Vanderbilt University School of Medicine

Martin, Peter R. , M.D.
Professor of Psychiatry
Professor of Pharmacology

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Phone Number: (615) 322-3527


Martin, Peter's picture

Office Address   Mailing Address

Suite 3068, Psychiatric Hospital at Vanderbilt

Suite 3068, Psychiatric Hospital at Vanderbilt 1601 23rd Avenue South, 3rd Floor 37232-8650

Research Keywords
addiction, opioids, alcohol-induced brain injury, functional MRI, MR spectroscopy, pharmacogenomics, neuroscience

Research Specialty
molecular basis, diagnosis, and treatment of drug use disorders with an emphasis on substance-induced mental disorders and co-occurring psychiatric disorders

Research Description
Dr. Martin's research and scholarly interests include the molecular basis, diagnosis, and treatment of drug use disorders with an emphasis on substance-induced mental disorders and co-occurring psychiatric disorders. This includes investigations of the molecular biology of thiamine; magnetic resonance spectroscopy and functional magnetic resonance imaging to elucidate the pathogenesis of addiction and alcohol-induced brain damage; the clinical pharmacology of addictive substances; pharmacogenomic factors in treatment of opioid dependence and psychiatric disorders during pregnancy.

Clinical Research Description
Dr. Martin's research and scholarly interests include the molecular basis, diagnosis, and treatment of drug use disorders with an emphasis on substance-induced mental disorders and co-occuring psychiatric disorders. This includes the clinical pharmacology of addictive substances and development of medications to use in the comprehensive pharmacopsychosocial treatment of addictive disorders.

Clinical Interests
Dr. Martin is interested in the role of alcohol and other drugs in the clinical presentation and course of human diseases--how they influence diagnosis and treatment in psychiatry and medicine. A specific interest is management of addiction and co-occurring other psychiatric disorders during pregnancy.

Martin, PR, Arria, AM, Fischer, G, Kaltenbach, K, Heil, SH, Stine, SM, Coyle, MG, Selby, P, Jones, HE. Psychopharmacologic management of opioid-dependent women during pregnancy. Am J Addict, 18(2), 148-56, 2009.

Jones, HE, Martin, PR, Heil, SH, Kaltenbach, K, Selby, P, Coyle, MG, Stine, SM, O''Grady, KE, Arria, AM, Fischer, G. Treatment of opioid-dependent pregnant women: clinical and research issues. J Subst Abuse Treat, 35(3), 245-59, 2008. PMCID:2633026

Reich, MS, Dietrich, MS, Finlayson, AJ, Fischer, EF, Martin, PR. Coffee and cigarette consumption and perceived effects in recovering alcoholics participating in Alcoholics Anonymous in Nashville, Tennessee, USA. Alcohol Clin Exp Res, 32(10), 1799-806, 2008. PMCID:2585746

Farah, A, de Paulis, T, Moreira, DP, Trugo, LC, Martin, PR. Chlorogenic acids and lactones in regular and water-decaffeinated arabica coffees. J Agric Food Chem, 54(2), 374-81, 2006.

Kranzler, HR, Mueller, T, Cornelius, J, Pettinati, HM, Moak, D, Martin, PR, Anthenelli, R, Brower, KJ, O''Malley, S, Mason, BJ, Hasin, D, Keller, M. Sertraline treatment of co-occurring alcohol dependence and major depression. J Clin Psychopharmacol, 26(1), 13-20, 2006.

Raj, V, Landess, JS, Martin, PR. Oxcarbazepine use in essential tremor. Ann Pharmacother, 40(10), 1876-9, 2006.

Farah, Adriana, de Paulis, Tomas, Trugo, Luiz C, Martin, Peter R. Effect of roasting on the formation of chlorogenic acid lactones in coffee. J Agric Food Chem, 53(5), 1505-13, 2005.

Garbutt JC, Kranzler HR, O'Malley SS, Gastfriend DR, Pettinati HM, Silverman BL, Loewy JW, Ehrich EW for the Vivitrex Study Group, including Martin PR at the Vanderbilt site. Efficacy and tolerability of long-acting injectable naltrexone for alcohol dependence: a randomized controlled trial. Journal of the American Medical Association, 293, 1617-1625, 2005.

