Vanderbilt University School of Medicine

Sahasrabuddhe, Vikrant V. , M.B.B.S., M.P.H., Dr.P.H.
Research Associate Professor of Medicine

Lab Url: N/A

Phone Number: +1-240-276-7332

Email Address:vikrant.sahasrabuddhe@vanderbilt.edu

Sahasrabuddhe, Vikrant's picture

Office Address   Mailing Address

Currently serving as Senior Biomedical Scientist-Intergovernmental Personnel Act Mobility Program detailee in the Division of Cancer Prevention, National Cancer Institute (NCI), National Institutes of Health (NIH)

NCI/NIH address: 9609 Medical Center Drive, 5E-338, Bethesda, Maryland 20892-9783 (for US Postal Service delivery) Rockville, Maryland 20850 (for non-USPS courier delivery and campus visits)


Research Keywords
Cancer Epidemiology, Cancer Prevention, Infection-associated Cancers, Cervical Cancer, HPV, Anogenital Cancers, Hepatobiliary Cancers, Global Health

Clinical Research Description
Dr. Vikrant Sahasrabuddhe is a clinical epidemiologist and cancer prevention researcher who received his medical degree from the University of Pune in India, his master's and doctorate degrees in public health from the University of Alabama at Birmingham, and completed fellowship training in epidemiology at the Johns Hopkins University Bloomberg School of Public Health and at the National Cancer Institute. Dr. Sahasrabuddhe has served on the faculty at the Vanderbilt University School of Medicine since 2005, and is currently based as a Senior Biomedical Scientist-Intergovernmental Personnel Act Mobility Program detailee in the Division of Cancer Prevention at the National Cancer Institute, National Institutes of Health.

Dr. Sahasrabuddhe has conducted both clinic-based and population-based research on infection-associated cervical, anogenital, and hepatobiliary cancers with high or rising incidence and mortality burden. As Program Director of the Vanderbilt Institute for Global Health's HIV-Cervical Cancer Prevention Program, he has spearheaded clinical and public health efforts for the development, implementation, and evaluation of cervical cancer prevention interventions in global resource constrained settings, through collaborative research, training, and service initiatives.

Dr. Sahasrabuddhe's published works and research interests encompass a broad spectrum of clinical and translational research areas related to cancer prevention, including the evaluation of novel and low-cost cervical cancer screening approaches (visual imaging methods and HPV-based biomarkers), optimizing dosing and delivery of HPV vaccination, evaluating the repurposing of commonly-used medications for cancer prevention indications, measuring the effectiveness of scaling-up of cervical cancer prevention implementation programs, and demonstrating synergies in the horizontal integration of vertical public health initiatives.

Dr. Sahasrabuddhe led the initial development, and continues to advise the Cervical Cancer Prevention Program in Zambia-African Center of Excellence for Women's Cancer Control, the largest such program implementation initiative in sub-Saharan Africa. He serves as Protocol Co-Vice Chair of a NIH-funded multi-country randomized clinical trial evaluating a 'test-and-treat' approach for cervical cancer prevention in high-risk HIV-infected women in India, South Africa, Malawi, Botswana, Zimbabwe, Haiti, and Peru. In addition, he has collaborated on, and advised graduate and postdoctoral trainee-led research studies in India, Zambia, China, Thailand, and Tanzania.

Publications
Kreimer, AR, Sherman, ME, Sahasrabuddhe, VV, Safaeian, M. The case for conducting a randomized clinical trial to assess the efficacy of a single dose of prophylactic HPV vaccines among adolescents. J Natl Cancer Inst, 107(3), dju436, 2015.

McGlynn, KA, Hagberg, K, Chen, J, Graubard, BI, London, WT, Jick, S, Sahasrabuddhe, VV. Statin use and risk of primary liver cancer in the clinical practice research datalink. J Natl Cancer Inst, 107(4), djv009, 2015.

McGlynn, KA, Sahasrabuddhe, VV, Campbell, PT, Graubard, BI, Chen, J, Schwartz, LM, Petrick, JL, Alavanja, MC, Andreotti, G, Boggs, DA, Buring, JE, Chan, AT, Freedman, ND, Gapstur, SM, Hollenbeck, AR, Hou, L, King, LY, Koshiol, J, Linet, M, Palmer, JR, Poynter, JN, Purdue, M, Robien, K, Schairer, C, Sesso, HD, Sigurdson, A, Wactawski-Wende, J, Zeleniuch-Jacquotte, A. Reproductive factors, exogenous hormone use and risk of hepatocellular carcinoma among US women: results from the Liver Cancer Pooling Project. Br J Cancer, (/), Epub ahead of print, 2015.

