Vanderbilt University School of Medicine

Creech, Clarence Buddy , MD, MPH
Associate Professor of Pediatrics

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Phone Number: 6153430332


Creech, Clarence's picture

Office Address   Mailing Address

CCC-5311 MCN/D-7214 MCN

CCC-5311 MCN 37232

Research Specialty
Clinical and Translational Research in S. aureus; Human immune response to staphylococcal infections; staphylococcal vaccine development

Research Description
Dr. Creech and his colleagues seek to understand the clinical and molecular epidemiology of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA). The work of the group focuses on describing the changing dynamics of nasal colonization with CA-MRSA and on how these isolates differ from those that cause invasive staphylococcal disease. In addition, the laboratory studies the adaptive response to infection, focusing on the serum antibody response to critical staphylococcal antigens. Work in the Vanderbilt Vaccine Research Program, where Dr. Creech serves as Associate Director, is directed towards clinical trials of vaccines and therapeutics, including monoclonal antibodies targeting S. aureus, influenza vaccine trials, and malaria vaccines.

Clinical investigations in the group are led by Gayle Johnson, RN, Shanda Phillips, RN, Sheana Fox, RN, and others within the Vanderbilt Vaccine Research Program. The laboratory is directed by Ms. Elizabeth Saye, who has extensive experience in microbiology, molecular epidemiology, and human immunology.

Dr. Creech graduated cum laude from Vanderbilt University before attending the University of Tennessee College of Medicine. After graduating with high honors, he joined the pediatric housestaff at Vanderbilt Children's Hospital and was Chief Resident in Pediatrics in 2002. During his pediatric infectious diseases fellowship at Vanderbilt Children's Hospital, Dr. Creech completed the Masters in Public Health degree and became part of the Vanderbilt Clinical Research Scholars (VCRS) Program, a competitive NIH K12 award given to young investigators at VUMC. He joined the faculty in July 2006 as Assistant Professor of Pediatric Infectious Diseases and now serves as Associate Director of the Vaccine Research Program and Co-Director of the Pediatric Infectious Diseases Fellowship.

The group can be contacted by email ( or by phone: 615-322-8792 (VVRP).

Current Projects

Longitudinal Study of CA-MRSA Nasal Colonization in a Cohort of Healthy University Sports Participants

Targeted Molecular Epidemiology of CA-MRSA Isolates

Safety and Efficacy of a Candidate Staphylococcal Vaccine

Safety and Efficacy of a Candidate Monoclonal Antibody Directed at S. aureus

Safety and Immunogenicity of a Candidate Malaria Vaccine

Safety and Immunogenicity of Adjuvanted H5N1 Influenza Vaccine

Humoral Immune Response to Invasive Staphylococcal Infections in Children

Safety and Pharmacokinetics of Ceftaroline in Pediatrics

Clinical Interests
Recurrent Furunculosis
MRSA Infections

Thomsen, I, Creech, CB. Advances in the Diagnosis and Management of Pediatric Osteomyelitis. Curr Infect Dis Rep, , , 2011.

Thomsen, I, McKenna, BD, Saye, EJ, Jimenez, N, Edwards, KM, Creech, CB. Molecular distinctions exist between community-associated methicillin-resistant Staphylococcus aureus colonization and disease-associated isolates in children. Pediatr Infect Dis J, 30(5), 418-21, 2011.

Williams, DJ, Deis, JN, Tardy, J, Creech, CB. Culture-negative osteoarticular infections in the era of community-associated methicillin-resistant Staphylococcus aureus. Pediatr Infect Dis J, 30(6), 523-5, 2011.

Aston, JL, Dortch, MJ, Dossett, LA, Creech, CB, May, AK. Risk factors for treatment failure in patients receiving vancomycin for hospital-acquired methicillin-resistant Staphylococcus aureus pneumonia. Surg Infect (Larchmt), 11(1), 21-8, 2010.

Creech, CB, Litzner, B, Talbot, TR, Schaffner, W. Frequency of detection of methicillin-resistant Staphylococcus aureus from rectovaginal swabs in pregnant women. Am J Infect Control, 38(1), 72-4, 2010.

Creech, CB, Saye, E, McKenna, BD, Johnson, BG, Jimenez, N, Talbot, TR, Bossung, T, Gregory, A, Edwards, KM. One-year surveillance of methicillin-resistant Staphylococcus aureus nasal colonization and skin and soft tissue infections in collegiate athletes. Arch Pediatr Adolesc Med, 164(7), 615-20, 2010.

