Vanderbilt University School of Medicine

Wallace, Mark T. , Ph.D.
Director Vanderbilt Brain Institute
Professor of Hearing and Speech Sciences
Professor of Psychology
Professor of Psychiatry

Lab Url: http://kc.vanderbilt.edu/multisensory/index.html

Phone Number: (615) 936-6709

Email Address:mark.wallace@vanderbilt.edu

Wallace, Mark's picture

Office Address   Mailing Address

7110 & 7118 MRB III

BWC 8310 MCE ST Vanderbilt Bill Wilkerson Ctr 8242


Research Keywords
dyslexia, neurobiology, brain, vision, hearing, touch

Research Specialty
Multisensory processing, sensorimotor transformations, perception, dyslexia

Research Description
Multisensory processing, sensorimotor transformations, perception, dyslexia

Our lab is interested in better understanding how the brain synthesizes information from multiple sensory systems (e.g., vision, hearing, touch). Given that we are continually bombarded with sensory information, it seems intuitively obvious that one important brain function is to synthesize this multisensory information. Such multisensory integration enhances our ability to react to external events, as well as enriching our perception of those events and of the world. Nonetheless, despite the ubiquity and utility of multisensory processes, surprisingly little is known about their neural bases when compared with the individual sensory systems that contribute to them. Using a multidisciplinary approach, our lab seeks to fill this knowledge gap. A sampling of the techniques in use in the lab includes: animal behavior, neurophysiological recordings from single neurons and ensembles of neurons, neuroanatomical tract tracing, human psychophysics and fMRI. Currently, we are pursuing a number of questions related to multisensory processes. These include: (1) the development of cortical multisensory circuits, (2) developmental and adult plasticity in these circuits, (3) how multisensory signals are transformed into appropriate motor commands, (4) multisensory influences on normal human perception and performance, and (5) how abnormal multisensory processing may contribute to certain neurodevelopmental disabilities (e.g., dyslexia).

**** Inquiries from potential graduate students are welcome and encouraged****

For more information, see http://www.mc.vanderbilt.edu/reporter/?ID=4193.

Publications
Lovelace CT, Stein BE and Wallace MT.. An irrelevant light enhances auditory detection in humans: A psychophysical analysis of multisensory integration in stimulus detection.. Cogn. Brain Res, 17, 447-453, .

Krueger, J, Royal, DW, Fister, MC, Wallace, MT. Spatial receptive field organization of multisensory neurons and its impact on multisensory interactions. Hear Res, 258(1-2), 47-54, 2009.

Polley, DB, Hillock, AR, Spankovich, C, Popescu, MV, Royal, DW, Wallace, MT. Development and plasticity of intra- and intersensory information processing. J Am Acad Audiol, 19(10), 780-98, 2009.

Powers, AR, Hillock, AR, Wallace, MT. Perceptual training narrows the temporal window of multisensory binding. J Neurosci, 29(39), 12265-74, 2009. PMCID:2771316

Royal, DW, Carriere, BN, Wallace, MT. Spatiotemporal architecture of cortical receptive fields and its impact on multisensory interactions. Exp Brain Res, 198(2-3), 127-36, 2009.

Wallace, MT. Dyslexia: bridging the gap between hearing and reading. Curr Biol, 19(6), R260-2, 2009.

Carriere, BN, Royal, DW, Wallace, MT. Spatial heterogeneity of cortical receptive fields and its impact on multisensory interactions. J Neurophysiol, 99(5), 2357-68, 2008.

Carriere, B, Royal, DW, Perrault, TJ, Morrison, SP, Vaughan, JW, Stein, BE, Wallace, MT. Visual Deprivation Alters the Development of Cortical Multisensory Integration. J Neurophysiol, , , 2007.

Wallace, MT, Stein, BE. Early experience determines how the senses will interact. J Neurophysiol, 97(1), 921-6, 2007.

Wallace, MT, Carriere, BN, Perrault, TJ, Vaughan, JW, Stein, BE. The development of cortical multisensory integration. J Neurosci, 26(46), 11844-9, 2006.

Hairston, W David, Burdette, Jonathan H, Flowers, D Lynn, Wood, Frank B, Wallace, Mark T. Altered temporal profile of visual-auditory multisensory interactions in dyslexia. Exp Brain Res, 166(3-4), 474-80, 2005.

Laurienti, Paul J, Burdette, Jonathan H, Maldjian, Joseph A, Wallace, Mark T. Enhanced multisensory integration in older adults. Neurobiol Aging, , , 2005.

Laurienti, Paul J, Perrault, Thomas J, Stanford, Terrence R, Wallace, Mark T, Stein, Barry E. On the use of superadditivity as a metric for characterizing multisensory integration in functional neuroimaging studies. Exp Brain Res, 166(3-4), 289-97, 2005.

Perrault, Thomas J, Vaughan, J William, Stein, Barry E, Wallace, Mark T. Superior colliculus neurons use distinct operational modes in the integration of multisensory stimuli. J Neurophysiol, 93(5), 2575-86, 2005.

Burnett, L R, Stein, B E, Chaponis, D, Wallace, M T. Superior colliculus lesions preferentially disrupt multisensory orientation. Neuroscience, 124(3), 535-47, 2004.

Laurienti, Paul J, Kraft, Robert A, Maldjian, Joseph A, Burdette, Jonathan H, Wallace, Mark T. Semantic congruence is a critical factor in multisensory behavioral performance. Exp Brain Res, 158(4), 405-14, 2004.

