Vanderbilt University School of Medicine

Chaturvedi, Rupesh , Ph.D.
Assistant Professor of Medicine

Lab Url: N/A

Phone Number: 3435577


Chaturvedi, Rupesh's picture

Office Address   Mailing Address

MRB4 1015B

1030C MRB IV 0252

Research Keywords
Helicobacter pylori,Polyamines,Nitric oxide,Apoptosis,Biochemistry,Cancer,Gene regulation,Genomics,Immunology,Infectious disease,Signal transduction

Chaturvedi, R, Asim, M, Barry, DP, Frye, JW, Casero, RA, Wilson, KT. Spermine oxidase is a regulator of macrophage host response to Helicobacter pylori: enhancement of antimicrobial nitric oxide generation by depletion of spermine. Amino Acids, 46(3), 531-42, 2014.

Chaturvedi, R, Asim, M, Piazuelo, MB, Yan, F, Barry, DP, Sierra, JC, Delgado, AG, Hill, S, Casero, RA, Bravo, LE, Dominguez, RL, Correa, P, Polk, DB, Washington, MK, Rose, KL, Schey, KL, Morgan, DR, Peek, RM, Wilson, KT. Activation of EGFR and ERBB2 by Helicobacter pylori Results in Survival of Gastric Epithelial Cells with DNA Damage. Gastroenterology, , , 2014.

Shi, C, Washington, MK, Chaturvedi, R, Drosos, Y, Revetta, FL, Weaver, CJ, Buzhardt, E, Yull, FE, Blackwell, TS, Sosa-Pineda, B, Whitehead, RH, Beauchamp, RD, Wilson, KT, Means, AL. Fibrogenesis in pancreatic cancer is a dynamic process regulated by macrophage-stellate cell interaction. Lab Invest, , , 2014.

Barrett, CW, Ning, W, Chen, X, Smith, JJ, Washington, MK, Hill, KE, Coburn, LA, Peek, RM, Chaturvedi, R, Wilson, KT, Burk, RF, Williams, CS. Tumor suppressor function of the plasma glutathione peroxidase gpx3 in colitis-associated carcinoma. Cancer Res, 73(3), 1245-55, 2013.

Barrett, CW, Singh, K, Motley, AK, Lintel, MK, Matafonova, E, Bradley, AM, Ning, W, Poindexter, SV, Parang, B, Reddy, VK, Chaturvedi, R, Fingleton, BM, Washington, MK, Wilson, KT, Davies, SS, Hill, KE, Burk, RF, Williams, CS. Dietary selenium deficiency exacerbates DSS-induced epithelial injury and AOM/DSS-induced tumorigenesis. PLoS One, 8(7), e67845, 2013.

Coburn, LA, Horst, SN, Chaturvedi, R, Brown, CT, Allaman, MM, Scull, BP, Singh, K, Piazuelo, MB, Chitnavis, MV, Hodges, ME, Rosen, MJ, Williams, CS, Slaughter, JC, Beaulieu, DB, Schwartz, DA, Wilson, KT. High-throughput multi-analyte luminex profiling implicates eotaxin-1 in ulcerative colitis. PLoS One, 8(12), e82300, 2013.

Gobert, AP, Verriere, T, de Sablet, T, Peek, RM, Chaturvedi, R, Wilson, KT. Haem oxygenase-1 inhibits phosphorylation of the Helicobacter pylori oncoprotein CagA in gastric epithelial cells. Cell Microbiol, 15(1), 145-56, 2013.

Hardbower, DM, de Sablet, T, Chaturvedi, R, Wilson, KT. Chronic inflammation and oxidative stress: The smoking gun for Helicobacter pylori-induced gastric cancer. Gut Microbes, 4(6), 475-481, 2013.

Noto, JM, Khizanishvili, T, Chaturvedi, R, Piazuelo, MB, Romero-Gallo, J, Delgado, AG, Khurana, SS, Sierra, JC, Krishna, US, Suarez, G, Powell, AE, Goldenring, JR, Coffey, RJ, Yang, VW, Correa, P, Mills, JC, Wilson, KT, Peek, RM. Helicobacter pylori promotes the expression of Kr??ppel-like factor 5, a mediator of carcinogenesis, in vitro and in vivo. PLoS One, 8(1), e54344, 2013.

