Vanderbilt University School of Medicine

Pozzi, Ambra , Ph.D.
Professor of Medicine
Associate Professor of Molecular Physiology and Biophysics
Associate Professor of Cancer Biology

Lab Url: N/A

Phone Number: 615-322-4637

Email Address:ambra.pozzi@vanderbilt.edu

Pozzi, Ambra's picture

Office Address   Mailing Address

B-3115 MCN

B-3115 MCN 2372


Research Keywords
angiogenesis, tumors, integrins, metalloproteinases, growth factors, lipids,,Cancer,Diabetes,Kidney,Mouse,Receptor,Signal transduction,Vascular Biology

Research Specialty
Role of arachidonic acid derived lipids in angiogenesis and tumorigenesis

Research Description
Our laboratory studies the molecular mechanisms underlying tumor-associated angiogenesis in order to devise effective and well-tolerated anti-angiogenic therapies. We are analyzing the contribution of the cytochrome P450 monooxygenases in tumorigenesis. The cytochrome P450 monooxygenases oxidize arachinonic acid to a) HETEs (arachidonic acid w-hydroxylase), or b) EETs (arachinonic acid epoxygenase). Work from us and others has identified the endothelial P450 arachidonic acid epoxygenases (CYP2C) and their metabolites, the EETs as pro-angiogenic factors, and showed that reductions in endothelial EET levels leads to inhibition of tumor growth and angiogenesis. In this regard, disruption of the Cyp2c gene, or downregulation of its expression via activation of the peroxisomal proliferator activated receptor alpha (PPARalpha), reduces endothelial cell functions in vitro and tumor vascularization in vivo. Thus, we propose that Cyp2c and PPARalpha function as pro- and anti-tumorigenic genes, respectively. The overall goal of this research is to use established mouse models of cancer to define the role of PPARalpha and Cyp2c in cancer progression. Rotating students will have the opportunity to learn:

1) How to isolate and culture primary endothelial cells from various transgenic mouse lines.

2 How to assess in vitro the pro- and/or anti-angiogenic effects of various drugs.

3) How to assess in vivo the pro- and/or anti-angiogenic effects of various drugs.

4) How to isolate and analyze tumors following treatment with the drug of interest.


Publications
Borza, CM, Pozzi, A. The role of cell-extracellular matrix interactions in glomerular injury. Exp Cell Res, 318(9), 1001-10, 2012. PMCID:3386947

Borza, CM, Su, Y, Chen, X, Yu, L, Mont, S, Chetyrkin, S, Voziyan, P, Hudson, BG, Billings, PC, Jo, H, Bennett, JS, Degrado, WF, Eckes, B, Zent, R, Pozzi, A. Inhibition of integrin I?2I?1 ameliorates glomerular injury. J Am Soc Nephrol, 23(6), 1027-38, 2012. PMCID:3386947

Bulus, N, Feral, C, Pozzi, A, Zent, R. CD98 Increases Renal Epithelial Cell Proliferation by Activating MAPKs. PLoS One, 7(6), e40026, 2012. PMCID:3386947

Mathew, S, Chen, X, Pozzi, A, Zent, R. Integrins in renal development. Pediatr Nephrol, 27(6), 891-900, 2012. PMCID:3386947

Pozzi, A, Zent, R. Hold tight or you''ll fall off: CD151 helps podocytes stick in high-pressure situations. J Clin Invest, 122(1), 13-6, 2012. PMCID:3386947

Yu, L, Su, Y, Paueksakon, P, Cheng, H, Chen, X, Wang, H, Harris, RC, Zent, R, Pozzi, A. Integrin I?1/Akita double-knockout mice on a Balb/c background develop advanced features of human diabetic nephropathy. Kidney Int, 81(11), 1086-97, 2012. PMCID:3386947

