Vanderbilt University School of Medicine

Wood, Alastair J. , M.B.Ch.B.
Professor of Medicine, Emeritus

Lab Url: N/A

Phone Number: (615) 343-8701

Email Address:alastair.wood@vanderbilt.edu

Wood, Alastair's picture

Office Address   Mailing Address

550 RRB

550 RRB, 23rd Ave S at Pierce Ave 37232-6602


Research Description
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Publications
Muszkat, M, Kurnik, D, Solus, J, Sofowora, GG, Xie, HG, Jiang, L, McMunn, C, Ihrie, P, Harris, JR, Dawson, EP, Williams, SM, Wood, AJ, Michael Stein, C. Variation in the alpha2B-adrenergic receptor gene (ADRA2B) and its relationship to vascular response in vivo. Pharmacogenet Genomics, 15(6), 407-14, 2005.

Muszkat, M, Sofowora, GG, Xie, HG, Wood, AJ, Stein, CM. Alpha2B adrenergic receptor 301-303 deletion polymorphism and vascular alpha2 adrenergic receptor response. Pharmacogenet Genomics, 15(1), 23-8, 2005.

Sofowora, GG, Singh, I, He, HB, Wood, AJ, Stein, CM. Effect of acute transdermal estrogen administration on basal, mental stress and cold pressor-induced sympathetic responses in postmenopausal women. Clin Auton Res, 15(3), 193-9, 2005.

Dishy, V, Harris, PA, Pierce, R, Prasad, HC, Sofowora, G, Bonar, HL, Wood, AJ, Stein, CM. Sildenafil does not improve nitric oxide-mediated endothelium-dependent vascular responses in smokers. Br J Clin Pharmacol, 57(2), 209-12, 2004. PMCID:1884430

Dishy, V, Landau, R, Sofowora, GG, Xie, HG, Smiley, RM, Kim, RB, Byrne, DW, Wood, AJ, Stein, CM. Beta2-adrenoceptor Thr164Ile polymorphism is associated with markedly decreased vasodilator and increased vasoconstrictor sensitivity in vivo. Pharmacogenetics, 14(8), 517-22, 2004.

Drazen, J M, Green, M F, Wood, A J. The FDA, Politics and Plan B. The New England Journal of Medicine, 350, 1565-66, 2004.

Muszkat, M, Sofowora, GG, Wood, AJ, Stein, CM. Alpha2-adrenergic receptor-induced vascular constriction in blacks and whites. Hypertension, 43(1), 31-5, 2004.

Sofowora, GG, Dishy, V, Landau, R, Xie, HG, Prasad, HC, Byrne, DW, Smiley, RM, Kim, RB, Wood, AJ, Stein, CM. Alpha 1A-adrenergic receptor polymorphism and vascular response. Clin Pharmacol Ther, 75(6), 539-45, 2004.

Xie, HG, Wood, AJ, Kim, RB, Stein, CM, Wilkinson, GR. Genetic variability in CYP3A5 and its possible consequences. Pharmacogenomics, 5(3), 243-72, 2004.

Dishy, Victor, Gupta, Simi, Landau, Ruth, Xie, Hong-Guang, Kim, Richard B, Smiley, Richard M, Byrne, Daniel W, Wood, Alastair J, Stein, C Michael. G-protein beta3 subunit 825 C/T polymorphism is associated with weight gain during pregnancy. Pharmacogenetics, 13(4), 241-2, 2003.

Dishy, Victor, Sofowora, Gbenga G, Imamura, Hitoshi, Nishimi, Yukihide, Xie, Hong-Guang, Wood, Alastair J, Stein, C Michael. Nitric oxide production decreases after salt loading but is not related to blood pressure changes or nitric oxide-mediated vascular responses. J Hypertens, 21(1), 153-7, 2003.

Haas, DW, Wilkinson, GR, Kuritzkes, DR, Richman, DD, Nicotera, J, Mahon, LF, Sutcliffe, C, Siminski, S, Andersen, J, Coughlin, K, Clayton, EW, Haines, J, Marshak, A, Saag, M, Lawrence, J, Gustavson, J, Anne Bennett, J, Christensen, R, Matula, MA, Wood, AJ, , . A multi-investigator/institutional DNA bank for AIDS-related human genetic studies: AACTG Protocol A5128. HIV Clin Trials, 4(5), 287-300, 2003.