Noto, JM, Piazuelo, MB, Chaturvedi, R, Bartel, CA, Thatcher, EJ, Delgado, A, Romero-Gallo, J, Wilson, KT, Correa, P, Patton, JG, Peek, RM. Strain-specific suppression of microRNA-320 by carcinogenic Helicobacter pylori promotes expression of the antiapoptotic protein Mcl-1. Am J Physiol Gastrointest Liver Physiol, 305(11), G786-96, 2013.

Rosen, MJ, Chaturvedi, R, Washington, MK, Kuhnhein, LA, Moore, PD, Coggeshall, SS, McDonough, EM, Weitkamp, JH, Singh, AB, Coburn, LA, Williams, CS, Yan, F, Van Kaer, L, Peebles, RS, Wilson, KT. STAT6 deficiency ameliorates severity of oxazolone colitis by decreasing expression of claudin-2 and Th2-inducing cytokines. J Immunol, 190(4), 1849-58, 2013.

Sierra, JC, Hobbs, S, Chaturvedi, R, Yan, F, Wilson, KT, Peek, RM, Polk, DB. Induction of COX-2 expression by Helicobacter pylori is mediated by activation of epidermal growth factor receptor in gastric epithelial cells. Am J Physiol Gastrointest Liver Physiol, 305(2), G196-203, 2013.

Singh, K, Coburn, LA, Barry, DP, Asim, M, Scull, BP, Allaman, MM, Lewis, ND, Washington, MK, Rosen, MJ, Williams, CS, Chaturvedi, R, Wilson, KT. Deletion of cationic amino acid transporter 2 exacerbates dextran sulfate sodium colitis and leads to an IL-17-predominant T cell response. Am J Physiol Gastrointest Liver Physiol, 305(3), G225-40, 2013.

Williams, CS, Bradley, AM, Chaturvedi, R, Singh, K, Piazuelo, MB, Chen, X, McDonough, EM, Schwartz, DA, Brown, CT, Allaman, MM, Coburn, LA, Horst, SN, Beaulieu, DB, Choksi, YA, Washington, MK, Williams, AD, Fisher, MA, Zinkel, SS, Peek, RM, Wilson, KT, Hiebert, SW. MTG16 contributes to colonic epithelial integrity in experimental colitis. Gut, 62(10), 1446-55, 2013.

Chaturvedi, R, Singh, AB. HER2 as a therapeutic target in the gastric cancer: is it sufficient. Indian J Gastroenterol, , , 2012.

Chaturvedi, R, de Sablet, T, Coburn, LA, Gobert, AP, Wilson, KT. Arginine and polyamines in Helicobacter pylori-induced immune dysregulation and gastric carcinogenesis. Amino Acids, 42(2-3), 627-40, 2012. PMCID:3237590

Chaturvedi, R, de Sablet, T, Peek, R, Wilson, K. Spermine oxidase, a polyamine catabolic enzyme that links Helicobacter pylori CagA and gastric cancer risk. Gut Microbes, 3(1), 48-56, 2012. PMCID:3344856

Coburn, LA, Gong, X, Singh, K, Asim, M, Scull, BP, Allaman, MM, Williams, CS, Rosen, MJ, Washington, MK, Barry, DP, Piazuelo, MB, Casero, RA, Chaturvedi, R, Zhao, Z, Wilson, KT. L-arginine supplementation improves responses to injury and inflammation in dextran sulfate sodium colitis. PLoS One, 7(3), e33546, 2012. PMCID:3299802

Singh, K, Coburn, LA, Barry, DP, Boucher, JL, Chaturvedi, R, Wilson, KT. L-arginine uptake by cationic amino acid transporter 2 is essential for colonic epithelial cell restitution. Am J Physiol Gastrointest Liver Physiol, 302(9), G1061-73, 2012. PMCID:3299802

Wang, L, Liu, L, Shi, Y, Cao, H, Chaturvedi, R, Calcutt, MW, Hu, T, Ren, X, Wilson, KT, Polk, DB, Yan, F. Berberine induces caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factor. PLoS One, 7(5), e36418, 2012. PMCID:3344856

