody, TS, Chappell, JD. Reovirus replication protein ??2 influences cell tropism by promoting particle assembly within viral inclusions. J Virol, 86(20), 10979-87, 2012.
Sorci-Thomas, MG, Owen, JS, Fulp, B, Bhat, S, Zhu, X, Parks, JS, Shah, D, Jerome, WG, Gerelus, M, Zabalawi, M, Thomas, MJ. Nascent high density lipoproteins formed by ABCA1 resemble lipid rafts and are structurally organized by three apoA-I monomers. J Lipid Res, 53(9), 1890-909, 2012.
Yamamoto, S, Yancey, PG, Ikizler, TA, Jerome, WG, Kaseda, R, Cox, B, Bian, A, Shintani, A, Fogo, AB, Linton, MF, Fazio, S, Kon, V. Dysfunctional high-density lipoprotein in patients on chronic hemodialysis. J Am Coll Cardiol, 60(23), 2372-9, 2012.
Yu, SS, Lau, CM, Thomas, SN, Jerome, WG, Maron, DJ, Dickerson, JH, Hubbell, JA, Giorgio, TD. Size- and charge-dependent non-specific uptake of PEGylated nanoparticles by macrophages. Int J Nanomedicine, 7, 799-813, 2012. PMCID:3284223
Price RL, Jerome WG (editors). 2011. Basic Confocal Microscopy, Edition 1. Springer, New York. 302 pgs.
Huang, R, Silva, RA, Jerome, WG, Kontush, A, Chapman, MJ, Curtiss, LK, Hodges, TJ, Davidson, WS. Apolipoprotein A-I structural organization in high-density lipoproteins isolated from human plasma. Nat Struct Mol Biol, 18(4), 416-22, 2011.
Weibel, GL, Joshi, MR, Jerome, WG, Bates, SR, Yu, KJ, Phillips, MC, Rothblat, GH. Cytoskeleton disruption in J774 macrophages: Consequences for lipid droplet formation and cholesterol flux. Biochim Biophys Acta, , , 2011.
Gauthamadasa, K, Rosales, C, Pownall, HJ, Macha, S, Jerome, WG, Huang, R, Silva, RA. Speciated human high-density lipoprotein protein proximity profiles. Biochemistry, 49(50), 10656-65, 2010.
Gu, F, Jones, MK, Chen, J, Patterson, JC, Catte, A, Jerome, WG, Li, L, Segrest, JP. Structures of discoidal high density lipoproteins: a combined computational-experimental approach. J Biol Chem, 285(7), 4652-65, 2010.
Jerome, WG. Lysosomes, cholesterol and atherosclerosis. Clin Lipidol, 5(6), 853-865, 2010. PMCID:3105626
Jiang, M, Fernandez, S, Jerome, WG, He, Y, Yu, X, Cai, H, Boone, B, Yi, Y, Magnuson, MA, Roy-Burman, P, Matusik, RJ, Shappell, SB, Hayward, SW. Disruption of PPARgamma signaling results in mouse prostatic intraepithelial neoplasia involving active autophagy. Cell Death Differ, 17(3), 469-81, 2010.
Jiang, M, Jerome, WG, Hayward, SW. Autophagy in nuclear receptor PPARgamma-deficient mouse prostatic carcinogenesis. Autophagy, 6(1), 175-6, 2010.
Vaezi, MF, Slaughter, JC, Smith, BS, Washington, MK, Jerome, WG, Garrett, CG, Hagaman, D, Goutte, M. Dilated intercellular space in chronic laryngitis and gastro-oesophageal reflux disease: at baseline and post-lansoprazole therapy. Aliment Pharmacol Ther, 32(7), 916-24, 2010.
Chen, B, Ren, X, Neville, T, Jerome, WG, Hoyt, DW, Sparks, D, Ren, G, Wang, J. Apolipoprotein AI tertiary structures determine stability and phospholipid-binding activity of discoidal high-density lipoprotein particles of different sizes. Protein Sci, 18(5), 921-35, 2009.
