Vanderbilt University School of Medicine

Goldenring, James R. , M.D., Ph.D.
Professor of Surgery
Paul W. Sanger Chair in Experimental Surgery
Professor of Cell and Developmental Biology

Lab Url: http://www.mc.Vanderbilt.Edu/reporter/index.html?ID=2144&keywords=Goldenring&start=1&end=10

Phone Number: 615-936-3726

Email Address:jim.goldenring@vanderbilt.edu

Goldenring, James's picture

Office Address   Mailing Address

10-435G MRB IV

10-435G MRB IV 37232


Research Keywords
Gastric cancer Vesicle trafficking Protein kinases Rab proteins A-kinase anchoring proteins Centrosomes Golgi apparatus Membrane recycling Apical recycling systems Endocytosis Myosin V Gastric parietal cell Gastric metaplasia Epithelial biology RNA trafficking stress granules Cancer Protein structure,Biochemistry,Cancer,Cell cycle,Ion transport,Kinase,Knockout,Malignancy,Membrane,Molecular medicine,Pathology,Phosphorylation,Physiology,Post-transcriptional modification,Protein Structure,Proteomics,RNA editing,Signal transduction,Stem cells,Structural Biology

Research Description
Our laboratory studies a number of subjects that apply broadly to epithelial biology. We pursue three distinct programmatic areas. First, we are investigating the protein machinery required for the regulation of the recycling to the plasma membrane of receptors, ion transporters and ion channels. These studies focus on the ability of the Rab11 family of small GTPases (Rab11a, Rab11b and Rab25) to initiate and coordinate the assembly of multiprotein complexes regulating vesicle trafficking. Over the past several years, we have identified myosin Vb as the molecular motor involved in movement towards the plasma membrane. We have also identified a family of at least 8 other Rab11 family interacting proteins (Rab11-FIPs) that also participate in the regulation of plasma membrane recycling. Present investigations center on understanding the assembly of endogenous complexes, the regulation of recycling by novel protein kinase activities and the characterization of novel Rab11-FIP proteins. In addition, we have immunoisolated human parietal cell tubulovesicular recycling membrane vesicles and are performing a total proteomic analysis of the vesicle components. These proteomic studies are revealing unrecognized components of the membrane recycling pathways. Second, we have a long commitment to the study of cAMP-dependent protein kinase anchoring proteins (AKAP). Our present investigations focus on a multiply spliced family of 350-450 kDa AKAPs which we have designated AKAP350. We and others have found that AKAP350 is present at the Golgi apparatus and the centrosome and scaffolds a number of kinases and phosphatases including Type II A kinase, PKN, PKC-epsilon, CK1, phosphatase 1 and phosphatase 2a. In addition we have found that AKAP350 scaffolds Transforming acidic coiled-coil protein 3 and 4 at the centrosome, and a Chloride intracellular channel protein (CLIC5B) as well as cdc42-interacting protein 4 (CIP4) at the Golgi. Our present investigations center on both the investigation of the role of AKAP350 in regulating centrosome dynamics and the elucidation of AKAP350 function in regulating Golgi structure and function. Third, we have had a long-standing interest in gastritis, oxyntic atrophy and gastric cancer. We have identified a previously unrecognized metaplastic lineage associated with loss of gastric parietal cells. This lineage, designated Spasmolytic polypeptide expressing metaplasia (SPEM) is associated with gastric cancer in both humans as well as in mouse models of Helicobacter infection. Our present studies are using gene microarray and 2D-DIGE proteomics to analyze metaplastic lineages isoalted by laser capture microdissection. These studies seek to assemble a cohort of putative markers of the SPEM lineage. We will be using these markers to examine the relationship of SPEM with neoplastic transformation in humans.

Clinical Research Description
We have had a long-standing interest in gastritis, oxyntic atrophy and gastric cancer. We have identified a previously unrecognized metaplastic lineage associated with loss of gastric parietal cells. This lineage, designated Spasmolytic polypeptide expressing metaplasia (SPEM) is associated with gastric cancer in both humans as well as in mouse models of Helicobacter infection. Our present studies are using gene microarray and laser capture microdissection to assemble a cohort of putative markers of the SPEM lineage. We will be using these markers to examine the relationship of SPEM with neoplastic transformation. In addition, we will be testing these new markers for their utilitiy in identifying preneoplastic lesions in patients at risk for gastric cancer.

Publications
Aikou, S, Ohmoto, Y, Gunji, T, Matsuhashi, N, Ohtsu, H, Miura, H, Kubota, K, Yamagata, Y, Seto, Y, Nakajima, A, Goldenring, JR, Kaminishi, M, Nomura, S. Tests for Serum Levels of Trefoil Factor Family Proteins Can Improve Gastric Cancer Screening. Gastroenterology, , , 2011.

Ducharme, NA, Ham, AJ, Lapierre, LA, Goldenring, JR. Rab11-FIP2 influences multiple components of the endosomal system in polarized MDCK cells. Cell Logist, 1(2), 57-68, 2011. PMCID:3116584

Goldenring, JR, Nam, KT. Rab25 as a tumour suppressor in colon carcinogenesis. Br J Cancer, 104(1), 33-6, 2011. PMCID:3041130

Lapierre, LA, Caldwell, CM, Higginbotham, JN, Avant, KM, Hall, J, Beauchamp, RD, Goldenring, JR. Transformation of rat intestinal epithelial cells by overexpression of Rab25 is microtubule dependent. Cytoskeleton (Hoboken), 68(2), 97-111, 2011. PMCID:3041130

Mattaloni, SM, Kolobova, E, Favre, C, Marinelli, RA, Goldenring, JR, Larocca, MC. AKAP350 is involved in the development of apical "canalicular" structures in hepatic cells HepG2. J Cell Physiol, , , 2011. PMCID:3116584

Roland, JT, Bryant, DM, Datta, A, Itzen, A, Mostov, KE, Goldenring, JR. Rab GTPase-Myo5B complexes control membrane recycling and epithelial polarization. Proc Natl Acad Sci U S A, 108(7), 2789-94, 2011. PMCID:3041130

Goldenring, JR. Perspective: Innocence and due diligence: managing unfounded allegations of scientific misconduct. Acad Med, 85(3), 527-30, 2010. PMCID:2827957

Goldenring, JR, Nam, KT. Oxyntic atrophy, metaplasia, and gastric cancer. Prog Mol Biol Transl Sci, 96, 117-31, 2010. PMCID:3041130

Goldenring, JR, Nam, KT, Wang, TC, Mills, JC, Wright, NA. Spasmolytic polypeptide-expressing metaplasia and intestinal metaplasia: time for reevaluation of metaplasias and the origins of gastric cancer. Gastroenterology, 138(7), 2207-10, 2210.e1, 2010. PMCID:2935280

Lapierre, LA, Caldwell, CM, Higginbotham, JN, Avant, KM, Hall, J, Daniel Beauchamp, R, Goldenring, JR. Transformation of rat intestinal epithelial cells by overexpression of Rab25 is microtubule dependent. Cytoskeleton (Hoboken), , , 2010. PMCID:3041130

Lee, HJ, Nam, KT, Park, HS, Kim, MA, Lafleur, BJ, Aburatani, H, Yang, HK, Kim, WH, Goldenring, JR. Gene expression profiling of metaplastic lineages identifies CDH17 as a prognostic marker in early stage gastric cancer. Gastroenterology, 139(1), 213-25.e3, 2010. PMCID:2917327

Lennerz, JK, Kim, SH, Oates, EL, Huh, WJ, Doherty, JM, Tian, X, Bredemeyer, AJ, Goldenring, JR, Lauwers, GY, Shin, YK, Mills, JC. The transcription factor MIST1 is a novel human gastric chief cell marker whose expression is lost in metaplasia, dysplasia, and carcinoma. Am J Pathol, 177(3), 1514-33, 2010. PMCID:2997152

Matthies, HJ, Moore, JL, Saunders, C, Matthies, DS, Lapierre, LA, Goldenring, JR, Blakely, RD, Galli, A. Rab11 supports amphetamine-stimulated norepinephrine transporter trafficking. J Neurosci, 30(23), 7863-77, 2010. PMCID:2935280

Nam, KT, Lee, HJ, Smith, JJ, Lapierre, LA, Kamath, VP, Chen, X, Aronow, BJ, Yeatman, TJ, Bhartur, SG, Calhoun, BC, Condie, B, Manley, NR, Beauchamp, RD, Coffey, RJ, Goldenring, JR. Loss of Rab25 promotes the development of intestinal neoplasia in mice and is associated with human colorectal adenocarcinomas. J Clin Invest, 120(3), 840-9, 2010. PMCID:2827957

Nam, KT, Lee, HJ, Sousa, JF, Weis, VG, O''Neal, RL, Finke, PE, Romero-Gallo, J, Shi, G, Mills, JC, Peek, RM, Konieczny, SF, Goldenring, JR. Mature chief cells are cryptic progenitors for metaplasia in the stomach. Gastroenterology, 139(6), 2028-2037.e9, 2010. PMCID:2997152

Quante, M, Marrache, F, Goldenring, JR, Wang, TC. TFF2 mRNA transcript expression marks a gland progenitor cell of the gastric oxyntic mucosa. Gastroenterology, 139(6), 2018-2027.e2, 2010. PMCID:2997152

Shinohara, M, Mao, M, Keeley, TM, El-Zaatari, M, Lee, HJ, Eaton, KA, Samuelson, LC, Merchant, JL, Goldenring, JR, Todisco, A. Bone morphogenetic protein signaling regulates gastric epithelial cell development and proliferation in mice. Gastroenterology, 139(6), 2050-2060.e2, 2010. PMCID:2997152

Aikou, S, Fukushima, Y, Ogawa, M, Nozaki, K, Saito, T, Matsui, T, Goldenring, JR, Kaminishi, M, Nomura, S. Alterations in gastric mucosal lineages before or after acute oxyntic atrophy in gastrin receptor and h(2) histamine receptor-deficient mice. Dig Dis Sci, 54(8), 1625-35, 2009.