Sofowora, G G, Dishy, V, Muszkat, M, Xie, H G, Kim, R B, Harris, P A, Prasad, H C, Byrne, D W, Nair, U B, Wood, A J J, Stein, C M. A common beta1-adrenergic receptor polymorphism (Arg389Gly) affects blood pressure response to beta-blockade. Clin Pharmacol Ther, 73(4), 366-71, 2003.

Wood, A J. When increased therapeutic benefit comes at increased cost. The New Encgland Journal of Medicine, 346, 1819-21, 2002.

Wood, Alastair J. Variability in beta-adrenergic receptor response in the vasculature: Role of receptor polymorphism. J Allergy Clin Immunol, 110(6 Suppl), S318-21, 2002.

Dickmann, L J, Rettie, A E, Kneller, M B, Kim, R B, Wood, A J, Stein, C M, Wilkinson, G R, Schwarz, U I. Identification and functional characterization of a new CYP2C9 variant (CYP2C9*51) expressed among African Americans. Molecular Pharmacology, 60, 382-387, 2001.

Dishy, V, Sofowora, G G, Xie, H G, Kim, R B, Byrne, D W, Stein, C M, Wood, A J. The effect of common polymorphisms of the beta2-adrenergic receptor on agonist-mediated vascular desensitization. N Engl J Med, 345(14), 1030-5, 2001.

Dishy, V, Sofowora, G, Harris, P A, Kandcer, M, Zhan, F, Wood, A J, Stein, C M. The effect of sildenafil on nitric oxide-mediated vasodilation in healthy men. Clin Pharmacol Ther, 70(3), 270-9, 2001.

Sofowora, G, Dishy, V, Xie, H G, Imamura, H, Nishimi, Y, Morales, C R, Morrow, J D, Kim, R B, Stein, C M, Wood, A J. In-vivo effects of Glu298Asp endothelial nitric oxide synthase polymorphism. Pharmacogenetics, 11(9), 809-14, 2001.

Stein, C M, Lang, C C, Xie, H G, Wood, A J. Hypertension in black people: study of specific genotypes and phenotypes will provide a greater understanding of interindividual and interethnic variability in blood pressure regulation than studies based on race. Pharmacogenetics, 11(2), 95-110, 2001.

Stein, C M, Sadeque, A J, Murray, J J, Wandel, C, Kim, R B, Wood, A J. Cyclosporine pharmacokinetics and pharmacodynamics in African American and white subjects. Clin Pharmacol Ther, 69(5), 317-23, 2001.

Xie, H G, Dishy, V, Sofowora, G, Kim, R B, Landau, R, Smiley, R M, Zhou, H H, Wood, A J, Harris, P, Stein, C M. Arg389Gly beta 1-adrenoceptor polymorphism varies in frequency among different ethnic groups but does not alter response in vivo. Pharmacogenetics, 11(3), 191-7, 2001.

Xie, H G, Kim, R B, Wood, A J, Stein, C M. Molecular basis of ethnic differences in drug disposition and response. Annu Rev Pharmacol Toxicol, 41, 815-50, 2001.

Choo, E F, Leake, B, Wandel, C, Imamura, H, Wood, A J, Wilkinson, G R, Kim, R B. Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes. Drug Metab Dispos, 28(6), 655-60, 2000.

Editors of The New England Journal of Medicine. Looking back on the millennium in medicine. The New England Journal of Medicine, 352, 42-50, 2000.

He, H, Sadeque, A, Erve, J C, Wood, A J, Hachey, D L. Quantitation of loperamide and N-demethyl-loperamide in human plasma using electrospray ionization with selected reaction ion monitoring liquid chromatography-mass spectrometry. J Chromatogr B Biomed Sci Appl, 744(2), 323-31, 2000.

Sadeque, A J, Wandel, C, He, H, Shah, S, Wood, A J. Increased drug delivery to the brain by P-glycoprotein inhibition. Clin Pharmacol Ther, 68(3), 231-7, 2000.

Stein, C M, Lang, C C, Singh, I, He, H B, Wood, A J. Increased vascular adrenergic vasoconstriction and decreased vasodilation in blacks. Additive mechanisms leading to enhanced vascular reactivity. Hypertension, 36(6), 945-51, 2000.