Sun, Y, Ishibashi, M, Seimon, T, Lee, M, Sharma, SM, Fitzgerald, KA, Samokhin, AO, Wang, Y, Sayers, S, Aikawa, M, Jerome, WG, Ostrowski, MC, Bromme, D, Libby, P, Tabas, IA, Welch, CL, Tall, AR. Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K. Circ Res, 104(4), 455-65, 2009. PMCID:2680702
Ullery-Ricewick, JC, Cox, BE, Griffin, EE, Jerome, WG. Triglyceride alters lysosomal cholesterol metabolism in cholesteryl ester-laden macrophage foam cells. J Lipid Res, , , 2009. PMCID:2739755
Cao, Z, Li, C, Higginbotham, JN, Franklin, JL, Tabb, DL, Graves-Deal, R, Hill, S, Cheek, K, Jerome, WG, Lapierre, LA, Goldenring, JR, Ham, AJ, Coffey, RJ. Use of fluorescence-activated vesicle sorting for isolation of Naked2-associated, basolaterally targeted exocytic vesicles for proteomics analysis. Mol Cell Proteomics, 7(9), 1651-67, 2008. PMCID:2528074
Jerome, WG, Cox, BE, Griffin, EE, Ullery, JC. Lysosomal cholesterol accumulation inhibits subsequent hydrolysis of lipoprotein cholesteryl ester. Microsc Microanal, 14(2), 138-49, 2008.
Silva, RA, Huang, R, Morris, J, Fang, J, Gracheva, EO, Ren, G, Kontush, A, Jerome, WG, Rye, KA, Davidson, WS. Structure of apolipoprotein A-I in spherical high density lipoproteins of different sizes. Proc Natl Acad Sci U S A, 105(34), 12176-81, 2008. PMCID:2527885
Cox, BE, Griffin, EE, Ullery, JC, Jerome, WG. Effects of cellular cholesterol loading on macrophage foam cell lysosome acidification. J Lipid Res, 48(5), 1012-21, 2007.
Fan, D, Qiu, S, Overton, CD, Yancey, PG, Swift, LL, Jerome, WG, Linton, MF, Fazio, S. Impaired secretion of apolipoprotein E2 from macrophages. J Biol Chem, 282(18), 13746-53, 2007.
Yancey, PG, Jerome, WG, Yu, H, Griffin, EE, Cox, BE, Babaev, VR, Fazio, S, Linton, MF. Severely altered cholesterol homeostasis in macrophages lacking apoE and SR-BI. J Lipid Res, 48(5), 1140-9, 2007.
Zhang, Y, Vasudevan, S, Sojitrawala, R, Zhao, W, Cui, C, Xu, C, Fan, D, Newhouse, Y, Balestra, R, Jerome, WG, Weisgraber, K, Li, Q, Wang, J. A monomeric, biologically active, full-length human apolipoprotein E. Biochemistry, 46(37), 10722-32, 2007.
Brissova, M, Shostak, A, Shiota, M, Wiebe, PO, Poffenberger, G, Kantz, J, Chen, Z, Carr, C, Jerome, WG, Chen, J, Baldwin, HS, Nicholson, W, Bader, DM, Jetton, T, Gannon, M, Powers, AC. Pancreatic islet production of vascular endothelial growth factor--a is essential for islet vascularization, revascularization, and function. Diabetes, 55(11), 2974-85, 2006.
Catte, A, Patterson, JC, Jones, MK, Jerome, WG, Bashtovyy, D, Su, Z, Gu, F, Chen, J, Aliste, MP, Harvey, SC, Li, L, Weinstein, G, Segrest, JP. Novel changes in discoidal high density lipoprotein morphology: a molecular
dynamics study. Biophys J, 90(12), 4345-60, 2006. PMCID:1471865
Jerome, WG. Advanced atherosclerotic foam cell formation has features of an acquired lysosomal
storage disorder. Rejuvenation Res, 9(2), 245-55, 2006.
