Vanderbilt University School of Medicine

Matthews, Robert T. , Ph.D.
Research Associate Professor of Molecular Physiology and Biophysics

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Phone Number: (615) 343-5023


Matthews, Robert's picture

Office Address   Mailing Address

724 RRB

724 RRB 702 Light Hall 37232-0615

Arai, Munehito, Kondrashkina, Elena, Kayatekin, Can, Matthews, C Robert, Iwakura, Masahiro, Bilsel, Osman. Microsecond hydrophobic collapse in the folding of Escherichia coli dihydrofolate reductase, an alpha/beta-type protein. J Mol Biol, 368(1), 219-29, 2007.

Cheng, Hong, Sathiakumar, Nalini, Graff, John, Matthews, Robert, Delzell, Elizabeth. 1,3-Butadiene and leukemia among synthetic rubber industry workers: exposure-response relationships. Chem Biol Interact, 166(1-3), 15-24, 2007.

Gu, Zhenyu, Zitzewitz, Jill A, Matthews, C Robert. Mapping the structure of folding cores in TIM barrel proteins by hydrogen exchange mass spectrometry: the roles of motif and sequence for the indole-3-glycerol phosphate synthase from Sulfolobus solfataricus. J Mol Biol, 368(2), 582-94, 2007. PMCID:2040069

Massey, James M, Amps, Jeremy, Viapiano, Mariano S, Matthews, Russell T, Wagoner, Michelle R, Whitaker, Christopher M, Alilain, Warren, Yonkof, Alicia L, Khalyfa, Abdelnaby, Cooper, Nigel G F, Silver, Jerry, Onifer, Stephen M. Increased chondroitin sulfate proteoglycan expression in denervated brainstem targets following spinal cord injury creates a barrier to axonal regeneration overcome by chondroitinase ABC and neurotrophin-3. Exp Neurol, , , 2007. PMCID:2270474

McRae, Paulette A, Rocco, Mary M, Kelly, Gail, Brumberg, Joshua C, Matthews, Russell T. Sensory deprivation alters aggrecan and perineuronal net expression in the mouse barrel cortex. J Neurosci, 27(20), 5405-13, 2007.

Wu, Ying, Vadrevu, Ramakrishna, Kathuria, Sagar, Yang, Xiaoyan, Matthews, C Robert. A tightly packed hydrophobic cluster directs the formation of an off-pathway sub-millisecond folding intermediate in the alpha subunit of tryptophan synthase, a TIM barrel protein. J Mol Biol, 366(5), 1624-38, 2007. PMCID:1894912

Bender, Thomas J, Beall, Colleen, Cheng, Hong, Herrick, Robert F, Kahn, Amy R, Matthews, Robert, Sathiakumar, Nalini, Schymura, Maria J, Stewart, James H, Delzell, Elizabeth. Methodologic issues in follow-up studies of cancer incidence among occupational groups in the United States. Ann Epidemiol, 16(3), 170-9, 2006.

Bilsel, Osman, Matthews, C Robert. Molecular dimensions and their distributions in early folding intermediates. Curr Opin Struct Biol, 16(1), 86-93, 2006.

Chalmers, Iain, Matthews, Robert. What are the implications of optimism bias in clinical research. Lancet, 367(9509), 449-50, 2006.

Delzell, Elizabeth, Sathiakumar, Nalini, Graff, John, Macaluso, Maurizio, Maldonado, George, Matthews, Robert, , . An updated study of mortality among North American synthetic rubber industry workers. Res Rep Health Eff Inst, (132), 1-63; discussion 65-74, 2006.

Dino, M R, Harroch, S, Hockfield, S, Matthews, R T. Monoclonal antibody Cat-315 detects a glycoform of receptor protein tyrosine phosphatase beta/phosphacan early in CNS development that localizes to extrasynaptic sites prior to synapse formation. Neuroscience, 142(4), 1055-69, 2006.