Wandel, C, Kim, RB, Guengerich, FP, Wood, AJ. Mibefradil is a P-glycoprotein substrate and a potent inhibitor of both P-glycoprotein and CYP3A in vitro. Drug Metab Dispos, 28(8), 895-8, 2000.

Wandel, C, Witte, J S, Hall, J M, Stein, C M, Wood, A J, Wilkinson, G R. CYP3A activity in African American and European American men: population differences and functional effect of the CYP3A4*1B5'-promoter region polymorphism. Clin Pharmacol Ther, 68(1), 82-91, 2000.

Wood, A J. Thrombotic thrombocytopenic purpura and clopidogrel - A need for new approaches to drug safety. New England Journal of Medicine, 343, 1824-1826, 2000.

Xie, H G, Stein, C M, Kim, R B, Gainer, J V, Sofowora, G, Dishy, V, Brown, N J, Goree, R E, Haines, J L, Wood, A J. Human beta2-adrenergic receptor polymorphisms: no association with essential hypertension in black or white Americans. Clin Pharmacol Ther, 67(6), 670-5, 2000.

Caraco, Y, Sheller, J, Wood, A J. Impact of ethnic origin and quinidine coadministration on codeine's disposition and pharmacodynamic effects. J Pharmacol Exp Ther, 290(1), 413-22, 1999.

Kim, R B, Wandel, C, Leake, B, Cvetkovic, M, Fromm, M F, Dempsey, P J, Roden, M M, Belas, F, Chaudhary, A K, Roden, D M, Wood, A J, Wilkinson, G R. Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein. Pharm Res, 16(3), 408-14, 1999.

Kinirons, M T, Krivruk, Y, Wilkinson, G R, Wood, A J. Effects of ketoconazole on the erythromycin breath test and the dapsone recovery ratio. British Journal of Clinical Pharmacology, 47, 223-225, 1999.

Kinirons, M T, O'Shea, D, Kim, R B, Groopman, J D, Thummel, K E, Wood, A J, Wilkinson, G R. Failure of erythromycin breath test to correlate with midazolam clearance as a probe of cytochrome P4503A. Clin Pharmacol Ther, 66(3), 224-31, 1999.

Stein, C M, Murray, J J, Wood, A J. Inhibition of stimulated interleukin-2 production in whole blood: a practical measure of cyclosporine effect. Clin Chem, 45(9), 1477-84, 1999.

Wandel, C, Kim, R B, Kajiji, S, Guengerich, P, Wilkinson, G R, Wood, A J. P-glycoprotein and cytochrome P-450 3A inhibition: dissociation of inhibitory potencies. Cancer Res, 59(16), 3944-8, 1999.

Wood A J. The Safety of new Medicines: The importance of asking the right questions. Journal of the American Medical Association, 281, 1753-1754, 1999.

Xie, H G, Kim, R B, Stein, C M, Gainer, J V, Brown, N J, Wood, A J. Alpha1A-adrenergic receptor polymorphism: association with ethnicity but not essential hypertension. Pharmacogenetics, 9(5), 651-6, 1999.

Xie, H G, Kim, R B, Stein, C M, Wilkinson, G R, Wood, A J. Genetic polymorphism of (S)-mephenytoin 4'-hydroxylation in populations of African descent. Br J Clin Pharmacol, 48(3), 402-8, 1999. PMCID:2014331

Xie, H G, Stein, C M, Kim, R B, Wilkinson, G R, Flockhart, D A, Wood, A J. Allelic, genotypic and phenotypic distributions of S-mephenytoin 4'-hydroxylase (CYP2C19) in healthy Caucasian populations of European descent throughout the world. Pharmacogenetics, 9(5), 539-49, 1999.

Xie, H G, Stein, C M, Kim, R B, Xiao, Z S, He, N, Zhou, H H, Gainer, J V, Brown, N J, Haines, J L, Wood, A J. Frequency of functionally important beta-2 adrenoceptor polymorphisms varies markedly among African-American, Caucasian and Chinese individuals. Pharmacogenetics, 9(4), 511-6, 1999.

Brown, N J, Griffin, M R, Ray, W A, Meredith, S, Beers, M H, Marren, J, Robles, M, Stergachis, A, Wood, A J, Avorn, J. A model for improving medication use in home health care patients. J Am Pharm Assoc (Wash), 38(6), 696-702, 1998.