Griesser, M, Suzuki, T, Tejera, N, Mont, S, Boeglin, WE, Pozzi, A, Schneider, C. Biosynthesis of hemiketal eicosanoids by cross-over of the 5-lipoxygenase and cyclooxygenase-2 pathways. Proc Natl Acad Sci U S A, 108(17), 6945-50, 2011. PMCID:3084063

Kang, L, Ayala, JE, Lee-Young, RS, Zhang, Z, James, FD, Neufer, PD, Pozzi, A, Zutter, MM, Wasserman, DH. Diet-induced muscle insulin resistance is associated with extracellular matrix remodeling and interaction with integrin alpha2beta1 in mice. Diabetes, 60(2), 416-26, 2011. PMCID:3028340

Li, B, Pozzi, A, Young, PP. TNFalpha accelerates monocyte to endothelial transdifferentiation in tumors by the induction of integrin alpha5 expression and adhesion to fibronectin. Mol Cancer Res, 9(6), 702-11, 2011. PMCID:3157289

Pozzi, A, Zent, R. TGF-I? sequestration by mesangial cell integrin I?vI?8: A novel mechanism of glomerular endothelial cell regulation. Am J Pathol, 178(2), 485-9, 2011. PMCID:3069894

Pozzi, A, Zent, R. Extracellular matrix receptors in branched organs. Curr Opin Cell Biol, 23(5), 547-53, 2011. PMCID:3386947

Schneider, C, Pozzi, A. Cyclooxygenases and lipoxygenases in cancer. Cancer Metastasis Rev, 30(3-4), 277-94, 2011. PMCID:3386947

Borza, CM, Chen, X, Mathew, S, Mont, S, Sanders, CR, Zent, R, Pozzi, A. Integrin {alpha}1{beta}1 promotes caveolin-1 dephosphorylation by activating T cell protein-tyrosine phosphatase. J Biol Chem, 285(51), 40114-24, 2010. PMCID:3000994

Chen, X, Whiting, C, Borza, C, Hu, W, Mont, S, Bulus, N, Zhang, MZ, Harris, RC, Zent, R, Pozzi, A. Integrin alpha1beta1 regulates epidermal growth factor receptor activation by controlling peroxisome proliferator-activated receptor gamma-dependent caveolin-1 expression. Mol Cell Biol, 30(12), 3048-58, 2010. PMCID:2876688

Gewin L, Bulus N, Mernaugh G, Moeckel G, Harris RC, Moses HL, Pozzi A, Zent R. . TGF-I? Receptor Deletion in the Renal Collecting System Exacerbates Fibrosis. . J. A. Soc. Neph,, (Jun 24. [Epub ahead of print]), , 2010.

Gewin, L, Bulus, N, Mernaugh, G, Moeckel, G, Harris, RC, Moses, HL, Pozzi, A, Zent, R. TGF-beta receptor deletion in the renal collecting system exacerbates fibrosis. J Am Soc Nephrol, 21(8), 1334-43, 2010. PMCID:2938601

Pozzi, A, Popescu, V, Yang, S, Mei, S, Shi, M, Puolitaival, SM, Caprioli, RM, Capdevila, JH. The anti-tumorigenic properties of peroxisomal proliferator-activated receptor alpha are arachidonic acid epoxygenase-mediated. J Biol Chem, 285(17), 12840-50, 2010. PMCID:2876688

Pozzi, A, Zent, R. Regulation of endothelial cell functions by basement membrane- and arachidonic acid-derived products. Wiley Interdiscip Rev Syst Biol Med, 1(2), 254-72, 2010. PMCID:3000994

Riggins, KS, Mernaugh, G, Su, Y, Quaranta, V, Koshikawa, N, Seiki, M, Pozzi, A, Zent, R. MT1-MMP-mediated basement membrane remodeling modulates renal development. Exp Cell Res, 316(17), 2993-3005, 2010. PMCID:2945451

Turner J, Sazonova O, Wang H, Pozzi A, Wagner GF. . Induction of the renal stanniocalcin-1 gene in rodents by water deprivation. . Mol Cell Endocrinol, ([Epub ahead of print]), , 2010.