Wallace MT.. The development of multisensory processes. . Cogn. Processing, 5, 69-83, 2004.

Wallace, M T, Roberson, G E, Hairston, W D, Stein, B E, Vaughan, J W, Schirillo, J A. Unifying multisensory signals across time and space. Exp Brain Res, 158(2), 252-8, 2004.

Wallace, Mark T, Perrault, Thomas J, Hairston, W David, Stein, Barry E. Visual experience is necessary for the development of multisensory integration. J Neurosci, 24(43), 9580-4, 2004.

Wallace, Mark T, Ramachandran, Ramnarayan, Stein, Barry E. A revised view of sensory cortical parcellation. Proc Natl Acad Sci U S A, 101(7), 2167-72, 2004. PMCID:357070

Hairston, W D, Wallace, M T, Vaughan, J W, Stein, B E, Norris, J L, Schirillo, J A. Visual localization ability influences cross-modal bias. J Cogn Neurosci, 15(1), 20-9, 2003.

Hairston, W David, Laurienti, Paul J, Mishra, Gautam, Burdette, Jonathan H, Wallace, Mark T. Multisensory enhancement of localization under conditions of induced myopia. Exp Brain Res, 152(3), 404-8, 2003.

Laurienti, Paul J, Wallace, Mark T, Maldjian, Joseph A, Susi, Christina M, Stein, Barry E, Burdette, Jonathan H. Cross-modal sensory processing in the anterior cingulate and medial prefrontal cortices. Hum Brain Mapp, 19(4), 213-23, 2003.

Perrault, Thomas J, Vaughan, J William, Stein, Barry E, Wallace, Mark T. Neuron-specific response characteristics predict the magnitude of multisensory integration. J Neurophysiol, 90(6), 4022-6, 2003.

Wallace MT.. Cross-Modal Neural Development. In: Connectionist Models of Development, P. Quinlan (ed.) . Psychology Press. , , 311-343, 2003.

Laurienti, Paul J, Burdette, Jonathan H, Wallace, Mark T, Yen, Yi-Fen, Field, Aaron S, Stein, Barry E. Deactivation of sensory-specific cortex by cross-modal stimuli. J Cogn Neurosci, 14(3), 420-9, 2002.

Roberson G, Wallace MT, and Schirillo J. . The sensorimotor contingency of multisensory localization correlates with the conscious percept of spatial unity. . Behav. Brain Sci, 24(5), 239-240, 2002.

Stein BE, Wallace MT, Stanford TR, and Jiang W. . Cortex governs multisensory integration in the midbrain. . Neuroscientist, 8, 206-314, 2002.

Jiang, W, Wallace, M T, Jiang, H, Vaughan, J W, Stein, B E. Two cortical areas mediate multisensory integration in superior colliculus neurons. J Neurophysiol, 85(2), 506-22, 2001.

Kadunce DC, Vaughan JW, Wallace MT, and Stein BE. . The influence of visual and auditory receptive field organization on multisensory integration in the superior colliculus. . Exp. Brain Res, 139, 303-310, 2001.

Stein BE, Jiang W, Wallace MT, and Stanford TR.. Nonvisual influences on visual information processing in the superior colliculus. . Prog. Brain Res, 134, 143-56, 2001.

Stein, B E, Jiang, W, Wallace, M T, Stanford, T R. Nonvisual influences on visual-information processing in the superior colliculus. Prog Brain Res, 134, 143-56, 2001.

Wallace, M T, Stein, B E. Sensory and multisensory responses in the newborn monkey superior colliculus. J Neurosci, 21(22), 8886-94, 2001.

Wallace, M T, Stein, B E. Onset of cross-modal synthesis in the neonatal superior colliculus is gated by the development of cortical influences. J Neurophysiol, 83(6), 3578-82, 2000.

Stein BE, Wallace MT, and Stanford TR. . Development of multisensory integration: transforming sensory input into motor output. . Mental Retardation and Developmental Disabilities Research Reviews, 5(1), 72-85, 1999.

Wallace, M T, Meredith, M A, Stein, B E. Multisensory integration in the superior colliculus of the alert cat. J Neurophysiol, 80(2), 1006-10, 1998.

Kadunce, D C, Vaughan, J W, Wallace, M T, Benedek, G, Stein, B E. Mechanisms of within- and cross-modality suppression in the superior colliculus. J Neurophysiol, 78(6), 2834-47, 1997.

Wallace, M T, McHaffie, J G, Stein, B E. Visual response properties and visuotopic representation in the newborn monkey superior colliculus. J Neurophysiol, 78(5), 2732-41, 1997.

Wallace, M T, Stein, B E. Development of multisensory neurons and multisensory integration in cat superior colliculus. J Neurosci, 17(7), 2429-44, 1997.

Stein, B E, Wallace, M T. Comparisons of cross-modality integration in midbrain and cortex. Prog Brain Res, 112, 289-99, 1996.

Wallace, M T, Stein, B E. Sensory organization of the superior colliculus in cat and monkey. Prog Brain Res, 112, 301-11, 1996.

Wallace, M T, Wilkinson, L K, Stein, B E. Representation and integration of multiple sensory inputs in primate superior colliculus. J Neurophysiol, 76(2), 1246-66, 1996.


Postdoctoral Position Available
No

Postdoctoral Position Details
N/A

Updated Date
02/18/2010



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