Vanderbilt University School of Medicine

Sicinschi, Liviu A. , M.D., Ph.D.

Lab Url: http://:

Phone Number: (615) 343 8626


Sicinschi, Liviu's picture

Office Address   Mailing Address

VUMC, 2215 Garland Ave, MRB-4, Room 1005

Vanderbilt University Medical Center Division of Gastroenterology 37232-0252

Research Keywords
Helicobacter pylori, virulence factors/genes, cag Pathogenicity Island, Cytokine gene polymorphisms, H. pylori-host cell interactions, Molecular Biology,Bacteria,Cancer,Genome,Microbiology,Protein Structure,Tyrosine phosphorylation

Research Specialty
Epidemiology of Helicobacter pylori infection in populations with high and low risk for gastric cancer; molecular characterization of virulence genes of H. pylori; CagA protein C-terminal variations; Pathogenesis of H. pylori infection

Clinical Research Description
Epidemiologic and molecular aspects of infection with Helicobacter pylori; genetic variations of Helicobacter pylori virulence factors such as cagA and vacA virulence genes as well as of hopQ, homA and homB genes producing outer membrane proteins responsible for H. pylori attachment to gastric mucosa; the associations of H. pylori virulence factors with histo-pathological changes of gastric mucosa and clinical outcomes of infection in areas for high and low risk for gastric cancer; detection of multiple genetic pro-inflammatory polymorphisms in cytokine genes ( IL-1I? gene and the IL-1 receptor-antagonist gene IL-1RN) which may affect/ increase the risk for development of gastric cancer.

Schneider, BG, Peng, DF, Camargo, MC, Piazuelo, MB, Sicinschi, LA, Mera, R, Romero-Gallo, J, Delgado, AG, Bravo, LE, Wilson, KT, Peek, RM, Correa, P, El-Rifai, W. Promoter DNA hypermethylation in gastric biopsies from subjects at high and low risk for gastric cancer. Int J Cancer, , , 2010.

Schneider, N, Krishna, U, Romero-Gallo, J, Israel, DA, Piazuelo, MB, Camargo, MC, Sicinschi, LA, Schneider, BG, Correa, P, Peek Jr, RM. Role of Helicobacter pylori CagA Molecular Variations in Induction of Host Phenotypes with Carcinogenic Potential. J Infect Dis, , , 2009.

Sicinschi, LA, Correa, P, Peek, RM, Camargo, MC, Piazuelo, MB, Romero-Gallo, J, Hobbs, SS, Krishna, U, Delgado, A, Mera, R, Bravo, LE, Schneider, BG. CagA C-terminal variations in Helicobacter pylori strains from Colombian patients with gastric precancerous lesions. Clin Microbiol Infect, , , 2009.

Piazuelo, MB, Camargo, MC, Mera, RM, Delgado, AG, Peek, RM, Correa, H, Schneider, BG, Sicinschi, LA, Mora, Y, Bravo, LE, Correa, P. Eosinophils and mast cells in chronic gastritis: possible implications in carcinogenesis. Hum Pathol, 39(9), 1360-9, 2008. PMCID:2561958

Schneider, BG, Camargo, MC, Ryckman, KK, Sicinschi, LA, Piazuelo, MB, Zabaleta, J, Correa, P, Williams, SM. Cytokine polymorphisms and gastric cancer risk: an evolving view. Cancer Biol Ther, 7(2), 157-62, 2008.

Sicinschi, LA, Correa, P, Peek, RM, Camargo, MC, Delgado, A, Piazuelo, MB, Romero-Gallo, J, Bravo, LE, Schneider, BG. Helicobacter pylori genotyping and sequencing using paraffin-embedded biopsies from residents of colombian areas with contrasting gastric cancer risks. Helicobacter, 13(2), 135-45, 2008.

Camargo, MC, Mera, R, Correa, P, Peek, RM, Fontham, ET, Goodman, KJ, Piazuelo, MB, Sicinschi, L, Zabaleta, J, Schneider, BG. Interleukin-1beta and interleukin-1 receptor antagonist gene polymorphisms and gastric cancer: a meta-analysis. Cancer Epidemiol Biomarkers Prev, 15(9), 1674-87, 2006.

