Vanderbilt University School of Medicine

Venters, Bryan , PhD
Assistant Professor of Molecular Physiology & Biophysics

Lab Url:

Phone Number: (615) 322-4761


Venters, Bryan's picture

Office Address   Mailing Address

746 Robinson Research Building

746 RRB, Robinson Research Building 37232

Research Keywords
ChIP-exo, JAK-STAT pathway, Cancer, Next-gen sequencing, RNA-seq, Gene regulation, transcription, epigenetics

Research Specialty
The goal of my research is to understand the transcriptional mechanisms underpinning the JAK-STAT signaling pathway that lead to human disease and cancer.

Research Description
A fundamental question in molecular biology is how human disease is programmed into the genome. The overarching goal of my laboratory is to elucidate the transcription regulatory networks underlying oncogenic signaling pathways. STAT transcription factors in the JAK-STAT pathway (Janus Kinase-Signal Transducer and Activator of Transcription) are among the most frequently activated oncogenic proteins in cancer cells. My current research is focused on discovering how the JAK-STAT pathway is involved in the disease process using genetic, molecular, and next-gen sequencing approaches.

The goals of some current projects in my laboratory are to:

- Understand how STATs direct aberrant transcriptional programs in leukemia using stat-of-the-art functional genomics approaches

- Dissect the functional interdependencies among STATs on a genome-wide scale

- Identifying regulatory complexes that are recruited by the STAT transcription factors

- Discover novel molecular signatures in clinical samples with the future goal to better predict patient prognosis and identify new therapeutic targets

Venters, BJ, Irvin, JD, Gramlich, P, Pugh, BF. Genome-wide transcriptional dependence on conserved regions of Mot1. Mol Cell Biol, 31(11), 2253-61, 2011.

Venters, BJ, Wachi, S, Mavrich, TN, Andersen, BE, Jena, P, Sinnamon, AJ, Jain, P, Rolleri, NS, Jiang, C, Hemeryck-Walsh, C, Pugh, BF. A comprehensive genomic binding map of gene and chromatin regulatory proteins in Saccharomyces. Mol Cell, 41(4), 480-92, 2011.

Venters, BJ, Pugh, BF. How eukaryotic genes are transcribed. Crit Rev Biochem Mol Biol, 44(2-3), 117-41, 2009.

Venters, BJ, Pugh, BF. A canonical promoter organization of the transcription machinery and its regulators in the Saccharomyces genome. Genome Res, 19(3), 360-71, 2009.

Lee, C, Li, X, Hechmer, A, Eisen, M, Biggin, MD, Venters, BJ, Jiang, C, Li, J, Pugh, BF, Gilmour, DS. NELF and GAGA factor are linked to promoter-proximal pausing at many genes in Drosophila. Mol Cell Biol, 28(10), 3290-300, 2008.

Mavrich, TN, Ioshikhes, IP, Venters, BJ, Jiang, C, Tomsho, LP, Qi, J, Schuster, SC, Albert, I, Pugh, BF. A barrier nucleosome model for statistical positioning of nucleosomes throughout the yeast genome. Genome Res, 18(7), 1073-83, 2008.

Mavrich, TN, Jiang, C, Ioshikhes, IP, Li, X, Venters, BJ, Zanton, SJ, Tomsho, LP, Qi, J, Glaser, RL, Schuster, SC, Gilmour, DS, Albert, I, Pugh, BF. Nucleosome organization in the Drosophila genome. Nature, 453(7193), 358-62, 2008.

Yao, H, Li, P, Venters, BJ, Zheng, S, Thompson, PR, Pugh, BF, Wang, Y. Histone Arg modifications and p53 regulate the expression of OKL38, a mediator of apoptosis. J Biol Chem, 283(29), 20060-8, 2008.

Cheng, L, Naumann, TA, Horswill, AR, Hong, SJ, Venters, BJ, Tomsho, JW, Benkovic, SJ, Keiler, KC. Discovery of antibacterial cyclic peptides that inhibit the ClpXP protease. Protein Sci, 16(8), 1535-42, 2007.

Lessner, FH, Venters, BJ, Keiler, KC. Proteolytic adaptor for transfer-messenger RNA-tagged proteins from alpha-proteobacteria. J Bacteriol, 189(1), 272-5, 2007.

Venters, BJ, Pugh, BF. Chromatin meets RNA polymerase II. Genome Biol, 8(11), 319, 2007.

Postdoctoral Position Available

Postdoctoral Position Details

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