Vanderbilt University School of Medicine

Niswender, Kevin Dean , M.D., Ph.D.
Associate Professor of Medicine
Associate Professor of Molecular Physiology and Biophysics

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Phone Number: (615) 936-0500


Niswender, Kevin's picture

Office Address   Mailing Address

7435G MRB IV

722 PRB 37232-6303

Research Keywords
Diabetes, Endocrinology, Metabolism

Research Specialty
Diabetes, Endocrinology, and Metabolism

Branecky, KL, Niswender, KD, Pendergast, JS. Disruption of Daily Rhythms by High-Fat Diet Is Reversible. PLoS One, 10(9), e0137970, 2015.

Rojas, JM, Bruinstroop, E, Printz, RL, Alijagic-Boers, A, Foppen, E, Turney, MK, George, L, Beck-Sickinger, AG, Kalsbeek, A, Niswender, KD. Central nervous system neuropeptide Y regulates mediators of hepatic phospholipid remodeling and very low-density lipoprotein triglyceride secretion via sympathetic innervation. Mol Metab, 4(3), 210-21, 2015.

Kocalis, HE, Hagan, SL, George, L, Turney, MK, Siuta, MA, Laryea, GN, Morris, LC, Muglia, LJ, Printz, RL, Stanwood, GD, Niswender, KD. Rictor/mTORC2 facilitates central regulation of energy and glucose homeostasis. Mol Metab, 3(4), 394-407, 2014.

Morris, LC, Days, EL, Turney, M, Mi, D, Lindsley, CW, Weaver, CD, Niswender, KD. A Duplexed High-Throughput Screen to Identify Allosteric Modulators of the Glucagon-Like Peptide 1 and Glucagon Receptors. J Biomol Screen, 19(6), 847-858, 2014.

Morris, LC, Nance, KD, Gentry, PR, Days, EL, Weaver, CD, Niswender, CM, Thompson, AD, Jones, CK, Locuson, CW, Morrison, RD, Daniels, JS, Niswender, KD, Lindsley, CW. Discovery of (S)-2-cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379): a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM). J Med Chem, 57(23), 10192-7, 2014.

Pendergast, JS, Branecky, KL, Huang, R, Niswender, KD, Yamazaki, S. Wheel-running activity modulates circadian organization and the daily rhythm of eating behavior. Front Psychol, 5, 177, 2014.

Saunders, C, Siuta, M, Robertson, SD, Davis, AR, Sauer, J, Matthies, HJ, Gresch, PJ, Airey, DC, Lindsley, CW, Schetz, JA, Niswender, KD, Veenstra-Vanderweele, JM, Galli, A. Neuronal ablation of p-Akt at Ser473 leads to altered 5-HT1A/2A receptor function. Neurochem Int, 73, 113-21, 2014.

Silver, HJ, Kang, H, Keil, CD, Muldowney, JA, Kocalis, H, Fazio, S, Vaughan, DE, Niswender, KD. Consuming a balanced high fat diet for 16 weeks improves body composition, inflammation and vascular function parameters in obese premenopausal women. Metabolism, 63(4), 562-73, 2014.

Pendergast, JS, Branecky, KL, Yang, W, Ellacott, KL, Niswender, KD, Yamazaki, S. High-fat diet acutely affects circadian organisation and eating behavior. Eur J Neurosci, 37(8), 1350-6, 2013.

Pendergast, JS, Niswender, KD, Yamazaki, S. The complex relationship between the light-entrainable and methamphetamine-sensitive circadian oscillators: evidence from behavioral studies of Period-mutant mice. Eur J Neurosci, 38(7), 3044-53, 2013.

Silver, HJ, Niswender, KD, Kullberg, J, Berglund, J, Johansson, L, Bruvold, M, Avison, MJ, Welch, EB. Comparison of gross body fat-water magnetic resonance imaging at 3 Tesla to dual-energy X-ray absorptiometry in obese women. Obesity (Silver Spring), 21(4), 765-74, 2013.

West, J, Niswender, KD, Johnson, JA, Pugh, ME, Gleaves, L, Fessel, JP, Hemnes, AR. A potential role for insulin resistance in experimental pulmonary hypertension. Eur Respir J, 41(4), 861-71, 2013.

