Vanderbilt University School of Medicine

Conn, P. Jeffrey , Ph.D.
Professor of Pharmacology
Lee E. Limbird Chair in Pharmacology

Lab Url: http://www.connlab.com/

Phone Number: (615) 936-2478

Email Address:jeff.conn@vanderbilt.edu

Conn, P.'s picture

Office Address   Mailing Address

1215 Light Hall (2-7134)

417D Preston Research Building 23rd Avenue South at Pierce 37232-6600


Research Keywords
Parkinsons disease, Schizophrenia, metabotropic glutamate receptors, neurophysiology,Neuroscience,Pharmacology,Signal transduction

Research Specialty
Cellular/molecular mechanisms of regulation of neuronal function. Novel treatments for CNS disorders.

Research Description
The primary focus of research in our laboratory is to develop a detailed understanding of the cellular and molecular mechanisms by which transient activation of neurotransmitter receptors can induce long-lasting changes in neuronal excitability and synaptic transmission. Such lasting changes in neuronal function are likely to play an important role in a number of normal physiological processes, ranging from acute regulation of animal behavior to more lasting processes such as formation of long-term memory. In addition, these persistent changes are critical for development of a variety of chronic pathological conditions including, Parkinson's disease, schizophrenia epilepsy, drug dependence and other neurological and psychiatric disorders. Generally, neurotransmitters bring about such lasting changes in properties of cells by stimulating formation of intracellular second messengers and activating protein kinases that then alter the properties of key intracellular regulatory proteins. Thus, we have focused our efforts on the roles of G-protein-coupled receptors (GPCRs) and related second messenger/protein kinase systems in regulating neuronal function. We apply a highly multidisciplinary approach to answer these questions and employ a combination of biochemical, imaging, immunological, and molecular biological techniques to study neuromodulation. In all of our studies, our ultimate goal is to understand the impact of cellular and molecular changes to changes in intact neuronal networks and animal behavior that ultimately impact CNS disorders. Thus, we also employ a range of techniques in behavioral and systems neuroscience By developing this range of understanding, we hope to develop novel strategies for treatment of neurological and psychiatric disorders. We are especially interested in schizophrenia and Parkinson's disease.
While our interests in neuromodulation and G protein-mediated signaling are broad, in recent years we have focused primary attention on the physiological roles of a recently discovered family of G protein-coupled glutamate receptors termed metabotropic glutamate receptors (mGluRs). At a circuit level, we have placed a major emphasis on the roles of mGluRs in regulating transmission through the hippocampal formation and in through basal ganglia circuits involved in regulation of motor function and processing of information flow to the cortex. In addition to understanding the roles of mGluRs and other GPCRs in regulating transmission through these circuits, we are placing a significant effort on understanding the precise molecular mechanisms by which GPCRs and signaling cascades activated by these receptors modulate cell excitability and synaptic transmission. These studies are largely focused on identifying protein kinases and phosphatases involved in specific effects, substrates and phosphorylation sites involved, and the impact of such posttranslational changes on protein function. Finally, we are making rapid progress understanding the impact of these changes at a behavioral level. These studies are having a major impact on our understanding of the cellular and systems level mechanisms involved in regulation of complex aspects of animal behavior and disorders of the central nervous system.

Publications
Ayala, JE, Chen, Y, Banko, JL, Sheffler, DJ, Williams, R, Telk, AN, Watson, NL, Xiang, Z, Zhang, Y, Jones, PJ, Lindsley, CW, Olive, MF, Conn, PJ. mGluR5 Positive Allosteric Modulators Facilitate both Hippocampal LTP and LTD and Enhance Spatial Learning. Neuropsychopharmacology, , , 2009.

Bridges, TM, Marlo, JE, Niswender, CM, Jones, CK, Jadhav, SB, Gentry, PR, Plumley, HC, Weaver, CD, Conn, PJ, Lindsley, CW. Discovery of the First Highly M5-Preferring Muscarinic Acetylcholine Receptor Ligand, an M5 Positive Allosteric Modulator Derived from a Series of 5-Trifluoromethoxy N-Benzyl Isatins. J Med Chem, , , 2009.

Conn, PJ, Christopoulos, A, Lindsley, CW. Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders. Nat Rev Drug Discov, 8(1), 41-54, 2009.

Conn, PJ, Jones, CK. Promise of mGluR2/3 activators in psychiatry. Neuropsychopharmacology, 34(1), 248-9, 2009.

Conn, PJ, Jones, CK, Lindsley, CW. Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders. Trends Pharmacol Sci, 30(3), 148-55, 2009.

Conn, PJ, Lindsley, CW, Jones, CK. Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia. Trends Pharmacol Sci, 30(1), 25-31, 2009.

Engers, DW, Niswender, CM, Weaver, CD, Jadhav, S, Menon, UN, Zamorano, R, Conn, PJ, Lindsley, CW, Hopkins, CR. Synthesis and Evaluation of a Series of Heterobiarylamides That Are Centrally Penetrant Metabotropic Glutamate Receptor 4 (mGluR4) Positive Allosteric Modulators (PAMs). J Med Chem, , , 2009.

Engers, DW, Rodriguez, AL, Williams, R, Hammond, AS, Venable, D, Oluwatola, O, Sulikowski, GA, Conn, PJ, Lindsley, CW. Synthesis, SAR and unanticipated pharmacological profiles of analogues of the mGluR5 ago-potentiator ADX-47273. ChemMedChem, 4(4), 505-11, 2009.

Kennedy, JP, Conn, PJ, Lindsley, CW. A novel class of H3 antagonists derived from the natural product guided synthesis of unnatural analogs of the marine bromopyrrole alkaloid dispyrin. Bioorg Med Chem Lett, 19(12), 3204-8, 2009.

Kulkarni, SS, Zou, MF, Cao, J, Deschamps, JR, Rodriguez, AL, Conn, PJ, Newman, AH. Structure-Activity Relationships Comparing N-(6-Methylpyridin-yl)-Substituted Aryl Amides to 2-Methyl-6-(substituted-arylethynyl)pyridines or 2-Methyl-4-(substituted-arylethynyl)thiazoles as Novel Metabotropic Glutamate Receptor Subtype 5 Antagonists (dagger). J Med Chem, , , 2009.