Choy, A M, Lang, C C, Roden, D M, Robertson, D, Wood, A J, Robertson, R M, Biaggioni, I. Abnormalities of the QT interval in primary disorders of autonomic failure. Am Heart J, 136(4 Pt 1), 664-71, 1998.

He, H, Shay, S D, Caraco, Y, Wood, M, Wood, A J. Simultaneous determination of codeine and its seven metabolites in plasma and urine by high-performance liquid chromatography with ultraviolet and electrochemical detection. J Chromatogr B Biomed Sci Appl, 708(1-2), 185-93, 1998.

Kim, R B, Fromm, M F, Wandel, C, Leake, B, Wood, A J, Roden, D M, Wilkinson, G R. The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors. J Clin Invest, 101(2), 289-94, 1998. PMCID:508566

Robbins, I M, Cuiper, L L, Stein, C M, Wood, A J, He, H B, Parker, R, Christman, B W. Angiotensin II mediates systemic rebound hypertension after cessation of prostacyclin infusion in sheep. J Appl Physiol, 85(2), 731-7, 1998.

Stein, C M, Brown, N, Vaughan, D E, Lang, C C, Wood, A J. Regulation of local tissue-type plasminogen activator release by endothelium-dependent and endothelium-independent agonists in human vasculature. J Am Coll Cardiol, 32(1), 117-22, 1998.

Stein, C M, He, H B, Wood, A J. Basal and stimulated sympathetic responses after epinephrine: no evidence of augmented responses. Hypertension, 32(6), 1016-21, 1998.

Wandel, C, Lang, C C, Cowart, D C, Girard, A F, Bramer, S, Flockhart, D A, Wood, A J. Effect of CYP3A inhibition on vesnarinone metabolism in humans. Clin Pharmacol Ther, 63(5), 506-11, 1998.

Wood, A J. Ethnic differences in drug disposition and response. Ther Drug Monit, 20(5), 525-6, 1998.

Wood, A J, Stein, C M, Woosley, R. Making medicines safer--the need for an independent drug safety board. N Engl J Med, 339(25), 1851-4, 1998.

Caraco, Y, Sheller, J, Wood, A J. Pharmacogenetic determinants of codeine induction by rifampin: the impact on codeine's respiratory, psychomotor and miotic effects. J Pharmacol Exp Ther, 281(1), 330-6, 1997.

He, H, Stein, C M, Christman, B, Wood, A J. Determination of catecholamines in sheep plasma by high-performance liquid chromatography with electrochemical detection: comparison of deoxyepinephrine and 3,4-dihydroxybenzylamine as internal standard. J Chromatogr B Biomed Sci Appl, 701(1), 115-9, 1997.

Lang, C C, Rayos, G H, Chomsky, D B, Wood, A J, Wilson, J R. Effect of sympathoinhibition on exercise performance in patients with heart failure. Circulation, 96(1), 238-45, 1997.

Lang, C C, Stein, C M, He, H B, Belas, F J, Blair, I A, Wood, M, Wood, A J. Blunted blood pressure response to central sympathoinhibition in normotensive blacks: increased importance of nonsympathetic factors in blood pressure maintenance in blacks. Hypertension, 30(2 Pt 1), 157-62, 1997.

Lang, C C, Stein, C M, Nelson, R A, He, H B, Belas, F J, Blair, I A, Wood, M, Wood, A J. Sympathoinhibitory response to clonidine is blunted in patients with heart failure. Hypertension, 30(3 Pt 1), 392-7, 1997.

Stein, C M, Brown, N, Carlson, M G, Campbell, P, Wood, A J. Coadministration of glyburide and minoxidil, drugs with opposing effects on potassium channels. Clin Pharmacol Ther, 61(6), 662-8, 1997.

Stein, C M, Deegan, R, Wood, A J. Lack of correlation between arterial and venous beta-adrenergic receptor sensitivity. Hypertension, 29(6), 1273-7, 1997.

Stein, C M, Lang, C C, Nelson, R, Brown, M, Wood, A J. Vasodilation in black Americans: attenuated nitric oxide-mediated responses. Clin Pharmacol Ther, 62(4), 436-43, 1997.