Dove, DE, Su, YR, Zhang, W, Jerome, WG, Swift, LL, Linton, MF, Fazio, S. ACAT1 deficiency disrupts cholesterol efflux and alters cellular morphology
in macrophages. Arterioscler Thromb Vasc Biol, 25(1), 128-34, 2005.
Griffin, EE, Ullery, JC, Cox, BE, Jerome, WG. Aggregated LDL and lipid dispersions induce lysosomal cholesteryl ester accumulation
in macrophage foam cells. J Lipid Res, , , 2005.
Jerome, WG, Handt, S, Hantgan, RR. Endothelial cells organize fibrin clots into structures that are more resistant
to lysis. Microsc Microanal, 11(3), 268-77, 2005.
Ren, X, Zhao, L, Sivashanmugam, A, Miao, Y, Korando, L, Yang, Z, Reardon, CA, Getz, GS, Brouillette, CG, Jerome, WG, Wang, J. Engineering mouse apolipoprotein A-I into a monomeric, active protein useful
for structural determination. Biochemistry, 44(45), 14907-19, 2005.
Settle, SH, Washington, K, Lind, C, Itzkowitz, S, Fiske, WH, Burdick, JS, Jerome, WG, Ray, M, Weinstein, W, Coffey, RJ. Chronic treatment of M??n??trier''s disease with Erbitux: clinical efficacy
and insight into pathophysiology. Clin Gastroenterol Hepatol, 3(7), 654-9, 2005.
Swift, LL, Kakkad, B, Boone, C, Jovanovska, A, Jerome, WG, Mohler, PJ, Ong, DE. Microsomal triglyceride transfer protein expression in adipocytes: a new component
in fat metabolism. FEBS Lett, 579(14), 3183-9, 2005.
W. Gray Jerome, Stefan Handt, Roy R. Hantgan
. Endothelial Cells Organize Fibrin Clots into Structures That Are More Resistant to Lysis
. Microscopy and Microanalysis, 11(3), 268-277, 2005.
Wilkinson, M, Cline, M, Jerome, WG. Cytopathic herpesvirus infection in a green iguana (Iguana iguana). J Zoo Wildl Med, 36(4), 724-6, 2005.
de Grey, AD, Alvarez, PJ, Brady, RO, Cuervo, AM, Jerome, WG, McCarty, PL, Nixon, RA, Rittmann, BE, Sparrow, JR. Medical bioremediation: prospects for the application of microbial catabolic
diversity to aging and several major age-related diseases. Ageing Res Rev, 4(3), 315-38, 2005.
Fan, Daping, Li, Qianqian, Korando, Leslie, Jerome, W Gray, Wang, Jianjun. A monomeric human apolipoprotein E carboxyl-terminal domain. Biochemistry, 43(17), 5055-64, 2004.
Li, Cunxi, Franklin, Jeffrey L, Graves-Deal, Ramona, Jerome, W Gray, Cao, Zheng, Coffey, Robert J. Myristoylated Naked2 escorts transforming growth factor alpha to the basolateral plasma membrane of polarized epithelial cells. Proc Natl Acad Sci U S A, 101(15), 5571-6, 2004. PMCID:397424
Prentice, Erik, Jerome, W Gray, Yoshimori, Tamotsu, Mizushima, Noboru, Denison, Mark R. Coronavirus replication complex formation utilizes components of cellular autophagy. J Biol Chem, 279(11), 10136-41, 2004.
Jerome, W Gray, Yancey, Patricia G. The role of microscopy in understanding atherosclerotic lysosomal lipid metabolism. Microsc Microanal, 9(1), 54-67, 2003.
Swift, Larry L, Zhu, Mei-Ying, Kakkad, Bharati, Jovanovska, Aneta, Neely, M Diana, Valyi-Nagy, Klara, Roberts, Richard L, Ong, David E, Jerome, W Gray. Subcellular localization of microsomal triglyceride transfer protein. J Lipid Res, 44(10), 1841-9, 2003.
Grant, Kenneth, Jerome, W Gray. Laser capture microdissection as an aid to ultrastructural analysis. Microsc Microanal, 8(3), 170-5, 2002.