Martin, Peter R, Petry, Nancy M. Are non-substance-related addictions really addictions. Am J Addict, 14(1), 1-7, 2005.

Martin PR: Fundamental research, education, and dissemination of findings on coffee and health. In New Research on coffee and health; proceedings of the International Seminar on Coffee and Health 40th Anniversary Meeting of the International Coffee Organization. Cartagena (Colombia), September 15, 2003. Illy E and Pizano SD (ed.). Chinchina (Colombia), The Commodities Press, pp. 15-19, 2004

de Paulis T, Martin PR: Cerebral effects of noncaffeine constituents in roasted coffee. In Coffee, Tea, Chocolate and the Brain. Nehlig A (ed.). CRC Press, Boca Raton, pp. 187-195, 2004

Kranzler H, Wesson DR., Billot L for the Drug Abuse Sciences Naltrexone Depot Study Group, including Martin PR and Weinstein DD at the Vanderbilt site. Naltrexone depot for treatment of alcohol dependence: a multi-center, randomized, placebo-controlled clinical trial. Alcoholism: Clinical and Experimental Research, 28, 1051-1059, 2004.

de Paulis, Tomas, Commers, Patricia, Farah, Adriana, Zhao, Jiali, McDonald, Michael P, Galici, Ruggero, Martin, Peter R. 4-Caffeoyl-1,5-quinide in roasted coffee inhibits [3H]naloxone binding and reverses anti-nociceptive effects of morphine in mice. Psychopharmacology (Berl), 176(2), 146-53, 2004.

Martin, Peter R, Singleton, Charles K, Hiller-Sturmhofel, Susanne. The role of thiamine deficiency in alcoholic brain disease. Alcohol Res Health, 27(2), 134-42, 2003.

Parks, Mitchell H, Morgan, Victoria L, Pickens, David R, Price, Ronald R, Dietrich, Mary S, Nickel, Mark K, Martin, Peter R. Brain fMRI activation associated with self-paced finger tapping in chronic alcohol-dependent patients. Alcohol Clin Exp Res, 27(4), 704-11, 2003.

Sullivan, EV, Harding, AJ, Pentney, R, Dlugos, C, Martin, PR, Parks, MH, Desmond, JE, Chen, SH, Pryor, MR, De Rosa, E, Pfefferbaum, A. Disruption of frontocerebellar circuitry and function in alcoholism. Alcohol Clin Exp Res, 27(2), 301-9, 2003.

Martin PR: Addiction psychiatry: rising from the ashes of molecular genetics, internal medicine, clinical pharmacology, and psychiatry. In From Psychopharmacology to Neuropsychopharmacology in the 1980s and the Story of CINP, As Told in Autobiography. Ban TA, Healy D, Shorter E (eds.). Animula Publishing House, Budapest, pp 95-100, 2002

Parks, Mitchell H, Dawant, Benoit M, Riddle, William R, Hartmann, Steven L, Dietrich, Mary S, Nickel, Mark K, Price, Ronald R, Martin, Peter R. Longitudinal brain metabolic characterization of chronic alcoholics with proton magnetic resonance spectroscopy. Alcohol Clin Exp Res, 26(9), 1368-80, 2002.

de Paulis, Tomas, Schmidt, Dennis E, Bruchey, Aleksandra K, Kirby, Michael T, McDonald, Michael P, Commers, Patricia, Lovinger, David M, Martin, Peter R. Dicinnamoylquinides in roasted coffee inhibit the human adenosine transporter. Eur J Pharmacol, 442(3), 215-23, 2002.

