Vanderbilt University School of Medicine

Edgerton, Dale Scott , Ph.D.
Research Assistant Professor of Molecular Physiology and Biophysics

Lab Url: http://www.mc.vanderbilt.edu/diabetes/drtc/cores/hormone_assay/index.php

Phone Number: 615-343-3193

Email Address:dale.edgerton@vanderbilt.edu

Edgerton, Dale's picture

Office Address   Mailing Address

710 RRB 2200 Pierce Ave Nashville, TN 37232-0615

710 RRB 0615


Publications
Corbett, BA, Swain, DM, Newsom, C, Wang, L, Song, Y, Edgerton, D. Biobehavioral profiles of arousal and social motivation in autism spectrum disorders. J Child Psychol Psychiatry, , , 2013.

Edgerton, DS, An, Z, Johnson, KM, Farmer, T, Farmer, B, Neal, D, Cherrington, AD. Effects of intraportal exenatide on hepatic glucose metabolism in the conscious dog. Am J Physiol Endocrinol Metab, 305(1), E132-9, 2013.

Edgerton, DS, Cherrington, AD. Glucagon''s yin and yang effects on hepatic glucose production. Nat Med, 19(6), 674-5, 2013.

Ramnanan, CJ, Kraft, G, Smith, MS, Farmer, B, Neal, D, Williams, PE, Lautz, M, Farmer, T, Donahue, EP, Cherrington, AD, Edgerton, DS. Interaction between the central and peripheral effects of insulin in controlling hepatic glucose metabolism in the conscious dog. Diabetes, 62(1), 74-84, 2013.

Saraswathi, V, Ramnanan, CJ, Wilks, AW, Desouza, CV, Eller, AA, Murali, G, Ramalingam, R, Milne, GL, Coate, KC, Edgerton, DS. Impact of hematopoietic cyclooxygenase-1 deficiency on obesity-linked adipose tissue inflammation and metabolic disorders in mice. Metabolism, 62(11), 1673-85, 2013.

Winnick, JJ, Ramnanan, CJ, Saraswathi, V, Roop, J, Scott, M, Jacobson, P, Jung, P, Basu, R, Cherrington, AD, Edgerton, DS. Effects of 11??-hydroxysteroid dehydrogenase-1 inhibition on hepatic glycogenolysis and gluconeogenesis. Am J Physiol Endocrinol Metab, 304(7), E747-56, 2013.

Ramnanan, CJ, Edgerton, DS, Cherrington, AD. Evidence against a physiologic role for acute changes in CNS insulin action in the rapid regulation of hepatic glucose production. Cell Metab, 15(5), 656-64, 2012.

Edgerton, DS, Cherrington, AD. Glucagon as a critical factor in the pathology of diabetes. Diabetes, 60(2), 377-80, 2011.

Ramnanan, CJ, Edgerton, DS, Kraft, G, Cherrington, AD. Physiologic action of glucagon on liver glucose metabolism. Diabetes Obes Metab, 13 Suppl 1, 118-25, 2011.

Ramnanan, CJ, Saraswathi, V, Smith, MS, Donahue, EP, Farmer, B, Farmer, TD, Neal, D, Williams, PE, Lautz, M, Mari, A, Cherrington, AD, Edgerton, DS. Brain insulin action augments hepatic glycogen synthesis without suppressing glucose production or gluconeogenesis in dogs. J Clin Invest, 121(9), 3713-23, 2011.

Edgerton, DS, Basu, R, Ramnanan, CJ, Farmer, TD, Neal, D, Scott, M, Jacobson, P, Rizza, RA, Cherrington, AD. Effect of 11 beta-hydroxysteroid dehydrogenase-1 inhibition on hepatic glucose metabolism in the conscious dog. Am J Physiol Endocrinol Metab, 298(5), E1019-26, 2010.

Ramnanan, CJ, Edgerton, DS, Rivera, N, Irimia-Dominguez, J, Farmer, B, Neal, DW, Lautz, M, Donahue, EP, Meyer, CM, Roach, PJ, Cherrington, AD. Molecular characterization of insulin-mediated suppression of hepatic glucose production in vivo. Diabetes, 59(6), 1302-11, 2010.

Edgerton, DS, Cherrington, AD, Neal, DW, Scott, M, Lautz, M, Brown, N, Petro, J, Hobbs, CH, Leach, C, Del Parigi, A, Strack, TR. Inhaled insulin is associated with prolonged enhancement of glucose disposal in muscle and liver in the canine. J Pharmacol Exp Ther, 328(3), 970-5, 2009.

Edgerton, DS, Johnson, KM, Cherrington, AD. Current strategies for the inhibition of hepatic glucose production in type 2 diabetes. Front Biosci (Landmark Ed), 14, 1169-81, 2009.