Matthews, Robert. Isoproterenol-induced elevated bispectral indexes while undergoing radiofrequency ablation: a case report. AANA J, 74(3), 193-5, 2006.

Matthews, Robert. Profiling of CSF: reliability of diagnosis. PLoS Med, 3(10), e469; author reply e468, 2006. PMCID:1626570

Matthews, Robert, Franceschi, Dinko, Xia, Wenlang, Cabahug, Corazon, Schuman, Gail, Bernstein, Robert, Peyster, Robert. Parietal lobe epileptic focus identified on SPECT-MRI fusion imaging in a case of epilepsia partialis continua. Clin Nucl Med, 31(12), 826-8, 2006.

Simler, B Robert, Levy, Yaakov, Onuchic, Jos?? N, Matthews, C Robert. The folding energy landscape of the dimerization domain of Escherichia coli Trp repressor: a joint experimental and theoretical investigation. J Mol Biol, 363(1), 262-78, 2006. PMCID:1866298

Svensson, Anna-Karin E, Bilsel, Osman, Kondrashkina, Elena, Zitzewitz, Jill A, Matthews, C Robert. Mapping the folding free energy surface for metal-free human Cu,Zn superoxide dismutase. J Mol Biol, 364(5), 1084-102, 2006.

Svensson, Anna-Karin E, Zitzewitz, Jill A, Matthews, C Robert, Smith, Virginia F. The relationship between chain connectivity and domain stability in the equilibrium and kinetic folding mechanisms of dihydrofolate reductase from E.coli. Protein Eng Des Sel, 19(4), 175-85, 2006.

Viapiano, Mariano S, Matthews, Russell T. From barriers to bridges: chondroitin sulfate proteoglycans in neuropathology. Trends Mol Med, 12(10), 488-96, 2006.

Andrews, Zane B, Horvath, Balazs, Barnstable, Colin J, Elsworth, John, Elseworth, John, Yang, Lichuan, Beal, M Flynt, Roth, Robert H, Matthews, Russell T, Horvath, Tamas L. Uncoupling protein-2 is critical for nigral dopamine cell survival in a mouse model of Parkinson's disease. J Neurosci, 25(1), 184-91, 2005.

Beall, Colleen, Bender, Thomas J, Cheng, Hong, Herrick, Robert, Kahn, Amy, Matthews, Robert, Sathiakumar, Nalini, Schymura, Maria, Stewart, James, Delzell, Elizabeth. Mortality among semiconductor and storage device-manufacturing workers. J Occup Environ Med, 47(10), 996-1014, 2005.

Delzell, Elizabeth, Sathiakumar, Nalini, Graff, John, Matthews, Robert. Styrene and ischemic heart disease mortality among synthetic rubber industry workers. J Occup Environ Med, 47(12), 1235-43, 2005.

Egli, Regula E, Kash, Thomas L, Choo, Kevin, Savchenko, Valentina, Matthews, Robert T, Blakely, Randy D, Winder, Danny G. Norepinephrine modulates glutamatergic transmission in the bed nucleus of the stria terminalis. Neuropsychopharmacology, 30(4), 657-68, 2005.

Graff, John J, Sathiakumar, Nalini, Macaluso, Maurizio, Maldonado, George, Matthews, Robert, Delzell, Elizabeth. Chemical exposures in the synthetic rubber industry and lymphohematopoietic cancer mortality. J Occup Environ Med, 47(9), 916-32, 2005.

Herrick, Robert F, Stewart, James H, Blicharz, Drew, Beall, Colleen, Bender, Thomas, Cheng, Hong, Matthews, Robert, Sathiakumar, Nalini, Delzell, Elizabeth. Exposure assessment for retrospective follow-up studies of semiconductor- and storage device-manufacturing workers. J Occup Environ Med, 47(10), 983-95, 2005.

Matthews, Robert. No way to treat a patient: tens of thousands of people have been subjected to unnecessary drug trials. New Sci, 187(2507), 19, 2005.

Matthews, Robert. A risk we have to swallow: can we ever be sure that medicines are safe before they hit the market. New Sci, 185(2489), 23, 2005.