Antar, AA, Konopka, JL, Campbell, JA, Henry, RA, Perdigoto, AL, Carter, BD, Pozzi, A, Abel, TW, Dermody, TS. Junctional adhesion molecule-A is required for hematogenous dissemination of reovirus. Cell Host Microbe, 5(1), 59-71, 2009. PMCID:2642927

Crooke, CE, Pozzi, A, Carpenter, GF. PLC-gamma1 regulates fibronectin assembly and cell aggregation. Exp Cell Res, 315(13), 2207-14, 2009. PMCID:2719887

Nystr??m A, Shaik ZP, Gullberg D, Krieg T, Eckes B, Zent R, Pozzi A, Iozzo RV. . Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity. . Blood, 26;114(23):4897-906. , , 2009.

Pozzi, A, Voziyan, PA, Hudson, BG, Zent, R. Regulation of matrix synthesis, remodeling and accumulation in glomerulosclerosis. Curr Pharm Des, 15(12), 1318-33, 2009. PMCID:2719887

Pozzi, A, Zent, R, Chetyrkin, S, Borza, C, Bulus, N, Chuang, P, Chen, D, Hudson, B, Voziyan, P. Modification of collagen IV by glucose or methylglyoxal alters distinct mesangial cell functions. J Am Soc Nephrol, 20(10), 2119-25, 2009. PMCID:2876688

Red Brewer, M, Choi, SH, Alvarado, D, Moravcevic, K, Pozzi, A, Lemmon, MA, Carpenter, G. The juxtamembrane region of the EGF receptor functions as an activation domain. Mol Cell, 34(6), 641-51, 2009. PMCID:2719887

Smith, JP, Pozzi, A, Dhawan, P, Singh, AB, Harris, RC. Soluble HB-EGF induces epithelial-to-mesenchymal transition in inner medullary collecting duct cells by upregulating Snail-2. Am J Physiol Renal Physiol, 296(5), F957-65, 2009. PMCID:2681361

Yang, S, Wei, S, Pozzi, A, Capdevila, JH. The arachidonic acid epoxygenase is a component of the signaling mechanisms responsible for VEGF-stimulated angiogenesis. Arch Biochem Biophys, 489(1-2), 82-91, 2009. PMCID:2719887

Zhang, MZ, Xu, J, Yao, B, Yin, H, Cai, Q, Shrubsole, MJ, Chen, X, Kon, V, Zheng, W, Pozzi, A, Harris, RC. Inhibition of 11beta-hydroxysteroid dehydrogenase type II selectively blocks the tumor COX-2 pathway and suppresses colon carcinogenesis in mice and humans. J Clin Invest, 119(4), 876-85, 2009. PMCID:2662561

Zhang, X, Mernaugh, G, Yang, DH, Gewin, L, Srichai, MB, Harris, RC, Iturregui, JM, Nelson, RD, Kohan, DE, Abrahamson, D, F??ssler, R, Yurchenco, P, Pozzi, A, Zent, R. beta1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting duct structural integrity. Development, 136(19), 3357-66, 2009. PMCID:2876688

Abair, TD, Bulus, N, Borza, C, Sundaramoorthy, M, Zent, R, Pozzi, A. Functional Analysis of the cytoplasmic domain of the integrin {alpha}1 subunit in endothelial cells. Blood, , , 2008. PMCID:2569176

Abair, TD, Sundaramoorthy, M, Chen, D, Heino, J, Ivaska, J, Hudson, BG, Sanders, CR, Pozzi, A, Zent, R. Cross-talk between integrins alpha1beta1 and alpha2beta1 in renal epithelial cells. Exp Cell Res, 314(19), 3593-604, 2008. PMCID:2729514

Borza, CM, Borza, DB, Pedchenko, V, Saleem, MA, Mathieson, PW, Sado, Y, Hudson, HM, Pozzi, A, Saus, J, Abrahamson, DR, Zent, R, Hudson, BG. Human podocytes adhere to the KRGDS motif of the alpha3alpha4alpha5 collagen IV network. J Am Soc Nephrol, 19(4), 677-84, 2008. PMCID:2390958