Marlo, JE, Niswender, CM, Days, EL, Bridges, TM, Xiang, Y, Rodriguez, AL, Shirey, JK, Brady, AE, Nalywajko, T, Luo, Q, Austin, CA, Williams, MB, Kim, K, Williams, R, Orton, D, Brown, HA, Lindsley, CW, Weaver, CD, Conn, PJ. Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity. Mol Pharmacol, 75(3), 577-88, 2009. PMCID:2684909

Rodriguez, AL, Williams, R, Zhou, Y, Lindsley, SR, Le, U, Grier, MD, Weaver, CD, Conn, PJ, Lindsley, CW. Discovery and SAR of novel mGluR5 non-competitive antagonists not based on an MPEP chemotype. Bioorg Med Chem Lett, 19(12), 3209-13, 2009.

Sheffler, DJ, Williams, R, Bridges, TM, Xiang, Z, Kane, AS, Byun, NE, Jadhav, S, Mock, MM, Zheng, F, Lewis, LM, Jones, CK, Niswender, CM, Weaver, CD, Lindsley, CW, Conn, PJ. A Novel Selective Muscarinic Acetylcholine Receptor Subtype 1 (M1 mAChR) Antagonist Reduces Seizures Without Impairing Hippocampal-Dependent Learning. Mol Pharmacol, , , 2009. PMCID:2713127

Williams, R, Niswender, CM, Luo, Q, Le, U, Conn, PJ, Lindsley, CW. Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4). Part II: Challenges in hit-to-lead. Bioorg Med Chem Lett, 19(3), 962-6, 2009.

Bikbaev A, Neyman S, Ngomba RT, Conn J, Nicoletti F, Manahan-Vaughan D. MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE, 3(5), e2155, 2008.

Brady, AE, Jones, CK, Bridges, TM, Kennedy, JP, Thompson, AD, Heiman, JU, Breininger, ML, Gentry, PR, Yin, H, Jadhav, SB, Shirey, JK, Conn, PJ, Lindsley, CW. Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats. J Pharmacol Exp Ther, 327(3), 941-53, 2008. PMCID:2745822

Bridges, TM, Brady, AE, Kennedy, JP, Daniels, RN, Miller, NR, Kim, K, Breininger, ML, Gentry, PR, Brogan, JT, Jones, CK, Conn, PJ, Lindsley, CW. Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moieties. Bioorg Med Chem Lett, 18(20), 5439-42, 2008.

Chen, Y, Goudet, C, Pin, JP, Conn, PJ. N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors. Mol Pharmacol, 73(3), 909-18, 2008.

Conn, PJ, Roth, BL. Opportunities and challenges of psychiatric drug discovery: roles for scientists in academic, industry, and government settings. Neuropsychopharmacology, 33(9), 2048-60, 2008.

Conn, PJ, Tamminga, C, Schoepp, DD, Lindsley, C. Schizophrenia: moving beyond monoamine antagonists. Mol Interv, 8(2), 99-107, 2008.

Jones, CK, Brady, AE, Davis, AA, Xiang, Z, Bubser, M, Tantawy, MN, Kane, AS, Bridges, TM, Kennedy, JP, Bradley, SR, Peterson, TE, Ansari, MS, Baldwin, RM, Kessler, RM, Deutch, AY, Lah, JJ, Levey, AI, Lindsley, CW, Conn, PJ. Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats. J Neurosci, 28(41), 10422-33, 2008. PMCID:2577155

Jones, PJ, Xiang, Z, Conn, PJ. Metabotropic glutamate receptors mGluR4 and mGluR8 regulate transmission in the lateral olfactory tract-piriform cortex synapse. Neuropharmacology, 55, 440-446, 2008. PMCID:2644556

Lewis, LM, Sheffler, D, Williams, R, Bridges, TM, Kennedy, JP, Brogan, JT, Mulder, MJ, Williams, L, Nalywajko, NT, Niswender, CM, Weaver, CD, Conn, PJ, Lindsley, CW. Synthesis and SAR of selective muscarinic acetylcholine receptor subtype 1 (M1 mAChR) antagonists. Bioorg Med Chem Lett, 18(3), 885-90, 2008. PMCID:2275053

Miller, NR, Daniels, RN, Bridges, TM, Brady, AE, Conn, PJ, Lindsley, CW. Synthesis and SAR of analogs of the M1 allosteric agonist TBPB. Part II: Amides, sulfonamides and ureas--the effect of capping the distal basic piperidine nitrogen. Bioorg Med Chem Lett, 18(20), 5443-7, 2008.

Niswender, CM, Johnson, KA, Luo, Q, Ayala, JE, Kim, C, Conn, PJ, Weaver, CD. A novel assay of Gi/o-linked G protein-coupled receptor coupling to potassium channels provides new insights into the pharmacology of the group III metabotropic glutamate receptors. Mol Pharmacol, 73(4), 1213-24, 2008.

Niswender, CM, Johnson, KA, Weaver, CD, Jones, CK, Xiang, Z, Luo, Q, Rodriguez, AL, Marlo, JE, de Paulis, T, Thompson, AD, Days, EL, Nalywajko, T, Austin, CA, Williams, MB, Ayala, JE, Williams, R, Lindsley, CW, Conn, PJ. Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4. Mol Pharmacol, 74(5), 1345-58, 2008. PMCID:2574552

Niswender, CM, Lebois, EP, Luo, Q, Kim, K, Muchalski, H, Yin, H, Conn, PJ, Lindsley, CW. Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4): Part I. Discovery of pyrazolo[3,4-d]pyrimidines as novel mGluR4 positive allosteric modulators. Bioorg Med Chem Lett, 18(20), 5626-30, 2008.

Sharma, S, Rodriguez, AL, Conn, PJ, Lindsley, CW. Synthesis and SAR of a mGluR5 allosteric partial antagonist lead: unexpected modulation of pharmacology with slight structural modifications to a 5-(phenylethynyl)pyrimidine scaffold. Bioorg Med Chem Lett, 18(14), 4098-101, 2008. PMCID:2533619

Sheffler, DJ, Conn, PJ. Allosteric potentiators of metabotropic glutamate receptor subtype 1a differentially modulate independent signaling pathways in baby hamster kidney cells. Neuropharmacology, 55(4), 419-27, 2008. PMCID:2600811

Shirey, JK, Xiang, Z, Orton, D, Brady, AE, Johnson, KA, Williams, R, Ayala, JE, Rodriguez, AL, Wess, J, Weaver, D, Niswender, CM, Conn, PJ. An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission. Nat Chem Biol, 4(1), 42-50, 2008.

Ayala, JE, Niswender, CM, Luo, Q, Banko, JL, Conn, PJ. Group III mGluR regulation of synaptic transmission at the SC-CA1 synapse is developmentally regulated. Neuropharmacology, , , 2007. PMCID:2431171

Benneyworth, MA, Xiang, Z, Smith, RL, Garcia, EE, Conn, PJ, Sanders-Bush, E. A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosis. Mol Pharmacol, 72(2), 477-84, 2007.