Parham, GP, Mwanahamuntu, MH, Kapambwe, S, Muwonge, R, Bateman, AC, Blevins, M, Chibwesha, CJ, Pfaendler, KS, Mudenda, V, Shibemba, AL, Chisele, S, Mkumba, G, Vwalika, B, Hicks, ML, Vermund, SH, Chi, BH, Stringer, JS, Sankaranarayanan, R, Sahasrabuddhe, VV. Population-Level Scale-Up of Cervical Cancer Prevention Services in a Low-Resource Setting: Development, Implementation, and Evaluation of the Cervical Cancer Prevention Program in Zambia. PLoS One, 10(4), e0122169, 2015.

Bateman, AC, Parham, GP, Sahasrabuddhe, VV, Mwanahamuntu, MH, Kapambwe, S, Katundu, K, Nkole, T, Mulundika, J, Pfaendler, KS, Hicks, ML, Shibemba, A, Vermund, SH, Stringer, JS, Chibwesha, CJ. Clinical performance of digital cervicography and cytology for cervical cancer screening in HIV-infected women in Lusaka, Zambia. J Acquir Immune Defic Syndr, 67(2), 212-5, 2014.

Hagberg, KW, McGlynn, KA, Sahasrabuddhe, VV, Jick, S. Anti-diabetic medications and risk of primary liver cancer in persons with type II diabetes. Br J Cancer, 111(9), 1710-7, 2014.

McGlynn, KA, Divine, GW, Sahasrabuddhe, VV, Engel, LS, VanSlooten, A, Wells, K, Yood, MU, Alford, SH. Statin use and risk of hepatocellular carcinoma in a U.S. population. Cancer Epidemiol, 38(5), 523-7, 2014.

Mwanahamuntu, MH, Sahasrabuddhe, VV, Blevins, M, Kapambwe, S, Shepherd, BE, Chibwesha, C, Pfaendler, KS, Mkumba, G, Vwalika, B, Hicks, ML, Vermund, SH, Stringer, JS, Parham, GP. Monitoring the performance of 'screen-and-treat' cervical cancer prevention programs. Int J Gynaecol Obstet, 126(1), 88-9, 2014.

Sahasrabuddhe, VV, Gravitt, PE, Dunn, ST, Brown, D, Allen, RA, Eby, YJ, Smith, K, Zuna, RE, Zhang, RR, Gold, MA, Schiffman, M, Walker, JL, Castle, PE, Wentzensen, N. Comparison of human papillomavirus detections in urine, vulvar, and cervical samples from women attending a colposcopy clinic. J Clin Microbiol, 52(1), 187-92, 2014.

Sahasrabuddhe, VV, Gravitt, PE, Dunn, ST, Robbins, D, Brown, D, Allen, RA, Eby, YJ, Smith, KM, Zuna, RE, Zhang, RR, Gold, MA, Schiffman, M, Walker, JL, Castle, PE, Wentzensen, N. Evaluation of clinical performance of a novel urine-based HPV detection assay among women attending a colposcopy clinic. J Clin Virol, 60(4), 414-7, 2014.

Wentzensen, N, Follansbee, S, Borgonovo, S, Tokugawa, D, Sahasrabuddhe, VV, Chen, J, Lorey, TS, Gage, JC, Fetterman, B, Boyle, S, Sadorra, M, Tang, SD, Darragh, TM, Castle, PE. Analytic and clinical performance of cobas HPV testing in anal specimens from HIV-positive men who have sex with men. J Clin Microbiol, 52(8), 2892-7, 2014.

Wilson, L, Pawlita, M, Castle, PE, Waterboer, T, Sahasrabuddhe, V, Gravitt, PE, Schiffman, M, Wentzensen, N. Seroprevalence of 8 oncogenic human papillomavirus genotypes and acquired immunity against reinfection. J Infect Dis, 210(3), 448-55, 2014.

Zhang, HY, Fei, MD, Jiang, Y, Fei, QY, Qian, H, Xu, L, Jin, YN, Jiang, CQ, Li, HX, Tiggelaar, SM, Smith, JS, Sahasrabuddhe, VV, Qiao, YL. The diversity of human papillomavirus infection among human immunodeficiency virus-infected women in Yunnan, China. Virol J, 11(1), 202, 2014.