Cosgrove, D, Meehan, DT, Delimont, D, Pozzi, A, Chen, X, Rodgers, KD, Tempero, RM, Zallocchi, M, Rao, VH. Integrin alpha1beta1 regulates matrix metalloproteinases via P38 mitogen-activated protein kinase in mesangial cells: implications for Alport syndrome. Am J Pathol, 172(3), 761-73, 2008. PMCID:2258247

Erdogan, M, Pozzi, A, Bhowmick, N, Moses, HL, Zent, R. Transforming growth factor-beta (TGF-beta) and TGF-beta-associated kinase 1 are required for R-Ras-mediated transformation of mammary epithelial cells. Cancer Res, 68(15), 6224-31, 2008.

Macias-Perez, I, Borza, C, Chen, X, Yan, X, Ibanez, R, Mernaugh, G, Matrisian, LM, Zent, R, Pozzi, A. Loss of integrin alpha1beta1 ameliorates Kras-induced lung cancer. Cancer Res, 68(15), 6127-35, 2008.

Macias-Perez, IM, Zent, R, Carmosino, M, Breyer, MD, Breyer, RM, Pozzi, A. Mouse EP3 alpha, beta, and gamma receptor variants reduce tumor cell proliferation and tumorigenesis in vivo. J Biol Chem, 283(18), 12538-45, 2008. PMCID:2335350

Pozzi, A, Capdevila, JH. PPARalpha Ligands as Antitumorigenic and Antiangiogenic Agents. PPAR Res, 2008, 906542, 2008. PMCID:2517125

Pozzi, A, Jarad, G, Moeckel, GW, Coffa, S, Zhang, X, Gewin, L, Eremina, V, Hudson, BG, Borza, DB, Harris, RC, Holzman, LB, Phillips, CL, Fassler, R, Quaggin, SE, Miner, JH, Zent, R. Beta1 integrin expression by podocytes is required to maintain glomerular structural integrity. Dev Biol, 316(2), 288-301, 2008. PMCID:2396524

Pozzi, A, Zent, R. Integrins, extracellular matrix, and terminal differentiation of renal epithelial cells. J Am Soc Nephrol, 19(6), 1043-4, 2008.

Pyle, AL, Atkinson, JB, Pozzi, A, Reese, J, Eckes, B, Davidson, JM, Crimmins, DL, Young, PP. Regulation of the atheroma-enriched protein, SPRR3, in vascular smooth muscle cells through cyclic strain is dependent on integrin alpha1beta1/collagen interaction. Am J Pathol, 173(5), 1577-88, 2008. PMCID:2570146

Woodall, BP, Nystr??m, A, Iozzo, RA, Eble, JA, Niland, S, Krieg, T, Eckes, B, Pozzi, A, Iozzo, RV. Integrin alpha2beta1 is the required receptor for endorepellin angiostatic activity. J Biol Chem, 283(4), 2335-43, 2008.

Zhang, Z, Ramirez, NE, Yankeelov, TE, Li, Z, Ford, LE, Qi, Y, Pozzi, A, Zutter, MM. alpha2beta1 integrin expression in the tumor microenvironment enhances tumor angiogenesis in a tumor cell-specific manner. Blood, 111(4), 1980-8, 2008. PMCID:2234046

Chen, X, Abair, TD, Ibanez, MR, Su, Y, Frey, MR, Dise, RS, Polk, DB, Singh, AB, Harris, RC, Zent, R, Pozzi, A. Integrin alpha1beta1 controls reactive oxygen species synthesis by negatively regulating epidermal growth factor receptor-mediated Rac activation. Mol Cell Biol, 27(9), 3313-26, 2007. PMCID:1899972

Erdogan, M, Pozzi, A, Bhowmick, N, Moses, HL, Zent, R. Signaling pathways regulating TC21-induced tumorigenesis. J Biol Chem, 282(38), 27713-20, 2007.