Finlayson R, Sealy J, Martin PR: The differential diagnosis of problematic hypersexuality. Sexual Addiction and Compulsivity 8:241-251, 2001

Hubbard JR, Martin PR: Substance abuse in the mentally and physically disabled: an overview. In Substance Abuse in the Mentally and Physically Disabled. Hubbard JR and Martin PR (eds). Marcel Dekker, Inc., New York, NY, pp 1-10, 2001

Lehmann LP, Hubbard JR, Martin PR: Substance abuse and depression. In Substance Abuse in the Mentally and Physically Disabled. Hubbard JR and Martin PR (eds). Marcel Dekker, Inc., New York, NY, pp 33-58, 2001

Skerl D, Pan S, Li R, Fitzpatrick JM, Parks MH, Martin PR, Morgan VL, Dawant BM: Correction of geometric distortions in EP images using non-rigid registration to corresponding anatomic images. In Proc. SPIE 4322, Medical Imaging 2001: Image Processing. Sonka M and Hanson KM (eds), pp 58-68, 2001

Weinstein DD, Martin PR: Neurological disorders and head injuries. In Substance Abuse in the Mentally and Physically Disabled, Hubbard JR and Martin PR (eds). Marcel Dekker, Inc., New York, NY, pp 277-305, 2001

de Paulis T, Martin PR, Baker PS: Health effects from coffee consumption. In Coffee Futures: a source book of some critical issues confronting the coffee industry. Feriva S.A., Cali, Colombia, 2001

Singleton, C K, Martin, P R. Molecular mechanisms of thiamine utilization. Curr Mol Med, 1(2), 197-207, 2001.

Martin, P. R., Hubbard, J. R. Substance abuse related disorders. In M. Ebert, P. T. Loosen, & B. Nurcombe (Eds.), Current diagnosis and treatment in psychiatry, New York: McGraw-Hill, Inc., pp 233-259, 2000

Ragan, P.W., Martin, P.R. The psychobiology of sexual addiction. Sexual Addiction and Complusivity, (7), 161-175, 2000.

Hartmann, S L, Dawant, B M, Parks, M H, Schlack, H, Martin, P R. Image-guided MR spectroscopy volume of interest localization for longitudinal studies. Comput Med Imaging Graph, 22(6), 453-61, 1999.

Hartmann, S L, Parks, M H, Martin, P R, Dawant, B M. Automatic 3-D segmentation of internal structures of the head in MR images using a combination of similarity and free-form transformations: Part II, validation on severely atrophied brains. IEEE Trans Med Imaging, 18(10), 917-26, 1999.

Hartmann, S. L., Parks, M. H., Schlack, H., Riddle, W., Price, R. R., Martin, P. R., & Dawant, B. M.. Automatic computation of brain and cerebellum volumes in normal subjects and chronic alcoholics. Information Processing in Medical Imaging, Proceedings Lecture Notes in Computer Science, 1613, 430-435, 1999.

Onaivi, E S, Chaudhuri, G, Abaci, A S, Parker, M, Manier, D H, Martin, P R, Hubbard, J R. Expression of cannabinoid receptors and their gene transcripts in human blood cells. Prog Neuropsychopharmacol Biol Psychiatry, 23(6), 1063-77, 1999.

Ragan, P. W., Singleton, C. K., & Martin, P. R. Brain injury associated with chronic alcoholism. CNS Spectrums, 4, 66-87, 1999.

Pekovich, S R, Martin, P R, Singleton, C K. Thiamine deficiency decreases steady-state transketolase and pyruvate dehydrogenase but not alpha-ketoglutarate dehydrogenase mRNA levels in three human cell types. J Nutr, 128(4), 683-7, 1998.

Pekovich, S. R., Poggi, V., Martin, P. R., & Singleton, C. K.. Sensitivity to thiamine deficiency in cultured human cells is dependant on cell type and is enhanced in cells from thiamine-responsive megaloblastic anemia patients. J Nutr Biochem, 9, 215-222, 1998.

Franco SE, Hubbard JR, Martin PR: Stress and addiction. In Handbook of Stress Medicine: An Organ System Approach. Hubbard JR, Workman EA (eds). CRC Press, Boca Raton, pp 187-203, 1997

Hubbard JR, Martens J, Martin PR: Alcohol and other substances of abuse. In Primary Care Medicine for Psychiatrists: A Practitioner's Guide. Hubbard JR, Short D (eds). Plenum Publishing Corporation, New York, NY, pp 211-230, 1997

Wang, J J, Martin, P R, Singleton, C K. Aspartate 155 of human transketolase is essential for thiamine diphosphate-magnesium binding, and cofactor binding is required for dimer formation. Biochim Biophys Acta, 1341(2), 165-72, 1997.