Chen, Z, Schiffman, M, Herrero, R, DeSalle, R, Anastos, K, Segondy, M, Sahasrabuddhe, VV, Gravitt, PE, Hsing, AW, Burk, RD. Evolution and taxonomic classification of alphapapillomavirus 7 complete genomes: HPV18, HPV39, HPV45, HPV59, HPV68 and HPV70. PLoS One, 8(8), e72565, 2013.

De Vuyst, H, Alemany, L, Lacey, C, Chibwesha, CJ, Sahasrabuddhe, V, Banura, C, Denny, L, Parham, GP. The burden of human papillomavirus infections and related diseases in sub-saharan Africa. Vaccine, 31 Suppl 5, F32-46, 2013.

Godfrey, CC, Michelow, PM, Godard, M, Sahasrabuddhe, VV, Darden, J, Firnhaber, CS, Wetherall, NT, Bremer, J, Coombs, RW, Wilkin, T, , . Improving diagnostic capability for HPV disease internationally within the NIH-NIAID Division of AIDS Clinical Trial Networks. Am J Clin Pathol, 140(6), 881-9, 2013.

Mwanahamuntu, MH, Sahasrabuddhe, VV, Blevins, M, Kapambwe, S, Shepherd, BE, Chibwesha, C, Pfaendler, KS, Mkumba, G, Vwalika, B, Hicks, ML, Vermund, SH, Stringer, JS, Parham, GP. Utilization of cervical cancer screening services and trends in screening positivity rates in a ''screen-and-treat'' program integrated with HIV/AIDS care in Zambia. PLoS One, 8(9), e74607, 2013.

Sahasrabuddhe, VV, Castle, PE, Follansbee, S, Borgonovo, S, Tokugawa, D, Schwartz, LM, Lorey, TS, LaMere, BJ, Gage, JC, Fetterman, B, Boyle, S, Sadorra, M, Tang, SD, Darragh, TM, Wentzensen, N. Human papillomavirus genotype attribution and estimation of preventable fraction of anal intraepithelial neoplasia cases among HIV-infected men who have sex with men. J Infect Dis, 207(3), 392-401, 2013.

Sahasrabuddhe, VV, Gunja, MZ, Graubard, BI, Trabert, B, Schwartz, LM, Park, Y, Hollenbeck, AR, Freedman, ND, McGlynn, KA. Response. J Natl Cancer Inst, 105(9), 668- 71, 2013.

Schwartz, LM, Castle, PE, Follansbee, S, Borgonovo, S, Fetterman, B, Tokugawa, D, Lorey, TS, Sahasrabuddhe, VV, Luhn, P, Gage, JC, Darragh, TM, Wentzensen, N. Risk factors for anal HPV infection and anal precancer in HIV-infected men who have sex with men. J Infect Dis, 208(11), 1768-75, 2013.

Wilson, LE, Pawlita, M, Castle, PE, Waterboer, T, Sahasrabuddhe, V, Gravitt, PE, Schiffman, M, Wentzensen, N. Natural immune responses against eight oncogenic human papillomaviruses in the ASCUS-LSIL Triage Study. Int J Cancer, 133(9), 2172-81, 2013.

Brinton, LA, Sahasrabuddhe, VV, Scoccia, B. Fertility drugs and the risk of breast and gynecologic cancers. Semin Reprod Med, 30(2), 131-45, 2012.

Mane, A, Nirmalkar, A, Risbud, AR, Vermund, SH, Mehendale, SM, Sahasrabuddhe, VV. HPV genotype distribution in cervical intraepithelial neoplasia among HIV-infected women in Pune, India. PLoS One, 7(6), e38731, 2012.

Sahasrabuddhe, VV, Bhosale, RA, Kavatkar, AN, Nagwanshi, CA, Joshi, SN, Jenkins, CA, Shepherd, BE, Kelkar, RS, Sahay, S, Risbud, AR, Vermund, SH, Mehendale, SM. Comparison of visual inspection with acetic acid and cervical cytology to detect high-grade cervical neoplasia among HIV-infected women in India. Int J Cancer, 130(1), 234-40, 2012.

Sahasrabuddhe, VV, Gunja, MZ, Graubard, BI, Trabert, B, Schwartz, LM, Park, Y, Hollenbeck, AR, Freedman, ND, McGlynn, KA. Nonsteroidal anti-inflammatory drug use, chronic liver disease, and hepatocellular carcinoma. J Natl Cancer Inst, 104(23), 1808-14, 2012.

Sahasrabuddhe, VV, Parham, GP, Mwanahamuntu, MH, Vermund, SH. Cervical cancer prevention in low- and middle-income countries: feasible, affordable, essential. Cancer Prev Res (Phila), 5(1), 11-7, 2012.

