Vanderbilt University School of Medicine

Cobb, Charles E. , Ph.D.
Research Professor of Molecular Physiology and Biophysics

Lab Url: N/A

Phone Number: 615-322-0016

Email Address:charles.cobb@vanderbilt.edu

Cobb, Charles's picture

Office Address   Mailing Address

735A Light Hall

735 A Light Hall 0615


Research Keywords
Membrane Protein Structure and Function, Antioxidant Vitamins, ESR Spectroscopy, Fluorescence Spectroscopy,Membrane,Protein Structure,Spectroscopy

Research Description
.

Publications
Kim, S, Brandon, S, Zhou, Z, Cobb, CE, Edwards, SJ, Moth, CW, Parry, CS, Smith, JA, Lybrand, TP, Hustedt, EJ, Beth, AH. Determination of structural models of the complex between the cytoplasmic domain of erythrocyte band 3 and ankyrin-R repeats 13-24. J Biol Chem, 286(23), 20746-57, 2011.

May, JM, Li, L, Qu, ZC, Cobb, CE. Mitochondrial recycling of ascorbic acid as a mechanism for regenerating cellular ascorbate. Biofactors, 30(1), 35-48, 2007.

Zhou, Z, DeSensi, SC, Stein, RA, Brandon, S, Song, L, Cobb, CE, Hustedt, EJ, Beth, AH. Structure of the cytoplasmic domain of erythrocyte band 3 hereditary spherocytosis variant P327R: band 3 Tuscaloosa. Biochemistry, 46(36), 10248-57, 2007.

May, JM, Qu, ZC, Juliao, S, Cobb, CE. Ascorbic acid decreases oxidant stress in endothelial cells caused by the nitroxide tempol. Free Radic Res, 39(2), 195-202, 2005.

Zhou, Z, DeSensi, SC, Stein, RA, Brandon, S, Dixit, M, McArdle, EJ, Warren, EM, Kroh, HK, Song, L, Cobb, CE, Hustedt, EJ, Beth, AH. Solution structure of the cytoplasmic domain of erythrocyte membrane band 3 determined by site-directed spin labeling. Biochemistry, 44(46), 15115-28, 2005.

May, James M, Qu, Zhi-chao, Cobb, Charles E. Human erythrocyte recycling of ascorbic acid: relative contributions from the ascorbate free radical and dehydroascorbic acid. J Biol Chem, 279(15), 14975-82, 2004.

May, James M, Qu, Zhi-chao, Cobb, Charles E. Reduction and uptake of methylene blue by human erythrocytes. Am J Physiol Cell Physiol, 286(6), C1390-8, 2004.

Li, Xia, Cobb, Charles E, May, James M. Mitochondrial recycling of ascorbic acid from dehydroascorbic acid: dependence on the electron transport chain. Arch Biochem Biophys, 403(1), 103-10, 2002.

Blackman, S M, Hustedt, E J, Cobb, C E, Beth, A H. Flexibility of the cytoplasmic domain of the anion exchange protein, band 3, in human erythrocytes. Biophys J, 81(6), 3363-76, 2001. PMCID:1301793

Blackman, S.M, Hustedt, E.J., Cobb, C.E., and Beth, A.H. Flexibility of the cytoplasmic domain of the anion exchange protein, band 3, in human erythrocytes. Biophysical J., 81, 3363-3376, 2001.

Li, X, Cobb, C E, Hill, K E, Burk, R F, May, J M. Mitochondrial uptake and recycling of ascorbic acid. Arch Biochem Biophys, 387(1), 143-53, 2001.

May, J M, Qu, Z, Cobb, C E. Recycling of the ascorbate free radical by human erythrocyte membranes. Free Radic Biol Med, 31(1), 117-24, 2001.

May, J M, Qu, Z C, Xia, L, Cobb, C E. Nitrite uptake and metabolism and oxidant stress in human erythrocytes. Am J Physiol Cell Physiol, 279(6), C1946-54, 2000.

May, J M, Qu, Z c, Cobb, C E. Extracellular reduction of the ascorbate free radical by human erythrocytes. Biochem Biophys Res Commun, 267(1), 118-23, 2000.