Hantgan, Roy R, Stahle, Mary C, Jerome, W Gray, Nagaswami, Chandrasekaran, Weisel, John W. Tirofiban blocks platelet adhesion to fibrin with minimal perturbation of GpIIb/IIIa structure. Thromb Haemost, 87(5), 910-7, 2002.
Yancey, Patricia G, Miles, Stacia, Schwegel, Jennifer, Jerome, W Gray. Uptake and trafficking of mildly oxidized LDL and acetylated LDL in THP-1 cells does not explain the differences in lysosomal metabolism of these two lipoproteins. Microsc Microanal, 8(2), 81-93, 2002.
Bonnefoy, A, Liu, Q, Jerome, W G, Legrand, C, Frojmovic, M M. Platelets in suspension require preactivation to adhere to immobilized fibrinogen. Ann N Y Acad Sci, 936, 459-63, 2001.
Hantgan, R R, Stahle, M, Del Gaizo, V, Adams, M, Lasher, T, Jerome, W G, McKenzie, M, Lyles, D S. AlphaIIb's cytoplasmic domain is not required for ligand-induced clustering of integrin alphaIIbbeta3. Biochim Biophys Acta, 1540(1), 82-95, 2001.
Yancey PG, Jerome WG. Lysosomal cholesterol derived
oxidized low density lipoprotein is resistant to efflux. J Lipid Res, 42, 317-327, 2001.
Yancey, P G, Jerome, W G. Lysosomal cholesterol derived from mildly oxidized low density lipoprotein is resistant to efflux. J Lipid Res, 42(3), 317-27, 2001.
Cashell, A W, Jerome, W G, Flores, E. Signet ring stromal tumor of the ovary occurring in conjunction with brenner tumor. Gynecol Oncol, 77(2), 323-6, 2000.
Stokes, A H, Lewis, D Y, Lash, L H, Jerome, W G, Grant, K W, Aschner, M, Vrana, K E. Dopamine toxicity in neuroblastoma cells: role of glutathione depletion by L-BSO and apoptosis. Brain Res, 858(1), 1-8, 2000.
Avart, S J, Bernard, D W, Jerome, W G, Glick, J M. Cholesteryl ester hydrolysis in J774 macrophages occurs in the cytoplasm and lysosomes. J Lipid Res, 40(3), 405-14, 1999.
Kellner-Weibel G, Yancey PG, Jerome WG, Walser T,
Mason RP, Phillips
MC,Rothblat GH. Crystallization of free cholesterol in model
foam cells. Arterioscler Thromb Vasc Biol, 19, 1891-8, 1999.
Kellner-Weibel, G, Yancey, P G, Jerome, W G, Walser, T, Mason, R P, Phillips, M C, Rothblat, G H. Crystallization of free cholesterol in model macrophage foam cells. Arterioscler Thromb Vasc Biol, 19(8), 1891-8, 1999.
Hantgan RR, Jerome WG, Handt S. Platelets and
endothelial cells act in
concert to delay thrombolysis--evidence from an in vitro
model of the
human occlusive thrombus. Thromb Haemost, 79, 602-8, 1998.
Hantgan, R R, Jerome, W G, Handt, S. Platelets and endothelial cells act in concert to delay thrombolysis--evidence from an in vitro model of the human occlusive thrombus. Thromb Haemost, 79(3), 602-8, 1998.
Hantgan, R R, Jerome, W G, Hursting, M J. No effect of clot age or thrombolysis on argatroban's inhibition of thrombin. Blood, 92(6), 2064-74, 1998.
Jerome, W G, Cash, C, Webber, R, Horton, R, Yancey, P G. Lysosomal lipid accumulation from oxidized low density lipoprotein is correlated with hypertrophy of the Golgi apparatus and trans-Golgi network. J Lipid Res, 39(7), 1362-71, 1998.
Kellner-Weibel, G, Jerome, W G, Small, D M, Warner, G J, Stoltenborg, J K, Kearney, M A, Corjay, M H, Phillips, M C, Rothblat, G H. Effects of intracellular free cholesterol accumulation on macrophage viability: a model for foam cell death. Arterioscler Thromb Vasc Biol, 18(3), 423-31, 1998.
