Vanderbilt University School of
Sawyer, Douglas B. , M.D., Ph.D.
Professor of Medicine
Professor of Pharmacology
Lisa M. Jacobson Chair in Cardiovascular Medicine
Phone Number: 615-936-1713, 1720
359-61 Preston Research Building
361 Preston Research Building 37232-6300
Basic and translational research focused on mechanisms by which the heart maintains cardiac function and recovers after injury.
We are interested in how the adult heart maintains itself for the 3+ billion heartbeats it must deliver to carry us through life. We use molecular and cellular biological techniques to approach specific questions related to this theme. Our specific ideas and questions are motivated by a clinical interest in understanding the pathophysiology of and treating congestive heart failure.
One specific system under active investigation is the neuregulin/erbB signaling system. The growth factor neuregulin acts through receptor tyrosine kinases in the erbB family to modulate cell growth and survival in many tissues. We have been studying how this works in the heart. Our interest is motivated in part by the clinical observation that treating cancer victims with erbB2-targeted therapies promotes cardiac dysfunction, particularly in patients who have received concurrent anthracyclines. We are using isolated cardiac microvascular endothelial cells and myocytes in primary culture to dissect how this system works. Through a series of small and large animal studies, and most recently a clinical trial, we are part of a team examining whether recombinant neuregulin can be developed as a therapy for heart failure. In parallel, we are applying what we are learning to develop strategies to prevent cardiac injury (and promote repair) in situations such as anthracycline exposure, ischemia, and cardiac amyloidosis.
As part of the NHLBI funded U01 Progenitor Cell Biology Consortium we are working with the Hatzopoulos, Baldwin, and Hong laboratories to identify host factors that regulate myocardial regeneration. We have identified neuregulin as one of those factors that regulates biology of endothelial and myocardial progenitor cells. We are now looking at other factors that may be correctable at the systemic level in a way that optimizes myocardial and other organ function. These are being studied in cell, animal and human tissue studies. We anticipate applying what we learn to develop clinical trials in human heart failure.
We are examining how circulating levels of proteins known to play a role in cardiac growth and repair from basic research relate to clinical parameters such as risk of heart failure, cardiovascular function, and exercise capacity. We are doing this through collaborations with large epidemiological studies such as the Framingham Heart Study, as well as through specific clinical studies involving subjects with heart failure as well as normal volunteers. One goal in this work is to develop sets of parameters that will predict outcome in the setting of cardiac dysfunction.
A related area of interest is to develop strategies that can promote cardiac protection of cancer victims undergoing treatment with chemotherapy regimens that include anthracyclines and ErbB2-targeted therapies. An ongoing study in breast cancer patients is examining the potential of physical activity to prevent cardiovascular effects of cancer therapy.
We have been a part of a team of investigators examining the potential of recombinant neuregulin as a treatment for heart failure.
Congestive Heart Failure
Cardiovascular complications of cancer therapy
Bell, SP, Adkisson, DW, Ooi, H, Sawyer, DB, Lawson, MA, Kronenberg, MW. Impairment of subendocardial perfusion reserve and oxidative metabolism in nonischemic dilated cardiomyopathy. J Card Fail, 19(12), 802-10, 2013.
Galindo, CL, Ryzhov, S, Sawyer, DB. Neuregulin as a Heart Failure Therapy and Mediator of Reverse Remodeling. Curr Heart Fail Rep, , , 2013.
Geisberg, CA, Abdallah, WM, da Silva, M, Silverstein, C, Smith, HM, Abramson, V, Mayer, I, Means-Powell, J, Freehardt, D, White, B, Lenihan, D, Sawyer, DB. Circulating neuregulin during the transition from stage A to stage B/C heart failure in a breast cancer cohort. J Card Fail, 19(1), 10-5, 2013.
