Vanderbilt University School of Medicine

Correa, Pelayo , M.D.
Professor of Medicine
Anne Potter Wilson Chair in Medicine
Professor of Pathology, Microbiology and Immunology

Lab Url: N/A

Phone Number: 343 3958

Email Address:pelayo.correa@vanderbilt.edu

Correa, Pelayo's picture

Office Address   Mailing Address

1030E MRB IV 37232-0252


Research Specialty
Gastrointetinal cancer. Helicobacter pylori.

Publications
Correa, P. [A pioneer cancer registry in Latin America]. Salud Publica Mex, 56(5), 417, 2015.

Haley, KP, Delgado, AG, Piazuelo, MB, Mortensen, BL, Correa, P, Damo, SM, Chazin, WJ, Skaar, EP, Gaddy, JA. The human antimicrobial protein calgranulin C (S100A12) participates in control of Helicobacter pylori growth and regulation of virulence. Infect Immun, , , 2015.

Krakowiak, MS, Noto, JM, Piazuelo, MB, Hardbower, DM, Romero-Gallo, J, Delgado, A, Chaturvedi, R, Correa, P, Wilson, KT, Peek, RM. Matrix metalloproteinase 7 restrains Helicobacter pylori-induced gastric inflammation and premalignant lesions in the stomach by altering macrophage polarization. Oncogene, 34(14), 1865-71, 2015.

Suarez, G, Romero-Gallo, J, Piazuelo, MB, Wang, G, Maier, RJ, Forsberg, LS, Azadi, P, Gomez, MA, Correa, P, Peek, RM. Modification of Helicobacter pylori Peptidoglycan Enhances NOD1 Activation and Promotes Cancer of the Stomach. Cancer Res, 75(8), 1749-59, 2015.

Wroblewski, LE, Piazuelo, MB, Chaturvedi, R, Schumacher, M, Aihara, E, Feng, R, Noto, JM, Delgado, A, Israel, DA, Zavros, Y, Montrose, MH, Shroyer, N, Correa, P, Wilson, KT, Peek, RM. Helicobacter pylori targets cancer-associated apical-junctional constituents in gastroids and gastric epithelial cells. Gut, 64(5), 720-30, 2015.

Chaturvedi, R, Asim, M, Piazuelo, MB, Yan, F, Barry, DP, Sierra, JC, Delgado, AG, Hill, S, Casero, RA, Bravo, LE, Dominguez, RL, Correa, P, Polk, DB, Washington, MK, Rose, KL, Schey, KL, Morgan, DR, Peek, RM, Wilson, KT. Activation of EGFR and ERBB2 by Helicobacter pylori results in survival of gastric epithelial cells with DNA damage. Gastroenterology, 146(7), 1739-51.e14, 2014.

Chaturvedi, R, de Sablet, T, Asim, M, Piazuelo, MB, Barry, DP, Verriere, TG, Sierra, JC, Hardbower, DM, Delgado, AG, Schneider, BG, Israel, DA, Romero-Gallo, J, Nagy, TA, Morgan, DR, Murray-Stewart, T, Bravo, LE, Peek, RM, Fox, JG, Woster, PM, Casero, RA, Correa, P, Wilson, KT. Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase. Oncogene, , , 2014.

Epplein, M, Zheng, W, Li, H, Peek, RM, Correa, P, Gao, J, Michel, A, Pawlita, M, Cai, Q, Xiang, YB, Shu, XO. Diet, Helicobacter pylori strain-specific infection, and gastric cancer risk among Chinese men. Nutr Cancer, 66(4), 550-7, 2014.

Gobert, AP, Verriere, T, Asim, M, Barry, DP, Piazuelo, MB, de Sablet, T, Delgado, AG, Bravo, LE, Correa, P, Peek, RM, Chaturvedi, R, Wilson, KT. Heme oxygenase-1 dysregulates macrophage polarization and the immune response to Helicobacter pylori. J Immunol, 193(6), 3013-22, 2014.

Kodaman, N, Pazos, A, Schneider, BG, Piazuelo, MB, Mera, R, Sobota, RS, Sicinschi, LA, Shaffer, CL, Romero-Gallo, J, de Sablet, T, Harder, RH, Bravo, LE, Peek, RM, Wilson, KT, Cover, TL, Williams, SM, Correa, P. Human and Helicobacter pylori coevolution shapes the risk of gastric disease. Proc Natl Acad Sci U S A, 111(4), 1455-60, 2014.

Soutto, M, Peng, D, Katsha, A, Chen, Z, Piazuelo, MB, Washington, MK, Belkhiri, A, Correa, P, El-Rifai, W. Activation of ??-catenin signalling by TFF1 loss promotes cell proliferation and gastric tumorigenesis. Gut, , , 2014.

