Vanderbilt University School of Medicine

Damon, Bruce M. , Ph.D.
Associate Professor of Radiology and Radiological Sciences
Associate Professor of Molecular Physiology and Biophysics
Associate Professor of Biomedical Engineering

Lab Url: http://vuiis.vanderbilt.edu

Phone Number: (615) 322-8355

Email Address:bruce.damon@vanderbilt.edu

Damon, Bruce's picture

Office Address   Mailing Address

AA-3105 Medical Center North/VUIIS

1161 21st Avenue South MCN AA-1105 37232-2310


Research Keywords
NMR imaging, NMR spectroscopy, NMR relaxometry, Muscle structure-function relationships, Diffusion-tensor MRI muscle fiber tracking, NIR spectroscopy and tomography, electromyography, muscle fatigue,NMR,Spectroscopy

Research Specialty
Development and application of novel imaging and spectroscopic approaches to studying muscle function.

Research Description
The objectives of my research program are to develop new magnetic resonance imaging (MRI) approaches to the study of skeletal muscle structure and function in vivo, to implement these methods in applied physiology and clinical studies, and to provide leadership in these areas to the scientific community. We have several lines of research to support these objectives:

Muscle Structure-Function Relationships
The first line of research in my lab is to understand the relationships among muscle architecture and the internal spatial patterns of strain development, perfusion, and metabolism during contraction. An important theme of our studies to date has been technique development. One of the new capabilities that we have developed combines structural and diffusion-tensor MRI techniques to study skeletal muscle architecture. We are able to form a highly spatially resolved description of the principal architectural features of a muscle, including its line of action, its boundaries, the position and orientation of its internal aponeurosis, and the internal arrangement of its fibers. This description forms a structural scaffold for the muscle, onto which we can overlay functional information and understand it relative to the anatomy. Recently, we have also developed a method for measuring the strain tensor in isometrically contracting skeletal muscle and have combined this approach with diffusion-tensor MRI to provide evidence for a significant deviation of the principal axis of fiber shortening from the principal fiber direction and for the development of shear strain during contraction. We have also implemented or developed methods for measuring perfusion and oxyhemoglobin saturation during contraction using MRI. In the future, we will advance our methods further and conduct a comprehensive study of muscle structure-function relationships in healthy muscle. We will contrast these findings with those from Becker muscular dystrophy patients.

MRI Detection of Muscle Microvascular Dysfunction
A second project in my lab is the study of the functional status of the skeletal muscle microcirculation and its alteration in obesity and type 2 diabetes mellitus. We have developed a simple, non-invasive test in which we use MRI to read out changes in blood volume and blood oxygenation following a brief isometric muscle contraction. The MRI methods themselves are quite standard, are easily optimized and implemented, and provide data that are simple to analyze. After providing an initial description of the physiological basis of this protocol, we examined its reproducibility and the sensitivity of its parameter estimates to image noise. We have implemented this protocol in a recently completed study of obese persons with and without type 2 diabetes mellitus. We found that the blood volume responses to muscle contraction are depressed to similar degrees in these groups, as compared to age-, gender-, and race-matched lean subjects.

Multi-parametric Characterization of Muscle Damage in the Inflammatory Myopathies
A third aspect of my research program is the development of improved MRI methods for detecting and quantifying muscle damage. My Co-Principal Investigator, Professor Jane Park, other colleagues at Vanderbilt, and I have for several years been developing MRI-based methods for characterizing tissue microstructure in healthy and diseased tissues; these include measurements of the diffusion-tensor, MRI relaxation time constants, tissue water compartmentalization, perfusion, and tissue macromolecular content. These methods, we believe, will provide for quantitative measures of myofibril disruption, membrane damage, inflammation, and reduced perfusion in damaged muscle. We have designed a series of studies, involving both animal and human models of muscle damage, to test our hypotheses. Ultimately, we intend to apply these methods in studies of patients with inflammatory myopathies.




Publications
Berglund, ED, Lustig, DG, Baheza, RA, Hasenour, CM, Lee-Young, RS, Donahue, EP, Lynes, SE, Swift, LL, Charron, MJ, Damon, BM, Wasserman, DH. Hepatic glucagon action is essential for exercise-induced reversal of mouse fatty liver. Diabetes, 60(11), 2720-9, 2011.

