Vanderbilt University School of Medicine

Matthies, Heinrich J.G. , Ph.D.
Research Assistant Professor of Molecular Physiology and Biophysics

Lab Url: N/A

Phone Number: 615-936-3707


Matthies, Heinrich's picture

Office Address   Mailing Address

MRB III room 7125

702 Light Hall 0615

Bellot, M, Galandrin, S, Boularan, C, Matthies, HJ, Despas, F, Denis, C, Javitch, J, Mazeres, S, Sanni, SJ, Pons, V, Seguelas, MH, Hansen, JL, Pathak, A, Galli, A, Senard, JM, Gales, C. Dual agonist occupancy of AT1-R/alpha2C2C-AR heterodimers results in atypical Gs-PKA signaling. Nat Chem Biol, 11(4), 271-9, 2015.

Cartier, E, Hamilton, PJ, Belovich, AN, Shekar, A, Campbell, NG, Saunders, C, Andreassen, TF, Gether, U, Veenstra-Vanderweele, J, Sutcliffe, JS, Ulery-Reynolds, PG, Erreger, K, Matthies, HJ, Galli, A. Rare autism-associated variants implicate syntaxin 1 (STX1 R26Q) phosphorylation and the dopamine transporter (hDAT R51W) in dopamine neurotransmission and behaviors. EBioMedicine, 2(2), 135-146, 2015.

Hamilton, PJ, Shekar, A, Belovich, AN, Christianson, NB, Campbell, NG, Sutcliffe, JS, Galli, A, Matthies, HJ, Erreger, K. Zn(2+) reverses functional deficits in a de novo dopamine transporter variant associated with autism spectrum disorder. Mol Autism, 6, 8, 2015.

Bowton, E, Saunders, C, Reddy, IA, Campbell, NG, Hamilton, PJ, Henry, LK, Coon, H, Sakrikar, D, Veenstra-VanderWeele, JM, Blakely, RD, Sutcliffe, J, Matthies, HJ, Erreger, K, Galli, A. SLC6A3 coding variant Ala559Val found in two autism probands alters dopamine transporter function and trafficking. Transl Psychiatry, 4, e464, 2014.

Hamilton, PJ, Belovich, AN, Khelashvili, G, Saunders, C, Erreger, K, Javitch, JA, Sitte, HH, Weinstein, H, Matthies, HJ, Galli, A. PIP2 regulates psychostimulant behaviors through its interaction with a membrane protein. Nat Chem Biol, 10(7), 582-9, 2014.

Saunders, C, Siuta, M, Robertson, SD, Davis, AR, Sauer, J, Matthies, HJ, Gresch, PJ, Airey, DC, Lindsley, CW, Schetz, JA, Niswender, KD, Veenstra-Vanderweele, JM, Galli, A. Neuronal ablation of p-Akt at Ser473 leads to altered 5-HT1A/2A receptor function. Neurochem Int, 73, 113-21, 2014.

Buchmayer, F, Schicker, K, Steinkellner, T, Geier, P, St??biger, G, Hamilton, PJ, Jurik, A, Stockner, T, Yang, JW, Montgomery, T, Holy, M, Hofmaier, T, Kudlacek, O, Matthies, HJ, Ecker, GF, Bochkov, V, Galli, A, Boehm, S, Sitte, HH. Amphetamine actions at the serotonin transporter rely on the availability of phosphatidylinositol-4,5-bisphosphate. Proc Natl Acad Sci U S A, 110(28), 11642-7, 2013.

Hamilton, PJ, Campbell, NG, Sharma, S, Erreger, K, Hansen, FH, Saunders, C, Belovich, AN, Sahai, MA, Cook, EH, Gether, U, McHaourab, HS, Matthies, HJ, Sutcliffe, JS, Galli, A. Drosophila melanogaster: a novel animal model for the behavioral characterization of autism-associated mutations in the dopamine transporter gene. Mol Psychiatry, 18(12), 1235, 2013.

Hamilton, PJ, Campbell, NG, Sharma, S, Erreger, K, Herborg Hansen, F, Saunders, C, Belovich, AN, , , Sahai, MA, Cook, EH, Gether, U, McHaourab, HS, Matthies, HJ, Sutcliffe, JS, Galli, A. De novo mutation in the dopamine transporter gene associates dopamine dysfunction with autism spectrum disorder. Mol Psychiatry, 18(12), 1315-23, 2013.