Kanjanabuch, T, Ma, LJ, Chen, J, Pozzi, A, Guan, Y, Mundel, P, Fogo, AB. PPAR-gamma agonist protects podocytes from injury. Kidney Int, , , 2007.

Pozzi, A, Ibanez, MR, Gatica, AE, Yang, S, Wei, S, Mei, S, Falck, JR, Capdevila, JH. Peroxisomal proliferator activated receptor(alpha)-dependent inhibition of endothelial cell proliferation and tumorigenesis. J Biol Chem, , , 2007.

Rao, R, Redha, R, Macias-Perez, I, Su, Y, Hwang, MT, Hao, C, Zent, R, Breyer, MD, Pozzi, A. Prostaglandin E2-EP4 receptor promotes endothelial cell migration via ERK activation and angiogenesis in vivo. J Biol Chem, , , 2007.

Zent, R, Pozzi, A. Angiogenesis in diabetic nephropathy. Semin Nephrol, 27(2), 161-71, 2007.

Zhang, H, Lawson, WE, Polosukhin, VV, Pozzi, A, Blackwell, TS, Litingtung, Y, Chiang, C. Inhibitor of differentiation 1 promotes endothelial survival in a bleomycin model of lung injury in mice. Am J Pathol, 171(4), 1113-26, 2007. PMCID:1988863

Acuff, HB, Sinnamon, M, Fingleton, B, Boone, B, Levy, SE, Chen, X, Pozzi, A, Carbone, DP, Schwartz, DR, Moin, K, Sloane, BF, Matrisian, LM. Analysis of host- and tumor-derived proteinases using a custom dual species microarray reveals a protective role for stromal matrix metalloproteinase-12 in non-small cell lung cancer. Cancer Res, 66(16), 7968-75, 2006.

Borza, CM, Pozzi, A, Borza, DB, Pedchenko, V, Hellmark, T, Hudson, BG, Zent, R. Integrin alpha3beta1, a novel receptor for alpha3(IV) noncollagenous domain and a trans-dominant Inhibitor for integrin alphavbeta3. J Biol Chem, 281(30), 20932-9, 2006.

Kamiyama, M, Pozzi, A, Yang, L, DeBusk, LM, Breyer, RM, Lin, PC. EP2, a receptor for PGE2, regulates tumor angiogenesis through direct effects on endothelial cell motility and survival. Oncogene, 25(53), 7019-28, 2006.

Liang, XB, Ma, LJ, Naito, T, Wang, Y, Madaio, M, Zent, R, Pozzi, A, Fogo, AB. Angiotensin type 1 receptor blocker restores podocyte potential to promote glomerular endothelial cell growth. J Am Soc Nephrol, 17(7), 1886-95, 2006.

Moeckel, GW, Zhang, L, Chen, X, Rossini, M, Zent, R, Pozzi, A. Role of integrin alpha1beta1 in the regulation of renal medullary osmolyte concentration. Am J Physiol Renal Physiol, 290(1), F223-31, 2006.

Mu??oz, NM, Upton, M, Rojas, A, Washington, MK, Lin, L, Chytil, A, Sozmen, EG, Madison, BB, Pozzi, A, Moon, RT, Moses, HL, Grady, WM. Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation. Cancer Res, 66(20), 9837-44, 2006.

Nakagawa, K, Holla, VR, Wei, Y, Wang, WH, Gatica, A, Wei, S, Mei, S, Miller, CM, Cha, DR, Price, E, Zent, R, Pozzi, A, Breyer, MD, Guan, Y, Falck, JR, Waterman, MR, Capdevila, JH. Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel. J Clin Invest, 116(6), 1696-702, 2006. PMCID:1459070

Pozzi, A, Coffa, S, Bulus, N, Zhu, W, Chen, D, Chen, X, Mernaugh, G, Su, Y, Cai, S, Singh, A, Brissova, M, Zent, R. H-Ras, R-Ras, and TC21 Differentially Regulate Ureteric Bud Cell Branching Morphogenesis. Mol Biol Cell, , , 2006. PMCID:1415315

Zent, R, Pozzi, A. Antiangiogenic Therapy in Diabetic Nephropathy. J Am Soc Nephrol, , , 2006.