Yan, F, Wang, L, Shi, Y, Cao, H, Liu, L, Washington, MK, Chaturvedi, R, Israel, DA, Cao, H, Wang, B, Peek, RM, Wilson, KT, Polk, DB. Berberine promotes recovery of colitis and inhibits inflammatory responses in colonic macrophages and epithelial cells in DSS-treated mice. Am J Physiol Gastrointest Liver Physiol, 302(5), G504-14, 2012. PMCID:3237590

Barrett, CW, Fingleton, B, Williams, A, Ning, W, Fischer, MA, Washington, MK, Chaturvedi, R, Wilson, KT, Hiebert, SW, Williams, CS. MTGR1 Is Required for Tumorigenesis in the Murine AOM/DSS Colitis-Associated Carcinoma Model. Cancer Res, 71(4), 1302-12, 2011.

Barry, DP, Asim, M, Leiman, DA, de Sablet, T, Singh, K, Casero, RA, Chaturvedi, R, Wilson, KT. Difluoromethylornithine is a novel inhibitor of Helicobacter pylori growth, CagA translocation, and interleukin-8 induction. PLoS One, 6(2), e17510, 2011. PMCID:3046249

Barry, DP, Asim, M, Scull, BP, Piazuelo, MB, de Sablet, T, Lewis, ND, Coburn, LA, Singh, K, Ellies, LG, Gobert, AP, Chaturvedi, R, Wilson, KT. Cationic amino acid transporter 2 enhances innate immunity during Helicobacter pylori infection. PLoS One, 6(12), e29046, 2011. PMCID:3237590

Chaturvedi, R, Asim, M, Romero-Gallo, J, Barry, DP, Hoge, S, de Sablet, T, Delgado, AG, Wroblewski, LE, Piazuelo, MB, Yan, F, Israel, DA, Casero, RA, Correa, P, Gobert, AP, Polk, DB, Peek, RM, Wilson, KT. Spermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagA. Gastroenterology, 141(5), 1696-708.e1-2, 2011. PMCID:3237590

Dhawan, P, Ahmad, R, Chaturvedi, R, Smith, JJ, Midha, R, Mittal, MK, Krishnan, M, Chen, X, Eschrich, S, Yeatman, TJ, Harris, RC, Washington, MK, Wilson, KT, Beauchamp, RD, Singh, AB. Claudin-2 expression increases tumorigenicity of colon cancer cells: role of epidermal growth factor receptor activation. Oncogene, , , 2011. PMCID:3046249

Gobert AP, Chaturvedi R, Wilson KT.. Methods to evaluate alterations in polyamine metabolism caused by Helicobacter pylori infection.. Methods Mol Biol, (720), 409-25, 2011.

Gobert, AP, Asim, M, Piazuelo, MB, Verriere, T, Scull, BP, de Sablet, T, Glumac, A, Lewis, ND, Correa, P, Peek, RM, Chaturvedi, R, Wilson, KT. Disruption of nitric oxide signaling by Helicobacter pylori results in enhanced inflammation by inhibition of heme oxygenase-1. J Immunol, 187(10), 5370-9, 2011. PMCID:3237590

Lewis, ND, Asim, M, Barry, DP, de Sablet, T, Singh, K, Piazuelo, MB, Gobert, AP, Chaturvedi, R, Wilson, KT. Immune Evasion by Helicobacter pylori Is Mediated by Induction of Macrophage Arginase II. J Immunol, 186(6), 3632-41, 2011.

Peng, D, Belkhiri, A, Hu, T, Chaturvedi, R, Asim, M, Wilson, KT, Zaika, A, El-Rifai, W. Glutathione peroxidase 7 protects against oxidative DNA damage in oesophageal cells. Gut, , , 2011. PMCID:3237590

Rosen, MJ, Frey, MR, Washington, MK, Chaturvedi, R, Kuhnhein, LA, Matta, P, Revetta, FL, Wilson, KT, Polk, DB. STAT6 activation in ulcerative colitis: A new target for prevention of IL-13-induced colon epithelial cell dysfunction. Inflamm Bowel Dis, , , 2011.

Yan F, Cao H, Cover TL, Washington MK, Shi Y, Liu L, Chaturvedi R, Peek RM Jr, Wilson KT, Polk DB.. Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism.. J Clin Invest, (May 23.), pii: 44031, 2011.