Chen, Y, Nong, Y, Goudet, C, Hemstapat, K, de Paulis, T, Pin, JP, Conn, PJ. Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses. Mol Pharmacol, 71(5), 1389-98, 2007.

Hemstapat, K, Da Costa, H, Nong, Y, Brady, AE, Luo, Q, Niswender, CM, Tamagnan, GD, Conn, PJ. A novel family of potent negative allosteric modulators of group II metabotropic glutamate receptors. J Pharmacol Exp Ther, 322(1), 254-64, 2007.

Lindsley, CW, Weaver, D, Jones, C, Marnett, L, Conn, PJ. Preclinical drug discovery research and training at Vanderbilt. ACS Chem Biol, 2(1), 17-20, 2007.

Conn, PJ, Niswender, CM. mGluR7''s lucky number. Proc Natl Acad Sci U S A, 103(2), 251-2, 2006. PMCID:1326193

Galici, R, Jones, CK, Hemstapat, K, Nong, Y, Echemendia, NG, Williams, LC, De Paulis, T, Conn, PJ. Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice. J Pharmacol Exp Ther, , , 2006.

Hemstapat, K, de Paulis, T, Chen, Y, Brady, AE, Grover, VK, Alagille, D, Tamagnan, GD, Conn, PJ. A NOVEL CLASS OF POSITIVE ALLOSTERIC MODULATORS OF mGluR1 INTERACT WITH A SITE DISTINCT FROM THAT OF NEGATIVE ALLOSTERIC MODULATORS. Mol Pharmacol, , , 2006.

Lindsley, CW, Zhao, Z, Leister, WH, O''Brien, J, Lemaire, W, Williams, DL, Chen, TB, Chang, RS, Burno, M, Jacobson, MA, Sur, C, Kinney, GG, Pettibone, DJ, Tiller, PR, Smith, S, Tsou, NN, Duggan, ME, Conn, PJ, Hartman, GD. Design, synthesis, and in vivo efficacy of glycine transporter-1 (GlyT1) inhibitors derived from a series of [4-phenyl-1-(propylsulfonyl)piperidin-4-yl]methyl benzamides. ChemMedChem, 1(8), 807-11, 2006.

Marino, MJ, Conn, PJ. Glutamate-based therapeutic approaches: allosteric modulators of metabotropic glutamate receptors. Curr Opin Pharmacol, 6(1), 98-102, 2006.

de Paulis, T, Hemstapat, K, Chen, Y, Zhang, Y, Saleh, S, Alagille, D, Baldwin, RM, Tamagnan, GD, Conn, PJ. Substituent Effects of N-(1,3-Diphenyl-1H-pyrazol-5-yl)benzamides on Positive Allosteric Modulation of the Metabotropic Glutamate-5 Receptor in Rat Cortical Astrocytes. J Med Chem, 49(11), 3332-3344, 2006.

Alagarsamy, S, Saugstad, J, Warren, L, Mansuy, IM, Gereau, RW, Conn, PJ. NMDA-induced potentiation of mGluR5 is mediated by activation of protein phosphatase 2B/calcineurin. Neuropharmacology, 49 Suppl 1, 135-45, 2005.

Conn, PJ, Battaglia, G, Marino, MJ, Nicoletti, F. Metabotropic glutamate receptors in the basal ganglia motor circuit. Nat Rev Neurosci, 6(10), 787-98, 2005.

Galici, R, Echemendia, NG, Rodriguez, AL, Conn, PJ. A selective allosteric potentiator of metabotropic glutamate (mGlu) 2 receptors has effects similar to an orthosteric mGlu2/3 receptor agonist in mouse models predictive of antipsychotic activity. J Pharmacol Exp Ther, 315(3), 1181-7, 2005.

Kinney, GG, O''Brien, JA, Lemaire, W, Burno, M, Bickel, DJ, Clements, MK, Chen, TB, Wisnoski, DD, Lindsley, CW, Tiller, PR, Smith, S, Jacobson, MA, Sur, C, Duggan, ME, Pettibone, DJ, Conn, PJ, Williams, DL. A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models. J Pharmacol Exp Ther, 313(1), 199-206, 2005.

Niswender, CM, Jones, CK, Conn, PJ. New therapeutic frontiers for metabotropic glutamate receptors. Curr Top Med Chem, 5(9), 847-57, 2005.

Poisik, O, Raju, DV, Verreault, M, Rodriguez, A, Abeniyi, OA, Conn, PJ, Smith, Y. Metabotropic glutamate receptor 2 modulates excitatory synaptic transmission in the rat globus pallidus. Neuropharmacology, 49 Suppl 1, 57-69, 2005.

Rodriguez, AL, Nong, Y, Sekaran, NK, Alagille, D, Tamagnan, GD, Conn, PJ. A close structural analog of 2-methyl-6-(phenylethynyl)-pyridine acts as a neutral allosteric site ligand on metabotropic glutamate receptor subtype 5 and blocks the effects of multiple allosteric modulators. Mol Pharmacol, 68(6), 1793-802, 2005.

Valenti, O, Mannaioni, G, Seabrook, GR, Conn, PJ, Marino, MJ. Group III metabotropic glutamate-receptor-mediated modulation of excitatory transmission in rodent substantia nigra pars compacta dopamine neurons. J Pharmacol Exp Ther, 313(3), 1296-304, 2005.

Wittmann, M, Marino, MJ, Henze, DA, Seabrook, GR, Conn, PJ. Clozapine potentiation of N-methyl-D-aspartate receptor currents in the nucleus accumbens: role of NR2B and protein kinase A/Src kinases. J Pharmacol Exp Ther, 313(2), 594-603, 2005.

Zhang, Y, Rodriguez, AL, Conn, PJ. Allosteric potentiators of metabotropic glutamate receptor subtype 5 have differential effects on different signaling pathways in cortical astrocytes. J Pharmacol Exp Ther, 315(3), 1212-9, 2005.

Campbell, Una C., Lalwani, Kush, Hernandez, Lisa, Kinney, Gene G., Conn, P. Jeffrey, Bristow, Linda J.. The mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) potentiates PCP-induced cognitive deficits in rats. Psychopharmacology (Berl), , , 2004.