Hagan, S, Niswender, KD. Neuroendocrine regulation of food intake. Pediatr Blood Cancer, 58(1), 149-53, 2012. PMCID:3182178

Kocalis, HE, Turney, MK, Printz, RL, Laryea, GN, Muglia, LJ, Davies, SS, Stanwood, GD, McGuinness, OP, Niswender, KD. Neuron-specific deletion of peroxisome proliferator-activated receptor delta (PPAR??) in mice leads to increased susceptibility to diet-induced obesity. PLoS One, 7(8), e42981, 2012.

Pendergast, JS, Niswender, KD, Yamazaki, S. Tissue-specific function of Period3 in circadian rhythmicity. PLoS One, 7(1), e30254, 2012. PMCID:3256228

Pendergast, JS, Oda, GA, Niswender, KD, Yamazaki, S. Period determination in the food-entrainable and methamphetamine-sensitive circadian oscillator(s). Proc Natl Acad Sci U S A, 109(35), 14218-23, 2012.

Silver, HJ, Niswender, KD, Keil, CD, Jiang, L, Feng, Q, Chiu, S, Krauss, RM, Wilke, RA. CNR1 Genotype Influences HDL-Cholesterol Response to Change in Dietary Fat Intake. PLoS One, 7(5), e36166, 2012. PMCID:3342253

Niswender, KD. Basal insulin: physiology, pharmacology, and clinical implications. Postgrad Med, 123(4), 17-26, 2011. PMCID:3182178

Niswender, KD. Basal insulin: beyond glycemia. Postgrad Med, 123(4), 27-37, 2011. PMCID:3182178

Niswender, KD, Daws, LC, Avison, MJ, Galli, A. Insulin regulation of monoamine signaling: pathway to obesity. Neuropsychopharmacology, 36(1), 359-60, 2011. PMCID:3055525

Silver, HJ, Dietrich, MS, Niswender, KD. Effects of grapefruit, grapefruit juice and water preloads on energy balance, weight loss, body composition, and cardiometabolic risk in free-living obese adults. Nutr Metab (Lond), 8(1), 8, 2011. PMCID:3039556

Speed, N, Saunders, C, Davis, AR, Owens, WA, Matthies, HJ, Saadat, S, Kennedy, JP, Vaughan, RA, Neve, RL, Lindsley, CW, Russo, SJ, Daws, LC, Niswender, KD, Galli, A. Impaired striatal Akt signaling disrupts dopamine homeostasis and increases feeding. PLoS One, 6(9), e25169, 2011. PMCID:3182178

Silver, HJ, Welch, EB, Avison, MJ, Niswender, KD. Imaging body composition in obesity and weight loss: challenges and opportunities. Diabetes Metab Syndr Obes, 3, 337-47, 2010. PMCID:3047979

Siuta, MA, Robertson, SD, Kocalis, H, Saunders, C, Gresch, PJ, Khatri, V, Shiota, C, Kennedy, JP, Lindsley, CW, Daws, LC, Polley, DB, Veenstra-Vanderweele, J, Stanwood, GD, Magnuson, MA, Niswender, KD, Galli, A. Dysregulation of the norepinephrine transporter sustains cortical hypodopaminergia and schizophrenia-like behaviors in neuronal rictor null mice. PLoS Biol, 8(6), e1000393, 2010. PMCID:2882427

Posey, KA, Clegg, DJ, Printz, RL, Byun, J, Morton, GJ, Vivekanandan-Giri, A, Pennathur, S, Baskin, DG, Heinecke, JW, Woods, SC, Schwartz, MW, Niswender, KD. Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet. Am J Physiol Endocrinol Metab, 296(5), E1003-12, 2009. PMCID:2681305

Robinson, JR, Niswender, KD. What are the risks and the benefits of current and emerging weight-loss medications. Curr Diab Rep, 9(5), 368-75, 2009. PMCID:3047979

Huizinga, MM, Niswender, KD, Gebretsadik, T, Rothman, RL, Shintani, AK, Elasy, TA. Insulin Use and Weight Maintenance in Well-controlled Type 2 Diabetes: A Prospective Cohort Study. Obesity (Silver Spring), 16(8), 1933-1937, 2008. PMCID:2694404

Niswender, KD, Beech, BM. Obesity: increasing awareness of novel environmental factors. Diabetes, 57(7), 1786-7, 2008. PMCID:2453635

Stafford, JM, Yu, F, Printz, R, Hasty, AH, Swift, LL, Niswender, KD. Central nervous system neuropeptide Y signaling modulates VLDL triglyceride secretion. Diabetes, 57(6), 1482-90, 2008.