Eggers, CT, Schafer, JC, Goldenring, JR, Taylor, SS. D-AKAP2 interacts with Rab4 and Rab11 through its RGS domains and regulates transferrin receptor recycling. J Biol Chem, 284(47), 32869-80, 2009. PMCID:2781703

Fiske, WH, Tanksley, J, Nam, KT, Goldenring, JR, Slebos, RJ, Liebler, DC, Abtahi, AM, La Fleur, B, Ayers, GD, Lind, CD, Washington, MK, Coffey, RJ. Efficacy of cetuximab in the treatment of Menetrier''s disease. Sci Transl Med, 1(8), 8ra18, 2009. PMCID:2917327

Kolobova, E, Efimov, A, Kaverina, I, Rishi, AK, Schrader, JW, Ham, AJ, Larocca, MC, Goldenring, JR. Microtubule-dependent association of AKAP350A and CCAR1 with RNA stress granules. Exp Cell Res, 315(3), 542-55, 2009.

Nam, KT, Lee, HJ, Mok, H, Romero-Gallo, J, Crowe, JE, Peek, RM, Goldenring, JR. Amphiregulin-deficient mice develop spasmolytic polypeptide expressing metaplasia and intestinal metaplasia. Gastroenterology, 136(4), 1288-96, 2009.

Nozaki, K, Weis, V, Wang, TC, Falus, A, Goldenring, JR. Altered gastric chief cell lineage differentiation in histamine-deficient mice. Am J Physiol Gastrointest Liver Physiol, 296(6), G1211-20, 2009. PMCID:2697940

Roland, JT, Lapierre, LA, Goldenring, JR. Alternative splicing in class V myosins determines association with Rab10. J Biol Chem, 284(2), 1213-23, 2009. PMCID:2613619

Tzaban, S, Massol, RH, Yen, E, Hamman, W, Frank, SR, Lapierre, LA, Hansen, SH, Goldenring, JR, Blumberg, RS, Lencer, WI. The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity. J Cell Biol, 185(4), 673-84, 2009. PMCID:2711563

Weis, VG, Goldenring, JR. Current understanding of SPEM and its standing in the preneoplastic process. Gastric Cancer, 12(4), 189-97, 2009. PMCID:2827957

Cao, Z, Li, C, Higginbotham, JN, Franklin, JL, Tabb, DL, Graves-Deal, R, Hill, S, Cheek, K, Jerome, WG, Lapierre, LA, Goldenring, JR, Ham, AJ, Coffey, RJ. Use of fluorescence-activated vesicle sorting for isolation of naked2-associated, basolaterally-targeted exocytic vesicles for proteomic analysis. Mol Cell Proteomics, , , 2008. PMCID:2528074

Khandelwal, P, Ruiz, WG, Balestreire-Hawryluk, E, Weisz, OA, Goldenring, JR, Apodaca, G. Rab11a-dependent exocytosis of discoidal/fusiform vesicles in bladder umbrella cells. Proc Natl Acad Sci U S A, 105(41), 15773-8, 2008. PMCID:2572972

Nozaki, K, Ogawa, M, Williams, JA, Lafleur, BJ, Ng, V, Drapkin, RI, Mills, JC, Konieczny, SF, Nomura, S, Goldenring, JR. A molecular signature of gastric metaplasia arising in response to acute parietal cell loss. Gastroenterology, 134(2), 511-22, 2008.

Schonteich, E, Wilson, GM, Burden, J, Hopkins, CR, Anderson, K, Goldenring, JR, Prekeris, R. The Rip11/Rab11-FIP5 and kinesin II complex regulates endocytic protein recycling. J Cell Sci, 121(Pt 22), 3824-33, 2008.

Utley, TJ, Ducharme, NA, Varthakavi, V, Shepherd, BE, Santangelo, PJ, Lindquist, ME, Goldenring, JR, Crowe, JE. Respiratory syncytial virus uses a Vps4-independent budding mechanism controlled by Rab11-FIP2. Proc Natl Acad Sci U S A, 105(29), 10209-14, 2008. PMCID:2481327

Cresawn, KO, Potter, BA, Oztan, A, Guerriero, CJ, Ihrke, G, Goldenring, JR, Apodaca, G, Weisz, OA. Differential involvement of endocytic compartments in the biosynthetic traffic of apical proteins. EMBO J, 26(16), 3737-48, 2007. PMCID:1952228

Ducharme, NA, Williams, JA, Oztan, A, Apodaca, G, Lapierre, LA, Goldenring, JR. Rab11-FIP2 regulates differentiable steps in transcytosis. Am J Physiol Cell Physiol, 293(3), C1059-72, 2007.

Lapierre, LA, Avant, KM, Caldwell, CM, Ham, AJ, Hill, S, Williams, JA, Smolka, AJ, Goldenring, JR. Characterization of immunoisolated human gastric parietal cells tubulovesicles: identification of regulators of apical recycling. Am J Physiol Gastrointest Liver Physiol, , , 2007.

Leys, CM, Nomura, S, LaFleur, BJ, Ferrone, S, Kaminishi, M, Montgomery, E, Goldenring, JR. Expression and prognostic significance of prothymosin-alpha and ERp57 in human gastric cancer. Surgery, 141(1), 41-50, 2007.

Nam, KT, Varro, A, Coffey, RJ, Goldenring, JR. Potentiation of oxyntic atrophy-induced gastric metaplasia in amphiregulin-deficient mice. Gastroenterology, 132(5), 1804-19, 2007.

Nedvetsky, PI, Stefan, E, Frische, S, Santamaria, K, Wiesner, B, Valenti, G, Hammer, JA, Nielsen, S, Goldenring, JR, Rosenthal, W, Klussmann, E. A Role of myosin Vb and Rab11-FIP2 in the aquaporin-2 shuttle. Traffic, 8(2), 110-23, 2007.

Neel, NF, Lapierre, LA, Goldenring, JR, Richmond, A. RhoB plays an essential role in CXCR2 sorting decisions. J Cell Sci, 120(Pt 9), 1559-71, 2007.

Oztan, A, Silvis, M, Weisz, OA, Bradbury, NA, Hsu, SC, Goldenring, JR, Yeaman, C, Apodaca, G. Exocyst requirement for endocytic traffic directed toward the apical and basolateral poles of polarized MDCK cells. Mol Biol Cell, 18(10), 3978-92, 2007. PMCID:1995710

Que, J, Okubo, T, Goldenring, JR, Nam, KT, Kurotani, R, Morrisey, EE, Taranova, O, Pevny, LH, Hogan, BL. Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm. Development, 134(13), 2521-31, 2007.

Roland, JT, Kenworthy, AK, Peranen, J, Caplan, S, Goldenring, JR. Myosin Vb Interacts with Rab8a on a Tubular Network Containing EHD1 and EHD3. Mol Biol Cell, , , 2007. PMCID:1949367

Yoshizawa, N, Takenaka, Y, Yamaguchi, H, Tetsuya, T, Tanaka, H, Tatematsu, M, Nomura, S, Goldenring, JR, Kaminishi, M. Emergence of spasmolytic polypeptide-expressing metaplasia in Mongolian gerbils infected with Helicobacter pylori. Lab Invest, 87(12), 1265-76, 2007.

