Vanderbilt University School of Medicine

Harris, Raymond C. Jr., M.D.
Director, Division of Nephrology
Professor of Medicine
Ann and Roscoe R. Robinson Chair in Nephrology
Professor of Molecular Physiology and Biophysics

Lab Url: N/A

Phone Number: 615- 322-2150


Harris, Raymond's picture

Office Address   Mailing Address

C-3121 MCN 2372

Research Specialty
role of cycylooxygenase-2 in renal development and function; role of growth factors in recovery from acute renal injury; role of renin-angiotensin system in regulation of epithelial cell function

Chen, J, Chen, JK, Harris, RC. EGF receptor deletion in podocytes attenuates diabetic nephropathy. J Am Soc Nephrol, 26(5), 1115-25, 2015.

Cheng, H, Fan, X, Lawson, WE, Paueksakon, P, Harris, RC. Telomerase deficiency delays renal recovery in mice after ischemia-reperfusion injury by impairing autophagy. Kidney Int, 88(1), 85-94, 2015.

Fan, Y, Li, X, Xiao, W, Fu, J, Harris, RC, Lindenmeyer, M, Cohen, CD, Guillot, N, Baron, MH, Wang, N, Lee, K, He, JC, Schlondorff, D, Chuang, PY. BAMBI elimination enhances alternative TGF-?? signaling and glomerular dysfunction in diabetic mice. Diabetes, 64(6), 2220-33, 2015.

Ma, SK, Wang, Y, Chen, J, Zhang, MZ, Harris, RC, Chen, JK. Overexpression of G-protein-coupled receptor 40 enhances the mitogenic response to epoxyeicosatrienoic acids. PLoS One, 10(2), e0113130, 2015.

Neelisetty, S, Alford, C, Reynolds, K, Woodbury, L, Nlandu-Khodo, S, Yang, H, Fogo, AB, Hao, CM, Harris, RC, Zent, R, Gewin, L. Renal fibrosis is not reduced by blocking transforming growth factor-?? signaling in matrix-producing interstitial cells. Kidney Int, 88(3), 503-514, 2015.

Singh, SP, Tao, S, Fields, TA, Webb, S, Harris, RC, Rao, R. Glycogen synthase kinase-3 inhibition attenuates fibroblast activation and development of fibrosis following renal ischemia-reperfusion in mice. Dis Model Mech, 8(8), 931-40, 2015.

Wang, H, Chen, X, Su, Y, Paueksakon, P, Hu, W, Zhang, MZ, Harris, RC, Blackwell, TS, Zent, R, Pozzi, A. p47(phox) contributes to albuminuria and kidney fibrosis in mice. Kidney Int, 87(5), 948-62, 2015.

Zhang, MZ, Harris, RC. Antihypertensive mechanisms of intra-renal dopamine. Curr Opin Nephrol Hypertens, 24(2), 117-22, 2015.

Capdevila, JH, Pidkovka, N, Mei, S, Gong, Y, Falck, JR, Imig, JD, Harris, RC, Wang, W. The Cyp2c44 epoxygenase regulates epithelial sodium channel activity and the blood pressure responses to increased dietary salt. J Biol Chem, 289(7), 4377-86, 2014.

Cheng, H, Harris, RC. Renal endothelial dysfunction in diabetic nephropathy. Cardiovasc Hematol Disord Drug Targets, 14(1), 22-33, 2014.

Grove, KJ, Voziyan, PA, Spraggins, JM, Wang, S, Paueksakon, P, Harris, RC, Hudson, BG, Caprioli, RM. Diabetic nephropathy induces alterations in the glomerular and tubule lipid profiles. J Lipid Res, 55(7), 1375-1385, 2014.

Reisin, E, Harris, RC, Rahman, M. Commentary on the 2014 BP guidelines from the panel appointed to the Eighth Joint National Committee (JNC 8). J Am Soc Nephrol, 25(11), 2419-24, 2014.

Takahashi, T, Harris, RC. Role of endothelial nitric oxide synthase in diabetic nephropathy: lessons from diabetic eNOS knockout mice. J Diabetes Res, 2014, 590541, 2014.

Trachtman, H, Benzing, T, Sever, S, Harris, RC, Reiser, J. The grand challenge of nephrology. Front Med (Lausanne), 1, 28, 2014.

Wang, F, Jiang, R, Takahashi, K, Gore, J, Harris, RC, Takahashi, T, Quarles, CC. Longitudinal assessment of mouse renal injury using high-resolution anatomic and magnetization transfer MR imaging. Magn Reson Imaging, 32(9), 1125-32, 2014.

Wang, F, Jiang, RT, Tantawy, MN, Borza, DB, Takahashi, K, Gore, JC, Harris, RC, Takahashi, T, Quarles, CC. Repeatability and sensitivity of high resolution blood volume mapping in mouse kidney disease. J Magn Reson Imaging, 39(4), 866-71, 2014.

Zeng, F, Harris, RC. Epidermal growth factor, from gene organization to bedside. Semin Cell Dev Biol, 28, 2-11, 2014.

Zeng, F, Miyazawa, T, Kloepfer, LA, Harris, RC. Deletion of ErbB4 accelerates polycystic kidney disease progression in cpk mice. Kidney Int, 86(3), 538-47, 2014.

Zhang, MZ, Wang, Y, Paueksakon, P, Harris, RC. Epidermal growth factor receptor inhibition slows progression of diabetic nephropathy in association with a decrease in endoplasmic reticulum stress and an increase in autophagy. Diabetes, 63(6), 2063-72, 2014.