Wang, J J, Martin, P R, Singleton, C K. A transketolase assembly defect in a Wernicke-Korsakoff syndrome patient. Alcohol Clin Exp Res, 21(4), 576-80, 1997.

Waterhouse, G J, Roback, H B, Moore, R F, Martin, P R. Perspectives of treatment efficacy with the substance dependent physician: a national survey. J Addict Dis, 16(1), 123-38, 1997.

Welch, L W, Cunningham, A T, Eckardt, M J, Martin, P R. Fine motor speed deficits in alcoholic Korsakoff''s syndrome. Alcohol Clin Exp Res, 21(1), 134-9, 1997.

Welch, L W, Nimmerrichter, A, Gilliland, R, King, D E, Martin, P R. 'Wineglass' confabulations among brain-damaged alcoholics on the Wechsler Memory Scale-Revised visual reproduction subtest. Cortex, 33(3), 543-51, 1997.

Adinoff, B, Kiser, JM, Martin, PR, Linnoila, M. Response of dehydroepiandrosterone to corticotropin-releasing hormone stimulation in alcohol-dependent subjects. Biol Psychiatry, 40(12), 1305-7, 1996.

Eckardt, MJ, Rohrbaugh, JW, Stapleton, JM, Davis, EZ, Martin, PR, Weingartner, HJ. Attention-related brain potential and cognition in alcoholism-associated organic brain disorders. Biol Psychiatry, 39(2), 143-6, 1996.

Pekovich, S R, Martin, P R, Singleton, C K. Thiamine pyrophosphate-requiring enzymes are altered during pyrithiamine-induced thiamine deficiency in cultured human lymphoblasts. J Nutr, 126(7), 1791-8, 1996.

Roback, H B, Moore, R F, Waterhouse, G J, Martin, P R. Confidentiality dilemmas in group psychotherapy with substance-dependent physicians. Am J Psychiatry, 153(10), 1250-60, 1996.

Singleton, C K, Wang, J J, Shan, L, Martin, P R. Conserved residues are functionally distinct within transketolases of different species. Biochemistry, 35(49), 15865-9, 1996.

Welch, L W, Nimmerrichter, A, Kessler, R, King, D, Hoehn, R, Margolin, R, Martin, P R. Severe global amnesia presenting as Wernicke-Korsakoff syndrome but resulting from atypical lesions. Psychol Med, 26(2), 421-5, 1996.

Martin PR, Lovinger DM, Breese GR: Alcohol and other abused substances. In Principles of Pharmacology: Basic Concepts and Clinical Applications. Munson P, Mueller RA, Breese GR (eds). Chapman & Hall, New York, pp 417-452, 1995

Martin PR, Mathews GM: Complications: cognition. In Encyclopedia of Drugs and Alcohol. Jaffe JH (ed). MacMillan Publishing Company, Inc., New York, NY, pp 263-265, 1995

Lee, H, Tarter, J, Holburn, G E, Price, R R, Weinstein, D D, Martin, P R. In vivo localized proton NMR spectroscopy of thiamine-deficient rat brain. Magn Reson Med, 34(3), 313-8, 1995.

Martin, P R, Gibbs, S J, Nimmerrichter, A A, Riddle, W R, Welch, L W, Willcott, M R. Brain proton magnetic resonance spectroscopy studies in recently abstinent alcoholics. Alcohol Clin Exp Res, 19(4), 1078-82, 1995.

Martin, P R, McCool, B A, Singleton, C K. Molecular genetics of transketolase in the pathogenesis of the Wernicke-Korsakoff syndrome. Metab Brain Dis, 10(1), 45-55, 1995.