Hill, MF, Patel, AV, Murphy, A, Smith, HM, Galindo, CL, Pentassuglia, L, Peng, X, Lenneman, CG, Odiete, O, Friedman, DB, Kronenberg, MW, Zheng, S, Zhao, Z, Song, Y, Harrell, FE, Srinivas, M, Ganguly, A, Iaci, J, Parry, TJ, Caggiano, AO, Sawyer, DB. Intravenous glial growth factor 2 (GGF2) isoform of neuregulin-1?? improves left ventricular function, gene and protein expression in rats after myocardial infarction. PLoS One, 8(2), e55741, 2013.
Lenneman, AJ, Wang, L, Wigger, M, Frangoul, H, Harrell, FE, Silverstein, C, Sawyer, DB, Lenneman, CG. Heart transplant survival outcomes for adriamycin-dilated cardiomyopathy. Am J Cardiol, 111(4), 609-12, 2013.
Odiete, O, Konik, EA, Sawyer, DB, Hill, MF. Type 1 diabetes mellitus abrogates compensatory augmentation of myocardial neuregulin-1??/ErbB in response to myocardial infarction resulting in worsening heart failure. Cardiovasc Diabetol, 12, 52, 2013.
Sawyer, DB. Anthracyclines and heart failure. N Engl J Med, 368(12), 1154-6, 2013.
Collins, SP, Hart, KW, Lindsell, CJ, Fermann, GJ, Weintraub, NL, Miller, KF, Roll, SN, Sperling, MI, Sawyer, DB, Storrow, AB. Elevated urinary neutrophil gelatinase-associated lipocalcin after acute heart failure treatment is associated with worsening renal function and adverse events. Eur J Heart Fail, 14(9), 1020-9, 2012.
Collins, SP, Lindsell, CJ, Jenkins, CA, Harrell, FE, Fermann, GJ, Miller, KF, Roll, SN, Sperling, MI, Maron, DJ, Naftilan, AJ, McPherson, JA, Weintraub, NL, Sawyer, DB, Storrow, AB. Risk stratification in acute heart failure: rationale and design of the STRATIFY and DECIDE studies. Am Heart J, 164(6), 825-34, 2012.
Collins, SP, Lindsell, CJ, Storrow, AB, Fermann, GJ, Levy, PD, Pang, PS, Weintraub, N, Frank Peacock, W, Sawyer, DB, Gheorghiade, M. Early changes in clinical characteristics after emergency department therapy for acute heart failure syndromes: identifying patients who do not respond to standard therapy. Heart Fail Rev, 17(3), 387-94, 2012.
Geisberg, C, Pentassuglia, L, Sawyer, DB. Cardiac side effects of anticancer treatments: new mechanistic insights. Curr Heart Fail Rep, 9(3), 211-8, 2012.
Henry-Okafor, Q, Collins, SP, Jenkins, CA, Miller, KF, Maron, DJ, Naftilan, AJ, Weintraub, N, Fermann, GJ, McPherson, J, Menon, S, Sawyer, DB, Storrow, AB. Relationship between Uric Acid Levels and Diagnostic and Prognostic Outcomes in Acute Heart Failure. Open Biomark J, 5, 9-15, 2012.
Henry-Okafor, Q, Collins, SP, Jenkins, CA, Miller, KF, Maron, DJ, Naftilan, AJ, Weintraub, N, Fermann, GJ, McPherson, J, Menon, S, Sawyer, DB, Storrow, AB. Soluble ST2 as a Diagnostic and Prognostic Marker for Acute Heart Failure Syndromes. Open Biomark J, 2012(5), 1-8, 2012.
Odiete, O, Hill, MF, Sawyer, DB. Neuregulin in cardiovascular development and disease. Circ Res, 111(10), 1376-85, 2012.
Samaras, SE, Chen, B, Koch, SR, Sawyer, DB, Lim, CC, Davidson, JM. 26S proteasome regulation of Ankrd1/CARP in adult rat ventricular myocytes and human microvascular endothelial cells. Biochem Biophys Res Commun, 425(4), 830-5, 2012.