Matthews, Robert, Franceschi, Dinko, Cabahug, Corazon. Abdominal muscle uptake on FDG PET secondary to multiple rib fractures and use of accessory muscles of respiration. Clin Nucl Med, 30(5), 333-4, 2005.

Sloan, Kevin E, Stewart, Jean K, Treloar, Allison F, Matthews, Russell T, Jay, Daniel G. CD155/PVR enhances glioma cell dispersal by regulating adhesion signaling and focal adhesion dynamics. Cancer Res, 65(23), 10930-7, 2005.

Viapiano, Mariano S, Bi, Wenya Linda, Piepmeier, Joseph, Hockfield, Susan, Matthews, Russell T. Novel tumor-specific isoforms of BEHAB/brevican identified in human malignant gliomas. Cancer Res, 65(15), 6726-33, 2005.

Wintrode, Patrick L, Rojsajjakul, Teerapat, Vadrevu, Ramakrishna, Matthews, C Robert, Smith, David L. An obligatory intermediate controls the folding of the alpha-subunit of tryptophan synthase, a TIM barrel protein. J Mol Biol, 347(5), 911-9, 2005.

Wu, Ying, Vadrevu, Ramakrishna, Yang, Xiaoyan, Matthews, C Robert. Specific structure appears at the N terminus in the sub-millisecond folding intermediate of the alpha subunit of tryptophan synthase, a TIM barrel protein. J Mol Biol, 351(3), 445-52, 2005.

Ibarra-Molero, Beatriz, Zitzewitz, Jill A, Matthews, C Robert. Salt-bridges can stabilize but do not accelerate the folding of the homodimeric coiled-coil peptide GCN4-p1. J Mol Biol, 336(5), 989-96, 2004.

Kelsey, John E, Mague, Stephen D, Pijanowski, Reyna S, Harris, Ryan C, Kleckner, Nancy W, Matthews, Russell T. NMDA receptor antagonists ameliorate the stepping deficits produced by unilateral medial forebrain bundle injections of 6-OHDA in rats. Psychopharmacology (Berl), 175(2), 179-88, 2004.

Matthews, Robert A J. Inference with legal evidence: common sense is necessary, but not sufficient. Med Sci Law, 44(3), 189-92, 2004.

Matthews, Robert T, Coker, Olusegun, Winder, Danny G. A novel mouse brain slice preparation of the hippocampo-accumbens pathway. J Neurosci Methods, 137(1), 49-60, 2004.

Rojsajjakul, Teerapat, Wintrode, Patrick, Vadrevu, Ramakrishna, Robert Matthews, C, Smith, David L. Multi-state unfolding of the alpha subunit of tryptophan synthase, a TIM barrel protein: insights into the secondary structure of the stable equilibrium intermediates by hydrogen exchange mass spectrometry. J Mol Biol, 341(1), 241-53, 2004.

Simler, B Robert, Doyle, Brandon L, Matthews, C Robert. Zinc binding drives the folding and association of the homo-trimeric gamma-carbonic anhydrase from Methanosarcina thermophila. Protein Eng Des Sel, 17(3), 285-91, 2004.

Arai, Munehito, Kataoka, Mikio, Kuwajima, Kunihiro, Matthews, C Robert, Iwakura, Masahiro. Effects of the difference in the unfolded-state ensemble on the folding of Escherichia coli dihydrofolate reductase. J Mol Biol, 329(4), 779-91, 2003.

Delzell, Elizabeth, Brown, David A, Matthews, Robert. Mortality among hourly motor vehicle manufacturing workers. J Occup Environ Med, 45(8), 813-30, 2003.

Deyrup, Leif D, Matthews, Robert W. A simple technique for milking the venom of a small parasitic wasp, Melittobia digitata (Hymenoptera: Eulophidae). Toxicon, 42(2), 217-8, 2003.