Doherty, JJ, Alagarsamy, S, Bough, KJ, Conn, PJ, Dingledine, R, Mott, DD. Metabotropic glutamate receptors modulate feedback inhibition in a developmentally regulated manner in rat dentate gyrus. J Physiol, 561(Pt 2), 395-401, 2004. PMCID:1665349

Lindsley, CW, Wisnoski, DD, Leister, WH, O''brien, JA, Lemaire, W, Williams, DL, Burno, M, Sur, C, Kinney, GG, Pettibone, DJ, Tiller, PR, Smith, S, Duggan, ME, Hartman, GD, Conn, PJ, Huff, JR. Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo. J Med Chem, 47(24), 5825-8, 2004.

Marino, M.J., Bradley, S.R. , Awad, H., Wittmann, M., Conn, P.J. Localization and physiological roles of metabotropic glutamate receptors in the indirect pathway of the basal ganglia. Movement Disorders, in press, , 2004.

O''Brien, Julie A, Lemaire, Wei, Wittmann, Marion, Jacobson, Marlene A, Ha, Sookhee N, Wisnoski, David D, Lindsley, Craig W, Schaffhauser, Herve J, Rowe, Blake, Sur, Cyrille, Duggan, Mark E, Pettibone, Douglas J, Conn, P Jeffrey, Williams, David L. A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 (mGluR5) in rat forebrain. J Pharmacol Exp Ther, , , 2004.

Williams JB, Mallorga PJ, Conn PJ, Pettibone DJ, Sur C. . Effects of typical and atypical antipsychotics on human glycine transporters.. Schizophrenia Res, (in press), , 2004.

Sorensen SD, Conn PJ. G protein-coupled receptor kinases regulate metabotropic glutamate receptor 5 function and expression. Neuropharmacology, 44(6), 699-706, 2003 .

Conn, P Jeffrey. Physiological roles and therapeutic potential of metabotropic glutamate receptors. Ann N Y Acad Sci, 1003, 12-21, 2003.

Junge, Candice E, Sugawara, Taku, Mannaioni, Guido, Alagarsamy, Sudar, Conn, P Jeffrey, Brat, Daniel J, Chan, Pak H, Traynelis, Stephen F. The contribution of protease-activated receptor 1 to neuronal damage caused by transient focal cerebral ischemia. Proc Natl Acad Sci U S A, 100(22), 13019-24, 2003. PMCID:240737

Kinney, Gene G, Burno, Maryann, Campbell, Una C, Hernandez, Lisa M, Rodriguez, Dana, Bristow, Linda J, Conn, P Jeffrey. Metabotropic glutamate subtype 5 receptors modulate locomotor activity and sensorimotor gating in rodents. J Pharmacol Exp Ther, 306(1), 116-23, 2003.

Kinney, Gene G, Sur, Cyrille, Burno, Maryann, Mallorga, Pierre J, Williams, Jacinta B, Figueroa, David J, Wittmann, Marion, Lemaire, Wei, Conn, P Jeffrey. The glycine transporter type 1 inhibitor N-[3-(4''-fluorophenyl)-3-(4''-phenylphenoxy)propyl]sarcosine potentiates NMDA receptor-mediated responses in vivo and produces an antipsychotic profile in rodent behavior. J Neurosci, 23(20), 7586-91, 2003.

Mallorga, Pierre J, Williams, Jacinta B, Jacobson, Marlene, Marques, Rosemary, Chaudhary, Ashok, Conn, P Jeffrey, Pettibone, Douglas J, Sur, Cyrille. Pharmacology and expression analysis of glycine transporter GlyT1 with [3H]-(N-[3-(4''-fluorophenyl)-3-(4''phenylphenoxy)propyl])sarcosine. Neuropharmacology, 45(5), 585-93, 2003.

Marino M, Valenti O, Conn PJ. Glutamate receptors and Parkinson's disease : opportunities for intervention. Drugs Aging, 20(5), 377-97, 2003.

Marino, Michael J, Valenti, Ornella, Conn, P Jeffrey. Glutamate receptors and Parkinson''s disease: opportunities for intervention. Drugs Aging, 20(5), 377-97, 2003.

Marino, Michael J, Valenti, Ornella, O''Brien, Julie A, Williams, David L, Conn, P Jeffrey. Modulation of inhibitory transmission in the rat globus pallidus by activation of mGluR4. Ann N Y Acad Sci, 1003, 435-7, 2003.

Marino, Michael J, Williams, David L, O''Brien, Julie A, Valenti, Ornella, McDonald, Terrence P, Clements, Michelle K, Wang, Ruiping, DiLella, Anthony G, Hess, J Fred, Kinney, Gene G, Conn, P Jeffrey. Allosteric modulation of group III metabotropic glutamate receptor 4: a potential approach to Parkinson''s disease treatment. Proc Natl Acad Sci U S A, 100(23), 13668-73, 2003. PMCID:263871

O''Brien, Julie A, Lemaire, Wei, Chen, Tsing-Bau, Chang, Raymond S L, Jacobson, Marlene A, Ha, Sookhee N, Lindsley, Craig W, Schaffhauser, Herv?? J, Sur, Cyrille, Pettibone, Douglas J, Conn, P Jeffrey, Williams, David L. A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5. Mol Pharmacol, 64(3), 731-40, 2003.

Poisik, O., Marino, M.J. and Conn, P.J. Distinct functional roles of the group I metabotropic glutamate receptors 1 and 5 in the rat globus pallidus. J. Neurosci. , 23(1), 122-130, 2003.

Poisik, OV, Mannaioni, G, Traynelis, S, Smith, Y, Conn, PJ. Distinct functional roles of the metabotropic glutamate receptors 1 and 5 in the rat globus pallidus. J Neurosci, 23(1), 122-30, 2003.

Sorensen SD, Conn PJ. G protein-coupled receptor kinases regulate metabotropic glutamate receptor 5 function and expression. Neuropharmacology , 44(6), 699-706, 2003.

Sorensen, SD, Conn, PJ. G protein-coupled receptor kinases regulate metabotropic glutamate receptor 5 function and expression. Neuropharmacology, 44(6), 699-706, 2003.

Sur, Cyrille, Mallorga, Pierre J, Wittmann, Marion, Jacobson, Marlene A, Pascarella, Danette, Williams, Jacinta B, Brandish, Philip E, Pettibone, Douglas J, Scolnick, Edward M, Conn, P Jeffrey. N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-D-aspartate receptor activity. Proc Natl Acad Sci U S A, 100(23), 13674-9, 2003. PMCID:263872

Valenti, Ornella, Marino, Michael J, Conn, P Jeffrey. Modulation of excitatory transmission onto midbrain dopaminergic neurons of the rat by activation of group III metabotropic glutamate receptors. Ann N Y Acad Sci, 1003, 479-80, 2003.