Sicinschi, LA, Lopez-Carrillo, L, Camargo, MC, Correa, P, Sierra, RA, Henry, RR, Chen, J, Zabaleta, J, Piazuelo, MB, Schneider, BG. Gastric cancer risk in a Mexican population: role of Helicobacter pylori CagA positive infection and polymorphisms in interleukin-1 and -10 genes. Int J Cancer, 118(3), 649-57, 2006.

Zabaleta, J, Camargo, MC, Piazuelo, MB, Fontham, E, Schneider, BG, Sicinschi, LA, Ferrante, W, Balart, L, Correa, P, Ochoa, AC. Association of interleukin-1beta gene polymorphisms with precancerous gastric lesions in African Americans and Caucasians. Am J Gastroenterol, 101(1), 163-71, 2006.

Sicinschi, LA, Correa, P, Bravo, LE, Schneider, BG. A positive assay for identification of cagA negative strains of Helicobacter pylori. J Microbiol Methods, 55(3), 625-33, 2003.

Sicinschi, LA, Correa, P, Bravo, LE, Schneider, BG. Detection and typing of Helicobacter pylori cagA/vacA genes by radioactive, one-step polymerase chain reaction in stool samples from children. J Microbiol Methods, 52(2), 197-207, 2003.

Sicinschi, LA, Correa, P, Schneider, BG. Comparison of genotyping of Helicobacter pylori cagA and vacA virulence genes from gastric biopsies and stool specimens. Helicobacter, 8(6), 601-7, 2003.

Vorobiev, AA, Sichinskii, LA, Dratvin, SA. The potentials for the laboratory diagnosis of infections caused by bacteria in the genus Campylobacter. Zh Mikrobiol Epidemiol Immunobiol, (1), 95-103, 2000 [In Russian].

Liviu Sicinschi. The Identification of Campylobacter microorganisms. Chapter 35 in Clinical Microbiology, Textbook for medical students by Dumitru Buiuc, Bucharest, Romania, Vol 1, 731-742, 2000 [In Romanian].

Liviu Sicinschi, Francis Megraud. The possibility of diagnosis of Campylobacter infections and their place in the structure of diarrhoeal disease in children in the Republic of Moldova. The Medical Surgery Journal (Revista Medico-Chirurgicala); Romania, Iasi, 104(1), p.103-112, 2000.

Liviu Sicinschi. The Campylobacter Infection. New aspects of Laboratory Diagnosis. Monograph, Medicine (Chisinau, Moldova)(.), 329 pg, 1999 [In Romanian].

Galetchi P, Sicinschi L, Plugaru S, Cotici A, Calancea A, Popovici L, Vorojbit V. Note-book (Guidance) for work in microbiology, virology and immunology laboratory. Methodical elaborations for medical students; Ed. Medicine, Chisinau, Moldova, volumes 1 and 2, 1-66 and 1-105, 1998 and 1999.

L.Sicinschi. Genotypic identification of isolated Campylobacter strains using the Polymerase Chain Reaction. Curierul Medical (Moldova), 6, 65-69, 1997.

L.Sicinschi. The optimization of Laboratory Diagnosis of Campylobacter Infection under elaboration of New Culture Media and usage of Molecular Biology Methods. Dissertation Autoreport for PhD degree, , 37 pages, 1997.

L.Sicinschi. Campylobacter strains through traditional enzymatic tests and Molecular Hybridization Method. Curierul Medical (Moldova), 1, 26-32, 1996.

Sicinschi, L. [The antibiotic susceptibility of Campylobacter strains isolated in Moldova. The possibilities for estimation and the results. Bacteriol Virusol Parazitol Epidemiol, 41(3-4), 123-9, 1996.

L.Sicinschi. Campylobacteriosis in the context of Acute Diarrhoeic Disease in Republic of Moldova. ?The pollution of environment and health?. Conference Materials. Chişinău, Moldova, , 78-86, 1995.

L.Sicinschi. The nutrient requirements and biochemical activity of Campylobacter strains isolated in the Republic of Moldova. Bulletin of Academy of Sciences of Republic of Moldova: Biology and Chemistry sciences, 1, 39-45, 1995.

Sicinschi L. Laboratory Diagnosis of campylobacterioses. Methodical Instructions (Guidance) for bacteriologists, Ed. Science, Chişinău, Moldova, 1-49, 1995.