Ducharme, NA, Hales, CM, Lapierre, LA, Ham, AJ, Oztan, A, Apodaca, G, Goldenring, JR. MARK2/EMK1/Par-1Balpha phosphorylation of Rab11-family interacting protein 2 is necessary for the timely establishment of polarity in Madin-Darby canine kidney cells. Mol Biol Cell, 17(8), 3625-37, 2006. PMCID:1525241

Goldenring, JR, Nomura, S. Differentiation of the gastric mucosa III. Animal models of oxyntic atrophy and metaplasia. Am J Physiol Gastrointest Liver Physiol, 291(6), G999-1004, 2006.

Jin, M, Goldenring, JR. The Rab11-FIP1/RCP gene codes for multiple protein transcripts related to the plasma membrane recycling system. Biochim Biophys Acta, 1759(6), 281-95, 2006.

Lang, MR, Lapierre, LA, Frotscher, M, Goldenring, JR, Knapik, EW. Secretory COPII coat component Sec23a is essential for craniofacial chondrocyte maturation. Nat Genet, 38(10), 1198-203, 2006.

Leys, CM, Nomura, S, Rudzinski, E, Kaminishi, M, Montgomery, E, Washington, MK, Goldenring, JR. Expression of Pdx-1 in human gastric metaplasia and gastric adenocarcinoma. Hum Pathol, 37(9), 1162-8, 2006.

Lis??, MF, Wong, TP, Trinh, A, Hines, RM, Liu, L, Kang, R, Hines, DJ, Lu, J, Goldenring, JR, Wang, YT, El-Husseini, A. Involvement of myosin Vb in glutamate receptor trafficking. J Biol Chem, 281(6), 3669-78, 2006.

Ogawa, M, Nomura, S, Car, BD, Goldenring, JR. Omeprazole treatment ameliorates oxyntic atrophy induced by DMP-777. Dig Dis Sci, 51(3), 431-9, 2006.

Pooley, RD, Reddy, S, Soukoulis, V, Roland, JT, Goldenring, JR, Bader, DM. CytLEK1 is a regulator of plasma membrane recycling through its interaction with SNAP-25. Mol Biol Cell, 17(7), 3176-86, 2006. PMCID:1483049

Varthakavi, V, Smith, RM, Martin, KL, Derdowski, A, Lapierre, LA, Goldenring, JR, Spearman, P. The Pericentriolar Recycling Endosome Plays a Key Role in Vpu-mediated Enhancement of HIV-1 Particle Release. Traffic, 7(3), 298-307, 2006.

Welch, DC, Wirth, PS, Goldenring, JR, Ness, E, Jagasia, M, Washington, K. Gastric graft-versus-host disease revisited: does proton pump inhibitor therapy affect endoscopic gastric biopsy interpretation. Am J Surg Pathol, 30(4), 444-9, 2006.

Cecilia Larocca, M, Jin, M, Goldenring, JR. AKAP350 modulates microtubule dynamics. Eur J Cell Biol, , , 2005.

Greengauz-Roberts, O, St??ppler, H, Nomura, S, Yamaguchi, H, Goldenring, JR, Podolsky, RH, Lee, JR, Dynan, WS. Saturation labeling with cysteine-reactive cyanine fluorescent dyes provides increased sensitivity for protein expression profiling of laser-microdissected clinical specimens. Proteomics, 5(7), 1746-57, 2005.

Nomura, S, Settle, SH, Leys, CM, Means, AL, Peek, RM, Leach, SD, Wright, CV, Coffey, RJ, Goldenring, JR. Evidence for repatterning of the gastric fundic epithelium associated with M??n??trier''s disease and TGFalpha overexpression. Gastroenterology, 128(5), 1292-305, 2005.

Nomura, S, Yamaguchi, H, Ogawa, M, Wang, TC, Lee, JR, Goldenring, JR. Alterations in gastric mucosal lineages induced by acute oxyntic atrophy in wild-type and gastrin-deficient mice. Am J Physiol Gastrointest Liver Physiol, 288(2), G362-75, 2005.

Ogawa, M, Nomura, S, Varro, A, Wang, TC, Goldenring, JR. Altered metaplastic response of waved-2 EGF receptor mutant mice to acute oxyntic atrophy. Am J Physiol Gastrointest Liver Physiol, , , 2005.

Robert, ME, Washington, MK, Lee, JR, Goldenring, JR, Bronner, MP, Goldblum, JR, Greenson, JK, Haber, MM, Hart, JA, Lamps, LW, Lauwers, GY, Lewin, D, Lazenby, AJ, Montgomery, E, Crawford, JM. Rab11a immunohistochemical analysis does not distinguish indefinite, low-, and high-grade dysplasia in Barrett esophagus. Am J Clin Pathol, 124(4), 519-27, 2005.

Fan, Guo-Huang, Lapierre, Lynne A, Goldenring, James R, Sai, Jiqing, Richmond, Ann. Rab11-family interacting protein 2 and myosin Vb are required for CXCR2 recycling and receptor-mediated chemotaxis. Mol Biol Cell, 15(5), 2456-69, 2004. PMCID:404037

Houghton, Jeanmarie, Stoicov, Calin, Nomura, Sachiyo, Rogers, Arlin B, Carlson, Jane, Li, Hanchen, Cai, Xun, Fox, James G, Goldenring, James R, Wang, Timothy C. Gastric cancer originating from bone marrow-derived cells. Science, 306(5701), 1568-71, 2004.

Larocca, M Cecilia, Shanks, Ryan A, Tian, Lan, Nelson, David L, Stewart, Donn M, Goldenring, James R. AKAP350 interaction with cdc42 interacting protein 4 at the golgi apparatus. Mol Biol Cell, 15(6), 2771-81, 2004. PMCID:420101

Li, Yi, Wandinger-Ness, Angela, Goldenring, James R, Cover, Timothy L. Clustering and redistribution of late endocytic compartments in response to Helicobacter pylori vacuolating toxin. Mol Biol Cell, 15(4), 1946-59, 2004. PMCID:379289

Nomura, S, Yamaguchi, H., Wang, T.C, Lee, J.R. and Goldenring, J.R.. Alterations in gastric mucosal lineages by acute oxyntic atrophy in wild type and gastrin deficient mice. Amer. J. Physiol., (in press), , 2004.

Nomura, Sachiyo, Baxter, Tammy, Yamaguchi, Hirokazu, Leys, Charles, Vartapetian, Andrey B, Fox, James G, Lee, Jeffrey R, Wang, Timothy C, Goldenring, James R. Spasmolytic polypeptide expressing metaplasia to preneoplasia in H. felis-infected mice. Gastroenterology, 127(2), 582-94, 2004.

Provance, D William, Gourley, Christopher R, Silan, Colleen M, Cameron, L C, Shokat, Kevan M, Goldenring, James R, Shah, Kavita, Gillespie, Peter G, Mercer, John A. Chemical-genetic inhibition of a sensitized mutant myosin Vb demonstrates a role in peripheral-pericentriolar membrane traffic. Proc Natl Acad Sci U S A, 101(7), 1868-73, 2004. PMCID:357019

Smolka, Adam J, Goldenring, James R, Gupta, Sandeep, Hammond, Charles E. Inhibition of gastric H,K-ATPase activity and gastric epithelial cell IL-8 secretion by the pyrrolizine derivative ML 3000. BMC Gastroenterol, 4(1), 4, 2004. PMCID:368434

Berryman, Mark A, Goldenring, James R. CLIC4 is enriched at cell-cell junctions and colocalizes with AKAP350 at the centrosome and midbody of cultured mammalian cells. Cell Motil Cytoskeleton, 56(3), 159-72, 2003.

Brock, Sean C, Goldenring, James R, Crowe, James E. Apical recycling systems regulate directional budding of respiratory syncytial virus from polarized epithelial cells. Proc Natl Acad Sci U S A, 100(25), 15143-8, 2003. PMCID:299925

Fan, Guo-Huang, Lapierre, Lynne A, Goldenring, James R, Richmond, Ann. Differential regulation of CXCR2 trafficking by Rab GTPases. Blood, 101, 2115-24, 2003.

Halldorsdottir, Anna Margrat, Siggurdsdottir, Margrat, Jonasson, Jan Gunnlaugur, Oddsdottir, Margrat, Magnusson, Janas, Lee, Jeffrey R, Goldenring, James R. Spasmolytic polypeptide-expressing metaplasia (SPEM) associated with gastric cancer in Iceland. Dig Dis Sci, 48, 431-41, 2003.

Hobdy-Henderson, Karen C, Hales, Chadwick M, Lapierre, Lynne A, Cheney, Richard E, Goldenring, James R. Dynamics of the apical plasma membrane recycling system during cell division. Traffic, 4(10), 681-93, 2003.

Lapierre, Lynne A, Dorn, Matthew C, Zimmerman, C Faith, Navarre, Jennifer, Burnette, Jason O, Goldenring, James R. Rab11b resides in a vesicular compartment distinct from Rab11a in parietal cells and other epithelial cells. Exp Cell Res, 290(2), 322-31, 2003.