Stein, C M, Nelson, R, He, H B, Wood, M, Wood, A J. Norepinephrine release in the human forearm: effects of epinephrine. Hypertension, 30(5), 1078-84, 1997.

Stein, C M, Wood, A J, Pincus, T. Implementation of multiple outpatient formularies: undesirable effects. Clin Pharmacol Ther, 61(1), 1-7, 1997.

Tateishi, T, Soucek, P, Caraco, Y, Guengerich, F P, Wood, A J. Colchicine biotransformation by human liver microsomes. Identification of CYP3A4 as the major isoform responsible for colchicine demethylation. Biochem Pharmacol, 53(1), 111-6, 1997.

Caraco, Y, Lagerstrom, P O, Wood, A J. Ethnic and genetic determinants of omeprazole disposition and effect. Clin Pharmacol Ther, 60(2), 157-67, 1996.

Caraco, Y, Sheller, J, Wood, A J. Pharmacogenetic determination of the effects of codeine and prediction of drug interactions. J Pharmacol Exp Ther, 278(3), 1165-74, 1996.

Caraco, Y, Tateishi, T, Guengerich, F P, Wood, A J. Microsomal codeine N-demethylation: cosegregation with cytochrome P4503A4 activity. Drug Metab Dispos, 24(7), 761-4, 1996.

Caraco, Y, Wilkinson, G R, Wood, A J. Differences between white subjects and Chinese subjects in the in vivo inhibition of cytochrome P450s 2C19, 2D6, and 3A by omeprazole. Clin Pharmacol Ther, 60(4), 396-404, 1996.

Kinirons, M T, Lang, C C, He, H B, Ghebreselasie, K, Shay, S, Robin, D W, Wood, A J. Triazolam pharmacokinetics and pharmacodynamics in Caucasians and Southern Asians: ethnicity and CYP3A activity. Br J Clin Pharmacol, 41(1), 69-72, 1996.

Lang, C C, Brown, R M, Kinirons, M T, Deathridge, M A, Guengerich, F P, Kelleher, D, O'Briain, D S, Ghishan, F K, Wood, A J. Decreased intestinal CYP3A in celiac disease: reversal after successful gluten-free diet: a potential source of interindividual variability in first-pass drug metabolism. Clin Pharmacol Ther, 59(1), 41-6, 1996.

Lang, C C, Stein, C M, He, H B, Wood, A J. Angiotensin converting enzyme inhibition and sympathetic activity in healthy subjects. Clin Pharmacol Ther, 59(6), 668-74, 1996.

Robin, D W, Hasan, S S, Edeki, T, Lichtenstein, M J, Shiavi, R G, Wood, A J. Increased baseline sway contributes to increased losses of balance in older people following triazolam. J Am Geriatr Soc, 44(3), 300-4, 1996.

Stein, C M, Kinirons, M T, Pincus, T, Wilkinson, G R, Wood, A J. Comparison of the dapsone recovery ratio and the erythromycin breath test as in vivo probes of CYP3A activity in patients with rheumatoid arthritis receiving cyclosporine. Clin Pharmacol Ther, 59(1), 47-51, 1996.

Tateishi, T, Krivoruk, Y, Ueng, Y F, Wood, A J, Guengerich, F P, Wood, M. Identification of human liver cytochrome P-450 3A4 as the enzyme responsible for fentanyl and sufentanil N-dealkylation. Anesth Analg, 82(1), 167-72, 1996.

Caraco, Y, Tateishi, T, Wood, A J. Interethnic difference in omeprazole's inhibition of diazepam metabolism. Clin Pharmacol Ther, 58(1), 62-72, 1995.

Deegan, R, He, H B, Krivoruk, Y, Wood, A J, Wood, M. Regulation of norepinephrine release by beta 2-adrenergic receptors during halothane anesthesia. Anesthesiology, 82(6), 1417-25, 1995.

Lang, C C, Stein, C M, Brown, R M, Deegan, R, Nelson, R, He, H B, Wood, M, Wood, A J. Attenuation of isoproterenol-mediated vasodilatation in blacks. N Engl J Med, 333(3), 155-60, 1995.

Stein, C M, He, H, Pincus, T, Wood, A J. Cyclosporine impairs vasodilation without increased sympathetic activity in humans. Hypertension, 26(4), 705-10, 1995.