Conrad, KL, Davis, AR, Silberman, Y, Sheffler, DJ, Shields, AD, Saleh, SA, Sen, N, Matthies, HJ, Javitch, JA, Lindsley, CW, Winder, DG. Yohimbine depresses excitatory transmission in BNST and impairs extinction of cocaine place preference through orexin-dependent, norepinephrine-independent processes. Neuropsychopharmacology, 37(10), 2253-66, 2012.

Cremona, ML, Matthies, HJ, Pau, K, Bowton, E, Speed, N, Lute, BJ, Anderson, M, Sen, N, Robertson, SD, Vaughan, RA, Rothman, JE, Galli, A, Javitch, JA, Yamamoto, A. Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DAT. Nat Neurosci, 14(4), 469-77, 2011.

Hughes, SE, Beeler, JS, Seat, A, Slaughter, BD, Unruh, JR, Bauerly, E, Matthies, HJ, Hawley, RS. Gamma-tubulin is required for bipolar spindle assembly and for proper kinetochore microtubule attachments during prometaphase I in Drosophila oocytes. PLoS Genet, 7(8), e1002209, 2011.

Speed, N, Saunders, C, Davis, AR, Owens, WA, Matthies, HJ, Saadat, S, Kennedy, JP, Vaughan, RA, Neve, RL, Lindsley, CW, Russo, SJ, Daws, LC, Niswender, KD, Galli, A. Impaired striatal Akt signaling disrupts dopamine homeostasis and increases feeding. PLoS One, 6(9), e25169, 2011.

Bowton, E, Saunders, C, Erreger, K, Sakrikar, D, Matthies, HJ, Sen, N, Jessen, T, Colbran, RJ, Caron, MG, Javitch, JA, Blakely, RD, Galli, A. Dysregulation of dopamine transporters via dopamine D2 autoreceptors triggers anomalous dopamine efflux associated with attention-deficit hyperactivity disorder. J Neurosci, 30(17), 6048-57, 2010.

Matthies, HJ, Moore, JL, Saunders, C, Matthies, DS, Lapierre, LA, Goldenring, JR, Blakely, RD, Galli, A. Rab11 supports amphetamine-stimulated norepinephrine transporter trafficking. J Neurosci, 30(23), 7863-77, 2010.

Robertson, SD, Matthies, HJ, Owens, WA, Sathananthan, V, Christianson, NS, Kennedy, JP, Lindsley, CW, Daws, LC, Galli, A. Insulin reveals Akt signaling as a novel regulator of norepinephrine transporter trafficking and norepinephrine homeostasis. J Neurosci, 30(34), 11305-16, 2010.

Speed, NK, Matthies, HJ, Kennedy, JP, Vaughan, RA, Javitch, JA, Russo, SJ, Lindsley, CW, Niswender, K, Galli, A. Akt-dependent and isoform-specific regulation of dopamine transporter cell surface expression. ACS Chem Neurosci, 1(7), 476-81, 2010.

Matthies, HJ, Han, Q, Shields, A, Wright, J, Moore, JL, Winder, DG, Galli, A, Blakely, RD. Subcellular localization of the antidepressant-sensitive norepinephrine transporter. BMC Neurosci, 10, 65, 2009.

Robertson, SD, Matthies, HJ, Galli, A. A closer look at amphetamine-induced reverse transport and trafficking of the dopamine and norepinephrine transporters. Mol Neurobiol, 39(2), 73-80, 2009.

Steiner, JA, Carneiro, AM, Wright, J, Matthies, HJ, Prasad, HC, Nicki, CK, Dostmann, WR, Buchanan, CC, Corbin, JD, Francis, SH, Blakely, RD. cGMP-dependent protein kinase Ialpha associates with the antidepressant-sensitive serotonin transporter and dictates rapid modulation of serotonin uptake. Mol Brain, 2, 26, 2009.

Mohrmann, R, Matthies, HJ, Woodruff, E, Broadie, K. Stoned B mediates sorting of integral synaptic vesicle proteins. Neuroscience, 153(4), 1048-63, 2008.

Cui, W, Sproul, LR, Gustafson, SM, Matthies, HJ, Gilbert, SP, Hawley, RS. Drosophila Nod protein binds preferentially to the plus ends of microtubules and promotes microtubule polymerization in vitro. Mol Biol Cell, 16(11), 5400-9, 2005.