Lee, Jeffrey, Baxter, Tammy, Yamaguchi, Hirokazu, Wang, Timothy, Goldenring, James, Anderson, Mark. Differential Protein Analysis of Spasomolytic Polypeptide Expressing Metaplasia Using Laser Capture Microdissection and Two-dimensional Difference Gel Electrophoresis. Appl Immunohistochem Mol Morphol, 11, 188-193, 2003.

Hales, Chadwick M, Vaerman, Jean-Pierre, Goldenring, James R. Rab11 family interacting protein 2 associates with Myosin Vb and regulates plasma membrane recycling. J Biol Chem, 277, 50415-21, 2002.

Shanks, Ryan A, Larocca, M Cecilia, Berryman, Mark, Edwards, John C, Urushidani, Tetsuro, Navarre, Jennifer, Goldenring, James R. AKAP350 at the Golgi apparatus. II. Association of AKAP350 with a novel chloride intracellular channel (CLIC) family member. J Biol Chem, 277, 40973-80, 2002.

Shanks, Ryan A, Steadman, Brent T, Schmidt, P Henry, Goldenring, James R. AKAP350 at the Golgi apparatus. I. Identification of a distinct Golgi apparatus targeting motif in AKAP350. J Biol Chem, 277, 40967-72, 2002.

Steadman, Brent T, Schmidt, P Henry, Shanks, Ryan A, Lapierre, Lynne A, Goldenring, James R. Transforming acidic coiled-coil-containing protein 4 interacts with centrosomal AKAP350 and the mitotic spindle apparatus. J Biol Chem, 277, 30165-76, 2002.

Volpicelli, Laura A, Lah, James J, Fang, Guofu, Goldenring, James R, Levey, Allan I. Rab11a and myosin Vb regulate recycling of the M4 muscarinic acetylcholine receptor. J Neurosci, 22, 9776-84, 2002.

Wang, Timothy C, Goldenring, James R. Inflammation intersection: gp130 balances gut irritation and stomach cancer. Nat Med, 8, 1080-2, 2002.

Yamaguchi, H., GOLDENRING, J.R., Kaminishi, M. and Lee, J.R. Identification of spasmolytic polypeptide expressing metaplasia (SPEM) in remnant gastric cancer and surveillance postgastrectomy biopsies. Dig. Dis. Sci., 47, 573-578, 2002.

Yamaguchi, Hirokazu, Goldenring, James R, Kaminishi, Michio, Lee, Jeffrey R. Association of spasmolytic polypeptide-expressing metaplasia with carcinogen administration and oxyntic atrophy in rats. Lab Invest, 82, 1045-52, 2002.

Yamaguchi, Hirokazu, Goldenring, James R, Kaminishi, Michio, Lee, Jeffrey R, . Identification of spasmolytic polypeptide expressing metaplasia (SPEM) in remnant gastric cancer and surveillance postgastrectomy biopsies. Dig Dis Sci, 47, 573-8, 2002.

GOLDENRING, J.R., Aron, L.M., Lapierre, L.A., Navarre, J. and Casanova, J.E. Expression and properties of Rab25 in polarized Madin-Darby canine kidney cells. Meth. Enzymol, 329, 225-234, 2001.

Goldenring, J M, Allred, G, . Post-rape care in hospital emergency rooms. Am J Public Health, 91, 1169-70, 2001. PMCID:1446730

Goldenring, J R. Pools of actin in polarized cells: some filaments are more stable than others. Focus on 'Functionally distinct pools of actin in secretory cells'. Am J Physiol Cell Physiol, 281(2), C386-7, 2001.

Goldenring, J R, Aron, L M, Lapierre, L A, Navarre, J, Casanova, J E. Expression and properties of Rab25 in polarized Madin-Darby canine kidney cells. Methods Enzymol, 329, 225-34, 2001.

Hales, C M, Griner, R, Hobdy-Henderson, K C, Dorn, M C, Hardy, D, Kumar, R, Navarre, J, Chan, E K, Lapierre, L A, Goldenring, J R. Identification and characterization of a family of Rab11-interacting proteins. J Biol Chem, 276(42), 39067-75, 2001.

Hales, C.M., Griner, R., Navarre, J., Dorn, M.C., Hardy, D., Kumar, R., Chan, E.K.L., Lapierre, L.A. and GOLDENRING, J.R. Identification and characterization of a family of Rab11 interacting proteins. J. Biol. Chem., 276, 39067-75, 2001.

Lapierre, L A, Kumar, R, Hales, C M, Navarre, J, Bhartur, S G, Burnette, J O, Provance, D W, Mercer, J A, B??hler, M, Goldenring, J R. Myosin vb is associated with plasma membrane recycling systems. Mol Biol Cell, 12(6), 1843-57, 2001. PMCID:37346

Lapierre, L.A., Kumar, R., Hales, C.M., Navarre, J., Bhartur, S.G., Burnette, J.O., Provance, W., Jr., Mercer, J., Bahler, M. and GOLDENRING, J.R. Myosin Vb is associated with plasma membrane recycling systems. Mol. Biol. Cell., 12, 1843-1857, 2001.

Wang, E, Pennington, J G, Goldenring, J R, Hunziker, W, Dunn, K W, . Brefeldin A rapidly disrupts plasma membrane polarity by blocking polar sorting in common endosomes of MDCK cells. J Cell Sci, 114, 3309-21, 2001.

Wang, E., Pennington, J.G., GOLDENRING, J.R., Hunziker, W. and Dunn, K.W. Brefeldin A rapidly disrupts plasma membrane polarity by blocking polar sorting in common endosomes of MDCK cells. J. Cell Sci., 114, 3309-21, 2001.

Bhartur, S G, Calhoun, B C, Woodrum, J, Kurkjian, J, Iyer, S, Lai, F, Goldenring, J R. Genomic structure of murine Rab11 family members. Biochem Biophys Res Commun, 269(2), 611-7, 2000.

Bhartur, S.G., Calhoun, B.C., Woodrum, J., Kurkjian, J., Iyer, S., Lai, F. and GOLDENRING, J.R. Genomic structure of murine Rab11 family members. Biochem. Biophys. Res. Commun, 269, 611-617, 2000.

Burdick, J S, Chung, E, Tanner, G, Sun, M, Paciga, J E, Cheng, J Q, Washington, K, Goldenring, J R, Coffey, R J. Treatment of Menetrier's disease with a monoclonal antibody against the epidermal growth factor receptor. N Engl J Med, 343(23), 1697-701, 2000.

Burdick, J.S., Chung, E., Lindberg, G., Tanner, G., Washington, K., GOLDENRING, J.R and Coffey, R.J. Treatament of Menetrier?s disease with a monoclonal antibody against epidermal growth factor receptor. New Eng. J. Med., 343, 1697-1701, 2000.

GOLDENRING, J.R., Ray, G .S., Coffey, R.J., Jr., Meunier, P., Haley, P., Barnes, T.B., Car, B.D. Reversible drug-induced oxyntic atrophy in rats. Gastroenterology, 118, 1080-1093, 2000.

Goldenring, J R, Ray, G S, Coffey, R J, Meunier, P C, Haley, P J, Barnes, T B, Car, B D. Reversible drug-induced oxyntic atrophy in rats. Gastroenterology, 118(6), 1080-93, 2000.

Goldenring, J R, Ray, G S, Lee, J R. Rab11 in dysplasia of Barrett''s epithelia. Yale J Biol Med, 72(2-3), 113-20, 2000. PMCID:2579020

Lee, M P, Ravenel, J D, Hu, R J, Lustig, L R, Tomaselli, G, Berger, R D, Brandenburg, S A, Litzi, T J, Bunton, T E, Limb, C, Francis, H, Gorelikow, M, Gu, H, Washington, K, Argani, P, Goldenring, J R, Coffey, R J, Feinberg, A P. Targeted disruption of the Kvlqt1 gene causes deafness and gastric hyperplasia in mice. J Clin Invest, 106(12), 1447-55, 2000. PMCID:387258

Lee, M.P., Ravenal, J.D., Hu, R., Lustig, L.R., Tomaeli, G., Brandenburg, S.A., Litzi, T.J., Bunton, T.E., Limb, C., Francis, H., Gorelikow, M., Gu, H., Washington, K., Argani, P., GOLDENRING, J.R., Coffey, R.J., and Feinberg, A.P. Targeted disruption of the Kvlqt1 gene cause deafness and gastric hyperplasia in mice. J. Clin. Invest., 106, 1447-1455, 2000.

Wang, T C, Dangler, C A, Chen, D, Goldenring, J R, Koh, T, Raychowdhury, R, Coffey, R J, Ito, S, Varro, A, Dockray, G J, Fox, J G. Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer. Gastroenterology, 118(1), 36-47, 2000.