Sicinschi L., Antohi E., Melnic V., Macalet T. Bacteriological and Clinical Diagnosis of Acute Diarrheic Disease in children, caused by Campylobacter. Curierul Medical (Moldova), 2, 31-34, 1995.

Sicinschi, L. [The comparative identification of Campylobacter strains by traditional enzymatic tests and the gene amplification reaction. Bacteriol Virusol Parazitol Epidemiol, 40(3-4), 221-6, 1995.

Sicinschi, LA. Enrichment medium for isolation of Campylobacter jejuni-Campylobacter coli. Rev Med Chir Soc Med Nat Iasi, 99(1-2), 139-43, 1995.

Stonnet, V, Sicinschi, L, Megraud, F, Guesdon, JL. Rapid detection of Campylobacter jejuni and Campylobacter coli isolated from clinical specimens using the polymerase chain reaction. Eur J Clin Microbiol Infect Dis, 14(4), 355-9, 1995.

L.Sicinschi. The investigation of immune response in children through ELISA test with Campylobacter endemic strains. Medical Surgery Journal (Revista Medico-Chirurgicala), Romania, Iasi, 98(1-4), 91-93, 1994.

L.Sicinschi. Preservation Culture Medium for Campylobacter jejuni/coli. Romanian Archives of Microbiology and Immunology (Romania, Bucharest), 53(3), 169-173, 1994.

Sicinschi L., Melnic V. Suggestions on microbiological diagnosis of Campylobacter infection. (Results of identification of the first culture of Campylobacter). Curierul Medical (Moldova), 1-2, 35-37, 1994.

V.Stonnet, L.Sicinschi, F.Megraud, J.-L.Guesdon. Rapid detection of Campylobacter jejuni isolated from Clinical Specimens using the Polymerase Chain Reaction. Journal of European MSA, 3(1, Edit A), 15-20, 1994.

L.Sicinschi. Candidoses. Microbiological investigations and its etiological importance. Curierul Medical (Moldova), 3-4, 53-59, 1992.

Postolaki I., Nakhaba V., Sicinschi L., Gonde G. Evaluation des rezultats de la identification biochimique des enterobacteries. Problems actuels de la Medcine en Guinee. Universite de Conacry, Guinee, 1, 104-107, 1991 [In French].

L.Sicinschi. Campylobacterioses: etiology and laboratory diagnosis (Review). Health Care (Moldova), 3, 51-55, 1991.

Sicinschi L. Aerobic and facultative anaerobic Gram negative bacteria, glucose fermenting and non-fermenting. Test-programmes for young bacteriologists knowledge verification, Ed. Science. Chisinau, Moldova, 1-68, 1991.

Nahaba, V, Galetchi, P, Sicinschi, LA. [An evaluation of the results of the biochemical identification of enterobacteria. Rev Med Chir Soc Med Nat Iasi, 94(2), 358, 1990.

Nahaba, V, Sicinschi, L. [The evaluation of the results of determining bacterial sensitivity to antibiotics by the diffusion in gel method. Rev Med Chir Soc Med Nat Iasi, 94(3-4), 541-2, 1990.

Sicinschi L. The microbiology and diagnosis of infections caused by Opportunistic Enterobacteria. New genera of enterobacteria. A methodical elaboration (guidance) for bacteriologists, Ed. Science, Chisinau, Moldova, 1-60, 1990.

Sicinschi L. Microbiological diagnosis of infections caused by pathogenic enterobacteria. A methodical elaboration (guidance) for bacteriologists, Ed. Science, Chisinau, Moldova, 1-80, 1990.

Sichinskii, LA. [Method of accelerated detection of the causative agents of dysentery and their antigens in water. Gig Sanit, (1), 37-8, 1986 [In Russian].

Nikitin, VM, Sichinskii, LA. [Serodiagnosis of dysentery using Shigella diagnostic agents (synthetic colored and erythrocytic). Lab Delo, (7), 432-4, 1985 [In Russian].

L.Sicinschi. Express immunological methods for laboratory diagnosis of bacterial dysentery. Autoreport of Dissertation for DMSc (Doctor of Medical Sciences) degree. Moscow, Russia, , 1-26, 1984.

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