Edgerton, DS, Johnson, KM, Neal, DW, Scott, M, Hobbs, CH, Zhang, X, Duttaroy, A, Cherrington, AD. Inhibition of dipeptidyl peptidase-4 by vildagliptin during glucagon-like Peptide 1 infusion increases liver glucose uptake in the conscious dog. Diabetes, 58(1), 243-9, 2009.

Edgerton, DS, Ramnanan, CJ, Grueter, CA, Johnson, KM, Lautz, M, Neal, DW, Williams, PE, Cherrington, AD. Effects of insulin on the metabolic control of hepatic gluconeogenesis in vivo. Diabetes, 58(12), 2766-75, 2009.

An, Z, DiCostanzo, CA, Moore, MC, Edgerton, DS, Dardevet, DP, Neal, DW, Cherrington, AD. Effects of the nitric oxide donor SIN-1 on net hepatic glucose uptake in the conscious dog. Am J Physiol Endocrinol Metab, 294(2), E300-6, 2008.

Johnson, KM, Edgerton, DS, Rodewald, T, Scott, M, Farmer, B, Neal, D, Cherrington, AD. Intraportally delivered GLP-1, in the presence of hyperglycemia induced via peripheral glucose infusion, does not change whole body glucose utilization. Am J Physiol Endocrinol Metab, 294(2), E380-4, 2008.

Cherrington, AD, Moore, MC, Sindelar, DK, Edgerton, DS. Insulin action on the liver in vivo. Biochem Soc Trans, 35(Pt 5), 1171-4, 2007.

Johnson, KM, Edgerton, DS, Rodewald, T, Scott, M, Farmer, B, Neal, D, Cherrington, AD. Intraportal GLP-1 infusion increases nonhepatic glucose utilization without changing pancreatic hormone levels. Am J Physiol Endocrinol Metab, 293(4), E1085-91, 2007.

Nelson, RH, Edgerton, DS, Basu, R, Roesner, JC, Cherrington, AD, Miles, JM. Triglyceride uptake and lipoprotein lipase-generated fatty acid spillover in the splanchnic bed of dogs. Diabetes, 56(7), 1850-5, 2007.

Rivera, N, Everett-Grueter, CA, Edgerton, DS, Rodewald, T, Neal, DW, Nishimura, E, Larsen, MO, Jacobsen, LO, Kristensen, K, Brand, CL, Cherrington, AD. A novel glucagon receptor antagonist, NNC 25-0926, blunts hepatic glucose production in the conscious dog. J Pharmacol Exp Ther, 321(2), 743-52, 2007.

Basu, R, Edgerton, DS, Singh, RJ, Cherrington, A, Rizza, RA. Splanchnic cortisol production in dogs occurs primarily in the liver: evidence for substantial hepatic specific 11beta hydroxysteroid dehydrogenase type 1 activity. Diabetes, 55(11), 3013-9, 2006.

Edgerton, DS, Cherrington, AD, Williams, P, Neal, DW, Scott, M, Bowen, L, Wilson, W, Hobbs, CH, Leach, C, Kuo, MC, Strack, TR. Inhalation of human insulin (exubera) augments the efficiency of muscle glucose uptake in vivo. Diabetes, 55(12), 3604-10, 2006.

Edgerton, DS, Jacobson, PB, Opgenorth, TJ, Zinker, B, Beno, D, von Geldern, T, Ohman, L, Scott, M, Neal, D, Cherrington, AD. Selective antagonism of the hepatic glucocorticoid receptor reduces hepatic glucose production. Metabolism, 55(9), 1255-62, 2006.

Edgerton, DS, Lautz, M, Scott, M, Everett, CA, Stettler, KM, Neal, DW, Chu, CA, Cherrington, AD. Insulin''s direct effects on the liver dominate the control of hepatic glucose production. J Clin Invest, 116(2), 521-7, 2006.

Edgerton, DS, Stettler, KM, Neal, DW, Scott, M, Bowen, L, Wilson, W, Hobbs, CH, Leach, C, Strack, TR, Cherrington, AD. Inhalation of human insulin is associated with improved insulin action compared with subcutaneous injection and endogenous secretion in dogs. J Pharmacol Exp Ther, 319(3), 1258-64, 2006.

Everett-Grueter, C, Edgerton, DS, Donahue, EP, Vaughan, S, Chu, CA, Sindelar, DK, Cherrington, AD. The effect of an acute elevation of NEFA concentrations on glucagon-stimulated hepatic glucose output. Am J Physiol Endocrinol Metab, 291(3), E449-59, 2006.