Martin, PR, Adinoff, B, Lane, E, Stapleton, JM, Bone, GA, Weingartner, H, Linnoila, M, Eckardt, MJ. Fluvoxamine treatment of alcoholic amnestic disorder. Eur Neuropsychopharmacol, 5(1), 27-33, 1995.

Singleton, C K, Pekovich, S R, McCool, B A, Martin, P R. The thiamine-dependent hysteretic behavior of human transketolase: implications for thiamine deficiency. J Nutr, 125(2), 189-94, 1995.

. Weinstein DD, Martin PR: Psychiatric implications of alcoholism and traumatic brain injury. American Journal on Addictions, 4, 285-296, 1995.

Linnoila M, Fawcett J, Fuller RK, Harford TC, Martin PR, Meyer RE, Romach MK, Sellers EM: Evaluation of pharmacologic treatments for alcohol abuse, dependence and their complications. In Clinical Evaluation of Psychotropic Drugs: Principles and Guidance. Prien RF and Robinson DS (eds). Raven Press, Ltd., New York, pp 625-649, 1994

Gauvin, DV, Briscoe, RJ, Goulden, KL, Wojnicki, FH, Russin, R, Martin, PR, Holloway, FA. Influence of thiamine on the behavioral sensitivity to ethanol. Alcohol Clin Exp Res, 18(6), 1398-405, 1994.

Joyce, EM, Rio, DE, Ruttimann, UE, Rohrbaugh, JW, Martin, PR, Rawlings, RR, Eckardt, MJ. Decreased cingulate and precuneate glucose utilization in alcoholic Korsakoff''s syndrome. Psychiatry Res, 54(3), 225-39, 1994.

Martin, P R, Pekovich, S R, McCool, B A, Whetsell, W O, Singleton, C K. Thiamine utilization in the pathogenesis of alcohol-induced brain damage. Alcohol Alcohol Suppl, 2, 273-9, 1994.

Martin PR, Charness ME: Molecular mechanisms of brain damage in alcoholism. Introduction to the symposium. Alcoholism: Clinical and Experimental Research 17:1, 1993

Martin PR, Nimmerrichter A: Pharmacologic treatment of alcohol-induced brain damage. In Alcohol-Induced Brain Damage. Hunt WA, Nixon SJ (eds). NIAAA Research Monographs, Washington, DC, pp 461-477, 1993

Martin PR, Welch L: Psychopharmacologic treatment of memory disorders. In American Psychiatric Press Review of Psychiatry, Volume 12. Oldman JM, Riba MB, Tasman A (eds). American Psychiatric Press, Washington, DC, pp 805-830, 1993

Adinoff, B, Martin, PR, Eckardt, MJ, Linnoila, M. Role of DHEA and DHEA-S in Alzheimer''s disease. Am J Psychiatry, 150(9), 1432-3, 1993.

Martin, P R, McCool, B A, Singleton, C K. Genetic sensitivity to thiamine deficiency and development of alcoholic organic brain disease. Alcohol Clin Exp Res, 17(1), 31-7, 1993.

McCool, B A, Plonk, S G, Martin, P R, Singleton, C K. Cloning of human transketolase cDNAs and comparison of the nucleotide sequence of the coding region in Wernicke-Korsakoff and non-Wernicke-Korsakoff individuals. J Biol Chem, 268(2), 1397-404, 1993.

George, DT, Lindquist, T, Rawlings, RR, Eckardt, MJ, Moss, H, Mathis, C, Martin, PR, Linnoila, M. Pharmacologic maintenance of abstinence in patients with alcoholism: no efficacy of 5-hydroxytryptophan or levodopa. Clin Pharmacol Ther, 52(5), 553-60, 1992.

Martin, PR, Rio, D, Adinoff, B, Johnson, JL, Bisserbe, JC, Rawlings, RR, Rohrbaugh, JW, Stapleton, JM, Eckardt, MJ. Regional cerebral glucose utilization in chronic organic mental disorders associated with alcoholism. J Neuropsychiatry Clin Neurosci, 4(2), 159-67, 1992.