Atochina-Vasserman, EN, Biktasova, A, Abramova, E, Cheng, DS, Polosukhin, VV, Tanjore, H, Takahashi, S, Sonoda, H, Foye, L, Venkov, C, Ryzhov, SV, Novitskiy, S, Shlonimskaya, N, Ikeda, M, Blackwell, TS, Lawson, WE, Gow, AJ, Harris, RC, Dikov, MM, Tchekneva, EE. Aquaporin 11 insufficiency modulates kidney susceptibility to oxidative stress. Am J Physiol Renal Physiol, 304(10), F1295-307, 2013.

Chen, J, Chen, MX, Fogo, AB, Harris, RC, Chen, JK. mVps34 deletion in podocytes causes glomerulosclerosis by disrupting intracellular vesicle trafficking. J Am Soc Nephrol, 24(2), 198-207, 2013.

Harris, RC. The best-laid plans. Am J Physiol Renal Physiol, 304(8), F1086-7, 2013.

Pidkovka, N, Rao, R, Mei, S, Gong, Y, Harris, RC, Wang, WH, Capdevila, JH. Epoxyeicosatrienoic acids (EETs) regulate epithelial sodium channel activity by extracellular signal-regulated kinase 1/2 (ERK1/2)-mediated phosphorylation. J Biol Chem, 288(7), 5223-31, 2013.

Zhang, MZ, Wang, Y, Yao, B, Gewin, L, Wei, S, Capdevila, JH, Harris, RC. Role of epoxyeicosatrienoic acids (EETs) in mediation of dopamine''s effects in the kidney. Am J Physiol Renal Physiol, 305(12), F1680-6, 2013.

Bartlett, CS, Boyd, KL, Harris, RC, Zent, R, Breyer, RM. EP1 disruption attenuates end-organ damage in a mouse model of hypertension. Hypertension, 60(5), 1184-91, 2012.

Chen, J, Chen, JK, Harris, RC. Angiotensin II induces epithelial-to-mesenchymal transition in renal epithelial cells through reactive oxygen species/Src/caveolin-mediated activation of an epidermal growth factor receptor-extracellular signal-regulated kinase signaling pathway. Mol Cell Biol, 32(5), 981-91, 2012.

Chen, J, Chen, JK, Harris, RC. Deletion of the epidermal growth factor receptor in renal proximal tubule epithelial cells delays recovery from acute kidney injury. Kidney Int, 82(1), 45-52, 2012.

Cheng, H, Wang, H, Fan, X, Paueksakon, P, Harris, RC. Improvement of endothelial nitric oxide synthase activity retards the progression of diabetic nephropathy in db/db mice. Kidney Int, 82(11), 1176-83, 2012.

Gewin, L, Vadivelu, S, Neelisetty, S, Srichai, MB, Paueksakon, P, Pozzi, A, Harris, RC, Zent, R. Deleting the TGF-?? receptor attenuates acute proximal tubule injury. J Am Soc Nephrol, 23(12), 2001-11, 2012.

Harris, RC. Abnormalities in renal dopamine signaling and hypertension: the role of GRK4. Curr Opin Nephrol Hypertens, 21(1), 61-5, 2012.

Harris, RC. Podocyte ACE2 protects against diabetic nephropathy. Kidney Int, 82(3), 255-6, 2012.

Harris, RC, Zhang, MZ. Dopamine, the kidney, and hypertension. Curr Hypertens Rep, 14(2), 138-43, 2012.

Howard, C, Tao, S, Yang, HC, Fogo, AB, Woodgett, JR, Harris, RC, Rao, R. Specific deletion of glycogen synthase kinase-3?? in the renal proximal tubule protects against acute nephrotoxic injury in mice. Kidney Int, 82(9), 1000-9, 2012.

Jiang, R, Wang, S, Takahashi, K, Fujita, H, Fruci, CR, Breyer, MD, Harris, RC, Takahashi, T. Generation of a conditional allele for the mouse endothelial nitric oxide synthase gene. Genesis, 50(9), 685-92, 2012.

Tantawy, MN, Jiang, R, Wang, F, Takahashi, K, Peterson, TE, Zemel, D, Hao, CM, Fujita, H, Harris, RC, Quarles, CC, Takahashi, T. Assessment of renal function in mice with unilateral ureteral obstruction using 99mTc-MAG3 dynamic scintigraphy. BMC Nephrol, 13, 168, 2012.

Yang, S, Yao, B, Zhou, Y, Yin, H, Zhang, MZ, Harris, RC. Intrarenal dopamine modulates progressive angiotensin II-mediated renal injury. Am J Physiol Renal Physiol, 302(6), F742-9, 2012.

Yu, L, Su, Y, Paueksakon, P, Cheng, H, Chen, X, Wang, H, Harris, RC, Zent, R, Pozzi, A. Integrin ??1/Akita double-knockout mice on a Balb/c background develop advanced features of human diabetic nephropathy. Kidney Int, 81(11), 1086-97, 2012.

Zhang, MZ, Wang, S, Yang, S, Yang, H, Fan, X, Takahashi, T, Harris, RC. Role of blood pressure and the renin-angiotensin system in development of diabetic nephropathy (DN) in eNOS-/- db/db mice. Am J Physiol Renal Physiol, 302(4), F433-8, 2012.