Wang, T.C., Dangler, C.A., Chen, D., GOLDENRING, J.R., Koh, T., Raychowdhury, R., Coffey, R.J., Ito, S., Varro, A., Cockray, G.J. and Fox, J.G. Synergistic interaction between hypergastrinemia and Helicobacter infection in a gastric cancer mouse model. Gastroenterology, 118, 36-47, 2000.

Wang, X, Kumar, R, Navarre, J, Casanova, J E, Goldenring, J R. Regulation of vesicle trafficking in madin-darby canine kidney cells by Rab11a and Rab25. J Biol Chem, 275(37), 29138-46, 2000.

Wang, X., Kumar, R., Navarre, J., Casanova, J.E. and GOLDENRING, J.R. Regulation of membrane trafficking in MDCK cells by Rab11a and Rab25. J. Biol. Chem., 275, 29138-29146, 2000.

Casanova, J E, Wang, X, Kumar, R, Bhartur, S G, Navarre, J, Woodrum, J E, Altschuler, Y, Ray, G S, Goldenring, J R. Association of Rab25 and Rab11a with the apical recycling system of polarized Madin-Darby canine kidney cells. Mol Biol Cell, 10(1), 47-61, 1999. PMCID:25153

Casanova, J.E., Wang, X., Kumar, R., Bhartur, S.G., Navarre, J., Woodrum, J.E., Ray, G.S. and GOLDENRING, J.R. Rab11a and Rab25 association with the apical recycling system of polarized MDCK cells. Mol. Biol. Cell., 10, 47-61, 1999.

Lapierre, L A, Tuma, P L, Navarre, J, Goldenring, J R, Anderson, J M. VAP-33 localizes to both an intracellular vesicle population and with occludin at the tight junction. J Cell Sci, 112 ( Pt 21), 3723-32, 1999.

Schmidt, P H, Dransfield, D T, Claudio, J O, Hawley, R G, Trotter, K W, Milgram, S L, Goldenring, J R. AKAP350, a multiply spliced protein kinase A-anchoring protein associated with centrosomes. J Biol Chem, 274(5), 3055-66, 1999.

Schmidt, P H, Lee, J R, Joshi, V, Playford, R J, Poulsom, R, Wright, N A, Goldenring, J R. Identification of a metaplastic cell lineage associated with human gastric adenocarcinoma. Lab Invest, 79(6), 639-46, 1999.

Schmidt, P.H., Dransfield, D.T., Claudio, J.T., Hawley, R.G., Trotter, K.W., Milgram, S.L. and GOLDENRING, J.R. AKAP350: A multiply spliced A-kinase anchoring protein associated with centrosomes. J. Biol. Chem. , 274, 3055-3066, 1999.

Schmidt, P.H., Lee, J.R., Joshi, V., Playford, R.J., Poulsom, R., Wright, N.A. and GOLDENRING, J.R. Identification of a metaplastic cell lineage associated with human gastric adenocarcinoma. Lab. Invest., 79, 639-646, 1999.

Song, S Y, Gannon, M, Washington, M K, Scoggins, C R, Meszoely, I M, Goldenring, J R, Marino, C R, Sandgren, E P, Coffey, R J, Wright, C V, Leach, S D. Expansion of Pdx1-expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor alpha. Gastroenterology, 117(6), 1416-26, 1999.

Song, S.Y., Gannon, M., Washington, M.K., Scogins, C.R., Meszoely, I.M., GOLDENRING, J.R., Marino, C.R., Sandgren, E.P., Coffey, R.J., Jr., Wright, C.V.E. and Leach, S.D. Expansion of pdx1-expressing pancreatic epithelium and initiation of islet neogenesis in transgenic mice overexpressing TGF. Gastroenterology. , 117, 1416-1426, 1999.

Bhartur, S G, Goldenring, J R. Mapping of ezrin dimerization using yeast two-hybrid screening. Biochem Biophys Res Commun, 243(3), 874-7, 1998.

Calhoun, B C, Lapierre, L A, Chew, C S, Goldenring, J R. Rab11a redistributes to apical secretory canaliculus during stimulation of gastric parietal cells. Am J Physiol, 275(1 Pt 1), C163-70, 1998.

Calhoun, B.C. and GOLDENRING, J.R. Rab11 redistributes to the apical secretory canaliculus during stimulation of gastric parietal cells. Amer. J. Physiol., 275, C163-C170, 1998.

Majumdar, A P, Goldenring, J R. Localization and significance of pp55, a gastric mucosal membrane protein with tyrosine kinase activity. Am J Physiol, 274(5 Pt 1), G863-70, 1998.

Okamoto, C T, Karam, S M, Jeng, Y Y, Forte, J G, Goldenring, J R. Identification of clathrin and clathrin adaptors on tubulovesicles of gastric acid secretory (oxyntic) cells. Am J Physiol, 274(4 Pt 1), C1017-29, 1998.

Okamoto, C. T., Karam, S. M., Jeng, Y. Y., Forte, J.G. and GOLDENRING, J.R. Identification of a clathrin adapter (AP-1)-related complex on tubulovesicles of gastric acid secretory (oxyntic) cells. Am. J. Physiol., 274, C1017-C1029, 1998.

Wang, T C, Goldenring, J R, Dangler, C, Ito, S, Mueller, A, Jeon, W K, Koh, T J, Fox, J G. Mice lacking secretory phospholipase A2 show altered apoptosis and differentiation with Helicobacter felis infection. Gastroenterology, 114(4), 675-89, 1998.

Wang, T.C., GOLDENRING, J.R., Dangler, C., Millar, A., Jeon, W.K., Ito, S., Koh, T.J. and Fox, J.G. C57BL/6 mice deficient in secretory phospholipase A2 show increased apoptosis and altered cellular differentiation during Helicobacter felis infection. Gastroenterology, 114, 675-689, 1998.

Beall, A C, Kato, K, Goldenring, J R, Rasmussen, H, Brophy, C M. Cyclic nucleotide-dependent vasorelaxation is associated with the phosphorylation of a small heat shock-related protein. J Biol Chem, 272(17), 11283-7, 1997.

Calhoun, B C, Goldenring, J R. Rab proteins in gastric parietal cells: evidence for the membrane recycling hypothesis. Yale J Biol Med, 69(1), 1-8, 1997. PMCID:2588980

Calhoun, B C, Goldenring, J R. Two Rab proteins, vesicle-associated membrane protein 2 (VAMP-2) and secretory carrier membrane proteins (SCAMPs), are present on immunoisolated parietal cell tubulovesicles. Biochem J, 325 ( Pt 2), 559-64, 1997. PMCID:1218595

Calhoun, B.C. and GOLDENRING, J.R. Two rab proteins, VAMP-2 and SCAMPs are present on immunoisolated parietal cell tubulovesicles. Biochem. J., 325, 559-564, 1997.

Dransfield, D T, Bradford, A J, Smith, J, Martin, M, Roy, C, Mangeat, P H, Goldenring, J R. Ezrin is a cyclic AMP-dependent protein kinase anchoring protein. EMBO J, 16(1), 35-43, 1997. PMCID:1169611

Dransfield, D T, Yeh, J L, Bradford, A J, Goldenring, J R. Identification and characterization of a novel A-kinase-anchoring protein (AKAP120) from rabbit gastric parietal cells. Biochem J, 322 ( Pt 3), 801-8, 1997. PMCID:1218258

Dransfield, D.T., Bradford, A.J., Martin, M., Mangeat, P.H. and GOLDENRING, J.R. Ezrin is a cyclic AMP-dependent protein kinase anchoring protein (AKAP). EMBO J., 16, 35-43, 1997.

Dransfield, D.T., Bradford, A.J., Yeh, J., and GOLDENRING, J.R. Identification and characterization of a novel A-kinase anchoring protein (AKAP120). Biochem J., 322, 801-807, 1997.

Green, E G, Ramm, E, Riley, N M, Spiro, D J, Goldenring, J R, Wessling-Resnick, M. Rab11 is associated with transferrin-containing recycling compartments in K562 cells. Biochem Biophys Res Commun, 239(2), 612-6, 1997.

Green, E.G., Ramm, E., Riley, N.M., Spiro, D.J., Goldenring, J.R. and Wessling-Resnick, M. Rab11 is associated with transferrin-containing recycling compartments in K562 cells. Biochem. Biophys. Res. Commun., 239, 612-617, 1997.

Joshi, V, Ray, G S, Goldenring, J R. Inhibition of parietal cell acid secretion is mediated by the classical epidermal growth factor receptor. Dig Dis Sci, 42(6), 1194-8, 1997.

Koh, T J, Goldenring, J R, Ito, S, Mashimo, H, Kopin, A S, Varro, A, Dockray, G J, Wang, T C. Gastrin deficiency results in altered gastric differentiation and decreased colonic proliferation in mice. Gastroenterology, 113(3), 1015-25, 1997.