Martin PR, Kutcher M, Morey LC, Fjetland OK, Ban TA: Depressive symptomatology associated with alcoholism using the CODE-DD. In Functional Psychoses Today. Aguglia E and Ban TA (eds). John Libbey, Rome, pp 305-314, 1991

Sunderland T, Molchan S, Martinez R, Vitiello B, Martin PR: Drug challenge strategies in Alzheimers disease: a focus on the scopolamine model. In Alzheimer Disease: Current Research in Early Diagnosis. Becker RE and Giacobini E(eds). Taylor & Francis, Publishers, New York, pp 173-191, 1991

Adinoff, B, Martin, PR, Eckardt, MJ, Bone, GH, Gold, PW, Linnoila, M. Pituitary-adrenal responses to oCRH and central neuropeptide levels in alcohol amnestic disorder. Biol Psychiatry, 29(11), 1153-5, 1991.

Adinoff, B, Nemeroff, CB, Bissette, G, Martin, PR, Linnoila, M. Inverse relationship between CSF TRH concentrations and the TSH response to TRH in abstinent alcohol-dependent patients. Am J Psychiatry, 148(11), 1586-8, 1991.

Adinoff, B, Risher-Flowers, D, De Jong, J, Ravitz, B, Bone, GH, Nutt, DJ, Roehrich, L, Martin, PR, Linnoila, M. Disturbances of hypothalamic-pituitary-adrenal axis functioning during ethanol withdrawal in six men. Am J Psychiatry, 148(8), 1023-5, 1991.

Adinoff, B, Martin, PR, Bone, GH, Eckardt, MJ, Roehrich, L, George, DT, Moss, HB, Eskay, R, Linnoila, M, Gold, PW. Hypothalamic-pituitary-adrenal axis functioning and cerebrospinal fluid corticotropin releasing hormone and corticotropin levels in alcoholics after recent and long-term abstinence. Arch Gen Psychiatry, 47(4), 325-30, 1990.

Eckardt, MJ, Rohrbaugh, JW, Rio, DE, Martin, PR. Positron emission tomography as a technique for studying the chronic effects of alcohol on the human brain. Ann Med, 22(5), 341-5, 1990.

Morey LC, Martin PR: Assessment of alcoholism and substance abuse. In Measuring Mental Illness. Psychometric Assessment for Clinicians. Wetzler S (ed). American Psychiatric Press, Washington, DC, pp 161-181, 1989

Bone, GH, Majchrowicz, E, Martin, PR, Linnoila, M, Nutt, DJ. A comparison of calcium antagonists and diazepam in reducing ethanol withdrawal tremors. Psychopharmacology (Berl), 99(3), 386-8, 1989.

Martin, P R, Eckardt, M J, Linnoila, M. Treatment of chronic organic mental disorders associated with alcoholism. Recent Dev Alcohol, 7, 329-50, 1989.

Martin, PR, Adinoff, B, Eckardt, MJ, Stapleton, JM, Bone, GA, Rubinow, DR, Lane, EA, Linnoila, M. Effective pharmacotherapy of alcoholic amnestic disorder with fluvoxamine. Preliminary findings. Arch Gen Psychiatry, 46(7), 617-21, 1989.

Martin, PR, Impeduglia, G, Giri, PR, Karanian, J. Acceleration of ethanol metabolism by past thiamine deficiency. Alcohol Clin Exp Res, 13(3), 457-60, 1989.

Martin, PR, Levin, S, Impeduglia, G, Choe, Y, Karanian, J, Mukherjee, AB. Thiamine deficiency in utero alters response to ethanol in adulthood. Psychopharmacology (Berl), 97(2), 253-6, 1989.

Eckardt, MJ, Rawlings, RR, Graubard, BI, Faden, V, Martin, PR, Gottschalk, LA. Neuropsychological performance and treatment outcome in male alcoholics. Alcohol Clin Exp Res, 12(1), 88-93, 1988.

Nutt DJ, Adinoff B, Ravitz B, George DT, Flowers D, Eckardt MJ, Bone GHA, Martin PR, Linnoila M. Cerebro-spinal studies in alcoholics and violent offenders. Australian Alcohol and Drug Review, 7, 105-108, 1988.