Zent, R, Yan, X, Su, Y, Hudson, BG, Borza, DB, Moeckel, GW, Qi, Z, Sado, Y, Breyer, MD, Voziyan, P, Pozzi, A. Glomerular injury is exacerbated in diabetic integrin alpha1-null mice. Kidney Int, 70(3), 460-70, 2006.

Chen, X, Su, Y, Fingleton, B, Acuff, H, Matrisian, LM, Zent, R, Pozzi, A. Orthotopic models of lung cancer to follow primary and metastatic NSCLC growth in integrin α1-null mice. Clin. Exp. Metastasis, , , 2005, In press.

Br?!bek, J, Constancio, SS, Siesser, PF, Shin, NY, Pozzi, A, Hanks, SK. Crk-associated substrate tyrosine phosphorylation sites are critical for invasion and metastasis of SRC-transformed cells. Mol Cancer Res, 3(6), 307-15, 2005.

Cai, S, Bulus, N, Fonseca-Siesser, PM, Chen, D, Hanks, SK, Pozzi, A, Zent, R. CD98 modulates integrin beta1 function in polarized epithelial cells. J Cell Sci, 118(Pt 5), 889-99, 2005.

Chen, X, Su, Y, Fingleton, B, Acuff, H, Matrisian, LM, Zent, R, Pozzi, A. Increased plasma MMP9 in integrin alpha1-null mice enhances lung metastasis of colon carcinoma cells. Int J Cancer, 116(1), 52-61, 2005.

Chen, X, Su, Y, Fingleton, B, Acuff, H, Matrisian, LM, Zent, R, Pozzi, A. An orthotopic model of lung cancer to analyze primary and metastatic NSCLC growth in integrin alpha1-null mice. Clin Exp Metastasis, 22(2), 185-93, 2005.

Frank, DB, Abtahi, A, Yamaguchi, DJ, Manning, S, Shyr, Y, Pozzi, A, Baldwin, HS, Johnson, JE, de Caestecker, MP. Bone morphogenetic protein 4 promotes pulmonary vascular remodeling in hypoxic pulmonary hypertension. Circ Res, 97(5), 496-504, 2005.

Mernaugh, RL, Yan, H, Chen, D, Edl, J, Hanley, G, Pozzi, A, Zent, R. Production and characterization of mouse ureteric bud cell-specific rat hybridoma antibodies utilizing subtractive immunization and high-throughput screening. J Immunol Methods, 306(1-2), 115-27, 2005.

Pozzi, A, Macias-Perez, I, Abair, T, Wey, S, Su, Y, Zent, R, Falk, JR, Capdevila, JH. Charaterization of 5,6-and 8,9-Epoxyeicosatrienoic acids (5,6- AND 8,9-EET) as potent in vivo angiogenic lipids. J Biol Chem, , , 2005.

Thomas, EK, Nakamura, M, Wienke, D, Isacke, CM, Pozzi, A, Liang, P. Endo180 binds to the C-terminal region of alpha 1(I) collagen. J Biol Chem, , , 2005.

Brantley-Sieders, DM, Caughron, J, Hicks, D, Pozzi, A, Ruiz, JC, Chen, J. EphA2 receptor tyrosine kinase regulates endothelial cell migration and vascular assembly through phosphoinositide 3-kinase-mediated Rac1 GTPase activation. J Cell Sci, 117(Pt 10), 2037-49, 2004.

Br?!bek, J, Constancio, SS, Shin, NY, Pozzi, A, Weaver, AM, Hanks, SK. CAS promotes invasiveness of Src-transformed cells. Oncogene, 23(44), 7406-15, 2004.