Huang, FD, Matthies, HJ, Speese, SD, Smith, MA, Broadie, K. Rolling blackout, a newly identified PIP2-DAG pathway lipase required for Drosophila phototransduction. Nat Neurosci, 7(10), 1070-8, 2004.

Rohrbough, J, Rushton, E, Palanker, L, Woodruff, E, Matthies, HJ, Acharya, U, Acharya, JK, Broadie, K. Ceramidase regulates synaptic vesicle exocytosis and trafficking. J Neurosci, 24(36), 7789-803, 2004.

Zhang, YQ, Matthies, HJ, Mancuso, J, Andrews, HK, Woodruff, E, Friedman, D, Broadie, K. The Drosophila fragile X-related gene regulates axoneme differentiation during spermatogenesis. Dev Biol, 270(2), 290-307, 2004.

Matthies, HJ, Broadie, K. Techniques to dissect cellular and subcellular function in the Drosophila nervous system. Methods Cell Biol, 71, 195-265, 2003.

Beumer, K, Matthies, HJ, Bradshaw, A, Broadie, K. Integrins regulate DLG/FAS2 via a CaM kinase II-dependent pathway to mediate synapse elaboration and stabilization during postembryonic development. Development, 129(14), 3381-91, 2002.

Matthies, HJ, Baskin, RJ, Hawley, RS. Orphan kinesin NOD lacks motile properties but does possess a microtubule-stimulated ATPase activity. Mol Biol Cell, 12(12), 4000-12, 2001.

Zhang, YQ, Bailey, AM, Matthies, HJ, Renden, RB, Smith, MA, Speese, SD, Rubin, GM, Broadie, K. Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function. Cell, 107(5), 591-603, 2001.

Matthies, HJ, Messina, LG, Namba, R, Greer, KJ, Walker, MY, Hawley, RS. Mutations in the alpha-tubulin 67C gene specifically impair achiasmate segregation in Drosophila melanogaster. J Cell Biol, 147(6), 1137-44, 1999.

Sekelsky, JJ, McKim, KS, Messina, L, French, RL, Hurley, WD, Arbel, T, Chin, GM, Deneen, B, Force, SJ, Hari, KL, Jang, JK, Lauren??on, AC, Madden, LD, Matthies, HJ, Milliken, DB, Page, SL, Ring, AD, Wayson, SM, Zimmerman, CC, Hawley, RS. Identification of novel Drosophila meiotic genes recovered in a P-element screen. Genetics, 152(2), 529-42, 1999.

Sharp, DJ, McDonald, KL, Brown, HM, Matthies, HJ, Walczak, C, Vale, RD, Mitchison, TJ, Scholey, JM. The bipolar kinesin, KLP61F, cross-links microtubules within interpolar microtubule bundles of Drosophila embryonic mitotic spindles. J Cell Biol, 144(1), 125-38, 1999.

Matthies, HJ, McDonald, HB, Goldstein, LS, Theurkauf, WE. Anastral meiotic spindle morphogenesis: role of the non-claret disjunctional kinesin-like protein. J Cell Biol, 134(2), 455-64, 1996.

Matthies, HJ, Miller, RJ, Palfrey, HC. Calmodulin binding to and cAMP-dependent phosphorylation of kinesin light chains modulate kinesin ATPase activity. J Biol Chem, 268(15), 11176-87, 1993.

Ewald, DA, Matthies, HJ, Perney, TM, Walker, MW, Miller, RJ. The effect of down regulation of protein kinase C on the inhibitory modulation of dorsal root ganglion neuron Ca2+ currents by neuropeptide Y. J Neurosci, 8(7), 2447-51, 1988.

Matthies, HJ, Palfrey, HC, Miller, RJ. Calmodulin- and protein phosphorylation-independent release of catecholamines from PC-12 cells. FEBS Lett, 229(2), 238-42, 1988.

Matthies, HJ, Palfrey, HC, Hirning, LD, Miller, RJ. Down regulation of protein kinase C in neuronal cells: effects on neurotransmitter release. J Neurosci, 7(4), 1198-206, 1987.

Lange, Y, Matthies, H, Steck, TL. Cholesterol oxidase susceptibility of the red cell membrane. Biochim Biophys Acta, 769(3), 551-62, 1984.

Lange, Y, Matthies, HJ. Transfer of cholesterol from its site of synthesis to the plasma membrane. J Biol Chem, 259(23), 14624-30, 1984.

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