Stein, C M, Nelson, R, Brown, M, He, H, Wood, M, Wood, A J. Dietary sodium intake modulates systemic but not forearm norepinephrine release. Clin Pharmacol Ther, 58(4), 425-33, 1995.

Stein, C M, Nelson, R, Brown, M, Wood, M, Wood, A J. Dietary sodium intake modulates vasodilation mediated by nitroprusside but not by methacholine in the human forearm. Hypertension, 25(6), 1220-3, 1995.

Stein, C M, Nelson, R, Deegan, R, He, H, Inagami, T, Frazer, M, Badr, K F, Wood, M, Wood, A J. Tachyphylaxis of human forearm vascular responses does not occur rapidly after exposure to isoproterenol. Hypertension, 25(6), 1294-300, 1995.

Stein, C M, Nelson, R, Deegan, R, He, H, Wood, M, Wood, A J. Forearm beta adrenergic receptor-mediated vasodilation is impaired, without alteration of forearm norepinephrine spillover, in borderline hypertension. J Clin Invest, 96(1), 579-85, 1995. PMCID:185232

Tateishi, T, Wood, A J, Guengerich, F P, Wood, M. Biotransformation of tritiated fentanyl in human liver microsomes. Monitoring metabolism using phenylacetic acid and 2-phenylethanol. Biochem Pharmacol, 50(11), 1921-4, 1995.

Wood, A J. Mechanisms for interethnic differences in antihypertensive drug response. Am J Hypertens, 8(12 Pt 2), 128s, 1995.

Zhou, H H, Wood, A J. Stereoselective disposition of carvedilol is determined by CYP2D6. Clin Pharmacol Ther, 57(5), 518-24, 1995.

Deegan, R, Wood, A J. Beta-receptor antagonism does not fully explain esmolol-induced hypotension. Clin Pharmacol Ther, 56(2), 223-8, 1994.

He, H, Edeki, T I, Wood, A J. Determination of low plasma timolol concentrations following topical application of timolol eye drops in humans by high-performance liquid chromatography with electrochemical detection. J Chromatogr B Biomed Appl, 661(2), 351-6, 1994.

Krivoruk, Y, Kinirons, M T, Wood, A J, Wood, M. Metabolism of cytochrome P4503A substrates in vivo administered by the same route: lack of correlation between alfentanil clearance and erythromycin breath test. Clin Pharmacol Ther, 56(6 Pt 1), 608-14, 1994.

Deegan, R, He, H B, Wood, A J, Wood, M. Effect of enflurane and isoflurane on norepinephrine kinetics: a new approach to assessment of sympathetic function during anesthesia. Anesth Analg, 77(1), 49-54, 1993.

Kinirons, M T, O'Shea, D, Downing, T E, Fitzwilliam, A T, Joellenbeck, L, Groopman, J D, Wilkinson, G R, Wood, A J. Absence of correlations among three putative in vivo probes of human cytochrome P4503A activity in young healthy men. Clin Pharmacol Ther, 54(6), 621-9, 1993.

Robin, D W, Lee, M, Hasan, S S, Wood, A J. Triazolam in cirrhosis: pharmacokinetics and pharmacodynamics. Clin Pharmacol Ther, 54(6), 630-7, 1993.

Stein, M, Deegan, R, He, H, Wood, A J. Beta-adrenergic receptor-mediated release of norepinephrine in the human forearm. Clin Pharmacol Ther, 54(1), 58-64, 1993.

Stein, M, Deegan, R, Wood, A J. Long-term exposure to beta 2-receptor agonist specifically desensitizes beta-receptor-mediated venodilation. Clin Pharmacol Ther, 54(2), 187-93, 1993.

Zhou, H H, Sheller, J R, Nu, H, Wood, M, Wood, A J. Ethnic differences in response to morphine. Clin Pharmacol Ther, 54(5), 507-13, 1993.

Bluhm, R E, Bobbitt, R G, Welch, L W, Wood, A J, Bonfiglio, J F, Sarzen, C, Heath, A J, Branch, R A. Elemental mercury vapour toxicity, treatment, and prognosis after acute, intensive exposure in chloralkali plant workers. Part I: History, neuropsychological findings and chelator effects. Hum Exp Toxicol, 11(3), 201-10, 1992.