Geisberg, CA, Wang, G, Safa, RN, Smith, HM, Anderson, B, Peng, XY, Veerkamp, B, Zhao, DX, Blakemore, D, Yu, C, Sawyer, DB. Circulating neuregulin-1?? levels vary according to the angiographic severity of coronary artery disease and ischemia. Coron Artery Dis, 22(8), 577-82, 2011.
Hao, J, Sawyer, DB, Hatzopoulos, AK, Hong, CC. Recent Progress on Chemical Biology of Pluripotent Stem Cell Self-renewal, Reprogramming and Cardiomyogenesis. Rec Pat Regen Med, 1(3), 263-274, 2011.
Sawyer, DB. Oxidative stress in heart failure: what are we missing. Am J Med Sci, 342(2), 120-4, 2011.
Sawyer, DB, Caggiano, A. Neuregulin-1?? for the treatment of systolic heart failure. J Mol Cell Cardiol, 51(4), 501-5, 2011.
Geisberg, CA, Sawyer, DB. Mechanisms of anthracycline cardiotoxicity and strategies to decrease cardiac damage. Curr Hypertens Rep, 12(6), 404-10, 2010.
Calderwood, SK, Khaleque, MA, Sawyer, DB, Ciocca, DR. Heat shock proteins in cancer: chaperones of tumorigenesis. Trends Biochem Sci, 31(3), 164-72, 2006.
Izumiya, Y, Shiojima, I, Sato, K, Sawyer, DB, Colucci, WS, Walsh, K. Vascular endothelial growth factor blockade promotes the transition from compensatory
cardiac hypertrophy to failure in response to pressure overload. Hypertension, 47(5), 887-93, 2006.
Kotlyar, E, Vita, JA, Winter, MR, Awtry, EH, Siwik, DA, Keaney, JF, Sawyer, DB, Cupples, LA, Colucci, WS, Sam, F. The relationship between aldosterone, oxidative stress, and inflammation in
chronic, stable human heart failure. J Card Fail, 12(2), 122-7, 2006.
Kuramochi, Y, Guo, X, Sawyer, DB. Neuregulin activates erbB2-dependent src/FAK signaling and cytoskeletal remodeling
in isolated adult rat cardiac myocytes. J Mol Cell Cardiol, , , 2006. PMCID:1847613
Kuramochi, Y, Guo, X, Sawyer, DB, Lim, CC. Rapid electrical stimulation induces early activation of kinase signal transduction
pathways and apoptosis in adult rat ventricular myocytes. Exp Physiol, 91(4), 773-80, 2006.
Cote, GM, Miller, TA, Lebrasseur, NK, Kuramochi, Y, Sawyer, DB. Neuregulin-1alpha and beta isoform expression in cardiac microvascular endothelial
cells and function in cardiac myocytes in vitro. Exp Cell Res, 311(1), 135-46, 2005.
Daosukho, C, Ittarat, W, Lin, SM, Sawyer, DB, Kiningham, K, Lien, YC, St Clair, DK. Induction of manganese superoxide dismutase (MnSOD) mediates cardioprotective
effect of tamoxifen (TAM). J Mol Cell Cardiol, 39(5), 792-803, 2005.
LeBrasseur, NK, Mizer, KC, Parkington, JD, Sawyer, DB, Fielding, RA. The expression of neuregulin and erbB receptors in human skeletal muscle: effects
of progressive resistance training. Eur J Appl Physiol, 94(4), 371-5, 2005.
Lim, CC, Sawyer, DB. Modulation of cardiac function: titin springs into action. J Gen Physiol, 125(3), 249-52, 2005. PMCID:2234017
Miller, TA, LeBrasseur, NK, Cote, GM, Trucillo, MP, Pimentel, DR, Ido, Y, Ruderman, NB, Sawyer, DB. Oleate prevents palmitate-induced cytotoxic stress in cardiac myocytes. Biochem Biophys Res Commun, 336(1), 309-15, 2005.