Valenti, Ornella, Marino, Michael J, Wittmann, Marion, Lis, Edward, DiLella, Anthony G, Kinney, Gene G, Conn, P Jeffrey. Group III metabotropic glutamate receptor-mediated modulation of the striatopallidal synapse. J Neurosci, 23(18), 7218-26, 2003.

Williams, David L, O''Brien, Julie A, Lemaire, Wei, Chen, Tsing-Bau, Chang, Raymond S L, Jacobson, Marlene A, Ha, Sookhee N, Wisnoski, David D, Lindsley, Craig W, Sur, Cyrille, Duggan, Mark E, Pettibone, Douglas J, Conn, P Jeffrey. Difference in mGluR5 interaction between positive allosteric modulators from two structural classes. Ann N Y Acad Sci, 1003, 481-4, 2003.

Williams, J., Mallorga, P., Patel, S., Conn, P.J., Pettibone, D., Austin, C. and Sur, C. Development of a scintillation proximity assay for analysis of Na+/Cl- dependent neurotransmitter transporter activity. Analytical Biochem., 321, 31-37, 2003.

Marino MJ, Conn P.J. Modulation of the Basal Ganglia by metabotropic glutamate receptors: potential for novel therapeutics. Curr Drug Target CNS Neurol Disord., 1(3), 239-50 , 2002 .

Alagarsamy, Sudar, Rouse, Susan T, Junge, Candace, Hubert, G W, Gutman, David, Smith, Yoland, Conn, P Jeffrey. NMDA-induced phosphorylation and regulation of mGluR5. Pharmacol Biochem Behav, 73(2), 299-306, 2002.

Besong, Gilbert, Battaglia, Giuseppe, D''Onofrio, Mara, Di Marco, Roberto, Ngomba, Richard Teke, Storto, Marianna, Castiglione, Marzia, Mangano, Katia, Busceti, Carla L, Nicoletti, Ferdinando R, Bacon, Kevin, Tusche, Michael, Valenti, Ornella, Conn, Peter Jeffrey, Bruno, Valeria, Nicoletti, Ferdinando. Activation of group III metabotropic glutamate receptors inhibits the production of RANTES in glial cell cultures. J Neurosci, 22(13), 5403-11, 2002.

Fontana, J, Fulton, D, Chen, Y, Fairchild, TA, McCabe, TJ, Fujita, N, Tsuruo, T, Sessa, WC. Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release. Circ Res, 90(8), 866-73, 2002.

Marino MJ, Conn PJ. Direct and indirect modulation of the N-Methyl D-Aspartate receptor. Curr Drug Target CNS Neurol Disord., 1(1), 1-16., 2002.

Marino, M J, Awad, H, Poisik, O, Wittmann, M, Conn, P J. Localization and physiological roles of metabotropic glutamate receptors in the direct and indirect pathways of the basal ganglia. Amino Acids, 23(1-3), 185-91, 2002.

Marino, M J, Awad-Granko, H, Ciombor, K J, Conn, P J. Haloperidol-induced alteration in the physiological actions of group I mGlus in the subthalamic nucleus and the substantia nigra pars reticulata. Neuropharmacology, 43(2), 147-59, 2002.

Marino, MJ, Conn, PJ. Direct and indirect modulation of the N-methyl D-aspartate receptor. Curr Drug Targets CNS Neurol Disord, 1(1), 1-16, 2002.

Peavy RD, Chang MS, Sanders-Bush E, Conn PJ. Metabotropic glutamate receptor 5-induced phosphorylation of extracellular signal-regulated kinase in astrocytes depends on transactivation of the epidermal growth factor receptor. J Neurosci, 21(24), 9619-28, 2002.

Peavy, Richard D, Sorensen, Scott D, Conn, P Jeffrey. Differential regulation of metabotropic glutamate receptor 5-mediated phosphoinositide hydrolysis and extracellular signal-regulated kinase responses by protein kinase C in cultured astrocytes. J Neurochem, 83(1), 110-8, 2002.

Saugstad, Julie A, Yang, Sufang, Pohl, Jan, Hall, Randy A, Conn, P Jeffrey. Interaction between metabotropic glutamate receptor 7 and alpha tubulin. J Neurochem, 80(6), 980-8, 2002.

Schoepp DD, Conn PJ. Metabotropic glutamate receptors. Pharmacol Biochem Behav., 74(1), 255-6, 2002.

Schoepp, DD, Conn, PJ. Metabotropic glutamate receptors. Pharmacol Biochem Behav, 74(1), 255-6, 2002.

Scotland, RS, Morales-Ruiz, M, Chen, Y, Yu, J, Rudic, RD, Fulton, D, Gratton, JP, Sessa, WC. Functional reconstitution of endothelial nitric oxide synthase reveals the importance of serine 1179 in endothelium-dependent vasomotion. Circ Res, 90(8), 904-10, 2002.

Sorensen SD, Macek TA, Cai Z, Saugstad JA, Conn PJ. Dissociation of protein kinase-mediated regulation of metabotropic glutamate receptor 7 (mGluR7) interactions with calmodulin and regulation of mGluR7 function. Mol Pharmacol,, 61(6), 1303-1312, 2002.

Sorensen, SD, Macek, TA, Cai, Z, Saugstad, JA, Conn, PJ. Dissociation of protein kinase-mediated regulation of metabotropic glutamate receptor 7 (mGluR7) interactions with calmodulin and regulation of mGluR7 function. Mol Pharmacol, 61(6), 1303-12, 2002.

Valenti, Ornella, Conn, P Jeffrey, Marino, Michael J. Distinct physiological roles of the Gq-coupled metabotropic glutamate receptors Co-expressed in the same neuronal populations. J Cell Physiol, 191(2), 125-37, 2002.

Wittmann, Marion, Marino, Michael J, Conn, P Jeffrey. Dopamine modulates the function of group II and group III metabotropic glutamate receptors in the substantia nigra pars reticulata. J Pharmacol Exp Ther, 302(2), 433-41, 2002.

Alagarsamy, S, Sorensen, S D, Conn, P J. Coordinate regulation of metabotropic glutamate receptors. Curr Opin Neurobiol, 11(3), 357-62, 2001.

Awad-Granko, H, Conn, P J. Activation of groups I or III metabotropic glutamate receptors inhibits excitatory transmission in the rat subthalamic nucleus. Neuropharmacology, 41(1), 32-41, 2001.

Cai, Z, Saugstad, J A, Sorensen, S D, Ciombor, K J, Zhang, C, Schaffhauser, H, Hubalek, F, Pohl, J, Duvoisin, R M, Conn, P J. Cyclic AMP-dependent protein kinase phosphorylates group III metabotropic glutamate receptors and inhibits their function as presynaptic receptors. J Neurochem, 78(4), 756-66, 2001.