Zhang, MZ, Yao, B, Yang, S, Jiang, L, Wang, S, Fan, X, Yin, H, Wong, K, Miyazawa, T, Chen, J, Chang, I, Singh, A, Harris, RC. CSF-1 signaling mediates recovery from acute kidney injury. J Clin Invest, 122(12), 4519-32, 2012.

Zhang, MZ, Yao, B, Yang, S, Yang, H, Wang, S, Fan, X, Yin, H, Fogo, AB, Moeckel, GW, Harris, RC. Intrarenal dopamine inhibits progression of diabetic nephropathy. Diabetes, 61(10), 2575-84, 2012.

Breyer, MD, Tchekneva, E, Qi, Z, Takahashi, T, Fogo, AB, Zhao, HJ, Harris, RC. Genetics of diabetic nephropathy: lessons from mice. Semin Nephrol, 27(2), 237-47, 2007.

Chen, J, Chen, JK, Falck, JR, Anjaiah, S, Capdevila, JH, Harris, RC. Mitogenic activity and signaling mechanism of 2-(14,15- epoxyeicosatrienoyl)glycerol, a novel cytochrome p450 arachidonate metabolite. Mol Cell Biol, 27(8), 3023-34, 2007. PMCID:1899952

Chen, X, Abair, TD, Ibanez, MR, Su, Y, Frey, MR, Dise, RS, Polk, DB, Singh, AB, Harris, RC, Zent, R, Pozzi, A. Integrin {alpha}1{beta}1 Controls Reactive Oxygen Species Synthesis by Negatively Regulating Epidermal Growth Factor Receptor-Mediated Rac Activation. Mol Cell Biol, 27(9), 3313-26, 2007. PMCID:1899972

Cheng, H, Wang, S, Jo, YI, Hao, CM, Zhang, M, Fan, X, Kennedy, C, Breyer, MD, Moeckel, GW, Harris, RC. Overexpression of cyclooxygenase-2 predisposes to podocyte injury. J Am Soc Nephrol, 18(2), 551-9, 2007.

Kanetsuna, Y, Takahashi, K, Nagata, M, Gannon, MA, Breyer, MD, Harris, RC, Takahashi, T. Deficiency of endothelial nitric-oxide synthase confers susceptibility to diabetic nephropathy in nephropathy-resistant inbred mice. Am J Pathol, 170(5), 1473-84, 2007. PMCID:1854944

Chen, J, Chen, JK, Neilson, EG, Harris, RC. Role of EGF receptor activation in angiotensin II-induced renal epithelial cell hypertrophy. J Am Soc Nephrol, 17(6), 1615-23, 2006.

Cheng, H, Harris, RC. Potential side effects of renin inhibitors--mechanisms based on comparison with other renin-angiotensin blockers. Expert Opin Drug Saf, 5(5), 631-41, 2006.

Harris, RC. COX-2 and the kidney. J Cardiovasc Pharmacol, 47 Suppl 1, S37-42, 2006.

Harris, RC, Neilson, EG. Toward a unified theory of renal progression. Annu Rev Med, 57, 365-80, 2006.

Kanetsuna, Y, Hirano, K, Nagata, M, Gannon, MA, Takahashi, K, Harris, RC, Breyer, MD, Takahashi, T. Characterization of diabetic nephropathy in a transgenic model of hypoinsulinemic diabetes. Am J Physiol Renal Physiol, 291(6), F1315-22, 2006.

Yao, B, Xu, J, Qi, Z, Harris, RC, Zhang, MZ. Role of renal cortical cyclooxygenase-2 expression in hyperfiltration in rats with high-protein intake. Am J Physiol Renal Physiol, 291(2), F368-74, 2006.

Zhang, MZ, Yao, B, Cheng, HF, Wang, SW, Inagami, T, Harris, RC. Renal cortical cyclooxygenase 2 expression is differentially regulated by angiotensin II AT(1) and AT(2) receptors. Proc Natl Acad Sci U S A, 103(43), 16045-50, 2006. PMCID:1635124

Zhao, HJ, Wang, S, Cheng, H, Zhang, MZ, Takahashi, T, Fogo, AB, Breyer, MD, Harris, RC. Endothelial nitric oxide synthase deficiency produces accelerated nephropathy in diabetic mice. J Am Soc Nephrol, 17(10), 2664-9, 2006.

Breyer, MD, B??ttinger, E, Brosius, FC, Coffman, TM, Fogo, A, Harris, RC, Heilig, CW, Sharma, K. Diabetic nephropathy: of mice and men. Adv Chronic Kidney Dis, 12(2), 128-45, 2005.

Breyer, MD, B??ttinger, E, Brosius, FC, Coffman, TM, Harris, RC, Heilig, CW, Sharma, K, , . Mouse models of diabetic nephropathy. J Am Soc Nephrol, 16(1), 27-45, 2005.

Chen, JK, Chen, J, Neilson, EG, Harris, RC. Role of mammalian target of rapamycin signaling in compensatory renal hypertrophy. J Am Soc Nephrol, 16(5), 1384-91, 2005.

Cheng, H, Zhang, M, Moeckel, GW, Zhao, Y, Wang, S, Qi, Z, Breyer, MD, Harris, RC. Expression of mediators of renal injury in the remnant kidney of ROP mice is attenuated by cyclooxygenase-2 inhibition. Nephron Exp Nephrol, 101(3), e75-85, 2005.