Yan, F, Cao, H, Cover, TL, Washington, MK, Shi, Y, Liu, L, Chaturvedi, R, Peek, RM, Wilson, KT, Polk, DB. Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism. J Clin Invest, 121(6), 2242-53, 2011. PMCID:3104743

de Sablet, T, Piazuelo, MB, Shaffer, CL, Schneider, BG, Asim, M, Chaturvedi, R, Bravo, LE, Sicinschi, LA, Delgado, AG, Mera, RM, Israel, DA, Romero-Gallo, J, Peek, RM, Cover, TL, Correa, P, Wilson, KT. Phylogeographic origin of Helicobacter pylori is a determinant of gastric cancer risk. Gut, , , 2011.

Asim, M, Chaturvedi, R, Hoge, S, Lewis, ND, Singh, K, Barry, DP, Algood, HS, de Sablet, T, Gobert, AP, Wilson, KT. Helicobacter pylori induces ERK-dependent formation of a phospho-C-FOS/C-JUN AP-1 complex that causes apoptosis in macrophages. J Biol Chem, , , 2010.

Chaturvedi, R, Asim, M, Hoge, S, Lewis, ND, Singh, K, Barry, DP, de Sablet, T, Piazuelo, MB, Sarvaria, AR, Cheng, Y, Closs, EI, Casero, RA, Gobert, AP, Wilson, KT. Polyamines Impair Immunity to Helicobacter pylori by Inhibiting L-Arginine Uptake Required for Nitric Oxide Production. Gastroenterology, , , 2010.

Ghoshal, UC, Chaturvedi, R, Correa, P. The enigma of Helicobacter pylori infection and gastric cancer. Indian J Gastroenterol, , , 2010.

Goettel, JA, Algood, HM, Olivares-Villag??mez, D, Washington, MK, Chaturvedi, R, Wilson, KT, Kaer, LV, Polk, DB. KSR1 Protects From Interleukin-10 Deficiency-Induced Colitis in Mice by Suppressing T-Lymphocyte Interferon-I? Production. Gastroenterology, , , 2010.

Hong, SK, Chaturvedi, R, Piazuelo, MB, Coburn, LA, Williams, CS, Delgado, AG, Casero, RA, Schwartz, DA, Wilson, KT. Increased expression and cellular localization of spermine oxidase in ulcerative colitis and relationship to disease activity. Inflamm Bowel Dis, , , 2010.

Hong, SK, Maltz, BE, Coburn, LA, Slaughter, JC, Chaturvedi, R, Schwartz, DA, Wilson, KT. Increased serum levels of L-arginine in ulcerative colitis and correlation with disease severity. Inflamm Bowel Dis, 16(1), 105-11, 2010. PMCID:2795785

Lewis, ND, Asim, M, Barry, DP, Singh, K, de Sablet, T, Boucher, JL, Gobert, AP, Chaturvedi, R, Wilson, KT. Arginase II restricts host defense to Helicobacter pylori by attenuating inducible nitric oxide synthase translation in macrophages. J Immunol, 184(5), 2572-82, 2010. PMCID:2841360

Ogden, SR, Noto, JM, Allen, SS, Patel, DA, Romero-Gallo, J, Washington, MK, Fingleton, B, Israel, DA, Lewis, ND, Wilson, KT, Chaturvedi, R, Zhao, Z, Shyr, Y, Peek, RM. Matrix metalloproteinase-7 and premalignant host responses in Helicobacter pylori-infected mice. Cancer Res, 70(1), 30-5, 2010. PMCID:2841360

Singh, K, Chaturvedi, R, Barry, DP, Coburn, LA, Asim, M, Lewis, ND, Piazuelo, MB, Washington, MK, Vitek, MP, Wilson, KT. The apolipoprotein E-mimetic peptide COG112 inhibits NF-{kappa}B signaling, proinflammatory cytokine expression, and disease activity in murine models of colitis. J Biol Chem, , , 2010.

Yan, F, Cao, H, Chaturvedi, R, Krishna, U, Hobbs, SS, Dempsey, PJ, Peek, RM, Cover, TL, Washington, MK, Wilson, KT, Polk, DB. Epidermal growth factor receptor activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis. Gastroenterology, 136(4), 1297-1307, e1-3, 2009.