Edgerton, DS, Neal, DW, Scott, M, Bowen, L, Wilson, W, Hobbs, CH, Leach, C, Sivakumaran, S, Strack, TR, Cherrington, AD. Inhalation of insulin (Exubera) is associated with augmented disposal of portally infused glucose in dogs. Diabetes, 54(4), 1164-70, 2005.

Gustavson, SM, Rajotte, RV, Hunkeler, D, Lakey, JR, Edgerton, DS, Neal, DW, Snead, WL, Penaloza, AR, Cherrington, AD. Islet auto-transplantation into an omental or splenic site results in a normal beta cell but abnormal alpha cell response to mild non-insulin-induced hypoglycemia. Am J Transplant, 5(10), 2368-77, 2005.

Jacobson, PB, von Geldern, TW, Ohman, L, Osterland, M, Wang, J, Zinker, B, Wilcox, D, Nguyen, PT, Mika, A, Fung, S, Fey, T, Goos-Nilsson, A, Grynfarb, M, Barkhem, T, Marsh, K, Beno, DW, Nga-Nguyen, B, Kym, PR, Link, JT, Tu, N, Edgerton, DS, Cherrington, A, Efendic, S, Lane, BC, Opgenorth, TJ. Hepatic glucocorticoid receptor antagonism is sufficient to reduce elevated hepatic glucose output and improve glucose control in animal models of type 2 diabetes. J Pharmacol Exp Ther, 314(1), 191-200, 2005.

Cardin, Sylvain, Pagliassotti, Michael J, Moore, Mary Courtney, Edgerton, Dale S, Lautz, Margaret, Farmer, Ben, Neal, Doss W, Cherrington, Alan D. Vagal cooling and concomitant portal norepinephrine infusion do not reduce net hepatic glucose uptake in conscious dogs. Am J Physiol Regul Integr Comp Physiol, 287(4), R742-8, 2004.

Cherrington, Alan D, Neal, Doss W, Edgerton, Dale S, Glass, Dana, Bowen, Larry, Hobbs, Charles H, Leach, Chet, Rosskamp, Ralf, Strack, Thomas R. Inhalation of insulin in dogs: assessment of insulin levels and comparison to subcutaneous injection. Diabetes, 53(4), 877-81, 2004.

Edgerton, Dale S, Cardin, Sylvain, Neal, Doss, Farmer, Ben, Lautz, Margaret, Pan, Catherine, Cherrington, Alan D. Effects of hyperglycemia on hepatic gluconeogenic flux during glycogen phosphorylase inhibition in the conscious dog. Am J Physiol Endocrinol Metab, 286(4), E510-22, 2004.

Moore, Mary Courtney, Cardin, Sylvain, Edgerton, Dale S, Farmer, Ben, Neal, Doss W, Lautz, Margaret, Cherrington, Alan D. Unlike mice, dogs exhibit effective glucoregulation during low-dose portal and peripheral glucose infusion. Am J Physiol Endocrinol Metab, 286(2), E226-33, 2004.

Edgerton, Dale S, Cardin, Sylvain, Pan, Catherine, Neal, Doss, Farmer, Ben, Converse, Margaret, Cherrington, Alan D. Effects of insulin deficiency or excess on hepatic gluconeogenic flux during glycogenolytic inhibition in the conscious dog. Diabetes, 51(11), 3151-62, 2002.

Cardin, S, Jackson, P A, Edgerton, D S, Neal, D W, Coffey, C S, Cherrington, A D. Effect of vagal cooling on the counterregulatory response to hypoglycemia induced by a low dose of insulin in the conscious dog. Diabetes, 50(3), 558-64, 2001.

Edgerton, D S, Cardin, S, Emshwiller, M, Neal, D, Chandramouli, V, Schumann, W C, Landau, B R, Rossetti, L, Cherrington, A D. Small increases in insulin inhibit hepatic glucose production solely caused by an effect on glycogen metabolism. Diabetes, 50(8), 1872-82, 2001.

Hornbuckle, L A, Edgerton, D S, Ayala, J E, Svitek, C A, Oeser, J K, Neal, D W, Cardin, S, Cherrington, A D, O''Brien, R M. Selective tonic inhibition of G-6-Pase catalytic subunit, but not G-6-P transporter, gene expression by insulin in vivo. Am J Physiol Endocrinol Metab, 281(4), E713-25, 2001.

Cardin, S, Emshwiller, M, Jackson, P A, Snead, W L, Hastings, J, Edgerton, D S, Cherrington, A D. Portal glucose infusion increases hepatic glycogen deposition in conscious unrestrained rats. J Appl Physiol, 87(4), 1470-5, 1999.


Postdoctoral Position Available
N/A

Postdoctoral Position Details
N/A

Updated Date
01/17/2014



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