Peng, X, Chen, B, Lim, CC, Sawyer, DB. The Cardiotoxicology of Anthracycline Chemotherapeutics: TRANSLATING MOLECULAR
MECHANISM INTO PREVENTATIVE MEDICINE. Mol Interv, 5(3), 163-71, 2005.
Peng, X, Guo, X, Borkan, SC, Bharti, A, Kuramochi, Y, Calderwood, S, Sawyer, DB. Heat shock protein 90 stabilization of ErbB2 expression is disrupted by ATP
depletion in myocytes. J Biol Chem, 280(13), 13148-52, 2005.
Sam, F, Kerstetter, DL, Pimental, DR, Mulukutla, S, Tabaee, A, Bristow, MR, Colucci, WS, Sawyer, DB. Increased reactive oxygen species production and functional alterations in
antioxidant enzymes in human failing myocardium. J Card Fail, 11(6), 473-80, 2005.
Sawyer, DB. Heart failure research continues to reveal the flaws in nature''s unintelligent
design. Circulation, 112(19), 2891-3, 2005.
Trueblood, NA, Inscore, PR, Brenner, D, Lugassy, D, Apstein, CS, Sawyer, DB, Colucci, WS. Biphasic temporal pattern in exercise capacity after myocardial infarction
in the rat: relationship to left ventricular remodeling. Am J Physiol Heart Circ Physiol, 288(1), H244-9, 2005.
Kuramochi, Y, Cote, GM, Guo, X, Lebrasseur, NK, Cui, L, Liao, R, Sawyer, DB. Cardiac endothelial cells regulate reactive oxygen species-induced cardiomyocyte
apoptosis through neuregulin-1beta/erbB4 signaling. J Biol Chem, 279(49), 51141-7, 2004.
Kuramochi, Y, Lim, CC, Guo, X, Colucci, WS, Liao, R, Sawyer, DB. Myocyte contractile activity modulates norepinephrine cytotoxicity and survival
effects of neuregulin-1beta. Am J Physiol Cell Physiol, 286(2), C222-9, 2004.
Lim, CC, Zuppinger, C, Guo, X, Kuster, GM, Helmes, M, Eppenberger, HM, Suter, TM, Liao, R, Sawyer, DB. Anthracyclines induce calpain-dependent titin proteolysis and necrosis in cardiomyocytes. J Biol Chem, 279(9), 8290-9, 2004.
Maytin, M, Siwik, DA, Ito, M, Xiao, L, Sawyer, DB, Liao, R, Colucci, WS. Pressure overload-induced myocardial hypertrophy in mice does not require gp91phox. Circulation, 109(9), 1168-71, 2004.
Sundstr??m, J, Evans, JC, Benjamin, EJ, Levy, D, Larson, MG, Sawyer, DB, Siwik, DA, Colucci, WS, Sutherland, P, Wilson, PW, Vasan, RS. Relations of plasma matrix metalloproteinase-9 to clinical cardiovascular risk
factors and echocardiographic left ventricular measures: the Framingham Heart Study. Circulation, 109(23), 2850-6, 2004.
Sundstr??m, J, Evans, JC, Benjamin, EJ, Levy, D, Larson, MG, Sawyer, DB, Siwik, DA, Colucci, WS, Wilson, PW, Vasan, RS. Relations of plasma total TIMP-1 levels to cardiovascular risk factors and
echocardiographic measures: the Framingham heart study. Eur Heart J, 25(17), 1509-16, 2004.
Tanaka, Y, Koido, S, Xia, J, Ohana, M, Liu, C, Cote, GM, Sawyer, DB, Calderwood, S, Gong, J. Development of antigen-specific CD8+ CTL in MHC class I-deficient mice through
CD4 to CD8 conversion. J Immunol, 172(12), 7848-58, 2004.