Bluhm, R E, Breyer, J A, Bobbitt, R G, Welch, L W, Wood, A J, Branch, R A. Elemental mercury vapour toxicity, treatment, and prognosis after acute, intensive exposure in chloralkali plant workers. Part II: Hyperchloraemia and genitourinary symptoms. Hum Exp Toxicol, 11(3), 211-5, 1992.

Edeki, T, Robin, D W, Prakash, C, Blair, I A, Wood, A J. Sensitive assay for triazolam in plasma following low oral doses. J Chromatogr, 577(1), 190-4, 1992.

He, H B, Deegan, R J, Wood, M, Wood, A J. Optimization of high-performance liquid chromatographic assay for catecholamines. Determination of optimal mobile phase composition and elimination of species-dependent differences in extraction recovery of 3,4-dihydroxybenzylamine. J Chromatogr, 574(2), 213-8, 1992.

Yun, C H, Wood, M, Wood, A J, Guengerich, F P. Identification of the pharmacogenetic determinants of alfentanil metabolism: cytochrome P-450 3A4. An explanation of the variable elimination clearance. Anesthesiology, 77(3), 467-74, 1992.

Zhou, H H, Adedoyin, A, Wood, A J. Differing effect of atropine on heart rate in Chinese and white subjects. Clin Pharmacol Ther, 52(2), 120-4, 1992.

Zhou, H H, Whelan, E, Wood, A J. Lack of effect of ageing on the stereochemical disposition of propranolol. Br J Clin Pharmacol, 33(1), 121-3, 1992. PMCID:1381211

Deegan, R, He, H B, Wood, A J, Wood, M. Effects of anesthesia on norepinephrine kinetics. Comparison of propofol and halothane anesthesia in dogs. Anesthesiology, 75(3), 481-8, 1991.

Perry, S M, Whelan, E, Shay, S, Wood, A J, Wood, M. Effect of i.v. anaesthesia with propofol on drug distribution and metabolism in the dog. Br J Anaesth, 66(1), 66-72, 1991.

Robin, D W, Hasan, S S, Lichtenstein, M J, Shiavi, R G, Wood, A J. Dose-related effect of triazolam on postural sway. Clin Pharmacol Ther, 49(5), 581-8, 1991.

Wood, A J, Zhou, H H. Ethnic differences in drug disposition and responsiveness. Clin Pharmacokinet, 20(5), 350-73, 1991.

Zhou, H H, Wood, A J. Increased suppression of exercise-induced increase in renin by propranolol in Chinese subjects. Clin Pharmacol Ther, 50(2), 150-6, 1991.

Funck-Brentano, C, Silberstein, D J, Roden, D M, Wood, A J, Woosley, R L. A mechanism of D-(+)-sotalol effects on heart rate not related to beta-adrenoceptor antagonism. Br J Clin Pharmacol, 30(2), 195-202, 1990. PMCID:1368218

Lee, J T, Kroemer, H K, Silberstein, D J, Funck-Brentano, C, Lineberry, M D, Wood, A J, Roden, D M, Woosley, R L. The role of genetically determined polymorphic drug metabolism in the beta-blockade produced by propafenone. N Engl J Med, 322(25), 1764-8, 1990.

Merrell, W J, Gordon, L, Wood, A J, Shay, S, Jackson, E K, Wood, M. The effect of halothane on morphine disposition: relative contributions of the liver and kidney to morphine glucuronidation in the dog. Anesthesiology, 72(2), 308-14, 1990.

Murray, K T, Reilly, C, Koshakji, R P, Roden, D M, Lineberry, M D, Wood, A J, Siddoway, L A, Barbey, J T, Woosley, R L. Suppression of ventricular arrhythmias in man by d-propranolol independent of beta-adrenergic receptor blockade. J Clin Invest, 85(3), 836-42, 1990. PMCID:296501

Naslund, T, Silberstein, D J, Merrell, W J, Nadeau, J H, Wood, A J. Low sodium intake corrects abnormality in beta-receptor-mediated arterial vasodilation in patients with hypertension: correlation with beta-receptor function in vitro. Clin Pharmacol Ther, 48(1), 87-95, 1990.

Zhou, H H, Anthony, L B, Roden, D M, Wood, A J. Quinidine reduces clearance of (+)-propranolol more than (-)-propranolol through marked reduction in 4-hydroxylation. Clin Pharmacol Ther, 47(6), 686-93, 1990.