Ray, G S, Lee, J R, Nwokeji, K, Mills, L R, Goldenring, J R. Increased immunoreactivity for Rab11, a small GTP-binding protein, in low-grade dysplastic Barrett''s epithelia. Lab Invest, 77(5), 503-11, 1997.

Ray, G.S., Lee, J., Nwokeji, K., Mills, L. and GOLDENRING, J.R. Increased immunoreactivity for Rab11, a small GTP-binding protein, in low grade dysplasic Barrett?s epithelia. Lab. Invest., 77, 503-511, 1997.

Canfield, V, West, A B, Goldenring, J R, Levenson, R. Genetic ablation of parietal cells in transgenic mice: a new model for analyzing cell lineage relationships in the gastric mucosa. Proc Natl Acad Sci U S A, 93(6), 2431-5, 1996. PMCID:39814

GOLDENRING, J.R., Ray, G.S., Soroka, C.J., Smith, J., Modlin, I.M., Meise, K.S. and Coffey, R.J., Jr. Over-expression of transforming growth factor-alpha alters the differentiation of gastric cell lineages. Dig. Dis. Sci., 41, 773-784, 1996.

GOLDENRING, J.R., Smith, J., Vaughan, H.D., Cameron, P., Hawkins, W. and Navarre, J. Rab11 is an apically located small GTP-binding protein in epithelial tissues. Amer. J. Physiol., 270, G515-G525, 1996.

Goldenring, J R, Poulsom, R, Ray, G S, Wright, N, Meise, K S, Coffey, R J. Expression of trefoil peptides in the gastric mucosa of transgenic mice overexpressing transforming growth factor-alpha. Growth Factors, 13(1-2), 111-9, 1996.

Goldenring, J R, Ray, G S, Soroka, C J, Smith, J, Modlin, I M, Meise, K S, Coffey, R J. Overexpression of transforming growth factor-alpha alters differentiation of gastric cell lineages. Dig Dis Sci, 41(4), 773-84, 1996.

Goldenring, J R, Smith, J, Vaughan, H D, Cameron, P, Hawkins, W, Navarre, J. Rab11 is an apically located small GTP-binding protein in epithelial tissues. Am J Physiol, 270(3 Pt 1), G515-25, 1996.

Matovcik, L M, Maranto, A R, Soroka, C J, Gorelick, F S, Smith, J, Goldenring, J R. Co-distribution of calmodulin-dependent protein kinase II and inositol trisphosphate receptors in an apical domain of gastrointestinal mucosal cells. J Histochem Cytochem, 44, 1243-50, 1996.

Modlin, I M, Zhu, Z, Tang, L H, Kidd, M, Lawton, G P, Miu, K, Powers, R E, Goldenring, J R, Pasikhov, D, Soroka, C J. Evidence for a regulatory role for histamine in gastric enterochromaffin-like cell proliferation induced by hypergastrinemia. Digestion, 57, 310-21, 1996.

Navarre, J, Bradford, A J, Calhoun, B C, Goldenring, J R. Quenching of endogenous peroxidase in western blot. Biotechniques, 21(6), 990-2, 1996.

Parente, J A, Goldenring, J R, Petropoulos, A C, Hellman, U, Chew, C S. Purification, cloning, and expression of a novel, endogenous, calcium-sensitive, 28-kDa phosphoprotein. J Biol Chem, 271(33), 20096-101, 1996.

Parente, J.A., GOLDENRING, J.R., Petropoulos, A.C., Hellman, U. and Chew, C.S. Purification, cloning and expression of a novel endogenous, calcium-sensitive, 28 kDa phosphoprotein. J. Biol. Chem., 271, 20096-20101, 1996.

Ray, G S, Jackson, M W, Goldenring, J R. Foveolar hyperplasia following partial gastrectomy results from expansion of surface mucous cell compartment. Dig Dis Sci, 41(10), 2016-24, 1996.

Sheehan, D, Ray, G S, Calhoun, B C, Goldenring, J R. A somatodendritic distribution of Rab11 in rabbit brain neurons. Neuroreport, 7(7), 1297-300, 1996.

Bergh, C M, Brophy, C M, Dransfield, D T, Lincoln, T, Goldenring, J R, Rasmussen, H. Impaired cyclic nucleotide-dependent vasorelaxation in human umbilical artery smooth muscle. Am J Physiol, 268(1 Pt 2), H202-12, 1995.

Dransfield, D T, Bradford, A J, Goldenring, J R. Distribution of A-kinase anchoring proteins in parietal cells. Biochim Biophys Acta, 1269(3), 215-20, 1995.

Quin, J A, Sgambati, S A, Goldenring, J R, Basson, M D, Fielding, L P, Modlin, I M, Ballantyne, G H. PYY inhibition of VIP-stimulated ion transport in the rabbit distal ileum. J Surg Res, 58, 111-5, 1995.

Tang, L H, Modlin, I M, Caulfield, T A, Goldenring, J R. A novel serine-specific kinase activity associated with exocrine secretory granules. Am J Physiol, 269, G481-9, 1995.

GOLDENRING, J.R., Soroka, C.J., Shen, R.K., Tang, L.H., Rodriguez, W., Vaughan, J.D., Stoche, S.A. and Modlin, I.M. Enrichment of rab11, a low molecular weight GTPase, in gastric parietal cells. Amer. J. Physiol., 267, G187-G194, 1994.

Goldenring, J R, Soroka, C J, Shen, K R, Tang, L H, Rodriguez, W, Vaughan, H D, Stoch, S A, Modlin, I M. Enrichment of rab11, a small GTP-binding protein, in gastric parietal cells. Am J Physiol, 267(2 Pt 1), G187-94, 1994.

Modlin, I M, Goldenring, J R, Lawton, G P, Hunt, R. Aspects of the theoretical basis and clinical relevance of low acid states. Am J Gastroenterol, 89(3), 308-18, 1994.

Modlin, I M, Kumar, R R, Soroka, C J, Ahlman, H, Nilsson, O, Goldenring, J R. Histamine as an intermediate growth factor in genesis of gastric ECLomas associated with hypergastrinemia in mastomys. Dig Dis Sci, 39(7), 1446-53, 1994.

Ballantyne, G H, Goldenring, J R, Fleming, F X, Rush, S, Flint, J S, Fielding, L P, Binder, H J, Modlin, I M. Inhibition of VIP-stimulated ion transport by a novel Y-receptor phenotype in rabbit distal colon. Am J Physiol, 264(5 Pt 1), G848-54, 1993.

Ballantyne, G H, Goldenring, J R, Savoca, P E, Kranz, H K, Adrian, T E, Bilchik, A J, Modlin, I M. Cyclic AMP-mediated release of peptide YY (PYY) from the isolated perfused rabbit distal colon. Regul Pept, 47(2), 117-26, 1993.

Chough, S P, Goldenring, J R, Hurst, R D, Ballantyne, G H, Modlin, I M. Calcium modulation of the effects of serotonin, carbachol, and histamine on rabbit ileal ion transport. Yale J Biol Med, 66(6), 525-40, 1993. PMCID:2588855

GOLDENRING, J.R., Shen, R.K., Vaughan, H.D. and Modlin, I.M. Identification of a small GTP-binding protein, Rab25, expressed in the gastrointestinal mucosa, kidney and lung. J. Biol. Chem., 268, 18419-18422, 1993.

Goldenring, J R, Shen, K R, Vaughan, H D, Modlin, I M. Identification of a small GTP-binding protein, Rab25, expressed in the gastrointestinal mucosa, kidney, and lung. J Biol Chem, 268(25), 18419-22, 1993.

Goldenring, J R, Tsunoda, Y, Stoch, S A, Coffey, R J, Modlin, I M. Transforming growth factor-alpha (TGF alpha) inhibition of parietal cell secretion: structural requirements for activity. Regul Pept, 43(1-2), 37-47, 1993.

Mamiya, N, Goldenring, J R, Tsunoda, Y, Modlin, I M, Yasui, K, Usuda, N, Ishikawa, T, Natsume, A, Hidaka, H. Inhibition of acid secretion in gastric parietal cells by the Ca2+/calmodulin-dependent protein kinase II inhibitor KN-93. Biochem Biophys Res Commun, 195(2), 608-15, 1993.

Matovcik, L M, Haimowitz, B, Goldenring, J R, Czernik, A J, Gorelick, F S. Distribution of calcium/calmodulin-dependent protein kinase II in rat ileal enterocytes. Am J Physiol, 264(4 Pt 1), C1029-36, 1993.

Soroka, C J, Chew, C S, Hanzel, D K, Smolka, A, Modlin, I M, Goldenring, J R. Characterization of membrane and cytoskeletal compartments in cultured parietal cells: immunofluorescence and confocal microscopic examination. Eur J Cell Biol, 60(1), 76-87, 1993.