Niswender, KD, Magnuson, MA. Obesity and the beta cell: lessons from leptin. J Clin Invest, 117(10), 2753-6, 2007. PMCID:1994637

Saraswathi, V, Gao, L, Morrow, JD, Chait, A, Niswender, KD, Hasty, AH. Fish oil increases cholesterol storage in white adipose tissue with concomitant decreases in inflammation, hepatic steatosis, and atherosclerosis in mice. J Nutr, 137(7), 1776-82, 2007.

Gelling, RW, Morton, GJ, Morrison, CD, Niswender, KD, Myers, MG, Rhodes, CJ, Schwartz, MW. Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes. Cell Metab, 3(1), 67-73, 2006.

Morrison, CD, Morton, GJ, Niswender, KD, Gelling, RW, Schwartz, MW. Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that requires phosphatidylinositol 3-OH-kinase signaling. Am J Physiol Endocrinol Metab, 289(6), E1051-7, 2005.

Morton, GJ, Blevins, JE, Williams, DL, Niswender, KD, Gelling, RW, Rhodes, CJ, Baskin, DG, Schwartz, MW. Leptin action in the forebrain regulates the hindbrain response to satiety signals. J Clin Invest, 115(3), 703-10, 2005. PMCID:548313

Morton, GJ, Gelling, RW, Niswender, KD, Morrison, CD, Rhodes, CJ, Schwartz, MW. Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons. Cell Metab, 2(6), 411-20, 2005.

Niswender, KD, Baskin, DG, Schwartz, MW. Insulin and its evolving partnership with leptin in the hypothalamic control of energy homeostasis. Trends Endocrinol Metab, 15(8), 362-9, 2004.

Schwartz, MW, Niswender, KD. Adiposity signaling and biological defense against weight gain: absence of protection or central hormone resistance. J Clin Endocrinol Metab, 89(12), 5889-97, 2004.

Morton, GJ, Niswender, KD, Rhodes, CJ, Myers, MG, Blevins, JE, Baskin, DG, Schwartz, MW. Arcuate nucleus-specific leptin receptor gene therapy attenuates the obesity phenotype of Koletsky (fa(k)/fa(k)) rats. Endocrinology, 144(5), 2016-24, 2003.

Niswender, KD, Gallis, B, Blevins, JE, Corson, MA, Schwartz, MW, Baskin, DG. Immunocytochemical detection of phosphatidylinositol 3-kinase activation by insulin and leptin. J Histochem Cytochem, 51(3), 275-83, 2003.

Niswender, KD, Morrison, CD, Clegg, DJ, Olson, R, Baskin, DG, Myers, MG, Seeley, RJ, Schwartz, MW. Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia. Diabetes, 52(2), 227-31, 2003.

Niswender, KD, Schwartz, MW. Insulin and leptin revisited: adiposity signals with overlapping physiological and intracellular signaling capabilities. Front Neuroendocrinol, 24(1), 1-10, 2003.

Niswender, KD, Morton, GJ, Stearns, WH, Rhodes, CJ, Myers, MG, Schwartz, MW. Intracellular signalling. Key enzyme in leptin-induced anorexia. Nature, 413(6858), 794-5, 2001.

Kupershmidt, S, Yang, T, Anderson, ME, Wessels, A, Niswender, KD, Magnuson, MA, Roden, DM. Replacement by homologous recombination of the minK gene with lacZ reveals restriction of minK expression to the mouse cardiac conduction system. Circ Res, 84(2), 146-52, 1999.

