Vanderbilt University School of Medicine

Charles, P. David , M.D.
Assistant Dean for Medical School Admissions
Professor of Neurology

Lab Url: http://www.mc.vanderbilt.edu/neurology/faculty/charles.htm

Phone Number: Office (615) 936-0060

Email Address:david.charles@vanderbilt.edu

Charles, P.'s picture

Office Address   Mailing Address

1161 21st Avenue South, Suite A1106 MCN

Department of Neurology Suite A-1106 MCN 37232


Clinical Research Description
The Treatment of Parkinson's Disease with Deep Brain Stimulation

We are currently treating Parkinson's disease patients with deep brain stimulation of the bilateral subthalamic nucleus. This recently FDA approved therapy is an exciting new intervention for some Parkinson's disease patients. We are investigating the effects of bilateral subthalamic nucleus stimulation in early stage Parkinson's disease to better understand if this treatment may slow the progression of the disease.

Treatment of Spasticity in Adults

Spasticity is a condition that is very prevalent in people with mental retardation or cerebral palsy. The presence of spasticity can often make performance of activities of daily living and caregiving very difficulty. We are currently investigating the impact of a comprehensive spasticity management program applied to people with mental retardation living in a developmental center.

Cervical Dystonia

Cervical dystonia causes painful muscle contractions and abnormal head position. We are comparing the pain relief that people with cervical dystonia experience after neurotoxin injection to the pain relief experienced in people without cervical dystonia.

Clinical Interests
Movement Disorders, Parkinson's Disease, Dystonia, Tremor, Spasticity, Deep Brain Stimulation, Neurotoxin Injection

Publications
Newman, William J, Davis, Thomas L, Padaliya, Bimal B, Covington, Cassondra D, Gill, Chandler E, Abramovitch, Anna I, Charles, P David. Erratum: Botulinum toxin type a therapy during pregnancy. Mov Disord 2004;19(11):1384-1385. Mov Disord, 20(1), 121, 2005.

Charles, P David. Botulinum neurotoxin serotype A: a clinical update on non-cosmetic uses. Am J Health Syst Pharm, 61(22 Suppl 6), S11-23, 2004.

Charles, P David, Padaliya, Bimal B, Newman, William J, Gill, Chandler E, Covington, Cassondra D, Fang, John Y, So, Stephanie A, Tramontana, Michael G, Konrad, Peter E, Davis, Thomas L. Deep brain stimulation of the subthalamic nucleus reduces antiparkinsonian medication costs. Parkinsonism Relat Disord, 10(8), 475-9, 2004.

Newman, William J, Davis, Thomas L, Padaliya, Bimal B, Padaliya, Bismal B, Covington, Cassondra D, Gill, Chandler E, Abramovitch, Anna I, Charles, P David. Botulinum toxin type A therapy during pregnancy. Mov Disord, 19(11), 1384-5, 2004.

Padaliya, Bimal B, Davis, Thomas L, Newman, William J, Konrad, Peter E, Covington, Cassondra D, Gill, Chandler E, Abramovitch, Anna I, Charles, P David. Bilateral globus pallidus internus deep brain stimulation therapy for primary generalized dystonia. Tenn Med, 97(7), 317-8, 2004.

Covington, Cassondra, Taylor, Henry, Gill, Chandler, Padaliya, Bimal, Newman, William, Smart, John R, Charles, P David. Prolonged survival in hydranencephaly: a case report. Tenn Med, 96(9), 423-4, 2003.

Damian, Myrandele, Davis, Thomas L, Konrad, Peter E, Roberts, Amanda G, Pfister, Alyssa A, Charles, P David. Deep brain stimulation: a new treatment for Parkinson''s disease. Tenn Med, 96(1), 33-5, 2003.

Gill, Chandler, Covington, Cassondra, Padaliya, Bimal, Newman, William, Pomeroy, Terri, Charles, P David. Successful treatment of childhood spasticity secondary to cerebral palsy using Botox. Tenn Med, 96(11), 511-3, 2003.

Pfister, Alyssa A, Roberts, Amanda G, Taylor, Henry M, Noel-Spaudling, Shayla, Damian, M Myrandele, Charles, P David. Spasticity in adults living in a developmental center. Arch Phys Med Rehabil, 84(12), 1808-12, 2003.

Roberts, A G, Graves, C R, Konrad, P E, Groomes, T E, Pfister, A A, Damian, M M, Charles, P D. Intrathecal baclofen pump implantation during pregnancy. Neurology, 61(8), 1156-7, 2003.

Austin, M T, Davis, T L, Robertson, D, Charles, P D. Multiple system atrophy: clinical presentation and diagnosis. Tenn Med, 92(2), 55-7, 1999.

Charles, P D, Esper, G J, Davis, T L, Maciunas, R J, Robertson, D. Classification of tremor and update on treatment. Am Fam Physician, 59(6), 1565-72, 1999.

Charles, P D, Scherokman, B, Jozefowicz, R F. How much neurology should a medical student learn? a position statement of the AAN Undergraduate Education Subcommittee. Acad Med, 74(1), 23-6, 1999.

Charles, P D. A perspective on financial incentives in health care. Tenn Med, 91(10), 386-7, 1998.

Charles, P D, Abou-Khalil, B, Atkinson, D S, Bakar, M, Mayville, C L, Kirshner, H S. Occipital pole area and language dominance. J Neuroimaging, 7(2), 89-91, 1997.

Charles, P D, Davis, T L, Shannon, K M, Hook, M A, Warner, J S. Tongue protrusion dystonia: treatment with botulinum toxin. South Med J, 90(5), 522-5, 1997.

Charles, P D, Maciunas, R J, Davis, T L, Drowota, F R, Truett, A A, Giles, J T, Cheney, J T, Robertson, D. Thalamic stimulation: an innovative treatment for tremor. Tenn Med, 90(7), 275-7, 1997.

Esper, G J, Charles, P D, Davis, T L, Robertson, D. Adult-onset focal dystonias: presentation and treatment options. Tenn Med, 90(1), 18-20, 1997.

Atkinson, D S, Abou-Khalil, B, Charles, P D, Welch, L. Midsagittal corpus callosum area, intelligence, and language dominance in epilepsy. J Neuroimaging, 6(4), 235-9, 1996.

Charles, P D, Davis, T L. Drug therapy for Parkinson''s disease. South Med J, 89(9), 851-6, 1996.

Charles, P D, Davis, T L, Robertson, D, Fenichel, G M. Dystonia and unique muscle features. A 23-year follow-up and correction of diagnosis in two brothers. Arch Neurol, 52(8), 825-6, 1995.

Davis, T L, Charles, P D, Burns, R S. Clonazepam-sensitive intermittent dystonic tremor. South Med J, 88(10), 1069-71, 1995.

Charles, P D, Abou-Khalil, R, Abou-Khalil, B, Wertz, R T, Ashmead, D H, Welch, L, Kirshner, H S. MRI asymmetries and language dominance. Neurology, 44(11), 2050-4, 1994.

Charles, P D, Davis, T L. Sumatriptan for migraine. Am J Med Sci, 307(6), 445-7, 1994.

Charles, P D, Fenichel, G M. Sneddon and antiphospholipid antibody syndromes causing bilateral thalamic infarction. Pediatr Neurol, 10(3), 262-3, 1994.


Postdoctoral Position Available
N/A

Postdoctoral Position Details
N/A

Updated Date
08/16/2007



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