Diano, Sabrina, Matthews, Russell T, Patrylo, Peter, Yang, Lichuan, Beal, M Flint, Barnstable, Colin J, Horvath, Tamas L. Uncoupling protein 2 prevents neuronal death including that occurring during seizures: a mechanism for preconditioning. Endocrinology, 144(11), 5014-21, 2003.

Horvath, Tamas L, Diano, Sabrina, Leranth, Csaba, Garcia-Segura, Luis Miguel, Cowley, Michael A, Shanabrough, Marya, Elsworth, John D, Sotonyi, Peter, Roth, Robert H, Dietrich, Edwin H, Matthews, Russel T, Barnstable, Colin J, Redmond, D Eugene. Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinson's disease. Endocrinology, 144(7), 2757-60, 2003.

Matthews, Robert. Researchers' links with biomed industry lead to bias in clinical trials. New Sci, 177(2380), 8, 2003.

Matthews, Robert A J. Homeopathic arnica. J R Soc Med, 96(4), 205-6; author reply 206-7, 2003. PMCID:539465

Svensson, Anna-Karin E, O'Neill, John C, Matthews, C Robert. The coordination of the isomerization of a conserved non-prolyl cis peptide bond with the rate-limiting steps in the folding of dihydrofolate reductase. J Mol Biol, 326(2), 569-83, 2003.

Trejo, Leonard J, Wheeler, Kevin R, Jorgensen, Charles C, Rosipal, Roman, Clanton, Sam T, Matthews, Bryan, Hibbs, Andrew D, Matthews, Robert, Krupka, Michael. Multimodal neuroelectric interface development. IEEE Trans Neural Syst Rehabil Eng, 11(2), 199-204, 2003.

Vadrevu, Ramakrishna, Falzone, Christopher J, Matthews, C Robert. Partial NMR assignments and secondary structure mapping of the isolated alpha subunit of Escherichia coli tryptophan synthase, a 29-kD TIM barrel protein. Protein Sci, 12(1), 185-91, 2003. PMCID:2312393

Viapiano, Mariano S, Matthews, Russell T, Hockfield, Susan. A novel membrane-associated glycovariant of BEHAB/brevican is up-regulated during rat brain development and in a rat model of invasive glioma. J Biol Chem, 278(35), 33239-47, 2003.

Wu, Ying, Matthews, C Robert. Proline replacements and the simplification of the complex, parallel channel folding mechanism for the alpha subunit of Trp synthase, a TIM barrel protein. J Mol Biol, 330(5), 1131-44, 2003.

C??nsoli, Fernando L, Williams, Howard J, Vinson, S Bradleigh, Matthews, Robert W, Cooperband, Miriam F. Trans-bergamotenes-male pheromone of the ectoparasitoid Melittobia digitata. J Chem Ecol, 28(8), 1675-89, 2002.

Forsyth, William R, Matthews, C Robert. Folding mechanism of indole-3-glycerol phosphate synthase from Sulfolobus solfataricus: a test of the conservation of folding mechanisms hypothesis in (beta(alpha))(8) barrels. J Mol Biol, 320(5), 1119-33, 2002.

Honda, Yasushi, Beall, Colleen, Delzell, Elizabeth, Oestenstad, Kent, Brill, Ilene, Matthews, Robert. Mortality among workers at a talc mining and milling facility. Ann Occup Hyg, 46(7), 575-85, 2002.

Knappenberger, Jane A, Smith, Jennifer E, Thorpe, Sarah H, Zitzewitz, Jill A, Matthews, C Robert. A buried polar residue in the hydrophobic interface of the coiled-coil peptide, GCN4-p1, plays a thermodynamic, not a kinetic role in folding. J Mol Biol, 321(1), 1-6, 2002.

Matthews, Robert A J. Response to Worthington on nutritional quality of organic versus conventional fruits, vegetables, and grains. J Altern Complement Med, 8(6), 695-6, 2002.