Lu, JT, Son, YJ, Lee, J, Jetton, TL, Shiota, M, Moscoso, L, Niswender, KD, Loewy, AD, Magnuson, MA, Sanes, JR, Emeson, RB. Mice lacking alpha-calcitonin gene-related peptide exhibit normal cardiovascular regulation and neuromuscular development. Mol Cell Neurosci, 14(2), 99-120, 1999.

Postic, C, Shiota, M, Niswender, KD, Jetton, TL, Chen, Y, Moates, JM, Shelton, KD, Lindner, J, Cherrington, AD, Magnuson, MA. Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem, 274(1), 305-15, 1999.

Evans, TJ, Miller, MA, Ganjam, VK, Niswender, KD, Ellersieck, MR, Krause, WJ, Youngquist, RS. Morphometric analysis of endometrial periglandular fibrosis in mares. Am J Vet Res, 59(10), 1209-14, 1998.

Ji, QS, Winnier, GE, Niswender, KD, Horstman, D, Wisdom, R, Magnuson, MA, Carpenter, G. Essential role of the tyrosine kinase substrate phospholipase C-gamma1 in mammalian growth and development. Proc Natl Acad Sci U S A, 94(7), 2999-3003, 1997. PMCID:20311

Niswender, KD, Li, J, Powell, MR, Loos, KR, Roberts, RM, Keisler, DH, Smith, MF. Effect of variants of interferon-tau with mutations near the carboxyl terminus on luteal life span in sheep. Biol Reprod, 56(1), 214-20, 1997.

Niswender, KD, Postic, C, Jetton, TL, Bennett, BD, Piston, DW, Efrat, S, Magnuson, MA. Cell-specific expression and regulation of a glucokinase gene locus transgene. J Biol Chem, 272(36), 22564-9, 1997.

Niswender, KD, Postic, C, Shiota, M, Jetton, TL, Magnuson, MA. Effects of altered glucokinase gene copy number on blood glucose homoeostasis. Biochem Soc Trans, 25(1), 113-7, 1997.

Niswender, KD, Shiota, M, Postic, C, Cherrington, AD, Magnuson, MA. Effects of increased glucokinase gene copy number on glucose homeostasis and hepatic glucose metabolism. J Biol Chem, 272(36), 22570-5, 1997.

Qu, S, Niswender, KD, Ji, Q, van der Meer, R, Keeney, D, Magnuson, MA, Wisdom, R. Polydactyly and ectopic ZPA formation in Alx-4 mutant mice. Development, 124(20), 3999-4008, 1997.

Hawkins, DE, Niswender, KD, Oss, GM, Moeller, CL, Odde, KG, Sawyer, HR, Niswender, GD. An increase in serum lipids increases luteal lipid content and alters the disappearance rate of progesterone in cows. J Anim Sci, 73(2), 541-5, 1995.

Niswender, KD, Blackman, SM, Rohde, L, Magnuson, MA, Piston, DW. Quantitative imaging of green fluorescent protein in cultured cells: comparison of microscopic techniques, use in fusion proteins and detection limits. J Microsc, 180 ( Pt 2), 109-16, 1995.

Postic, C, Niswender, KD, Decaux, JF, Parsa, R, Shelton, KD, Gouhot, B, Pettepher, CC, Granner, DK, Girard, J, Magnuson, MA. Cloning and characterization of the mouse glucokinase gene locus and identification of distal liver-specific DNase I hypersensitive sites. Genomics, 29(3), 740-50, 1995.

Morita, H, Yano, Y, Niswender, KD, May, JM, Whitesell, RR, Wu, L, Printz, RL, Granner, DK, Magnuson, MA, Powers, AC. Coexpression of glucose transporters and glucokinase in Xenopus oocytes indicates that both glucose transport and phosphorylation determine glucose utilization. J Clin Invest, 94(4), 1373-82, 1994. PMCID:295259

Niswender, GD, McNatty, KP, Smith, P, Niswender, KD, Farin, CE, Sawyer, HR. Numbers of steroidogenic luteal cells in Booroola Merino ewes. J Reprod Fertil, 90(1), 185-90, 1990.

Sawyer, HR, Niswender, KD, Braden, TD, Niswender, GD. Nuclear changes in ovine luteal cells in response to PGF2 alpha. Domest Anim Endocrinol, 7(2), 229-37, 1990.

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