Zhou, H H, Anthony, L B, Wood, A J, Wilkinson, G R. Induction of polymorphic 4'-hydroxylation of S-mephenytoin by rifampicin. Br J Clin Pharmacol, 30(3), 471-5, 1990. PMCID:1368151

Zhou, H H, Wood, A J. Differences in stereoselective disposition of propranolol do not explain sensitivity differences between white and Chinese subjects: correlation between the clearance of (-)- and (+)-propranolol. Clin Pharmacol Ther, 47(6), 719-23, 1990.

Anthony, L, Koshakji, R, Wood, A J. Multiple pathways of propranolol's metabolism are inhibited by debrisoquin. Clin Pharmacol Ther, 46(3), 297-300, 1989.

Bullington, J, Mouton Perry, S M, Rigby, J, Pinkerton, M, Rogers, D, Lewis, T C, Preganz, P, Wood, A J, Wood, M. The effect of advancing age on the sympathetic response to laryngoscopy and tracheal intubation. Anesth Analg, 68(5), 603-8, 1989.

Kroemer, H K, Funck-Brentano, C, Silberstein, D J, Wood, A J, Eichelbaum, M, Woosley, R L, Roden, D M. Stereoselective disposition and pharmacologic activity of propafenone enantiomers. Circulation, 79(5), 1068-76, 1989.

Prakash, C, Koshakji, R P, Wood, A J, Blair, I A. Simultaneous determination of propranolol enantiomers in plasma by high-performance liquid chromatography with fluorescence detection. J Pharm Sci, 78(9), 771-5, 1989.

Rigby, J W, Wood, A J. Use of N-ethylmaleimide to directly determine the proportion of beta-adrenergic receptors exhibiting high affinity for agonists on human mononuclear leukocyte membranes. Biochem Pharmacol, 38(17), 2755-61, 1989.

Shaheen, O, Biollaz, J, Koshakji, R P, Wilkinson, G R, Wood, A J. Influence of debrisoquin phenotype on the inducibility of propranolol metabolism. Clin Pharmacol Ther, 45(4), 439-43, 1989.

Silberstein, D J, Rigby, J, Merrell, J, Naslund, T, Wood, A J. Altered beta-adrenoceptor internalization does not explain reduced beta-adrenergic responsiveness in the elderly. J Clin Endocrinol Metab, 68(1), 131-4, 1989.

Whelan, E, Wood, A J, Koshakji, R, Shay, S, Wood, M. Halothane inhibition of propranolol metabolism is stereoselective. Anesthesiology, 71(4), 561-4, 1989.

Whelan, E, Wood, A J, Shay, S, Wood, M. Lack of effect of spinal anesthesia on drug metabolism. Anesth Analg, 69(3), 307-12, 1989.

Wood, A J. Calcium antagonists. Pharmacologic differences and similarities. Circulation, 80(6 Suppl), IV184-8, 1989.

Zhou, H H, Koshakji, R P, Silberstein, D J, Wilkinson, G R, Wood, A J. Altered sensitivity to and clearance of propranolol in men of Chinese descent as compared with American whites. N Engl J Med, 320(9), 565-70, 1989.

Zhou, H H, Silberstein, D J, Koshakji, R P, Wood, A J. Interindividual differences in beta-receptor density contribute to variability in response to beta-adrenoceptor antagonists. Clin Pharmacol Ther, 45(6), 587-92, 1989.

Naslund, T C, Merrell, W J, Nadeau, J H, Wood, A J. Alpha-adrenergic blockade makes minimal contribution to ketanserin's hypotensive effect. Clin Pharmacol Ther, 44(6), 699-703, 1988.

Reilly, C S, Merrell, J, Wood, A J, Koshakji, R P, Wood, M. Comparison of the effects of isoflurane or fentanyl-nitrous oxide anaesthesia on propranolol disposition in dogs. Br J Anaesth, 60(7), 791-6, 1988.

Wood, A J. Drug interactions in hypertension. Hypertension, 11(3 Pt 2), II1-3, 1988.

Koshakji, R P, Wood, A J. Improved high-performance liquid chromatographic method for the simultaneous determination of propranolol and 4-hydroxypropranolol in plasma with fluorescence detection. J Chromatogr, 422, 294-300, 1987.


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Updated Date
07/12/2005



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