Wei, J, Noto, JM, Zaika, E, Romero-Gallo, J, Piazuelo, MB, Schneider, B, El-Rifai, W, Correa, P, Peek, RM, Zaika, AI. Bacterial CagA protein induces degradation of p53 protein in a p14ARF-dependent manner. Gut, , , 2014.

Whary, MT, Muthupalani, S, Ge, Z, Feng, Y, Lofgren, J, Shi, HN, Taylor, NS, Correa, P, Versalovic, J, Wang, TC, Fox, JG. Helminth co-infection in Helicobacter pylori infected INS-GAS mice attenuates gastric premalignant lesions of epithelial dysplasia and glandular atrophy and preserves colonization resistance of the stomach to lower bowel microbiota. Microbes Infect, 16(4), 345-55, 2014.

Arboleda, RN, Schneider, BG, Bravo, LE, Romero-Gallo, J, Peek, RM, Mera, RM, Yepez, MC, Campo, C, Correa, P. Use of the noninvasive entero-test in the detection of Helicobacter pylori in children in an endemic area in Colombia. J Pediatr Gastroenterol Nutr, 57(2), 192-6, 2013.

Correa, P. Gastric cancer: overview. Gastroenterol Clin North Am, 42(2), 211-7, 2013.

Epplein, M, Xiang, YB, Cai, Q, Peek, RM, Li, H, Correa, P, Gao, J, Wu, J, Michel, A, Pawlita, M, Zheng, W, Shu, XO. Circulating cytokines and gastric cancer risk. Cancer Causes Control, 24(12), 2245-50, 2013.

Morgan, DR, Torres, J, Sexton, R, Herrero, R, Salazar-Mart??nez, E, Greenberg, ER, Bravo, LE, Dominguez, RL, Ferreccio, C, Lazcano-Ponce, EC, Meza-Montenegro, MM, Pe??a, EM, Pe??a, R, Correa, P, Mart??nez, ME, Chey, WD, Valdivieso, M, Anderson, GL, Goodman, GE, Crowley, JJ, Baker, LH. Risk of recurrent Helicobacter pylori infection 1 year after initial eradication therapy in 7 Latin American communities. JAMA, 309(6), 578-86, 2013.

Noto, JM, Gaddy, JA, Lee, JY, Piazuelo, MB, Friedman, DB, Colvin, DC, Romero-Gallo, J, Suarez, G, Loh, J, Slaughter, JC, Tan, S, Morgan, DR, Wilson, KT, Bravo, LE, Correa, P, Cover, TL, Amieva, MR, Peek, RM. Iron deficiency accelerates Helicobacter pylori-induced carcinogenesis in rodents and humans. J Clin Invest, 123(1), 479-92, 2013.

Noto, JM, Khizanishvili, T, Chaturvedi, R, Piazuelo, MB, Romero-Gallo, J, Delgado, AG, Khurana, SS, Sierra, JC, Krishna, US, Suarez, G, Powell, AE, Goldenring, JR, Coffey, RJ, Yang, VW, Correa, P, Mills, JC, Wilson, KT, Peek, RM. Helicobacter pylori promotes the expression of Kr??ppel-like factor 5, a mediator of carcinogenesis, in vitro and in vivo. PLoS One, 8(1), e54344, 2013.

Noto, JM, Piazuelo, MB, Chaturvedi, R, Bartel, CA, Thatcher, EJ, Delgado, A, Romero-Gallo, J, Wilson, KT, Correa, P, Patton, JG, Peek, RM. Strain-specific suppression of microRNA-320 by carcinogenic Helicobacter pylori promotes expression of the antiapoptotic protein Mcl-1. Am J Physiol Gastrointest Liver Physiol, 305(11), G786-96, 2013.

Piazuelo, MB, Correa, P. Gastric c??ncer: Overview. Colomb Med (Cali), 44(3), 192-201, 2013.

Schneider, BG, Piazuelo, MB, Sicinschi, LA, Mera, R, Peng, DF, Roa, JC, Romero-Gallo, J, Delgado, AG, de Sablet, T, Bravo, LE, Wilson, KT, El-Rifai, W, Peek, RM, Correa, P. Virulence of infecting Helicobacter pylori strains and intensity of mononuclear cell infiltration are associated with levels of DNA hypermethylation in gastric mucosae. Epigenetics, 8(11), 1153-61, 2013.

Correa, P, Piazuelo, MB. Evolutionary History of the Helicobacter pylori Genome: Implications for Gastric Carcinogenesis. Gut Liver, 6(1), 21-8, 2012.

Correa, P, Piazuelo, MB. The gastric precancerous cascade. J Dig Dis, 13(1), 2-9, 2012.

Epplein, M, Zheng, W, Xiang, YB, Peek, RM, Li, H, Correa, P, Gao, J, Michel, A, Pawlita, M, Cai, Q, Shu, XO. Prospective study of Helicobacter pylori biomarkers for gastric cancer risk among Chinese men. Cancer Epidemiol Biomarkers Prev, 21(12), 2185-92, 2012.