De Blasi, A, Conn, P J, Pin, J, Nicoletti, F. Molecular determinants of metabotropic glutamate receptor signaling. Trends Pharmacol Sci, 22(3), 114-20, 2001.

Mannaioni, G, Marino, M J, Valenti, O, Traynelis, S F, Conn, P J. Metabotropic glutamate receptors 1 and 5 differentially regulate CA1 pyramidal cell function. J Neurosci, 21(16), 5925-34, 2001.

Marino MJ, Wittmann M, Bradley SR, Hubert GW, Smith Y, Conn PJ. Activation of group I metabotropic glutamate receptors produces a direct excitation and disinhibition of GABAergic projection neurons in the substantia nigra pars reticulata. J Neurosci. , 21(18), 7001-7012, 2001.

Marino, MJ, Wittmann, M, Bradley, SR, Hubert, GW, Smith, Y, Conn, PJ. Activation of group I metabotropic glutamate receptors produces a direct excitation and disinhibition of GABAergic projection neurons in the substantia nigra pars reticulata. J Neurosci, 21(18), 7001-12, 2001.

Peavy, R D, Chang, M S, Sanders-Bush, E, Conn, P J. Metabotropic glutamate receptor 5-induced phosphorylation of extracellular signal-regulated kinase in astrocytes depends on transactivation of the epidermal growth factor receptor. J Neurosci, 21(24), 9619-28, 2001.

Wittmann, M, Hubert, G W, Smith, Y, Conn, P J. Activation of metabotropic glutamate receptor 1 inhibits glutamatergic transmission in the substantia nigra pars reticulata. Neuroscience, 105(4), 881-9, 2001.

Wittmann, M, Marino, M J, Bradley, S R, Conn, P J. Activation of group III mGluRs inhibits GABAergic and glutamatergic transmission in the substantia nigra pars reticulata. J Neurophysiol, 85(5), 1960-8, 2001.

Zheng F, Erreger K, Low CM, Banke T, Lee CJ, Conn PJ, Traynelis SF. Allosteric interaction between the amino terminal domain and the ligand binding domain of NR2A. Nat Neurosci. , 4(9), 894-901, 2001.

Zheng, F, Erreger, K, Low, CM, Banke, T, Lee, CJ, Conn, PJ, Traynelis, SF. Allosteric interaction between the amino terminal domain and the ligand binding domain of NR2A. Nat Neurosci, 4(9), 894-901, 2001.

Awad, H, Hubert, G W, Smith, Y, Levey, A I, Conn, P J. Activation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus. J Neurosci, 20(21), 7871-9, 2000.

Bradley, S R, Marino, M J, Wittmann, M, Rouse, S T, Awad, H, Levey, A I, Conn, P J. Activation of group II metabotropic glutamate receptors inhibits synaptic excitation of the substantia Nigra pars reticulata. J Neurosci, 20(9), 3085-94, 2000.

Dingledine, R, Conn, P J. Peripheral glutamate receptors: molecular biology and role in taste sensation. J Nutr, 130(4S Suppl), 1039S-42S, 2000.

Lie, A A, Becker, A, Behle, K, Beck, H, Malitschek, B, Conn, P J, Kuhn, R, Nitsch, R, Plaschke, M, Schramm, J, Elger, C E, Wiestler, O D, Bl??mcke, I. Up-regulation of the metabotropic glutamate receptor mGluR4 in hippocampal neurons with reduced seizure vulnerability. Ann Neurol, 47(1), 26-35, 2000.

Prince, H C, Tzingounis, A V, Levey, A I, Conn, P J. Functional downregulation of GluR2 in piriform cortex of kindled animals. Synapse, 38(4), 489-98, 2000.

Rouse, S T, Hamilton, S E, Potter, L T, Nathanson, N M, Conn, P J. Muscarinic-induced modulation of potassium conductances is unchanged in mouse hippocampal pyramidal cells that lack functional M1 receptors. Neurosci Lett, 278(1-2), 61-4, 2000.

Rouse, S T, Marino, M J, Bradley, S R, Awad, H, Wittmann, M, Conn, P J. Distribution and roles of metabotropic glutamate receptors in the basal ganglia motor circuit: implications for treatment of Parkinson''s disease and related disorders. Pharmacol Ther, 88(3), 427-35, 2000.

Schaffhauser, H, Cai, Z, Hubalek, F, Macek, T A, Pohl, J, Murphy, T J, Conn, P J. cAMP-dependent protein kinase inhibits mGluR2 coupling to G-proteins by direct receptor phosphorylation. J Neurosci, 20(15), 5663-70, 2000.

Alagarsamy, S, Marino, M J, Rouse, S T, Gereau, R W, Heinemann, S F, Conn, P J. Activation of NMDA receptors reverses desensitization of mGluR5 in native and recombinant systems. Nat Neurosci, 2(3), 234-40, 1999.

Alagarsamy, S, Rouse, S T, Gereau, R W, Heinemann, S F, Smith, Y, Conn, P J. Activation of N-methyl-D-aspartate receptors reverses desensitization of metabotropic glutamate receptor, mGluR5, in native and recombinant systems. Ann N Y Acad Sci, 868, 526-30, 1999.

Bradley, S R, Standaert, D G, Levey, A I, Conn, P J. Distribution of group III mGluRs in rat basal ganglia with subtype-specific antibodies. Ann N Y Acad Sci, 868, 531-4, 1999.

Bradley, S R, Standaert, D G, Rhodes, K J, Rees, H D, Testa, C M, Levey, A I, Conn, P J. Immunohistochemical localization of subtype 4a metabotropic glutamate receptors in the rat and mouse basal ganglia. J Comp Neurol, 407(1), 33-46, 1999.

Hay, M, McKenzie, H, Lindsley, K, Dietz, N, Bradley, S R, Conn, P J, Hasser, E M. Heterogeneity of metabotropic glutamate receptors in autonomic cell groups of the medulla oblongata of the rat. J Comp Neurol, 403(4), 486-501, 1999.

Khawaja, X Z, Liang, J J, Saugstad, J A, Jones, P G, Harnish, S, Conn, P J, Cockett, M I. Immunohistochemical distribution of RGS7 protein and cellular selectivity in colocalizing with Galphaq proteins in the adult rat brain. J Neurochem, 72(1), 174-84, 1999.

Kosinski, C M, Risso Bradley, S, Conn, P J, Levey, A I, Landwehrmeyer, G B, Penney, J B, Young, A B, Standaert, D G. Localization of metabotropic glutamate receptor 7 mRNA and mGluR7a protein in the rat basal ganglia. J Comp Neurol, 415(2), 266-84, 1999.