O''Brien, DP, Romero-Gallo, J, Schneider, BG, Chaturvedi, R, Delgado, A, Harris, EJ, Krishna, U, Ogden, SR, Israel, DA, Wilson, KT, Peek, RM. Regulation of the Helicobacter pylori cellular receptor decay-accelerating factor. J Biol Chem, , , 2008. PMCID:2527108

Singh, K, Chaturvedi, R, Asim, M, Barry, DP, Lewis, ND, Vitek, MP, Wilson, KT. The apolipoprotein E-mimetic peptide COG112 inhibits the inflammatory response to citrobacter rodentium in colonic epithelial cells by preventing NF-kappa B activation. J Biol Chem, , , 2008. PMCID:2423260

Chaturvedi, R, Asim, M, Lewis, ND, Algood, HM, Cover, TL, Kim, PY, Wilson, KT. L-arginine availability regulates inducible nitric oxide synthase-dependent host defense against Helicobacter pylori. Infect Immun, 75(9), 4305-15, 2007. PMCID:1951193

Bussiere, FI, Chaturvedi, R, Asim, M, Hoek, KL, Cheng, Y, Gainor, J, Scholz, A, Khan, WN, Wilson, KT. Low multiplicity of infection of Helicobacter pylori suppresses apoptosis of B lymphocytes. Cancer Res, 66(13), 6834-42, 2006.

Bussi??re, FI, Chaturvedi, R, Cheng, Y, Gobert, AP, Asim, M, Blumberg, DR, Xu, H, Kim, PY, Hacker, A, Casero, RA, Wilson, KT. Spermine causes loss of innate immune response to Helicobacter pylori by inhibition of inducible nitric-oxide synthase translation. J Biol Chem, 280(4), 2409-12, 2005.

Chaturvedi, R, Srivastava, RK, Hisatsune, A, Shankar, S, Lillehoj, EP, Kim, KC. Augmentation of Fas ligand-induced apoptosis by MUC1 mucin. Int J Oncol, 26(5), 1169-76, 2005.

Cheng, Y, Chaturvedi, R, Asim, M, Bussi??re, FI, Scholz, A, Xu, H, Casero, RA, Wilson, KT. Helicobacter pylori-induced macrophage apoptosis requires activation of ornithine decarboxylase by c-Myc. J Biol Chem, 280(23), 22492-6, 2005.

Chaturvedi, R, Cheng, Y, Asim, M, Bussi??re, FI, Xu, H, Gobert, AP, Hacker, A, Casero, RA, Wilson, KT. Induction of polyamine oxidase 1 by Helicobacter pylori causes macrophage apoptosis by hydrogen peroxide release and mitochondrial membrane depolarization. J Biol Chem, 279(38), 40161-73, 2004.

Gobert, AP, Cheng, Y, Akhtar, M, Mersey, BD, Blumberg, DR, Cross, RK, Chaturvedi, R, Drachenberg, CB, Boucher, JL, Hacker, A, Casero, RA, Wilson, KT. Protective role of arginase in a mouse model of colitis. J Immunol, 173(3), 2109-17, 2004.

Xu, H, Chaturvedi, R, Cheng, Y, Bussiere, FI, Asim, M, Yao, MD, Potosky, D, Meltzer, SJ, Rhee, JG, Kim, SS, Moss, SF, Hacker, A, Wang, Y, Casero, RA, Wilson, KT. Spermine oxidation induced by Helicobacter pylori results in apoptosis and DNA damage: implications for gastric carcinogenesis. Cancer Res, 64(23), 8521-5, 2004.

Tripathi, AK, Chaturvedi, R, Ahmad, R, Asim, M, Sawlani, KK, Singh, MK, Tripathi, P, Tekwani, BL. Flow cytometric analysis of aneuploidy and S-phase fraction in chronic myeloid leukemia patients: role in early detection of accelerated phase. Leuk Res, 27(10), 899-902, 2003.

Tripathi, AK, Chaturvedi, R, Ahmad, R, Asim, M, Sawlani, KK, Singh, RL, Tekwani, BL. Peripheral blood leucocytes ornithine decarboxylase activity in chronic myeloid leukemia patients: prognostic and therapeutic implications. Leuk Res, 26(4), 349-54, 2002.

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