Loh, JT, Friedman, DB, Piazuelo, MB, Bravo, LE, Wilson, KT, Peek, RM, Correa, P, Cover, TL. Analysis of Helicobacter pylori cagA promoter elements required for salt-induced upregulation of CagA expression. Infect Immun, 80(9), 3094-106, 2012.

Mera, RM, Bravo, LE, Goodman, KJ, Yepez, MC, Correa, P. Long-term effects of clearing Helicobacter pylori on growth in school-age children. Pediatr Infect Dis J, 31(3), 263-6, 2012.

Sicinschi, LA, Correa, P, Bravo, LE, Peek, RM, Wilson, KT, Loh, JT, Yepez, MC, Gold, BD, Thompson, DT, Cover, TL, Schneider, BG. Non-invasive genotyping of Helicobacter pylori cagA, vacA, and hopQ from asymptomatic children. Helicobacter, 17(2), 96-106, 2012.

Wei, J, Noto, J, Zaika, E, Romero-Gallo, J, Correa, P, El-Rifai, W, Peek, RM, Zaika, A. Pathogenic bacterium Helicobacter pylori alters the expression profile of p53 protein isoforms and p53 response to cellular stresses. Proc Natl Acad Sci U S A, 109(38), E2543-50, 2012.

Chaturvedi, R, Asim, M, Romero-Gallo, J, Barry, DP, Hoge, S, de Sablet, T, Delgado, AG, Wroblewski, LE, Piazuelo, MB, Yan, F, Israel, DA, Casero, RA, Correa, P, Gobert, AP, Polk, DB, Peek, RM, Wilson, KT. Spermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagA. Gastroenterology, 141(5), 1696-708.e1-2, 2011.

Correa, P, Piazuelo, MB. Helicobacter pylori Infection and Gastric Adenocarcinoma. US Gastroenterol Hepatol Rev, 7(1), 59-64, 2011.

Epplein, M, Signorello, LB, Zheng, W, Cai, Q, Hargreaves, MK, Michel, A, Pawlita, M, Fowke, JH, Correa, P, Blot, WJ. Helicobacter pylori prevalence and circulating micronutrient levels in a low-income United States population. Cancer Prev Res (Phila), 4(6), 871-8, 2011.

Epplein, M, Signorello, LB, Zheng, W, Peek, RM, Michel, A, Williams, SM, Pawlita, M, Correa, P, Cai, Q, Blot, WJ. Race, African ancestry, and Helicobacter pylori infection in a low-income United States population. Cancer Epidemiol Biomarkers Prev, 20(5), 826-34, 2011.

Gobert, AP, Asim, M, Piazuelo, MB, Verriere, T, Scull, BP, de Sablet, T, Glumac, A, Lewis, ND, Correa, P, Peek, RM, Chaturvedi, R, Wilson, KT. Disruption of nitric oxide signaling by Helicobacter pylori results in enhanced inflammation by inhibition of heme oxygenase-1. J Immunol, 187(10), 5370-9, 2011.

Loh, JT, Shaffer, CL, Piazuelo, MB, Bravo, LE, McClain, MS, Correa, P, Cover, TL. Analysis of cagA in Helicobacter pylori strains from Colombian populations with contrasting gastric cancer risk reveals a biomarker for disease severity. Cancer Epidemiol Biomarkers Prev, 20(10), 2237-49, 2011.

Nagy, TA, Wroblewski, LE, Wang, D, Piazuelo, MB, Delgado, A, Romero-Gallo, J, Noto, J, Israel, DA, Ogden, SR, Correa, P, Cover, TL, Peek, RM. ??-Catenin and p120 mediate PPAR??-dependent proliferation induced by Helicobacter pylori in human and rodent epithelia. Gastroenterology, 141(2), 553-64, 2011.

Soutto, M, Belkhiri, A, Piazuelo, MB, Schneider, BG, Peng, D, Jiang, A, Washington, MK, Kokoye, Y, Crowe, SE, Zaika, A, Correa, P, Peek, RM, El-Rifai, W. Loss of TFF1 is associated with activation of NF-??B-mediated inflammation and gastric neoplasia in mice and humans. J Clin Invest, 121(5), 1753-67, 2011.

de Sablet, T, Piazuelo, MB, Shaffer, CL, Schneider, BG, Asim, M, Chaturvedi, R, Bravo, LE, Sicinschi, LA, Delgado, AG, Mera, RM, Israel, DA, Romero-Gallo, J, Peek, RM, Cover, TL, Correa, P, Wilson, KT. Phylogeographic origin of Helicobacter pylori is a determinant of gastric cancer risk. Gut, 60(9), 1189-95, 2011.


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