Macek, T A, Schaffhauser, H, Conn, P J. Activation of PKC disrupts presynaptic inhibition by group II and group III metabotropic glutamate receptors and uncouples the receptor from GTP-binding proteins. Ann N Y Acad Sci, 868, 554-7, 1999.

Paradee, W, Melikian, H E, Rasmussen, D L, Kenneson, A, Conn, P J, Warren, S T. Fragile X mouse: strain effects of knockout phenotype and evidence suggesting deficient amygdala function. Neuroscience, 94(1), 185-92, 1999.

Rouse, S T, Marino, M J, Potter, L T, Conn, P J, Levey, A I. Muscarinic receptor subtypes involved in hippocampal circuits. Life Sci, 64(6-7), 501-9, 1999.

Bradley, S R, Rees, H D, Yi, H, Levey, A I, Conn, P J. Distribution and developmental regulation of metabotropic glutamate receptor 7a in rat brain. J Neurochem, 71(2), 636-45, 1998.

Macek, T A, Schaffhauser, H, Conn, P J. Protein kinase C and A3 adenosine receptor activation inhibit presynaptic metabotropic glutamate receptor (mGluR) function and uncouple mGluRs from GTP-binding proteins. J Neurosci, 18(16), 6138-46, 1998.

Marino, M J, Rouse, S T, Levey, A I, Potter, L T, Conn, P J. Activation of the genetically defined m1 muscarinic receptor potentiates N-methyl-D-aspartate (NMDA) receptor currents in hippocampal pyramidal cells. Proc Natl Acad Sci U S A, 95(19), 11465-70, 1998. PMCID:21666

Peavy, R D, Conn, P J. Phosphorylation of mitogen-activated protein kinase in cultured rat cortical glia by stimulation of metabotropic glutamate receptors. J Neurochem, 71(2), 603-12, 1998.

Saugstad, J A, Marino, M J, Folk, J A, Hepler, J R, Conn, P J. RGS4 inhibits signaling by group I metabotropic glutamate receptors. J Neurosci, 18(3), 905-13, 1998.

Zheng, F, Gingrich, M B, Traynelis, S F, Conn, P J. Tyrosine kinase potentiates NMDA receptor currents by reducing tonic zinc inhibition. Nat Neurosci, 1(3), 185-91, 1998.

Chen, YT, Henk, MJ, Carney, KJ, Wong, WD, Rothenberger, DA, Zheng, T, Feygin, M, Madoff, RD. Prognostic significance of tumor markers in colorectal cancer patients: DNA index, S-phase fraction, p53 expression, and Ki-67 index. J Gastrointest Surg, 1(3), 266-72; discussion 273, 1997.

Chung, D S, Traynelis, S F, Murphy, T J, Conn, P J. 4-Methylhomoibotenic acid activates a novel metabotropic glutamate receptor coupled to phosphoinositide hydrolysis. J Pharmacol Exp Ther, 283(2), 742-9, 1997.

Conn, P J, Pin, J P. Pharmacology and functions of metabotropic glutamate receptors. Annu Rev Pharmacol Toxicol, 37, 205-37, 1997.

Miller, H P, Levey, A I, Rothstein, J D, Tzingounis, A V, Conn, P J. Alterations in glutamate transporter protein levels in kindling-induced epilepsy. J Neurochem, 68(4), 1564-70, 1997.

Bradley, S R, Levey, A I, Hersch, S M, Conn, P J. Immunocytochemical localization of group III metabotropic glutamate receptors in the hippocampus with subtype-specific antibodies. J Neurosci, 16(6), 2044-56, 1996.

Macek, T A, Winder, D G, Gereau, R W, Ladd, C O, Conn, P J. Differential involvement of group II and group III mGluRs as autoreceptors at lateral and medial perforant path synapses. J Neurophysiol, 76(6), 3798-806, 1996.

Winder, D G, Conn, P J. Roles of metabotropic glutamate receptors in glial function and glial-neuronal communication. J Neurosci Res, 46(2), 131-7, 1996.

Winder, D G, Ritch, P S, Gereau, R W, Conn, P J. Novel glial-neuronal signalling by coactivation of metabotropic glutamate and beta-adrenergic receptors in rat hippocampus. J Physiol, 494 ( Pt 3), 743-55, 1996. PMCID:1160674

Gereau, R W, Conn, P J. Multiple presynaptic metabotropic glutamate receptors modulate excitatory and inhibitory synaptic transmission in hippocampal area CA1. J Neurosci, 15(10), 6879-89, 1995.

Gereau, R W, Conn, P J. Roles of specific metabotropic glutamate receptor subtypes in regulation of hippocampal CA1 pyramidal cell excitability. J Neurophysiol, 74(1), 122-9, 1995.

Gereau, R W, Winder, D G, Conn, P J. Pharmacological differentiation of the effects of co-activation of beta-adrenergic and metabotropic glutamate receptors in rat hippocampus. Neurosci Lett, 186(2-3), 119-22, 1995.

Prince, H K, Conn, P J, Blackstone, C D, Huganir, R L, Levey, A I. Down-regulation of AMPA receptor subunit GluR2 in amygdaloid kindling. J Neurochem, 64(1), 462-5, 1995.

Winder, D G, Conn, P J. Metabotropic glutamate receptor (mGluR)-mediated potentiation of cyclic AMP responses does not require phosphoinositide hydrolysis: mediation by a group II-like mGluR. J Neurochem, 64(2), 592-9, 1995.

Boss, V, Nutt, K M, Conn, P J. L-cysteine sulfinic acid as an endogenous agonist of a novel metabotropic receptor coupled to stimulation of phospholipase D activity. Mol Pharmacol, 45(6), 1177-82, 1994.

Chung, D S, Winder, D G, Conn, P J. 4-Bromohomoibotenic acid selectively activates a 1-aminocyclopentane-1S,3R-dicarboxylic acid-insensitive metabotropic glutamate receptor coupled to phosphoinositide hydrolysis in rat cortical slices. J Neurochem, 63(1), 133-9, 1994.

Desai, M A, McBain, C J, Kauer, J A, Conn, P J. Metabotropic glutamate receptor-induced disinhibition is mediated by reduced transmission at excitatory synapses onto interneurons and inhibitory synapses onto pyramidal cells. Neurosci Lett, 181(1-2), 78-82, 1994.

Gereau, R W, Conn, P J. A cyclic AMP-dependent form of associative synaptic plasticity induced by coactivation of beta-adrenergic receptors and metabotropic glutamate receptors in rat hippocampus. J Neurosci, 14(5 Pt 2), 3310-8, 1994.