Matthews, Russell T, Kelly, Gail M, Zerillo, Cynthia A, Gray, Grace, Tiemeyer, Michael, Hockfield, Susan. Aggrecan glycoforms contribute to the molecular heterogeneity of perineuronal nets. J Neurosci, 22(17), 7536-47, 2002.

Steinbach, Peter J, Ionescu, Roxana, Matthews, C Robert. Analysis of kinetics using a hybrid maximum-entropy/nonlinear-least-squares method: application to protein folding. Biophys J, 82(4), 2244-55, 2002. PMCID:1302017

Wallace, Louise A, Matthews, C Robert. Sequential vs. parallel protein-folding mechanisms: experimental tests for complex folding reactions. Biophys Chem, 101-102, 113-31, 2002.

Wallace, Louise A, Robert Matthews, C. Highly divergent dihydrofolate reductases conserve complex folding mechanisms. J Mol Biol, 315(2), 193-211, 2002.

Winder, Danny G, Egli, Regula E, Schramm, Nicole L, Matthews, Robert T. Synaptic plasticity in drug reward circuitry. Curr Mol Med, 2(7), 667-76, 2002.

Wu, Ying, Matthews, C Robert. A cis-prolyl peptide bond isomerization dominates the folding of the alpha subunit of Trp synthase, a TIM barrel protein. J Mol Biol, 322(1), 7-13, 2002.

Wu, Ying, Matthews, C Robert. Parallel channels and rate-limiting steps in complex protein folding reactions: prolyl isomerization and the alpha subunit of Trp synthase, a TIM barrel protein. J Mol Biol, 323(2), 309-25, 2002.

Yuan, W, Matthews, R T, Sandy, J D, Gottschall, P E. Association between protease-specific proteolytic cleavage of brevican and synaptic loss in the dentate gyrus of kainate-treated rats. Neuroscience, 114(4), 1091-101, 2002.

Nutt, C L, Matthews, R T, Hockfield, S. Glial tumor invasion: a role for the upregulation and cleavage of BEHAB/brevican. Neuroscientist, 7(2), 113-22, 2001.

Knapp, J A, Morris, N P, Henderson, Z, Matthews, R T. Electrophysiological characteristics of non-bursting, glutamate decarboxylase messenger RNA-positive neurons of the medial septum/diagonal band nuclei of guinea-pig and rat. Neuroscience, 98(4), 661-8, 2000.

Matthews, R T, Gary, S C, Zerillo, C, Pratta, M, Solomon, K, Arner, E C, Hockfield, S. Brain-enriched hyaluronan binding (BEHAB)/brevican cleavage in a glioma cell line is mediated by a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family member. J Biol Chem, 275(30), 22695-703, 2000.

O'Neill, J C, Robert Matthews, C. Localized, stereochemically sensitive hydrophobic packing in an early folding intermediate of dihydrofolate reductase from Escherichia coli. J Mol Biol, 295(4), 737-44, 2000.

Klivenyi, P, Ferrante, R J, Matthews, R T, Bogdanov, M B, Klein, A M, Andreassen, O A, Mueller, G, Wermer, M, Kaddurah-Daouk, R, Beal, M F. Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis. Nat Med, 5(3), 347-50, 1999.

Matthews, R T. Neurotensin depolarizes cholinergic and a subset of non-cholinergic septal/diagonal band neurons by stimulating neurotensin-1 receptors. Neuroscience, 94(3), 775-83, 1999.

Matthews, R T, Ferrante, R J, Klivenyi, P, Yang, L, Klein, A M, Mueller, G, Kaddurah-Daouk, R, Beal, M F. Creatine and cyclocreatine attenuate MPTP neurotoxicity. Exp Neurol, 157(1), 142-9, 1999.

Matthews, R T, Klivenyi, P, Mueller, G, Yang, L, Wermer, M, Thomas, C E, Beal, M F. Novel free radical spin traps protect against malonate and MPTP neurotoxicity. Exp Neurol, 157(1), 120-6, 1999.