Risher-Flowers, D, Adinoff, B, Ravitz, B, Bone, GH, Martin, PR, Nutt, D, Linnoila, M. Circadian rhythms of cortisol during alcohol withdrawal. Adv Alcohol Subst Abuse, 7(3-4), 37-41, 1988.

Stapleton JM, Eckardt MJ, Martin PR, Adinoff B, Roehrich L, Bone G, Rubinow D, Linnoila M. Treatment of alcoholic organic brain syndrome with the serotonin reuptake inhibitor fluvoxamine: A preliminary study. Advances in Alcohol and Substance Abuse, 7, 47-51, 1988.

Eckardt MJ, Martin PR: Diagnosis and treatment of chronic organic brain syndromes associated with alcoholism. Substance Abuse 8 (3), 14-20, 1987

Impeduglia, G, Martin, PR, Kwast, M, Hohlstein, LA, Roehrich, L, Majchrowicz, E. Influence of thiamine deficiency on the response to ethanol in two inbred rat strains. J Pharmacol Exp Ther, 240(3), 754-63, 1987.

Linnoila M, Eckardt MJ, Durcan M, Lister R, Martin PR. Interactions of serotonin with ethanol: clinical and animal studies. Psychopharmacology Bulletin, 23, 452-457, 1987.

Mukherjee, AB, Svoronos, S, Ghazanfari, A, Martin, PR, Fisher, A, Roecklein, B, Rodbard, D, Staton, R, Behar, D, Berg, CJ. Transketolase abnormality in cultured fibroblasts from familial chronic alcoholic men and their male offspring. J Clin Invest, 79(4), 1039-43, 1987. PMCID:424281

Martin PR, Mukherjee AB, Eckardt MJ: Alcoholic organic brain disease. In Biological Psychiatry 1985: Proceedings of the Fourth World Congress of Biological Psychiatry. Shagass C et al (eds). Elsevier, Amsterdam, pp 1220-1222, 1986

Adinoff, B, Majchrowicz, E, Martin, PR, Linnoila, M. The benzodiazepine antagonist Ro 15-1788 does not antagonize the ethanol withdrawal syndrome. Biol Psychiatry, 21(7), 643-9, 1986.

Eckardt, MJ, Martin, PR. Clinical assessment of cognition in alcoholism. Alcohol Clin Exp Res, 10(2), 123-7, 1986.

Eckardt, MJ, Rawlings, RR, Martin, PR. Biological correlates and detection of alcohol abuse and alcoholism. Prog Neuropsychopharmacol Biol Psychiatry, 10(2), 135-44, 1986.

Johnson, JL, Adinoff, B, Bisserbe, JC, Martin, PR, Rio, D, Rohrbaugh, JW, Zubovic, E, Eckardt, MJ. Assessment of alcoholism-related organic brain syndromes with positron emission tomography. Alcohol Clin Exp Res, 10(3), 237-40, 1986.

Martin, PR, Adinoff, B, Weingartner, H, Mukherjee, AB, Eckardt, MJ. Alcoholic organic brain disease: nosology and pathophysiologic mechanisms. Prog Neuropsychopharmacol Biol Psychiatry, 10(2), 147-64, 1986.

Martin, PR, Loewenstein, RJ, Kaye, WH, Ebert, MH, Weingartner, H, Gillin, JC. Sleep EEG in Korsakoff''s psychosis and Alzheimer''s disease. Neurology, 36(3), 411-4, 1986.

Moss, HB, Tamarkin, L, Majchrowicz, E, Martin, PR, Linnoila, M. Pineal function during ethanol intoxication, dependence, and withdrawal. Life Sci, 39(23), 2209-14, 1986.

Martin PR, Eckardt MJ: Pharmacological interventions in chronic organic brain syndromes associated with alcoholism. In Research Advances in New Psychopharmacological Treatments for Alcoholism. Naranjo CA, Sellers EM (eds). Elsevier, Amsterdam, pp. 257-272, 1985

Martin, PR, Majchrowicz, E, Tamborska, E, Marietta, C, Mukherjee, AB, Eckardt, MJ. Response to ethanol reduced by past thiamine deficiency. Science, 227(4692), 1365-8, 1985.