Cheng, HF, Harris, RC. Renal effects of non-steroidal anti-inflammatory drugs and selective cyclooxygenase-2 inhibitors. Curr Pharm Des, 11(14), 1795-804, 2005.


Rao, R, Zhang, MZ, Zhao, M, Cai, H, Harris, RC, Breyer, MD, Hao, CM. Lithium treatment inhibits renal GSK-3 activity and promotes cyclooxygenase 2-dependent polyuria. Am J Physiol Renal Physiol, 288(4), F642-9, 2005.

Singh, AB, Harris, RC. Autocrine, paracrine and juxtacrine signaling by EGFR ligands. Cell Signal, 17(10), 1183-93, 2005.

Yao, B, Harris, RC, Zhang, MZ. Interactions between 11beta-hydroxysteroid dehydrogenase and COX-2 in kidney. Am J Physiol Regul Integr Comp Physiol, 288(6), R1767-73, 2005.

Zhang, MZ, Yao, B, McKanna, JA, Harris, RC. Cross talk between the intrarenal dopaminergic and cyclooxygenase-2 systems. Am J Physiol Renal Physiol, 288(4), F840-5, 2005.

Chen, D, Roberts, R, Pohl, M, Nigam, S, Kreidberg, J, Wang, Z, Heino, J, Ivaska, J, Coffa, S, Harris, RC, Pozzi, A, Zent, R. Differential expression of collagen- and laminin-binding integrins mediates ureteric bud and inner medullary collecting duct cell tubulogenesis. Am J Physiol Renal Physiol, 287(4), F602-11, 2004.

Chen, X, Moeckel, G, Morrow, JD, Cosgrove, D, Harris, RC, Fogo, AB, Zent, R, Pozzi, A. Lack of integrin alpha1beta1 leads to severe glomerulosclerosis after glomerular injury. Am J Pathol, 165(2), 617-30, 2004. PMCID:1618576

Cheng, HF, Harris, RC. Cyclooxygenases, the kidney, and hypertension. Hypertension, 43(3), 525-30, 2004.

Fisher, ME, Rossini, M, Simmons, E, Harris, RC, Moeckel, G, Zent, R. A woman with chronic hepatitis C infection and nephrotic syndrome who developed multiple renal lesions after interferon alfa therapy. Am J Kidney Dis, 44(3), 567-73, 2004.

Harris, RC, Zhang, MZ, Cheng, HF. Cyclooxygenase-2 and the renal renin-angiotensin system. Acta Physiol Scand, 181(4), 543-7, 2004.

Qi, Z, Whitt, I, Mehta, A, Jin, J, Zhao, M, Harris, RC, Fogo, AB, Breyer, MD. Serial determination of glomerular filtration rate in conscious mice using FITC-inulin clearance. Am J Physiol Renal Physiol, 286(3), F590-6, 2004.

Shivakumar, BR, Wang, Z, Hammond, TG, Harris, RC. EP24.15 interacts with the angiotensin II type I receptor and bradykinin B2 receptor. Cell Biochem Funct, 23(3), 195-204, 2004.

Singh, AB, Harris, RC. Epidermal growth factor receptor activation differentially regulates claudin expression and enhances transepithelial resistance in Madin-Darby canine kidney cells. J Biol Chem, 279(5), 3543-52, 2004.

Singh, AB, Tsukada, T, Zent, R, Harris, RC. Membrane-associated HB-EGF modulates HGF-induced cellular responses in MDCK cells. J Cell Sci, 117(Pt 8), 1365-79, 2004.

Zhang, MZ, Mai, W, Li, C, Cho, SY, Hao, C, Moeckel, G, Zhao, R, Kim, I, Wang, J, Xiong, H, Wang, H, Sato, Y, Wu, Y, Nakanuma, Y, Lilova, M, Pei, Y, Harris, RC, Li, S, Coffey, RJ, Sun, L, Wu, D, Chen, XZ, Breyer, MD, Zhao, ZJ, McKanna, JA, Wu, G. PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells. Proc Natl Acad Sci U S A, 101(8), 2311-6, 2004. PMCID:356947

Zhang, MZ, Sanchez Lopez, P, McKanna, JA, Harris, RC. Regulation of cyclooxygenase expression by vasopressin in rat renal medulla. Endocrinology, 145(3), 1402-9, 2004.

Cheng, HF, Harris, RC. Does cyclooxygenase-2 affect blood pressure. Curr Hypertens Rep, 5(1), 87-92, 2003.

Harris, RC. Interactions between COX-2 and the renin-angiotensin system in the kidney. Acta Physiol Scand, 177(4), 423-7, 2003.

Harris, RC, Chung, E, Coffey, RJ. EGF receptor ligands. Exp Cell Res, 284(1), 2-13, 2003.

Means, AL, Ray, KC, Singh, AB, Washington, MK, Whitehead, RH, Harris, RC, Wright, CV, Coffey, RJ, Leach, SD. Overexpression of heparin-binding EGF-like growth factor in mouse pancreas results in fibrosis and epithelial metaplasia. Gastroenterology, 124(4), 1020-36, 2003.

Wang, Z, Chen, JK, Wang, SW, Moeckel, G, Harris, RC. Importance of functional EGF receptors in recovery from acute nephrotoxic injury. J Am Soc Nephrol, 14(12), 3147-54, 2003.