Beal, M F, Matthews, R T, Tieleman, A, Shults, C W. Coenzyme Q10 attenuates the 1-methyl-4-phenyl-1,2,3,tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged mice. Brain Res, 783(1), 109-14, 1998.

Keltner, J R, Wald, L L, Ledden, P J, Chen, Y C, Matthews, R T, K??estermann, E H, Baker, J R, Rosen, B R, Jenkins, B G. A localized double-quantum filter for the in vivo detection of brain glucose. Magn Reson Med, 39(4), 651-6, 1998.

Klivenyi, P, Matthews, R T, Wermer, M, Yang, L, MacGarvey, U, Becker, D A, Natero, R, Beal, M F. Azulenyl nitrone spin traps protect against MPTP neurotoxicity. Exp Neurol, 152(1), 163-6, 1998.

Matthews, R T, Yang, L, Browne, S, Baik, M, Beal, M F. Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects. Proc Natl Acad Sci U S A, 95(15), 8892-7, 1998. PMCID:21173

Matthews, R T, Yang, L, Jenkins, B G, Ferrante, R J, Rosen, B R, Kaddurah-Daouk, R, Beal, M F. Neuroprotective effects of creatine and cyclocreatine in animal models of Huntington's disease. J Neurosci, 18(1), 156-63, 1998.

Schulz, J B, Weller, M, Matthews, R T, Heneka, M T, Groscurth, P, Martinou, J C, Lommatzsch, J, von Coelln, R, W??llner, U, L??schmann, P A, Beal, M F, Dichgans, J, Klockgether, T. Extended therapeutic window for caspase inhibition and synergy with MK-801 in the treatment of cerebral histotoxic hypoxia. Cell Death Differ, 5(10), 847-57, 1998.

Yang, L, Matthews, R T, Schulz, J B, Klockgether, T, Liao, A W, Martinou, J C, Penney, J B, Hyman, B T, Beal, M F. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride neurotoxicity is attenuated in mice overexpressing Bcl-2. J Neurosci, 18(20), 8145-52, 1998.

Ayata, C, Ayata, G, Hara, H, Matthews, R T, Beal, M F, Ferrante, R J, Endres, M, Kim, A, Christie, R H, Waeber, C, Huang, P L, Hyman, B T, Moskowitz, M A. Mechanisms of reduced striatal NMDA excitotoxicity in type I nitric oxide synthase knock-out mice. J Neurosci, 17(18), 6908-17, 1997.

Beal, M F, Ferrante, R J, Browne, S E, Matthews, R T, Kowall, N W, Brown, R H. Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis. Ann Neurol, 42(4), 644-54, 1997.

Beal, M F, Matthews, R T. Coenzyme Q10 in the central nervous system and its potential usefulness in the treatment of neurodegenerative diseases. Mol Aspects Med, 18 Suppl, S169-79, 1997.

Chen, Y C, Galpern, W R, Brownell, A L, Matthews, R T, Bogdanov, M, Isacson, O, Keltner, J R, Beal, M F, Rosen, B R, Jenkins, B G. Detection of dopaminergic neurotransmitter activity using pharmacologic MRI: correlation with PET, microdialysis, and behavioral data. Magn Reson Med, 38(3), 389-98, 1997.

Fallon, J, Matthews, R T, Hyman, B T, Beal, M F. MPP+ produces progressive neuronal degeneration which is mediated by oxidative stress. Exp Neurol, 144(1), 193-8, 1997.

Ferrante, R J, Shinobu, L A, Schulz, J B, Matthews, R T, Thomas, C E, Kowall, N W, Gurney, M E, Beal, M F. Increased 3-nitrotyrosine and oxidative damage in mice with a human copper/zinc superoxide dismutase mutation. Ann Neurol, 42(3), 326-34, 1997.

Matthews, R T, Beal, M F, Fallon, J, Fedorchak, K, Huang, P L, Fishman, M C, Hyman, B T. MPP+ induced substantia nigra degeneration is attenuated in nNOS knockout mice. Neurobiol Dis, 4(2), 114-21, 1997.