Deis, JN, Creech, CB, Estrada, CM, Abramo, TJ. Procalcitonin as a marker of severe bacterial infection in children in the emergency department. Pediatr Emerg Care, 26(1), 51-60; quiz 61-3, 2010.

Dulek, DE, Williams, JV, Creech, CB, Schulert, AK, Frangoul, HA, Domm, J, Denison, MR, Chappell, JD. Use of intravenous zanamivir after development of oseltamivir resistance in a critically Ill immunosuppressed child infected with 2009 pandemic influenza A (H1N1) virus. Clin Infect Dis, 50(11), 1493-6, 2010.

House, DL, Chon, CH, Creech, CB, Skaar, EP, Li, D. Miniature on-chip detection of unpurified methicillin-resistant Staphylococcus aureus (MRSA) DNA using real-time PCR. J Biotechnol, 146(3), 93-9, 2010.

Jimenez-Truque, N, Thomsen, I, Saye, E, Creech, CB. Should higher vancomycin trough levels be targeted for invasive community-acquired methicillin-resistant Staphylococcus aureus infections in children. Pediatr Infect Dis J, 29(4), 368-70, 2010.

Thomsen, I, Dudney, H, Creech, CB. Searching for the holy grail of a staphylococcal vaccine. Hum Vaccin, 6(12), 1068-70, 2010.

Becker, SS, Russell, PT, Duncavage, JA, Creech, CB. Current issues in the management of sinonasal methicillin-resistant Staphylococcus aureus. Curr Opin Otolaryngol Head Neck Surg, 17(1), 2-5, 2009.

Creech, CB, Johnson, BG, Alsentzer, AR, Hohenboken, M, Edwards, KM, Talbot, TR. Vaccination as infection control: a pilot study to determine the impact of Staphylococcus aureus vaccination on nasal carriage. Vaccine, 28(1), 256-60, 2009.

Krause, JC, Ghandil, P, Chrabieh, M, Casanova, JL, Picard, C, Puel, A, Creech, CB. Very late-onset group B Streptococcus meningitis, sepsis, and systemic shigellosis due to interleukin-1 receptor-associated kinase-4 deficiency. Clin Infect Dis, 49(9), 1393-6, 2009.

Chappell, T, Creech, CB, Parra, D, Strauss, A, Scholl, F, Whitney, G. Presentation of pulmonary artery intimal sarcoma in an infant with a history of neonatal valvular pulmonic stenosis. Ann Thorac Surg, 85(3), 1092-4, 2008.

Creech, CB, Beekmann, SE, Chen, Y, Polgreen, PM. Variability among pediatric infectious diseases specialists in the treatment and prevention of methicillin-resistant Staphylococcus aureus skin and soft tissue infections. Pediatr Infect Dis J, 27(3), 270-2, 2008.

Creech, CB, Johnson, BG, Bartilson, RE, Yang, E, Barr, FE. Increasing use of extracorporeal life support in methicillin-resistant Staphylococcus aureus sepsis in children*. Pediatr Crit Care Med, 8(3), 231-5, 2007.

Piggott, CD, Hayes, B, Robb, CW, Thomas, L, Creech, CB, Smith, ML. Chemical burn induced by cutaneous exposure to a concentrated sodium hypochlorite and alkyl sulfate solution. Cutan Ocul Toxicol, 26(3), 189-94, 2007.

Creech, CB, Talbot, TR, Schaffner, W. Community-associated methicillin-resistant Staphylococcus aureus: the way to the wound is through the nose. J Infect Dis, 193(2), 169-71, 2006.

Jones, TF, Creech, CB, Erwin, P, Baird, SG, Woron, AM, Schaffner, W. Family outbreaks of invasive community-associated methicillin-resistant Staphylococcus aureus infection. Clin Infect Dis, 42(9), e76-8, 2006.

Pitchford, CW, Creech, CB, Peters, TR, Vnencak-Jones, CL. Bartonella henselae endocarditis in a child. Pediatr Cardiol, 27(6), 769-71, 2006.

Creech, CB, Kernodle, DS, Alsentzer, A, Wilson, C, Edwards, KM. Increasing rates of nasal carriage of methicillin-resistant Staphylococcus aureus in healthy children. Pediatr Infect Dis J, 24(7), 617-21, 2005.

Postdoctoral Position Available

Postdoctoral Position Details
None available at this time.

Updated Date

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