Chen, D, Roberts, R, Pohl, M, Nigam, S, Kreidberg, J, Wang, Z, Heino, J, Ivaska, J, Coffa, S, Harris, RC, Pozzi, A, Zent, R. Differential expression of collagen- and laminin-binding integrins mediates ureteric bud and inner medullary collecting duct cell tubulogenesis. Am J Physiol Renal Physiol, 287(4), F602-11, 2004.

Chen, X, Moeckel, G, Morrow, JD, Cosgrove, D, Harris, RC, Fogo, AB, Zent, R, Pozzi, A. Lack of integrin alpha1beta1 leads to severe glomerulosclerosis after glomerular injury. Am J Pathol, 165(2), 617-30, 2004. PMCID:1618576

Ma, LJ, Jha, S, Ling, H, Pozzi, A, Ledbetter, S, Fogo, AB. Divergent effects of low versus high dose anti-TGF-beta antibody in puromycin aminonucleoside nephropathy in rats. Kidney Int, 65(1), 106-15, 2004.

Pozzi, A, Yan, X, Macias-Perez, I, Wei, S, Hata, AN, Breyer, RM, Morrow, JD, Capdevila, JH. Colon carcinoma cell growth is associated with prostaglandin E2/EP4 receptor-evoked ERK activation. J Biol Chem, 279(28), 29797-804, 2004.

Moeckel, GW, Zhang, L, Fogo, AB, Hao, CM, Pozzi, A, Breyer, MD. COX2 activity promotes organic osmolyte accumulation and adaptation of renal medullary interstitial cells to hypertonic stress. J Biol Chem, 278(21), 19352-7, 2003.

Pozzi, A, Zent, R. Integrins: sensors of extracellular matrix and modulators of cell function. Nephron Exp Nephrol, 94(3), e77-84, 2003.

Brantley, DM, Cheng, N, Thompson, EJ, Lin, Q, Brekken, RA, Thorpe, PE, Muraoka, RS, Cerretti, DP, Pozzi, A, Jackson, D, Lin, C, Chen, J. Soluble Eph A receptors inhibit tumor angiogenesis and progression in vivo. Oncogene, 21(46), 7011-26, 2002.

Pozzi, A, LeVine, WF, Gardner, HA. Low plasma levels of matrix metalloproteinase 9 permit increased tumor angiogenesis. Oncogene, 21(2), 272-81, 2002.

Pozzi A, Moberg PE, Miles LA, Wagner S, Soloway P, Gardner HA. Elevated matrix metalloprotease and angiostatin levels in integrin alpha 1 knockout mice cause reduced tumor vascularization. Proc Natl Acad Sci U S A, 97(5), 2202-7, 2000.

Rose D.M., A. Pozzi, and R. Zent. Integrins as Therapeutic targets. Emerging Therapeutic Target. , 4(3), 387-411, 2000.

Gardner H, Broberg A, Pozzi A, Laato M, Heino J. Absence of integrin alpha1beta1 in the mouse causes loss of feedback regulation of collagen synthesis in normal and wounded dermis. J Cell Sci., 112, 263-72, 1999.

Giannelli G, Pozzi A, Stetler-Stevenson WG, Gardner HA, Quaranta V. Expression of matrix metalloprotease-2-cleaved laminin-5 in breast remodeling stimulated by sex steroids. Am J Pathol, 154(4), 1193-201, 1999.

Pozzi A, Wary KK, Giancotti FG, Gardner HA. Integrin alpha1beta1 mediates a unique collagen- dependent proliferation pathway in vivo. J Cell Biol, 142(2), 587-94, 1998.

Pozzi A, Risek B, Kiang DT, Gilula NB, Kumar NM. Analysis of multiple gap junction gene products in the rodent and human mammary gland. Exp Cell Res, 220(1), 212-9, 1995.


Postdoctoral Position Available
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Postdoctoral Position Details
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Updated Date
01/03/2012