Matthews, R T, Ferrante, R J, Jenkins, B G, Browne, S E, Goetz, K, Berger, S, Chen, I Y, Beal, M F. Iodoacetate produces striatal excitotoxic lesions. J Neurochem, 69(1), 285-9, 1997.

Matthews, R T, Yang, L, Beal, M F. S-Methylthiocitrulline, a neuronal nitric oxide synthase inhibitor, protects against malonate and MPTP neurotoxicity. Exp Neurol, 143(2), 282-6, 1997.

Randall, J M, Matthews, R T, Stiles, M A. Resonant frequencies of standing humans. Ergonomics, 40(9), 879-86, 1997.

Schulz, J B, Matthews, R T, Klockgether, T, Dichgans, J, Beal, M F. The role of mitochondrial dysfunction and neuronal nitric oxide in animal models of neurodegenerative diseases. Mol Cell Biochem, 174(1-2), 193-7, 1997.

Galpern, W R, Matthews, R T, Beal, M F, Isacson, O. NGF attenuates 3-nitrotyrosine formation in a 3-NP model of Huntington's disease. Neuroreport, 7(15-17), 2639-42, 1996.

Hantraye, P, Brouillet, E, Ferrante, R, Palfi, S, Dolan, R, Matthews, R T, Beal, M F. Inhibition of neuronal nitric oxide synthase prevents MPTP-induced parkinsonism in baboons. Nat Med, 2(9), 1017-21, 1996.

Kirschner, P B, Jenkins, B G, Schulz, J B, Finkelstein, S P, Matthews, R T, Rosen, B R, Beal, M F. NGF, BDNF and NT-5, but not NT-3 protect against MPP+ toxicity and oxidative stress in neonatal animals. Brain Res, 713(1-2), 178-85, 1996.

Matthews, R T, Beal, M F. Increased 3-nitrotyrosine in brains of Apo E-deficient mice. Brain Res, 718(1-2), 181-4, 1996.

Schulz, J B, Huang, P L, Matthews, R T, Passov, D, Fishman, M C, Beal, M F. Striatal malonate lesions are attenuated in neuronal nitric oxide synthase knockout mice. J Neurochem, 67(1), 430-3, 1996.

Schulz, J B, Matthews, R T, Henshaw, D R, Beal, M F. Neuroprotective strategies for treatment of lesions produced by mitochondrial toxins: implications for neurodegenerative diseases. Neuroscience, 71(4), 1043-8, 1996.

Beal, M F, Ferrante, R J, Henshaw, R, Matthews, R T, Chan, P H, Kowall, N W, Epstein, C J, Schulz, J B. 3-Nitropropionic acid neurotoxicity is attenuated in copper/zinc superoxide dismutase transgenic mice. J Neurochem, 65(2), 919-22, 1995.

Schulz, J B, Henshaw, D R, Matthews, R T, Beal, M F. Coenzyme Q10 and nicotinamide and a free radical spin trap protect against MPTP neurotoxicity. Exp Neurol, 132(2), 279-83, 1995.

Schulz, J B, Matthews, R T, Beal, M F. Role of nitric oxide in neurodegenerative diseases. Curr Opin Neurol, 8(6), 480-6, 1995.

Schulz, J B, Matthews, R T, Jenkins, B G, Brar, P, Beal, M F. Improved therapeutic window for treatment of histotoxic hypoxia with a free radical spin trap. J Cereb Blood Flow Metab, 15(6), 948-52, 1995.

Schulz, J B, Matthews, R T, Jenkins, B G, Ferrante, R J, Siwek, D, Henshaw, D R, Cipolloni, P B, Mecocci, P, Kowall, N W, Rosen, B R. Blockade of neuronal nitric oxide synthase protects against excitotoxicity in vivo. J Neurosci, 15(12), 8419-29, 1995.

Schulz, J B, Matthews, R T, Muqit, M M, Browne, S E, Beal, M F. Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice. J Neurochem, 64(2), 936-9, 1995.