Soroka, C.J., Chew, C.S., Modlin, I.M., Hanzel, D., Smolka, A. and GOLDENRING, J.R. Characterization of membrane and cytoskeletal compartments in cultured parietal cells using immunofluoresence and confocal microscopy. Eur. J. Cell Biol., 60, 76-87, 1993.

Tang, L H, Miller, M D, Goldenring, J R, Modlin, I M, Hersey, S J. Partial agonism by gastrin for a cholecystokinin receptor mediating pepsinogen secretion. Am J Physiol, 265(5 Pt 1), G865-72, 1993.

Tsunoda, Y, Modlin, I M, Goldenring, J R. Tyrosine kinase activities in the modulation of stimulated parietal cell acid secretion. Am J Physiol, 264(2 Pt 1), G351-6, 1993.

Tsunoda, Y., Modlin, I.M. and GOLDENRING, J.R. Tyrosine kinase activities in the modulation of stimulated parietal cell secretion. Am. J. Physiol., 264, G351-G356, 1993.

Dempsey, P J, Goldenring, J R, Soroka, C J, Modlin, I M, McClure, R W, Lind, C D, Ahlquist, D A, Pittelkow, M R, Lee, D C, Sandgren, E P. Possible role of transforming growth factor alpha in the pathogenesis of M??n??trier''s disease: supportive evidence form humans and transgenic mice. Gastroenterology, 103(6), 1950-63, 1992.

Funasaka, M, Fox, L M, Tang, L H, Modlin, I M, Goldenring, J R. The major calmodulin-binding protein in rabbit parietal cells is Ca2+/calmodulin-dependent protein kinase II. Biochem Int, 27(6), 1101-9, 1992.

GOLDENRING, J.R., Asher, V.A., Barreuther, M.F., Lewis, J.J., Lohmann, S., Walter, U. and Modlin, I.M. Stimulation of isolated gastric parietal cells activates dephosphorylation of membrane-bound Type II regulatory subunit of cyclic AMP-dependent protein kinase. Am. J. Physiol., 279, 763-773, 1992.

Goldenring, J R, Asher, V A, Barreuther, M F, Lewis, J J, Lohmann, S M, Walter, U, Modlin, I M. Dephosphorylation of cAMP-dependent protein kinase regulatory subunit in stimulated parietal cells. Am J Physiol, 262(4 Pt 1), G763-73, 1992.

Goldenring, J R, Tang, L H, Modlin, I M. Small GTP-binding proteins in parietal cells: candidate modulators of parietal cell membrane dynamics. Yale J Biol Med, 65(6), 597-605, 1992. PMCID:2589774

Modlin, I M, Kumar, R, Nangia, A, Soroka, C J, Pasikhov, D, Goldenring, J R. Gastrin-dependent inhibitory effects of octreotide on the genesis of gastric ECLomas. Surgery, 112(6), 1048-56; discussion 1056-8, 1992.

Reubi, J C, Waser, B, Horisberger, U, Halter, F, Soroka, C J, Kumar, R R, Goldenring, J R, Modlin, I M. Identification of somatostatin and gastrin receptors on enterochromaffin-like cells from Mastomys gastric tumors. Endocrinology, 131(1), 166-72, 1992.

Tang, L H, Stoch, S A, Modlin, I M, Goldenring, J R. Identification of rab2 as a tubulovesicle-membrane-associated protein in rabbit gastric parietal cells. Biochem J, 285 ( Pt 3), 715-9, 1992. PMCID:1132853

Tang, L.H., Stoch, S.A., Modlin, I.M. and GOLDENRING, J.R. Identification of rab2 as a tubulovesicle-membrane associated protein in rabbit parietal cells. Biochem. J., 285, 715-719, 1992.

Tsunoda, Y, Funasaka, M, Modlin, I M, Hidaka, H, Fox, L M, Goldenring, J R. An inhibitor of Ca2+/calmodulin-dependent protein kinase II, KN-62, inhibits cholinergic-stimulated parietal cell secretion. Am J Physiol, 262(1 Pt 1), G118-22, 1992.

Basson, M D, Goldenring, J R, Tang, L H, Lewis, J J, Padfield, P, Jamieson, J D, Modlin, I M. Redistribution of 23 kDa tubulovesicle-associated GTP-binding proteins during parietal cell stimulation. Biochem J, 279 ( Pt 1), 43-8, 1991. PMCID:1151544

Basson, M.D., GOLDENRING, J.R., Tang, L.H., Lewis, J.J., Padfield, P., Jamieson, J.J. and Modlin, I.M. Movement of a 23 kDa tubulovesicle-associated GTP-binding protein during parietal cell stimulation. Biochem. J., 279, 43-48, 1991.

Modlin, I M, Esterline, W, Kim, H, Goldenring, J R. Enterochromaffin-like cells and gastric argyrophil carcinoidosis. Acta Oncol, 30(4), 493-8, 1991.

Nilsson, O, Bilchik, A J, Goldenring, J R, Ballantyne, G H, Adrian, T E, Modlin, I M. Distribution and immunocytochemical colocalization of peptide YY and enteroglucagon in endocrine cells of the rabbit colon. Endocrinology, 129(1), 139-48, 1991.

Flint, J S, Ballantyne, G H, Goldenring, J R, Fielding, L P, Modlin, I M. Neuropeptide Y inhibition of vasoactive intestinal polypeptide-stimulated ion transport in the rabbit distal colon. Arch Surg, 125(12), 1561-3, 1990.

Lewis, J J, Goldenring, J R, Asher, V A, Modlin, I M. Effects of epidermal growth factor on signal transduction in rabbit parietal cells. Am J Physiol, 258(3 Pt 1), G476-83, 1990.

Lewis, J J, Goldenring, J R, Modlin, I M, Coffey, R J. Inhibition of parietal cell H+ secretion by transforming growth factor alpha: a possible autocrine regulatory mechanism. Surgery, 108(2), 220-6; discussion 226-7, 1990.

Lewis, J.J., GOLDENRING, J.R., Asher, V.A. and Modlin, I.M. The effects of epidermal growth factor (EGF) on signal transduction in the rabbit parietal cell. Amer. J. Physiol., 258, G476-483, 1990.

Adrian, T E, Goldenring, J R, Oddsdottir, M, Zdon, M J, Zucker, K A, Lewis, J J, Modlin, I M. A micromethod for the assay of cellular secretory physiology: application to rabbit parietal cells. Anal Biochem, 182(2), 346-52, 1989.

Adrian, T.E., GOLDENRING, J.R., Oddsdottir, M., Zdon, M.J., Zucker, K.A., Lewis, J.J., Modlin, I. M. A micromethod for the assay of cellular secretory physiology: Application to rabbit parietal cells. Anal. Biochem., 182, 346-352, 1989.

Goldenring, J R, Cahow, C E. Intrahepatic cholangiojejunostomy as a palliative procedure in primary sclerosing cholangitis. Arch Surg, 124(5), 565-7, 1989.

Lewis, J J, Goldenring, J R, Asher, V A, Modlin, I M. Pancreastatin: a novel peptide inhibitor of parietal cell signal transduction. Biochem Biophys Res Commun, 163(2), 667-73, 1989.

Oddsdottir, M, Goldenring, J R, Adrian, T E, Zdon, M J, Zucker, K A, Modlin, I M. Identification and characterization of a cytosolic 30 kDa histamine stimulated phosphoprotein in parietal cell cytosol. Biochem Biophys Res Commun, 154(2), 489-96, 1988.

Goldenring, J R, Oddsdottir, M, Modlin, I M. A novel protein kinase activity in rabbit gastric gland cytosol. Biochem Biophys Res Commun, 142(2), 559-66, 1987.

Kreutter, D, Kim, J Y, Goldenring, J R, Rasmussen, H, Ukomadu, C, DeLorenzo, R J, Yu, R K. Regulation of protein kinase C activity by gangliosides. J Biol Chem, 262(4), 1633-7, 1987.

Modlin, I M, Oddsdottir, M, Adrian, T E, Zdon, M J, Zucker, K A, Goldenring, J R. A specific histamine-stimulated phosphoprotein in isolated parietal cells. J Surg Res, 42(4), 348-53, 1987.

Oddsdottir, M, Modlin, I M, Zucker, K A, Zdon, M J, Goldenring, J R. A calmodulin dependent protein kinase in parietal cells. Biochem Biophys Res Commun, 148(3), 1390-7, 1987.

Taft, W C, Goldenring, J R, DeLorenzo, R J. Molecular mechanisms of neuronal excitability: possible involvement of CaM kinase II in seizure activity. Adv Exp Med Biol, 221, 409-25, 1987.