Zhang, MZ, Wang, SW, Cheng, H, Zhang, Y, McKanna, JA, Harris, RC. Regulation of renal cortical cyclooxygenase-2 in young rats. Am J Physiol Renal Physiol, 285(5), F881-8, 2003.

Cheng, H-F., Wang, J-L., Zhang, M-Z, McKanna, J.A. and Harris, R.C. Extracellular Chloride Regulates Renal Cortical Cyclooxygenase-2 (COX-2) Expression: Role of p38. Journal of Clinical Investigation. In Press

Burleigh, ME, Babaev, VR, Oates, JA, Harris, RC, Gautam, S, Riendeau, D, Marnett, LJ, Morrow, JD, Fazio, S, Linton, MF. Cyclooxygenase-2 promotes early atherosclerotic lesion formation in LDL receptor-deficient mice. Circulation, 105(15), 1816-23, 2002.

Capdevila, JH, Harris, RC, Falck, JR. Microsomal cytochrome P450 and eicosanoid metabolism. Cell Mol Life Sci, 59(5), 780-9, 2002.

Chen, JK, Capdevila, J, Harris, RC. Heparin-binding EGF-like growth factor mediates the biological effects of P450 arachidonate epoxygenase metabolites in epithelial cells. Proc Natl Acad Sci U S A, 99(9), 6029-34, 2002. PMCID:122896

Cheng, HF, Harris, RC. Cyclooxygenase-2 expression in cultured cortical thick ascending limb of Henle increases in response to decreased extracellular ionic content by both transcriptional and post-transcriptional mechanisms. Role of p38-mediated pathways. J Biol Chem, 277(47), 45638-43, 2002.

Cheng, HF, Wang, CJ, Moeckel, GW, Zhang, MZ, McKanna, JA, Harris, RC. Cyclooxygenase-2 inhibitor blocks expression of mediators of renal injury in a model of diabetes and hypertension. Kidney Int, 62(3), 929-39, 2002.

Cheng, HF, Wang, SW, Zhang, MZ, McKanna, JA, Breyer, R, Harris, RC. Prostaglandins that increase renin production in response to ACE inhibition are not derived from cyclooxygenase-1. Am J Physiol Regul Integr Comp Physiol, 283(3), R638-46, 2002.

Harris, RC. Cyclooxygenase-2 inhibition and renal physiology. Am J Cardiol, 89(6A), 10D-17D, 2002.

Harris, RC. Cyclooxygenase-2 and the kidney: functional and pathophysiological implications. J Hypertens Suppl, 20(6), S3-9, 2002.

Zhang, MZ, Hao, CM, Breyer, MD, Harris, RC, McKanna, JA. Mineralocorticoid regulation of cyclooxygenase-2 expression in rat renal medulla. Am J Physiol Renal Physiol, 283(3), F509-16, 2002.

Breyer, MD, Harris, RC. Cyclooxygenase 2 and the kidney. Curr Opin Nephrol Hypertens, 10(1), 89-98, 2001.

Chen, J-K, Zimpelmann, J., Harris, R.C. and Burns, K.D. Angiotensin IV induces tyrosine phosphorylation of focal adhesion kinase and paxillin in proximal tubule cells. Am. J. Physiol. , 280, F980-988, 2001.

Chen, JK, Capdevila, J, Harris, RC. Cytochrome p450 epoxygenase metabolism of arachidonic acid inhibits apoptosis. Mol Cell Biol, 21(18), 6322-31, 2001. PMCID:87364

Cheng, HF, Wang, JL, Zhang, MZ, Wang, SW, McKanna, JA, Harris, RC. Genetic deletion of COX-2 prevents increased renin expression in response to ACE inhibition. Am J Physiol Renal Physiol, 280(3), F449-56, 2001.

Harris, RC, Breyer, MD. Physiological regulation of cyclooxygenase-2 in the kidney. Am J Physiol Renal Physiol, 281(1), F1-11, 2001.

Sakai, M. Tsukada, T. and Harris, R.C. Induction of HB-EGF expression by reactive oxygen species: role of AP-1-mediated transcriptional activation. Experimental Nephrology , 9, 28-30, 2001.

Takemura, T., Hino, S., Kuwajima, H., Yanagida, H, Okada, M., Nagata, M, Sasaki, S., Barasch, J., Harris, R.C. and Yoshioka, K. Induction of collecting duct morphogenesis in vitro by heparin-binding EGF-like growth factor. J.A.S.N., 12, 964-972, 2001.

Capdevila, JH, Falck, JR, Harris, RC. Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase. J Lipid Res, 41(2), 163-81, 2000.

Chen, JK, Capdevila, J, Harris, RC. Overexpression of C-terminal Src kinase blocks 14, 15-epoxyeicosatrienoic acid-induced tyrosine phosphorylation and mitogenesis. J Biol Chem, 275(18), 13789-92, 2000.

Cheng, HF, Wang, JL, Zhang, MZ, McKanna, JA, Harris, RC. Role of p38 in the regulation of renal cortical cyclooxygenase-2 expression by extracellular chloride. J Clin Invest, 106(5), 681-8, 2000. PMCID:381289

Cheng, HF, Wang, JL, Zhang, MZ, McKanna, JA, Harris, RC. Nitric oxide regulates renal cortical cyclooxygenase-2 expression. Am J Physiol Renal Physiol, 279(1), F122-9, 2000.

Haralson, MA, DiMari, SJ, Hoover, RL, Harris, RC. Effects of epidermal growth factor on collagen expression by rat kidney mesangial cells in culture. Matrix Biol, 19(1), 47-59, 2000.