Shults, C W, Matthews, R T, Altar, C A, Hill, L R, Langlais, P J. A single intramesencephalic injection of brain-derived neurotrophic factor induces persistent rotational asymmetry in rats. Exp Neurol, 125(2), 183-94, 1994.

Champney, T H, Matthews, R T. Pineal serotonin is resistant to depletion by serotonergic neurotoxins in rats. J Pineal Res, 11(3-4), 163-7, 1991.

Griffith, W H, Sim, J A, Matthews, R T. Electrophysiologic characteristics of basal forebrain neurons in vitro. Adv Exp Med Biol, 295, 143-55, 1991.

Matthews, R T, Lee, W L. A comparison of extracellular and intracellular recordings from medial septum/diagonal band neurons in vitro. Neuroscience, 42(2), 451-62, 1991.

Kelsey, J E, Aranow, J S, Matthews, R T. Context-specific morphine withdrawal in rats: duration and effects of clonidine. Behav Neurosci, 104(5), 704-10, 1990.

Peterson, S L, Olsta, S A, Matthews, R T. Cocaine enhances medial prefrontal cortex neuron response to ventral tegmental area activation. Brain Res Bull, 24(2), 267-73, 1990.

Matthews, R T, Champney, T H, Frye, G D. Effects of (+-)3,4-methylenedioxymethamphetamine (MDMA) on brain dopaminergic activity in rats. Pharmacol Biochem Behav, 33(4), 741-7, 1989.

Matthews, R T. Effects of fencamfamine on single unit activity of mesencephalic dopaminergic neurons in rats. J Neural Transm, 71(1), 45-55, 1988.

Griffith, W H, Matthews, R T. Electrophysiology of AChE-positive neurons in basal forebrain slices. Neurosci Lett, 71(2), 169-74, 1986.

Matthews, R T, German, D C. Evidence for a functional role of dopamine type-1 (D-1) receptors in the substantia nigra of rats. Eur J Pharmacol, 120(1), 87-93, 1986.

Matthews, R T, McMillen, B A, Sallis, R, Blair, D. Effects of BMY 14802, a potential antipsychotic drug, on rat brain dopaminergic function. J Pharmacol Exp Ther, 239(1), 124-31, 1986.

Matthews, R T, German, D C. Electrophysiological evidence for excitation of rat ventral tegmental area dopamine neurons by morphine. Neuroscience, 11(3), 617-25, 1984.

Matthews, R T, McMillen, B A, Speciale, S G, Jarrah, H, Shore, P A, Sanghera, M K, Shepard, P D, German, D C. Effects of zoxazolamine and related centrally acting muscle relaxants on nigrostriatal dopaminergic neurons. Brain Res Bull, 12(5), 479-86, 1984.

Matthews, R T, Shore, P A. Similar potency ratios of amphetamine optical isomers for inhibition of dopamine uptake by synaptosomes of corpus striatum, olfactory tubercle and prefrontal cortex of the rat. Biochem Pharmacol, 33(17), 2817-9, 1984.

McMillen, B A, Matthews, R T, Sanghera, M K, Shepard, P D, German, D C. Dopamine receptor antagonism by the novel antianxiety drug, buspirone. J Neurosci, 3(4), 733-8, 1983.

Matthews, R T, Chiou, C Y. Effects of diethylcholine in two animal models of Parkinsonism tremors. Eur J Pharmacol, 56(1-2), 159-62, 1979.

Matthews, R T, Chiou, C Y. Effects of acute and chronic injections of carbachol in the rat caudate nucleus. Neuropharmacology, 18(3), 291-4, 1979.

Matthews, R T, Chiou, C Y. Choline and diethylcholine transport into a cholinergic clone of neuroblastoma cells. Biochem Pharmacol, 28(3), 405-9, 1979.

Matthews, R T, Chiou, C Y. Cholinergic stimulation of the caudate nucleus in rats: a model of Parkinson's disease. Neuropharmacology, 17(10), 879-82, 1978.

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