Yancey, P G, Jerome, W G. Lysosomal sequestration of free and esterified cholesterol from oxidized low density lipoprotein in macrophages of different species. J Lipid Res, 39(7), 1349-61, 1998.
Carlson, C S, O'Sullivan, M G, Jayo, M J, Anderson, D K, Harber, E S, Jerome, W G, Bullock, B C, Heberling, R L. Fatal disseminated cercopithecine herpesvirus 1 (herpes B infection in cynomolgus monkeys (Macaca fascicularis). Vet Pathol, 34(5), 405-14, 1997.
Jerome, W G, Lewis, J C. Cellular dynamics in early atherosclerotic lesion progression in white carneau pigeons. Spatial and temporal analysis of monocyte and smooth muscle invasion of the intima. Arterioscler Thromb Vasc Biol, 17(4), 654-64, 1997.
Tansey, J T, Thuren, T Y, Jerome, W G, Hantgan, R R, Grant, K, Waite, M. Hydrolysis of phosphatidylcholine by hepatic lipase in discoidal and spheroidal recombinant high-density lipoprotein. Biochemistry, 36(40), 12227-34, 1997.
Handt, S, Jerome, W G, Tietze, L, Hantgan, R R. Plasminogen activator inhibitor-1 secretion of endothelial cells increases fibrinolytic resistance of an in vitro fibrin clot: evidence for a key role of endothelial cells in thrombolytic resistance. Blood, 87(10), 4204-13, 1996.
Lyles, D S, McKenzie, M O, Kaptur, P E, Grant, K W, Jerome, W G. Complementation of M gene mutants of vesicular stomatitis virus by plasmid-derived M protein converts spherical extracellular particles into native bullet shapes. Virology, 217(1), 76-87, 1996.
Endenburg, S C, Hantgan, R R, Lindeboom-Blokzijl, L, Lankhof, H, Jerome, W G, Lewis, J C, Sixma, J J, de Groot, P G. On the role of von Willebrand factor in promoting platelet adhesion to fibrin in flowing blood. Blood, 86(11), 4158-65, 1995.
Braaten, J V, Jerome, W G, Hantgan, R R. Uncoupling fibrin from integrin receptors hastens fibrinolysis at the platelet-fibrin interface. Blood, 83(4), 982-93, 1994.
Jerome, WL. The scientific method. Br Dent J, 177(11-12), 401, 1994.
Lantz, P E, Jerome, W G, Jaworski, J A. Radiopaque deposits surrounding a contact small-caliber gunshot wound. Am J Forensic Med Pathol, 15(1), 10-3, 1994.
Tangirala, R K, Jerome, W G, Jones, N L, Small, D M, Johnson, W J, Glick, J M, Mahlberg, F H, Rothblat, G H. Formation of cholesterol monohydrate crystals in macrophage-derived foam cells. J Lipid Res, 35(1), 93-104, 1994.
Braaten, J V, Handt, S, Jerome, W G, Kirkpatrick, J, Lewis, J C, Hantgan, R R. Regulation of fibrinolysis by platelet-released plasminogen activator inhibitor 1: light scattering and ultrastructural examination of lysis of a model platelet-fibrin thrombus. Blood, 81(5), 1290-9, 1993.
Tangirala, R K, Mahlberg, F H, Glick, J M, Jerome, W G, Rothblat, G H. Lysosomal accumulation of unesterified cholesterol in model macrophage foam cells. J Biol Chem, 268(13), 9653-60, 1993.
Jerome, WL. Mercury from dental amalgam. Br Dent J, 173(7), 227-8, 1992.
Loeser, R, Carlson, C S, Tulli, H, Jerome, W G, Miller, L, Wallin, R. Articular-cartilage matrix gamma-carboxyglutamic acid-containing protein. Characterization and immunolocalization. Biochem J, 282 ( Pt 1), 1-6, 1992. PMCID:1130882
Moyer, C F, Jerome, W G, Taylor, R, Tulli, H, Reinisch, C L. Autoimmune vasculitis in MRL/Mp-lpr/lpr mice: orthochromatic basophils participate in the development of delayed-type hypersensitivity angiitis. Autoimmunity, 12(3), 159-65, 1992.