Harris, RC. Cyclooxygenase-2 in the kidney. J Am Soc Nephrol, 11(12), 2387-94, 2000.

Harris, RC, Cheng, H, Wang, J, Zhang, M, McKanna, JA. Interactions of the renin-angiotensin system and neuronal nitric oxide synthase in regulation of cyclooxygenase-2 in the macula densa. Acta Physiol Scand, 168(1), 47-51, 2000.

K??mhoff, M, Wang, JL, Cheng, HF, Langenbach, R, McKanna, JA, Harris, RC, Breyer, MD. Cyclooxygenase-2-selective inhibitors impair glomerulogenesis and renal cortical development. Kidney Int, 57(2), 414-22, 2000.

Wang, JL, Cheng, HF, Shappell, S, Harris, RC. A selective cyclooxygenase-2 inhibitor decreases proteinuria and retards progressive renal injury in rats. Kidney Int, 57(6), 2334-42, 2000.

Becker, BN, Kondo, S, Chen, JK, Harris, RC. Tyrosine kinase inhibition affects type 1 angiotensin II receptor internalization. J Recept Signal Transduct Res, 19(6), 975-93, 1999.

Chen, JK, Wang, DW, Falck, JR, Capdevila, J, Harris, RC. Transfection of an active cytochrome P450 arachidonic acid epoxygenase indicates that 14,15-epoxyeicosatrienoic acid functions as an intracellular second messenger in response to epidermal growth factor. J Biol Chem, 274(8), 4764-9, 1999.

Cheng, HF, Wang, JL, Zhang, MZ, Miyazaki, Y, Ichikawa, I, McKanna, JA, Harris, RC. Angiotensin II attenuates renal cortical cyclooxygenase-2 expression. J Clin Invest, 103(7), 953-61, 1999. PMCID:408259

Gibbs, SR, Goins, RA, Belvin, EL, Dimari, SJ, Merriam, AP, Bowling-Brown, S, Harris, RC, Haralson, MA. Characterization of the collagen phenotype of rabbit proximal tubule cells in culture. Connect Tissue Res, 40(3), 173-88, 1999.

Harris, RC. Potential mechanisms and physiologic actions of intracellular angiotensin II. Am J Med Sci, 318(6), 374-9, 1999.

Takemura, T, Hino, S, Murata, Y, Yanagida, H, Okada, M, Yoshioka, K, Harris, RC. Coexpression of CD9 augments the ability of membrane-bound heparin-binding epidermal growth factor-like growth factor (proHB-EGF) to preserve renal epithelial cell viability. Kidney Int, 55(1), 71-81, 1999.

Wang, JL, Cheng, HF, Harris, RC. Cyclooxygenase-2 inhibition decreases renin content and lowers blood pressure in a model of renovascular hypertension. Hypertension, 34(1), 96-101, 1999.

Zhang, MZ, Harris, RC, McKanna, JA. Regulation of cyclooxygenase-2 (COX-2) in rat renal cortex by adrenal glucocorticoids and mineralocorticoids. Proc Natl Acad Sci U S A, 96(26), 15280-5, 1999. PMCID:24811

Becker, BN, Yasuda, T, Kondo, S, Vaikunth, S, Homma, T, Harris, RC. Mechanical stretch/relaxation stimulates a cellular renin-angiotensin system in cultured rat mesangial cells. Exp Nephrol, 6(1), 57-66, 1998.

Chen, JK, Falck, JR, Reddy, KM, Capdevila, J, Harris, RC. Epoxyeicosatrienoic acids and their sulfonimide derivatives stimulate tyrosine phosphorylation and induce mitogenesis in renal epithelial cells. J Biol Chem, 273(44), 29254-61, 1998.

Cheng, HF, Wang, JL, Vinson, GP, Harris, RC. Young SHR express increased type 1 angiotensin II receptors in renal proximal tubule. Am J Physiol, 274(1 Pt 2), F10-7, 1998.

Harris, RC, Wang, JL, Cheng, HF, Zhang, MZ, McKanna, JA. Prostaglandins in macula densa function. Kidney Int Suppl, 67, S49-52, 1998.

McKanna, JA, Zhang, MZ, Wang, JL, Cheng, H, Harris, RC. Constitutive expression of cyclooxygenase-2 in rat vas deferens. Am J Physiol, 275(1 Pt 2), R227-33, 1998.

Miyazaki, Y, Tsuchida, S, Nishimura, H, Pope, JC, Harris, RC, McKanna, JM, Inagami, T, Hogan, BL, Fogo, A, Ichikawa, I. Angiotensin induces the urinary peristaltic machinery during the perinatal period. J Clin Invest, 102(8), 1489-97, 1998. PMCID:508998

Wang, JL, Cheng, HF, Zhang, MZ, McKanna, JA, Harris, RC. Selective increase of cyclooxygenase-2 expression in a model of renal ablation. Am J Physiol, 275(4 Pt 2), F613-22, 1998.

Becker, BN, Cheng, HF, Harris, RC. Apical ANG II-stimulated PLA2 activity and Na+ flux: a potential role for Ca2+-independent PLA2. Am J Physiol, 273(4 Pt 2), F554-62, 1997.

Becker, BN, Kondo, S, Cheng, HF, Harris, RC. Effect of glucose, pyruvate, and insulin on type 1 angiotensin II receptor expression in SV40-immortalized rabbit proximal tubule epithelial cells. Kidney Int, 52(1), 87-92, 1997.