Damon BM, Buck AKW, Ding Z. Diffusion-tensor MRI based skeletal muscle fiber tracking. Imaging in Medicine, 3(6), 675-687, 2011.

Elder, CP, Cook, RN, Wilkens, KL, Chance, MA, Sanchez, OA, Damon, BM. A method for detecting the temporal sequence of muscle activation during cycling using MRI. J Appl Physiol, 110(3), 826-33, 2011.

Englund, EK, Elder, CP, Xu, Q, Ding, Z, Damon, BM. Combined diffusion and strain tensor MRI reveals a heterogeneous, planar pattern of strain development during isometric muscle contraction. Am J Physiol Regul Integr Comp Physiol, 300(5), R1079-90, 2011.

Sanchez, OA, Copenhaver, EA, Chance, MA, Fowler, MJ, Towse, TF, Kent-Braun, JA, Damon, BM. Postmaximal contraction blood volume responses are blunted in obese and type 2 diabetic subjects in a muscle-specific manner. Am J Physiol Heart Circ Physiol, 301(2), H418-27, 2011.

Elder, CP, Cook, RN, Chance, MA, Copenhaver, EA, Damon, BM. Image-based calculation of perfusion and oxyhemoglobin saturation in skeletal muscle during submaximal isometric contractions. Magn Reson Med, 64(3), 852-61, 2010.

Heemskerk, AM, Sinha, TK, Wilson, KJ, Ding, Z, Damon, BM. Repeatability of DTI-based skeletal muscle fiber tracking. NMR Biomed, 23(3), 294-303, 2010.

Sanchez, OA, Copenhaver, EA, Elder, CP, Damon, BM. Absence of a significant extravascular contribution to the skeletal muscle BOLD effect at 3 T. Magn Reson Med, 64(2), 527-35, 2010.

Heemskerk, AM, Sinha, TK, Wilson, KJ, Ding, Z, Damon, BM. Quantitative assessment of DTI-based muscle fiber tracking and optimal tracking parameters. Magn Reson Med, 61(2), 467-72, 2009. PMCID:2632726

Kan, JH, Heemskerk, AM, Ding, Z, Gregory, A, Mencio, G, Spindler, K, Damon, BM. DTI-based muscle fiber tracking of the quadriceps mechanism in lateral patellar dislocation. J Magn Reson Imaging, 29(3), 663-70, 2009. PMCID:2676427

Lee DJ, Mencio GA, Hernanz-Schulman M, Nealy BJ, Damon BM, Kan JH. Comparison of acute and subacute treatment of buckle fractures in the pediatric population. Journal of Family Practice, 58, E1-E6, 2009.

Louie, EA, Gochberg, DF, Does, MD, Damon, BM. Transverse relaxation and magnetization transfer in skeletal muscle: effect of pH. Magn Reson Med, 61(3), 560-9, 2009. PMCID:2649690

Sanchez, OA, Louie, EA, Copenhaver, EA, Damon, BM. Repeatability of a dual gradient-recalled echo MRI method for monitoring post-isometric contraction blood volume and oxygenation changes. NMR Biomed, 22(7), 753-61, 2009.

Yankeelov, TE, Avison, MJ, Damon, BM, Manning, HC, Peterson, TE, Gore, JC. Frontiers of Biomedical Imaging Science 2009: workshop report and research opportunities. Cancer Res, 69(20), 7902-4, 2009.

Damon, BM. Effects of image noise in muscle diffusion tensor (DT)-MRI assessed using numerical simulations. Magn Reson Med, 60(4), 934-44, 2008. PMCID:2570042

Damon, BM, Wadington, MC, Lansdown, DA, Hornberger, JL. Spatial heterogeneity in the muscle functional MRI signal intensity time course: effect of exercise intensity. Magn Reson Imaging, 26, 1114-1121, 2008. PMCID:2614829

Kan, JH, Hernanz-Schulman, M, Damon, BM, Yu, C, Connolly, SA. MRI features of three paediatric intra-articular synovial lesions: a comparative study. Clin Radiol, 63(7), 805-12, 2008.