May, J M, Qu, Z, Morrow, J D, Cobb, C E. Ascorbate-dependent protection of human erythrocytes against oxidant stress generated by extracellular diazobenzene sulfonate. Biochem Pharmacol, 60(1), 47-53, 2000.

Ross, D, Mendiratta, S, Qu, Z C, Cobb, C E, May, J M. Ascorbate 6-palmitate protects human erythrocytes from oxidative damage. Free Radic Biol Med, 26(1-2), 81-9, 1999.

May, J M, Cobb, C E, Mendiratta, S, Hill, K E, Burk, R F. Reduction of the ascorbyl free radical to ascorbate by thioredoxin reductase. J Biol Chem, 273(36), 23039-45, 1998.

Hustedt, E J, Smirnov, A I, Laub, C F, Cobb, C E, Beth, A H. Molecular distances from dipolar coupled spin-labels: the global analysis of multifrequency continuous wave electron paramagnetic resonance data. Biophys J, 72(4), 1861-77, 1997. PMCID:1184380

Blackman, S M, Cobb, C E, Beth, A H, Piston, D W. The orientation of eosin-5-maleimide on human erythrocyte band 3 measured by fluorescence polarization microscopy. Biophys J, 71(1), 194-208, 1996. PMCID:1233471

May, J M, Qu, Z C, Cobb, C E. Accessibility and reactivity of ascorbate 6-palmitate bound to erythrocyte membranes. Free Radic Biol Med, 21(4), 471-80, 1996.

May, J M, Qu, Z C, Whitesell, R R, Cobb, C E. Ascorbate recycling in human erythrocytes: role of GSH in reducing dehydroascorbate. Free Radic Biol Med, 20(4), 543-51, 1996.

Scothorn, D J, Wojcicki, W E, Hustedt, E J, Beth, A H, Cobb, C E. Synthesis and characterization of a novel spin-labeled affinity probe of human erythrocyte band 3: characteristics of the stilbenedisulfonate binding site. Biochemistry, 35(21), 6931-43, 1996.

Cobb, C E, Hustedt, E J, Beechem, J M, Beth, A H. Protein rotational dynamics investigated with a dual EPR/optical molecular probe. Spin-labeled eosin. Biophys J, 64(3), 605-13, 1993. PMCID:1262372

Hustedt, E J, Cobb, C E, Beth, A H, Beechem, J M. Measurement of rotational dynamics by the simultaneous nonlinear analysis of optical and EPR data. Biophys J, 64(3), 614-21, 1993. PMCID:1262373

Cobb, C E, Beth, A H. Identification of the eosinyl-5-maleimide reaction site on the human erythrocyte anion-exchange protein: overlap with the reaction sites of other chemical probes. Biochemistry, 29(36), 8283-90, 1990.

Cobb, C E, Juliao, S, Balasubramanian, K, Staros, J V, Beth, A H. Effects of diethyl ether on membrane lipid ordering and on rotational dynamics of the anion exchange protein in intact human erythrocytes: correlations with anion exchange function. Biochemistry, 29(48), 10799-806, 1990.

Anjaneyulu, P S, Beth, A H, Cobb, C E, Juliao, S F, Sweetman, B J, Staros, J V. Bis(sulfo-N-succinimidyl) doxyl-2-spiro-5'-azelate: synthesis, characterization, and reaction with the anion-exchange channel in intact human erythrocytes. Biochemistry, 28(16), 6583-90, 1989.

Corbin, J D, Cobb, C E, Beebe, S J, Granner, D K, Koch, S R, Gettys, T W, Blackmore, P F, Francis, S H, Wells, J N. Mechanism and function of cAMP- and cGMP-dependent protein kinases. Adv Second Messenger Phosphoprotein Res, 21, 75-86, 1988.

Cobb, C E, Beth, A H, Corbin, J D. Purification and characterization of an inactive form of cAMP-dependent protein kinase containing bound cAMP. J Biol Chem, 262(34), 16566-74, 1987.


Postdoctoral Position Available
No

Postdoctoral Position Details
N/A

Updated Date
08/08/2011



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