Eckardt, MJ, Rawlings, RR, Ryback, RS, Martin, PR, Gottschalk, LA. Effects of abstinence on the ability of clinical laboratory tests to identify male alcoholics. Am J Clin Pathol, 82(3), 305-10, 1984.

Martin, PR, Ebert, MH, Gordon, EK, Linnoila, M, Kopin, IJ. Effects of clonidine on central and peripheral catecholamine metabolism. Clin Pharmacol Ther, 35(3), 322-7, 1984.

Martin, PR, Ebert, MH, Gordon, EK, Weingartner, H, Kopin, IJ. Catecholamine metabolism during clonidine withdrawal. Psychopharmacology (Berl), 84(1), 58-63, 1984.

Martin, PR, Higa, S, Burns, RS, Tamarkin, L, Ebert, MH, Markey, SP. Decreased 6-hydroxymelatonin excretion in Korsakoff''s psychosis. Neurology, 34(7), 966-8, 1984.

Martin, PR, Weingartner, H, Gordon, EK, Burns, RS, Linnoila, M, Kopin, IJ, Ebert, MH. Central nervous system catecholamine metabolism in Korsakoff''s psychosis. Ann Neurol, 15(2), 184-7, 1984.

Linnoila M, Martin PR: Benzodiazepines and alcoholism. In, Benzodiazepines Divided. Trimble MR (ed). John Wiley and Sons, London, pp. 291-308, 1983

Martin PR, Ebert MH, Gordon EK, Kopin IJ . Changes during clonidine treatment and clonidine withdrawal in urinary catecholamine metabolites in alcohol amnestic disorder . Psychopharmacology Bulletin, 19, 699-702, 1983.

Martin, PR, Ebert, MH, Gordon, EK, Kopin, IJ. Urinary catecholamine metabolites and effects of clonidine in patients with alcohol amnestic disorder. Clin Pharmacol Ther, 33(1), 19-27, 1983.

Weingartner, H, Grafman, J, Boutelle, W, Kaye, W, Martin, PR. Forms of memory failure. Science, 221(4608), 380-2, 1983.

Martin PR. The human genetics of alcoholism. Substance and Alcohol Actions/Misuse, 2, 389-406, 1981.

Martin, PR, Lefebvre, AM. Surgical treatment of sleep-apnea-associated psychosis. Can Med Assoc J, 124(8), 978-80, 1981. PMCID:1705384

Martin PR, Kapur BM, Whiteside EA, Janacek E, Sellers EM : Intravenous phenobarbital treatment of barbiturate and other hypnosedative withdrawal reactions: A pharmacokinetic approach. Addiction Research Foundation Substudy No. 1072, Toronto, 1979

Martin PR: Intravenous phenobarbital treatment of barbiturate and other hypnosedative withdrawal: A pharmacokinetic approach. Master of Science Thesis, Department of Pharmacology, University of Toronto, 1979

Sellers EM, Martin PR, Roy M, Sellers EA: Amphetamines. In Body Temperature: Regulation, Drug Effects and Therapeutic Indications. Lomax P, Schonbaum E (eds). Marcel Dekker, Inc., New York, pp. 461-498, 1979

Martin, PR, Bhushan, CM, Kapur, BM, Whiteside, EA, Sellers, EM. Intravenous phenobarbital therapy in barbiturate and other hypnosedative withdrawal reactions: a kinetic approach. Clin Pharmacol Ther, 26(2), 256-64, 1979.

MacLeod, SM, Sellers, EM, Giles, HG, Billings, BJ, Martin, PR, Greenblatt, DJ, Marshman, JA. Interaction of disulfiram with benzodiazepines. Clin Pharmacol Ther, 24(5), 583-9, 1978.

Sellers EM, Martin PR, Roy M, Sellers EA. Alterations in temperature regulation associated with amphetamines. Addiction Research Foundation Substudy No. 884, Toronto, 1977

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