Sahasrabuddhe, VV, Sherman, ME. Human papillomavirus vaccines for cervical cancer prevention: translating possibility into reality. J Natl Cancer Inst, 104(22), 1698-701, 2012.

Sahasrabuddhe, VV, Shiels, MS, McGlynn, KA, Engels, EA. The risk of hepatocellular carcinoma among individuals with acquired immunodeficiency syndrome in the United States. Cancer, 118(24), 6226-33, 2012.

Wentzensen, N, Follansbee, S, Borgonovo, S, Tokugawa, D, Schwartz, L, Lorey, TS, Sahasrabuddhe, VV, Lamere, B, Gage, JC, Fetterman, B, Darragh, TM, Castle, PE. Human papillomavirus genotyping, human papillomavirus mRNA expression, and p16/Ki-67 cytology to detect anal cancer precursors in HIV-infected MSM. AIDS, 26(17), 2185-92, 2012.

Zhang, HY, Tiggelaar, SM, Sahasrabuddhe, VV, Smith, JS, Jiang, CQ, Mei, RB, Wang, XG, Li, ZA, Qiao, YL. HPV prevalence and cervical intraepithelial neoplasia among HIV-infected women in Yunnan Province, China: a pilot study. Asian Pac J Cancer Prev, 13(1), 91-6, 2012.

Chen, Z, Schiffman, M, Herrero, R, Desalle, R, Anastos, K, Segondy, M, Sahasrabuddhe, VV, Gravitt, PE, Hsing, AW, Burk, RD. Evolution and taxonomic classification of human papillomavirus 16 (HPV16)-related variant genomes: HPV31, HPV33, HPV35, HPV52, HPV58 and HPV67. PLoS One, 6(5), e20183, 2011.

Mwanahamuntu, MH, Sahasrabuddhe, VV, Kapambwe, S, Pfaendler, KS, Chibwesha, C, Mkumba, G, Mudenda, V, Hicks, ML, Vermund, SH, Stringer, JS, Parham, GP. Advancing cervical cancer prevention initiatives in resource-constrained settings: insights from the Cervical Cancer Prevention Program in Zambia. PLoS Med, 8(5), e1001032, 2011.

Sahasrabuddhe, VV, Luhn, P, Wentzensen, N. Human papillomavirus and cervical cancer: biomarkers for improved prevention efforts. Future Microbiol, 6(9), 1083-98, 2011.

Bratcher, LF, Sahasrabuddhe, VV. The impact of antiretroviral therapy on HPV and cervical intraepithelial neoplasia: current evidence and directions for future research. Infect Agent Cancer, 5, 8, 2010.

Chirwa, S, Mwanahamuntu, M, Kapambwe, S, Mkumba, G, Stringer, J, Sahasrabuddhe, V, Pfaendler, K, Parham, G. Myths and misconceptions about cervical cancer among Zambian women: rapid assessment by peer educators. Glob Health Promot, 17(2 Suppl), 47-50, 2010.

Parham, GP, Mwanahamuntu, MH, Pfaendler, KS, Sahasrabuddhe, VV, Myung, D, Mkumba, G, Kapambwe, S, Mwanza, B, Chibwesha, C, Hicks, ML, Stringer, JS. eC3--a modern telecommunications matrix for cervical cancer prevention in Zambia. J Low Genit Tract Dis, 14(3), 167-73, 2010.

Parham, GP, Mwanahamuntu, MH, Sahasrabuddhe, VV, Westfall, AO, King, KE, Chibwesha, C, Pfaendler, KS, Mkumba, G, Mudenda, V, Kapambwe, S, Vermund, SH, Hicks, ML, Stringer, JS, Chi, BH. Implementation of cervical cancer prevention services for HIV-infected women in Zambia: measuring program effectiveness. HIV Ther, 4(6), 703-722, 2010.

Sahasrabuddhe, VV, Bhosale, RA, Joshi, SN, Kavatkar, AN, Nagwanshi, CA, Kelkar, RS, Jenkins, CA, Shepherd, BE, Sahay, S, Risbud, AR, Vermund, SH, Mehendale, SM. Prevalence and predictors of colposcopic-histopathologically confirmed cervical intraepithelial neoplasia in HIV-infected women in India. PLoS One, 5(1), e8634, 2010.