Gereau, R W, Conn, P J. Presynaptic enhancement of excitatory synaptic transmission by beta-adrenergic receptor activation. J Neurophysiol, 72(3), 1438-42, 1994.

Gereau, R W, Conn, P J. Potentiation of cAMP responses by metabotropic glutamate receptors depresses excitatory synaptic transmission by a kinase-independent mechanism. Neuron, 12(5), 1121-9, 1994.

Schoepp, D D, Conn, P J. Metabotropic glutamate receptors in brain function and pathology. Trends Pharmacol Sci, 14(1), 13-20, 1993.

Winder, D G, Conn, P J. Activation of metabotropic glutamate receptors increases cAMP accumulation in hippocampus by potentiating responses to endogenous adenosine. J Neurosci, 13(1), 38-44, 1993.

Winder, D G, Smith, T, Conn, P J. Pharmacological differentiation of metabotropic glutamate receptors coupled to potentiation of cyclic adenosine monophosphate responses and phosphoinositide hydrolysis. J Pharmacol Exp Ther, 266(2), 518-25, 1993.

Boss, V, Conn, P J. Metabotropic excitatory amino acid receptor activation stimulates phospholipase D in hippocampal slices. J Neurochem, 59(6), 2340-3, 1992.

Boss, V, Desai, M A, Smith, T S, Conn, P J. Trans-ACPD-induced phosphoinositide hydrolysis and modulation of hippocampal pyramidal cell excitability do not undergo parallel developmental regulation. Brain Res, 594(2), 181-8, 1992.

Chen, S J, Desai, M A, Klann, E, Winder, D G, Sweatt, J D, Conn, P J. Amygdala kindling alters protein kinase C activity in dentate gyrus. J Neurochem, 59(5), 1761-9, 1992.

Desai, M A, Smith, T S, Conn, P J. Multiple metabotropic glutamate receptors regulate hippocampal function. Synapse, 12(3), 206-13, 1992.

Winder, D G, Conn, P J. Activation of metabotropic glutamate receptors in the hippocampus increases cyclic AMP accumulation. J Neurochem, 59(1), 375-8, 1992.

Desai, M A, Conn, P J. Excitatory effects of ACPD receptor activation in the hippocampus are mediated by direct effects on pyramidal cells and blockade of synaptic inhibition. J Neurophysiol, 66(1), 40-52, 1991.

Desai, M A, Conn, P J. Selective activation of phosphoinositide hydrolysis by a rigid analogue of glutamate. Neurosci Lett, 109(1-2), 157-62, 1990.

Conn, P J, Kaczmarek, L K. The bag cell neurons of Aplysia. A model for the study of the molecular mechanisms involved in the control of prolonged animal behaviors. Mol Neurobiol, 3(4), 237-73, 1989.

Conn, P J, Strong, J A, Azhderian, E M, Nairn, A C, Greengard, P, Kaczmarek, L K. Protein kinase inhibitors selectively block phorbol ester- or forskolin-induced changes in excitability of Aplysia neurons. J Neurosci, 9(2), 473-9, 1989.

Conn, P J, Strong, J A, Kaczmarek, L K. Inhibitors of protein kinase C prevent enhancement of calcium current and action potentials in peptidergic neurons of Aplysia. J Neurosci, 9(2), 480-7, 1989.

Conn, P J, Janowsky, A, Sanders-Bush, E. Denervation supersensitivity of 5-HT-1c receptors in rat choroid plexus. Brain Res, 400(2), 396-8, 1987.

Conn, P J, Sanders-Bush, E. Relative efficacies of piperazines at the phosphoinositide hydrolysis-linked serotonergic (5-HT-2 and 5-HT-1c) receptors. J Pharmacol Exp Ther, 242(2), 552-7, 1987.

Conn, P J, Sanders-Bush, E. Central serotonin receptors: effector systems, physiological roles and regulation. Psychopharmacology (Berl), 92(3), 267-77, 1987.

Conn, P J, Sanders-Bush, E. Agonist-induced phosphoinositide hydrolysis in choroid plexus. J Neurochem, 47(6), 1754-60, 1986.

Conn, P J, Sanders-Bush, E. Biochemical characterization of serotonin stimulated phosphoinositide turnover. Life Sci, 38(7), 663-9, 1986.

Conn, P J, Sanders-Bush, E. Regulation of serotonin-stimulated phosphoinositide hydrolysis: relation to the serotonin 5-HT-2 binding site. J Neurosci, 6(12), 3669-75, 1986.

Conn, P J, Sanders-Bush, E, Hoffman, B J, Hartig, P R. A unique serotonin receptor in choroid plexus is linked to phosphatidylinositol turnover. Proc Natl Acad Sci U S A, 83(11), 4086-8, 1986. PMCID:323671

Sanders-Bush, E, Conn, P J. Effector systems coupled to serotonin receptors in brain: serotonin stimulated phosphoinositide hydrolysis. Psychopharmacol Bull, 22(3), 829-36, 1986.

Conn, P J, Sanders-Bush, E. Serotonin-stimulated phosphoinositide turnover: mediation by the S2 binding site in rat cerebral cortex but not in subcortical regions. J Pharmacol Exp Ther, 234(1), 195-203, 1985.

Conn, P J, Sanders-Bush, E. Selective 5HT-2 antagonists inhibit serotonin stimulated phosphatidylinositol metabolism in cerebral cortex. Neuropharmacology, 23(8), 993-6, 1984.


Postdoctoral Position Available
Yes

Postdoctoral Position Details
Postdoctoral position in cellular/molecular neurobiology is available at Vanderbilt University Medical Center. The successful candidate will join a research group that employs a highly multidisciplinary approach to explore the cellular and molecular mechanisms involved in neuromodulation and regulation of animal behavior. The laboratory uses a combination of biochemical, molecular biological, imaging, electrophysiological and behavioral techniques to study regulation of neuronal function by metabotropic glutamate receptors and other G-protein-linked receptors. Also, we have a strong interest in relating cellular and molecular changes to disorders of the central nervous system, including Parkinson's disease and Schizophrenia.

Research Faculty positions also available for outstanding candidates.

Send curriculum vita, three references, and statement of research interests to:

Dr. P. Jeffrey Conn,
Professor
Director, Program in Translational Neuropharmacology
Department of Pharmacology
Vanderbilt University Medical Center
23rd Avenue South at Pierce
452-B Preston Research Building
Nashville, TN 37232-6600

E-mail: jeff.conn@vanderbilt.edu

Updated Date
09/18/2009



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