Damon, BM, Hornberger, JL, Wadington, MC, Lansdown, DA, Kent-Braun, JA. Dual gradient-echo MRI of post-contraction changes in skeletal muscle blood volume and oxygenation. Magn Reson Med, 57(4), 670-9, 2007.

Damon, BM, Louie, EA, Sanchez, OA. Physiological basis of muscle functional MRI. J Gravit Physiol, 14(1), P85-8, 2007.

Damon, BM, Wadington, MC, Hornberger, JL, Lansdown, DA. Absolute and relative contributions of BOLD effects to the muscle functional MRI signal intensity time course: effect of exercise intensity. Magn Reson Med, 58(2), 335-45, 2007.

Heemskerk AM and Damon BM. Diffusion Tensor MRI Assessment of Skeletal Muscle Architecture. Current Medical Imaging Reviews, 3( ), 152-160, 2007.

Lansdown, DA, Ding, Z, Wadington, M, Hornberger, JL, Damon, BM. Quantitative Diffusion Tensor MRI-Based Fiber Tracking of Human Skeletal Muscle. J Appl Physiol, 103, 673-681, 2007.

Maguire, MA, Weaver, TW, Damon, BM. Delayed Blood Reoxygenation following Maximum Voluntary Contraction. Med Sci Sports Exerc, 39(2), 257-67, 2007.

Damon, BM, Gore, JC. Physiological basis of muscle functional MRI: predictions using a computer model. J Appl Physiol, 98(1), 264-73, 2005.

Damon BM, Gore JC. Biophysical basis of magnetic resonance imaging of small animals. Methods in Enzymology, 385(), 19-40, 2004.

Damon, BM, Gore, JC. Biophysical basis of magnetic resonance imaging of small animals. Methods Enzymol, 385, 19-40, 2004.

Wigmore DM, Damon BM, Pober DM, Kent-Braun JA.. MRI Measures of Perfusion-Related Changes in Human Skeletal Muscle During Progressive Contractions. Journal of Applied Physiology, 97(), 2385-2394, 2004.

Damon, BM, Hsu, AC, Stark, HJ, Dawson, MJ. The carnosine C-2 proton''s chemical shift reports intracellular pH in oxidative and glycolytic muscle fibers. Magn Reson Med, 49(2), 233-40, 2003.

Damon, BM, Wigmore, DM, Ding, Z, Gore, JC, Kent-Braun, JA. Cluster analysis of muscle functional MRI data. J Appl Physiol, 95(3), 1287-96, 2003.

Price TB, Kamen G, Damon BM, Knight CA, Applegate B, Gore JC, Eward K, Signorile JF. Comparison of MRI and EMG to study muscle activation by dynamic plantar flexion. Magnetic Resonance Imaging, 21(8), 853-861, 2003.

Damon BM, Ding Z, Anderson AW, Freyer AS, Gore JC. Validation of diffusion tensor MRI-based muscle fiber tracking. Magnetic Resonance in Medicine, 48, 97-104, 2002.

Damon BM, Gregory CD, Hall KL, Stark HJ, Gulani V, Dawson MJ. Intracellular acidification and volume increases explain 1H R2 decreases during exercise. Magnetic Resonance in Medicine, 47, 14-23, 2002.

Ivy JL, Goforth HW, Damon BM, McCauley TR, Parsons EC, Price TB. Early post-exercise muscle glycogen recovery is enhanced with a carbohydrate-protein supplement. Journal of Applied Physiology, 93, 1337-1344, 2002.

Bruce BC, Carragher BO, Damon BM, Dawson MJ, Eurell JA, Gregory CD, Lauterbur PC, Marjanovic MM, Mason-Fossum B, Morris HD, Potter CS, Thakkar U. Chickscope: an interactive MRI classroom curriculum innovation for K-12. Computers and Education Special Issue on Multimedia, 29, 73-87, 1997.


Postdoctoral Position Available
No

Postdoctoral Position Details
N/A

Updated Date
12/19/2011



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