Li, AH, Phanuphak, N, Sahasrabuddhe, VV, Chaithongwongwatthana, S, Vermund, SH, Jenkins, CA, Shepherd, BE, Teeratakulpisarn, N, van der Lugt, J, Avihingsanon, A, Ruxrungtham, K, Shikuma, C, Phanuphak, P, Ananworanich, J. Anal squamous intraepithelial lesions among HIV positive and HIV negative men who have sex with men in Thailand. Sex Transm Infect, 85(7), 503-7, 2009.

Mwanahamuntu, MH, Sahasrabuddhe, VV, Parham, GP. HPV screening for cervical cancer in rural India. N Engl J Med, 361(3), 305; author reply 306, 2009.

Mwanahamuntu, MH, Sahasrabuddhe, VV, Pfaendler, KS, Mudenda, V, Hicks, ML, Vermund, SH, Stringer, JS, Parham, GP. Implementation of ''see-and-treat'' cervical cancer prevention services linked to HIV care in Zambia. AIDS, 23(6), N1-5, 2009.

Sahasrabuddhe VV, Vermund SH. Current And Future Trends: Implications For HIV Prevention. Book Chapter in Mayer KH, Pizer HF (editors) , , , 2009.

Joshi, SN, Das, S, Thakar, M, Sahasrabuddhe, V, Kumar, BK, Callahan, M, Mauck, C. Colposcopically observed vascular changes in the cervix in relation to the hormonal levels and menstrual cycle. J Low Genit Tract Dis, 12(4), 293-9, 2008.

Mwanahamuntu, MH, Sahasrabuddhe, VV, Stringer, JS, Parham, GP. Integrating cervical cancer prevention in HIV/AIDS treatment and care programmes. Bull World Health Organ, 86(8), D-E, 2008.

Parham GP, Mwanahamuntu MH, Pfaendler KS, Mkumba G, Sahasrabuddhe VV, Hicks ML, Welty E, Stringer JS. Building a cervical cancer prevention program on an HIV care and treatment infrastructure in Zambia. Book chapter in Marlink RG, Teitelman SJ (editors) , , , 2008.

Pfaendler, KS, Mwanahamuntu, MH, Sahasrabuddhe, VV, Mudenda, V, Stringer, JS, Parham, GP. Management of cryotherapy-ineligible women in a "screen-and-treat" cervical cancer prevention program targeting HIV-infected women in Zambia: lessons from the field. Gynecol Oncol, 110(3), 402-7, 2008.

Sahasrabuddhe VV, Tharpe LE, Allen KL, Vermund SH. Public health interventions to prevent HIV: treatment of sexually transmitted infections and adult male circumcision. Book chapter in Marlink RG, Teitelman SJ (editors) , (/), , 2008.

Vermund, SH, Sahasrabuddhe, VV, Khedkar, S, Jia, Y, Etherington, C, Vergara, A. Building global health through a center-without-walls: the Vanderbilt Institute for Global Health. Acad Med, 83(2), 154-64, 2008.

Vikrant Sahasrabuddhe and Sanjay Mehendale . Female sex workers and the HIV/AIDS Epidemic in India. Book chapter in Sahni R, Kalyan Shankar V, Apte H (editors) , , , 2008.

Sahasrabuddhe, VV, Mwanahamuntu, MH, Vermund, SH, Huh, WK, Lyon, MD, Stringer, JS, Parham, GP. Prevalence and distribution of HPV genotypes among HIV-infected women in Zambia. Br J Cancer, 96(9), 1480-3, 2007.

Sahasrabuddhe, VV, Vermund, SH. The future of HIV prevention: control of sexually transmitted infections and circumcision interventions. Infect Dis Clin North Am, 21(1), 241-57, xi, 2007.

Parham, GP, Sahasrabuddhe, VV, Mwanahamuntu, MH, Shepherd, BE, Hicks, ML, Stringer, EM, Vermund, SH. Prevalence and predictors of squamous intraepithelial lesions of the cervix in HIV-infected women in Lusaka, Zambia. Gynecol Oncol, 103(3), 1017-22, 2006.

Sahasrabuddhe, V, Makhija, S. Double jeopardy: HIV and cervical cancer in Indian women. Int J Gynecol Cancer, 15(1), 1-3, 2005.

Sahasrabuddhe, VV, Gholap, TA, Jethava, YS, Joglekar, NS, Brahme, RG, Gaikwad, BA, Wankhede, AK, Mehendale, SM. Patient-led partner referral in a district hospital based STD clinic. J Postgrad Med, 48(2), 105-8, 2002.


Postdoctoral Position Available
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Postdoctoral Position Details
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Updated Date
03/24/2015



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