Harris, RC. Growth factors and cytokines in acute renal failure. Adv Ren Replace Ther, 4(2 Suppl 1), 43-53, 1997.

Harris, RC, Becker, BN, Cheng, HF. Acute and chronic mechanisms for regulating proximal tubule angiotensin II receptor expression. J Am Soc Nephrol, 8(2), 306-13, 1997.

Sakai, M, Zhang, M, Homma, T, Garrick, B, Abraham, JA, McKanna, JA, Harris, RC. Production of heparin binding epidermal growth factor-like growth factor in the early phase of regeneration after acute renal injury. Isolation and localization of bioactive molecules. J Clin Invest, 99(9), 2128-38, 1997. PMCID:508043

Takemura, T, Kondo, S, Homma, T, Sakai, M, Harris, RC. The membrane-bound form of heparin-binding epidermal growth factor-like growth factor promotes survival of cultured renal epithelial cells. J Biol Chem, 272(49), 31036-42, 1997.

Zhang, MZ, Wang, JL, Cheng, HF, Harris, RC, McKanna, JA. Cyclooxygenase-2 in rat nephron development. Am J Physiol, 273(6 Pt 2), F994-1002, 1997.

Becker, BN, Harris, RC. A potential mechanism for proximal tubule angiotensin II-mediated sodium flux associated with receptor-mediated endocytosis and arachidonic acid release. Kidney Int Suppl, 57, S66-72, 1996.

Cheng, HF, Becker, BN, Harris, RC. Dopamine decreases expression of type-1 angiotensin II receptors in renal proximal tubule. J Clin Invest, 97(12), 2745-52, 1996. PMCID:507367

Harris, RC. The macula densa: recent developments. J Hypertens, 14(7), 815-22, 1996.

Harris, RC, Cheng, HF. The intrarenal renin-angiotensin system: a paracrine system for the local control of renal function separate from the systemic axis. Exp Nephrol, 4 Suppl 1, 2-7, 1996.

Yasuda, T, Kondo, S, Homma, T, Harris, RC. Regulation of extracellular matrix by mechanical stress in rat glomerular mesangial cells. J Clin Invest, 98(9), 1991-2000, 1996. PMCID:507642

Becker, BN, Cheng, HF, Burns, KD, Harris, RC. Polarized rabbit type 1 angiotensin II receptors manifest differential rates of endocytosis and recycling. Am J Physiol, 269(4 Pt 1), C1048-56, 1995.

Burns, KD, Capdevila, J, Wei, S, Breyer, MD, Homma, T, Harris, RC. Role of cytochrome P-450 epoxygenase metabolites in EGF signaling in renal proximal tubule. Am J Physiol, 269(4 Pt 1), C831-40, 1995.

Cheng, HF, Becker, BN, Burns, KD, Harris, RC. Angiotensin II upregulates type-1 angiotensin II receptors in renal proximal tubule. J Clin Invest, 95(5), 2012-9, 1995. PMCID:295780

Harris, RC, Martinez-Maldonado, M. Angiotensin II-mediated renal injury. Miner Electrolyte Metab, 21(4-5), 328-35, 1995.

Homma, T, Sakai, M, Cheng, HF, Yasuda, T, Coffey, RJ, Harris, RC. Induction of heparin-binding epidermal growth factor-like growth factor mRNA in rat kidney after acute injury. J Clin Invest, 96(2), 1018-25, 1995. PMCID:185290

Threadgill, D.W., Dlugosz, A.A., Hansen, L., Tennenbaum, T., Lichi, U., Yee, D, LeMantia, C., Mourton, T., Herrup, K., Harris, RC, Barnard, J.A., Yuspa,S.H., Coffey, and Magnuson, T. Targeted disruption of mouse EGF-receptor: Evidence that genetic background affects mutant phenotype. Science, 269, 230-234, 1995.

Akai, Y, Homma, T, Burns, KD, Yasuda, T, Badr, KF, Harris, RC. Mechanical stretch/relaxation of cultured rat mesangial cells induces protooncogenes and cyclooxygenase. Am J Physiol, 267(2 Pt 1), C482-90, 1994.

Cheng, HF, Burns, KD, Harris, RC. Reduced proximal tubule angiotensin II receptor expression in streptozotocin-induced diabetes mellitus. Kidney Int, 46(6), 1603-10, 1994.

Harris, R.C., McKanna, J.A., Akai, Y., Jacobson, H.R., Dubois, R.N. and Breyer, M.D. Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction. J. Clin. Invest, 94, 2504-2510, 1994.

Harris, RC, Akai, Y, Yasuda, T, Homma, T. The role of physical forces in alterations of mesangial cell function. Kidney Int Suppl, 45, S17-21, 1994.

Harris, RC, Akai, Y, Yasuda, T, Homma, T. Role of physical factors in the regulation of mesangial cell growth and the interaction with vasoactive agents. Exp Nephrol, 2(2), 104, 1994.

Harris, RC, Ismail, N. Extrarenal complications of the nephrotic syndrome. Am J Kidney Dis, 23(4), 477-97, 1994.

Harris, RC, McKanna, JA, Akai, Y, Jacobson, HR, Dubois, RN, Breyer, MD. Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction. J Clin Invest, 94(6), 2504-10, 1994. PMCID:330084

Burns, KD, Homma, T, Harris, RC. The intrarenal renin-angiotensin system. Semin Nephrol, 13(1), 13-30, 1993.

