Vanderbilt University School of Medicine

Vickers, Kasey
Assistant Professor of Medicine
Assistant Professor of Molecular Physiology and Biophysics

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358 PRB

Research Keywords
Cardiovascular Disease; Lipoproteins; HDL; microRNAs

Research Description
To investigate mechanisms and consequences of HDL microRNA communication and systemic homeostasis. Short term goals include the characterization of microRNA regulatory modules controlling cholesterol biosynthesis. Moreover, we aim to determine i.) How microRNAs are selected and exported to HDL, ii.) How microRNAs are transported on HDL and altered in disease, and iii.) How microRNAs are transferred to recipient cells and regulate genes related to cholesterol and lipoprotein homeostasis.

Tabet, F, Vickers, KC, Cuesta Torres, LF, Wiese, CB, Shoucri, BM, Lambert, G, Catherinet, C, Prado-Lourenco, L, Levin, MG, Thacker, S, Sethupathy, P, Barter, PJ, Remaley, AT, Rye, KA. HDL-transferred microRNA-223 regulates ICAM-1 expression in endothelial cells. Nat Commun, 5, 3292, 2014.

Vickers, KC, Remaley, AT. HDL and cholesterol: life after the divorce. J Lipid Res, 55(1), 4-12, 2014.

Vickers, KC, Rye, KA, Tabet, F. MicroRNAs in the onset and development of cardiovascular disease. Clin Sci (Lond), 126(3), 183-94, 2014.

Feng, Q, Vickers, KC, Anderson, MP, Levin, MG, Chen, W, Harrison, DG, Wilke, RA. A common functional promoter variant links CNR1 gene expression to HDL cholesterol level. Nat Commun, 4, 1973, 2013.

Vickers, KC, Moore, KJ. Small RNA overcomes the challenges of therapeutic targeting of microsomal triglyceride transfer protein. Circ Res, 113(11), 1189-91, 2013.

Vickers, KC, Sethupathy, P, Baran-Gale, J, Remaley, AT. Complexity of microRNA function and the role of isomiRs in lipid homeostasis. J Lipid Res, 54(5), 1182-91, 2013.

Postdoctoral Position Available

Postdoctoral Position Details

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