GOLDENRING, J.R., Lasher, R.S., Vallano, M.L., Udea, T., Naito, S., Sternberger, N.H., Sternberger, L.A. and DeLorenzo, R.J. Association of synapsin I with neuronal cytoskeleton: Identification in cytoskeletal preparations in vitro and immunocytochemical localization in brain of synapsin I. J. Biol. Chem., 261, 8495 8504, 1986.

Goldenring, J R, DeLorenzo, R J. Phosphorylation of MAP-2 at distinct sites by calmodulin- and cyclic AMP-dependent kinases. Ann N Y Acad Sci, 466, 457-9, 1986.

Goldenring, J R, Lasher, R S, Vallano, M L, Ueda, T, Naito, S, Sternberger, N H, Sternberger, L A, DeLorenzo, R J. Association of synapsin I with neuronal cytoskeleton. Identification in cytoskeletal preparations in vitro and immunocytochemical localization in brain of synapsin I. J Biol Chem, 261(18), 8495-504, 1986.

Goldenring, J R, Modlin, I M, Tyshkov, M, Zdon, M J, Schafer, D E, Ballantyne, G H. A manganese-dependent protein kinase in gastric gland cytosol. Surgery, 100(2), 181-7, 1986.

Goldenring, J R, Vallano, M L, Lasher, R S, Ueda, T, DeLorenzo, R J. Association of calmodulin-dependent kinase II and its substrate proteins with neuronal cytoskeleton. Prog Brain Res, 69, 341-54, 1986.

Goldenring, J R, Wasterlain, C G, Oestreicher, A B, de Graan, P N, Farber, D B, Glaser, G, DeLorenzo, R J. Kindling induces a long-lasting change in the activity of a hippocampal membrane calmodulin-dependent protein kinase system. Brain Res, 377(1), 47-53, 1986.

Kim, J Y, Goldenring, J R, DeLorenzo, R J, Yu, R K. Gangliosides inhibit phospholipid-sensitive Ca2+-dependent kinase phosphorylation of rat myelin basic proteins. J Neurosci Res, 15(2), 159-66, 1986.

Sakakibara, M, Alkon, D L, DeLorenzo, R, Goldenring, J R, Neary, J T, Heldman, E. Modulation of calcium-mediated inactivation of ionic currents by Ca2+/calmodulin-dependent protein kinase II. Biophys J, 50(2), 319-27, 1986. PMCID:1329748

Vallano, M L, Goldenring, J R, Lasher, R S, Delorenzo, R J. Association of calcium/calmodulin-dependent kinase with cytoskeletal preparations: phosphorylation of tubulin, neurofilament, and microtubule-associated proteins. Ann N Y Acad Sci, 466, 357-74, 1986.

Billingsley, M L, Velletri, P A, Lovenberg, W, Kuhn, D, Goldenring, J R, DeLorenzo, R J. Is Ca2+-calmodulin-dependent protein phosphorylation in rat brain modulated by carboxylmethylation. J Neurochem, 44(5), 1442-50, 1985.

GOLDENRING, J.R., Vallano, M.L. and DeLorenzo, R.J. Phosphorylation of microtubule-associated protein 2 at distinct sites by calmodulin-dependent and cyclic-AMP-dependent kinases. J. Neurochem., 45, 900-905, 1985.

Goldenring, J R, Otis, L C, Yu, R K, DeLorenzo, R J. Calcium/ganglioside-dependent protein kinase activity in rat brain membrane. J Neurochem, 44(4), 1229-34, 1985.

Goldenring, J R, Vallano, M L, DeLorenzo, R J. Phosphorylation of microtubule-associated protein 2 at distinct sites by calmodulin-dependent and cyclic-AMP-dependent kinases. J Neurochem, 45(3), 900-5, 1985.

Larson, R E, Goldenring, J R, Vallano, M L, DeLorenzo, R J. Identification of endogenous calmodulin-dependent kinase and calmodulin-binding proteins in cold-stable microtubule preparations from rat brain. J Neurochem, 44(5), 1566-74, 1985.

Vallano, M L, Goldenring, J R, Buckholz, T M, Larson, R E, DeLorenzo, R J. Separation of endogenous calmodulin- and cAMP-dependent kinases from microtubule preparations. Proc Natl Acad Sci U S A, 82(10), 3202-6, 1985. PMCID:397743

Vallano, M.L., GOLDENRING, J.R., Buckholz, T.M., Larson, R.E. and DeLorenzo, R.J. Separation of endogenous calmodulin- and cAMP-dependent kinases from microtubule preparations. Proc. Natl. Acad. Sci., USA., 82, 3202-3206, 1985.

Goldenring, J R, Casanova, J E, DeLorenzo, R J. Tubulin-associated calmodulin-dependent kinase: evidence for an endogenous complex of tubulin with a calcium-calmodulin-dependent kinase. J Neurochem, 43(6), 1669-79, 1984.

Goldenring, J R, McGuire, J S, DeLorenzo, R J. Identification of the major postsynaptic density protein as homologous with the major calmodulin-binding subunit of a calmodulin-dependent protein kinase. J Neurochem, 42(4), 1077-84, 1984.

GOLDENRING, J.R., Gonzalez, B., McGuire, J.S., Jr. and DeLorenzo, R.J. 258: 12632-12640. Purification and characterization of a calmodulin-dependent kinase from rat brain cytosol able to phosphorylate tubulin and microtubule associated proteins. . J. Biol. Chem., 258, 12632-12640, 1983.

Goldenring, J R, Gonzalez, B, McGuire, J S, DeLorenzo, R J. Purification and characterization of a calmodulin-dependent kinase from rat brain cytosol able to phosphorylate tubulin and microtubule-associated proteins. J Biol Chem, 258(20), 12632-40, 1983.

Goldenring, J R, Batter, D K, Shaywitz, B A. Sulfanilic acid: behavioral change related to azo food dyes in developing rats. Neurobehav Toxicol Teratol, 4(1), 43-9, 1982.

Goldenring, J R, Gonzalez, B, DeLorenzo, R J. Isolation of brain Ca2+-calmodulin tubulin kinase containing calmodulin binding proteins. Biochem Biophys Res Commun, 108(1), 421-8, 1982.

Goldenring, J R, Shaywitz, B A, Wool, R S, Batter, D K, Anderson, G M, Cohen, D J. Environmental and biologic interactions on behavior: effects of artificial rearing in rat pups treated with 6-hydroxydopamine. Dev Psychobiol, 15(4), 297-307, 1982.

Goldenring, J R, Wool, R S, Shaywitz, B A, Batter, D K, Cohen, D J, Young, J G, Teicher, M H. Effects of continuous gastric infusion of food dyes on developing rat pups. Life Sci, 27(20), 1897-904, 1980.

Shaywitz, B A, Goldenring, J R, Wool, R S. Effects of chronic administration of food colorings on activity levels and cognitive performance in developing rat pups treated with 6-hydroxydopamine. Neurobehav Toxicol, 1(1), 41-7, 1979.


Postdoctoral Position Available
Yes

Postdoctoral Position Details
1) Postdoctoral Associate Position Available

Research in an NIH-funded program to investigate the roles of A-kinase Anchoring Protein 350 (AKAP350), a large multi-functional scaffolding protein, in regulation of RNA trafficking. RNA trafficking studies seek to examine the role of AKAP350 and its associated proteins CCAR1 and caprin-1 in microtubule dependent RNA movement in cells under both baseline physiology and stress. Studies involve a range of cell biological techniques including subcellular fractionation, live cell microscopy and confocal fluorescence microscopy. Biochemical techniques include yeast two-hybrid approaches (both conventional and split ubiquitin), direct protein interaction studies and analysis of 3''''-untranslated region interactions with protein including live cell imaging of RNA movement. Studies will also seek to evaluate the role of AKAP350 in speciific tissues using a newly developed knockout mouse modelSalary commensurate with experience.

Contact: James R. Goldenring, MD, PhD, Epithelial Biology Center, MRB IV, Rm 10435G, Vanderbilt University School of Medicine, 2213 Garland Ave, S., Nashville, TN 37232. Email: jim.goldenring@vanderbilt.edu.

2) Postdoctoral Associate Positions Available

Research in an NIH-funded program to investigate the Roles of class V myosin motors in regulating membrane trafficking. Projects are focused on determining the structural basis of myosin Vb interaction with Rab proteins and their effectors using recombinant proteins co-expressed in bacteria as a substrate fo r structure determinations by crystallography and/or cryo-EM. Salary commensurate with experience.

Contact: James R. Goldenring, MD, PhD, Epithelial Biology Center, MRB IV, Rm 10435G, Vanderbilt University School of Medicine, 2213 Garland Ave, S., Nashville, TN 37232. Email: jim.goldenring@vanderbilt.edu.


Updated Date
08/25/2011



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