Burns, KD, Inagami, T, Harris, RC. Cloning of a rabbit kidney cortex AT1 angiotensin II receptor that is present in proximal tubule epithelium. Am J Physiol, 264(4 Pt 2), F645-54, 1993.

Harris, RC, Burns, KD, Alattar, M, Homma, T, Nakamura, T. Hepatocyte growth factor stimulates phosphoinositide hydrolysis and mitogenesis in cultured renal epithelial cells. Life Sci, 52(13), 1091-100, 1993.

Homma, T, Zhang, JY, Shimizu, T, Prakash, C, Blair, IA, Harris, RC. Cyclooxygenase-derived metabolites of 8,9-epoxyeicosatrienoic acid are potent mitogens for cultured rat glomerular mesangial cells. Biochem Biophys Res Commun, 191(1), 282-8, 1993.

Takahashi, K, Harris, RC, Capdevila, JH, Karara, A, Makita, K, Jacobson, HR, Munger, KA, Badr, KF. Induction of renal arachidonate cytochrome P-450 epoxygenase after uninephrectomy: counterregulation of hyperfiltration. J Am Soc Nephrol, 3(8), 1496-500, 1993.

Harris, R.C. S6 kinase activity in proximal tubule cells. Evidence for activation by epidermal growth factor and angiotensin II in vitro and by contralateral nephrectomy in vivo. Am. J. Physiol., 263, F127-F134, 1992.

Harris, RC, Haralson, MA, Badr, KF. Continuous stretch-relaxation in culture alters rat mesangial cell morphology, growth characteristics, and metabolic activity. Lab Invest, 66(5), 548-54, 1992.

Homma, T, Akai, Y, Burns, KD, Harris, RC. Activation of S6 kinase by repeated cycles of stretching and relaxation in rat glomerular mesangial cells. Evidence for involvement of protein kinase C. J Biol Chem, 267(32), 23129-35, 1992.

McKanna, JA, Chuncharunee, A, Munger, KA, Breyer, JA, Cohen, S, Harris, RC. Localization of p35 (annexin I, lipocortin I) in normal adult rat kidney and during recovery from ischemia. J Cell Physiol, 153(3), 467-76, 1992.

Awazu, M, Kon, V, Harris, RC, Imada, T, Inagami, T, Ichikawa, I. Renal sympathetic nerves modulate glomerular ANP receptors and filtration. Am J Physiol, 261(1 Pt 2), F29-35, 1991.

Harris, RC. Potential physiologic roles for epidermal growth factor in the kidney. Am J Kidney Dis, 17(6), 627-30, 1991.

Homma, T, Harris, RC. Time-dependent biphasic regulation of Na+/K+/Cl- cotransport in rat glomerular mesangial cells. J Biol Chem, 266(21), 13553-9, 1991.

Harris, RC, Badr, KF. Recovery of prostaglandin synthesis in rat glomerular mesangial cells after aspirin inhibition: induction of cyclooxygenase activity by serum and epidermal growth factor. Prostaglandins, 39(2), 213-22, 1990.

Harris, RC, Homma, T, Jacobson, HR, Capdevila, J. Epoxyeicosatrienoic acids activate Na+/H+ exchange and are mitogenic in cultured rat glomerular mesangial cells. J Cell Physiol, 144(3), 429-37, 1990.

Harris, RC, Munger, KA, Badr, KF, Takahashi, K. Mediation of renal vascular effects of epidermal growth factor by arachidonate metabolites. FASEB J, 4(6), 1654-60, 1990.

Homma, T., Burns, K. and Harris R.C. Agonist stimulation of Na/K/Cl cotransport in cultured rat mesangial cells: Evidence for protein kinase C-dependent and calcium/calmodulin-dependent pathways. J. Biol. Chem., 265:, 17613-17620, 1990.

Kon, V, Harris, RC, Ichikawa, I. A regulatory role for large vessels in organ circulation. Endothelial cells of the main renal artery modulate intrarenal hemodynamics in the rat. J Clin Invest, 85(6), 1728-33, 1990. PMCID:296633

Badr, KF, DeBoer, DK, Takahashi, K, Harris, RC, Fogo, A, Jacobson, HR. Glomerular responses to platelet-activating factor in the rat: role of thromboxane A2. Am J Physiol, 256(1 Pt 2), F35-43, 1989.

Badr, KF, Mong, S, Hoover, RL, Schwartzberg, M, Ebert, J, Jacobson, HR, Harris, RC. Leukotriene D4 binding and signal transduction in rat glomerular mesangial cells. Am J Physiol, 257(2 Pt 2), F280-7, 1989.

Badr, KF, Murray, JJ, Breyer, MD, Takahashi, K, Inagami, T, Harris, RC. Mesangial cell, glomerular and renal vascular responses to endothelin in the rat kidney. Elucidation of signal transduction pathways. J Clin Invest, 83(1), 336-42, 1989. PMCID:303681

Harris, RC, Daniel, TO. Epidermal growth factor binding, stimulation of phosphorylation, and inhibition of gluconeogenesis in rat proximal tubule. J Cell Physiol, 139(2), 383-91, 1989.

Harris, R.C., Hoover, R.L., Jacobson, H.R. and Badr, K.F. Evidence for glomerular actions of epidermal growth factor in the rat. J. Clin Invest., 82, 1028-1039, 1988.

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