Taylor, R G, Jerome, W G, Lewis, J C. Ultrastructural localization of peroxidase in atherosclerotic lesions of pigeons. Exp Mol Pathol, 57(3), 167-79, 1992.
Thomas, M J, Hedrick, C C, Smith, S, Pang, J, Jerome, W G, Willard, A S, Shirley, P S. Superoxide generation by the human polymorphonuclear leukocyte in response to latex beads. J Leukoc Biol, 51(6), 591-6, 1992.
Barr, D A, Jerome, W G, Lewis, J C. Morphologic characteristics of naturally occurring atherosclerosis in the brachiocephalic artery of the pigeon. Exp Mol Pathol, 54(2), 99-111, 1991.
Jerome, W G, Minor, L K, Glick, J M, Rothblat, G H, Lewis, J C. Lysosomal lipid accumulation in vascular smooth muscle cells. Exp Mol Pathol, 54(2), 144-58, 1991.
Jones, N L, Jerome, W G, Lewis, J C. Pigeon monocyte/macrophage lysosomes during beta VLDL uptake. Induction of acid phosphatase activity. A model for complex arterial lysosomes. Am J Pathol, 139(2), 383-92, 1991. PMCID:1886089
Minor, L K, Mahlberg, F H, Jerome, W G, Lewis, J C, Rothblat, G H, Glick, J M. Lysosomal hydrolysis of lipids in a cell culture model of smooth muscle foam cells. Exp Mol Pathol, 54(2), 159-71, 1991.
Jerome, W G, Lewis, J C. Early atherogenesis in White Carneau pigeons: effect of a short-term regression diet. Exp Mol Pathol, 53(3), 223-38, 1990.
Mahlberg, F H, Glick, J M, Jerome, W G, Rothblat, G H. Metabolism of cholesteryl ester lipid droplets in a J774 macrophage foam cell model. Biochim Biophys Acta, 1045(3), 291-8, 1990.
Taylor, R G, Jerome, W G, Lewis, J C. Ultrastructural events associated with endothelial cell changes during the initiation and early progression of atherosclerosis. Adv Exp Med Biol, 273, 89-93, 1990.
Noseda, A, White, J G, Godwin, P L, Jerome, W G, Modest, E J. Membrane damage in leukemic cells induced by ether and ester lipids: an electron microscopic study. Exp Mol Pathol, 50(1), 69-83, 1989.
Jerome, W G, Lewis, J C. Early atherogenesis in the White Carneau pigeon. III. Lipid accumulation in nascent foam cells. Am J Pathol, 128(2), 253-64, 1987. PMCID:1899621
Jerome, W G, Lewis, J C. Early atherogenesis in White Carneau pigeons. II. Ultrastructural and cytochemical observations. Am J Pathol, 119(2), 210-22, 1985. PMCID:1887902
Lewis, J C, Taylor, R G, Jerome, W G. Foam cell characteristics in coronary arteries and aortas of White Carneau pigeons with moderate hypercholesterolemia. Ann N Y Acad Sci, 454, 91-100, 1985.
Jerome, W G, Lewis, J C. Early atherogenesis in White Carneau pigeons. I. Leukocyte margination and endothelial alterations at the celiac bifurcation. Am J Pathol, 116(1), 56-68, 1984. PMCID:1900365
Jerome, W G, Cardell, R R. Observations on the role of smooth endoplasmic reticulumin glucocorticoid-induced hepatic glycogen deposition. Tissue Cell, 15(5), 711-27, 1983.
Jerome, W G, Lewis, J C, Taylor, R G, White, M S. Concurrent endothelial cell turnover and leukocyte margination in early atherosclerosis. Scan Electron Microsc, (Pt 3), 1453-9, 1983.
Jerome, W G. Medical electron microscopy. Invest Urol, 19(3), 131-5, 1981.
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