Arad, M, Moskowitz, IP, Patel, VV, Ahmad, F, Perez-Atayde, AR, Sawyer, DB, Walter, M, Li, GH, Burgon, PG, Maguire, CT, Stapleton, D, Schmitt, JP, Guo, XX, Pizard, A, Kupershmidt, S, Roden, DM, Berul, CI, Seidman, CE, Seidman, JG. Transgenic mice overexpressing mutant PRKAG2 define the cause of Wolff-Parkinson-White
syndrome in glycogen storage cardiomyopathy. Circulation, 107(22), 2850-6, 2003.
Fukazawa, R, Miller, TA, Kuramochi, Y, Frantz, S, Kim, YD, Marchionni, MA, Kelly, RA, Sawyer, DB. Neuregulin-1 protects ventricular myocytes from anthracycline-induced apoptosis
via erbB4-dependent activation of PI3-kinase/Akt. J Mol Cell Cardiol, 35(12), 1473-9, 2003.
Helmes, M, Lim, CC, Liao, R, Bharti, A, Cui, L, Sawyer, DB. Titin determines the Frank-Starling relation in early diastole. J Gen Physiol, 121(2), 97-110, 2003. PMCID:2217323
Jain, M, Brenner, DA, Cui, L, Lim, CC, Wang, B, Pimentel, DR, Koh, S, Sawyer, DB, Leopold, JA, Handy, DE, Loscalzo, J, Apstein, CS, Liao, R. Glucose-6-phosphate dehydrogenase modulates cytosolic redox status and contractile
phenotype in adult cardiomyocytes. Circ Res, 93(2), e9-16, 2003.
Kwon, SH, Pimentel, DR, Remondino, A, Sawyer, DB, Colucci, WS. H(2)O(2) regulates cardiac myocyte phenotype via concentration-dependent activation
of distinct kinase pathways. J Mol Cell Cardiol, 35(6), 615-21, 2003.
Lebrasseur, NK, Cot??, GM, Miller, TA, Fielding, RA, Sawyer, DB. Regulation of neuregulin/ErbB signaling by contractile activity in skeletal
muscle. Am J Physiol Cell Physiol, 284(5), C1149-55, 2003.
Remondino, A, Kwon, SH, Communal, C, Pimentel, DR, Sawyer, DB, Singh, K, Colucci, WS. Beta-adrenergic receptor-stimulated apoptosis in cardiac myocytes is mediated
by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of the mitochondrial pathway. Circ Res, 92(2), 136-8, 2003.
Vasan, RS, Sullivan, LM, D''Agostino, RB, Roubenoff, R, Harris, T, Sawyer, DB, Levy, D, Wilson, PW. Serum insulin-like growth factor I and risk for heart failure in elderly individuals
without a previous myocardial infarction: the Framingham Heart Study. Ann Intern Med, 139(8), 642-8, 2003.
Vasan, RS, Sullivan, LM, Roubenoff, R, Dinarello, CA, Harris, T, Benjamin, EJ, Sawyer, DB, Levy, D, Wilson, PW, D''Agostino, RB, , . Inflammatory markers and risk of heart failure in elderly subjects without
prior myocardial infarction: the Framingham Heart Study. Circulation, 107(11), 1486-91, 2003.
Communal, C, Colucci, WS, Remondino, A, Sawyer, DB, Port, JD, Wichman, SE, Bristow, MR, Singh, K. Reciprocal modulation of mitogen-activated protein kinases and mitogen-activated
protein kinase phosphatase 1 and 2 in failing human myocardium. J Card Fail, 8(2), 86-92, 2002.
Sawyer, DB, Loscalzo, J. Myocardial hibernation: restorative or preterminal sleep. Circulation, 105(13), 1517-9, 2002.
Sawyer, DB, Siwik, DA, Xiao, L, Pimentel, DR, Singh, K, Colucci, WS. Role of oxidative stress in myocardial hypertrophy and failure. J Mol Cell Cardiol, 34(4), 379-88, 2002.
Sawyer, DB, Suter, TM, Apstein, CS. The sting of salt on an old, but open, wound--is Na(+) the cause of mitochondrial
and myocardial injury during ischemia/reperfusion. J Mol Cell Cardiol, 34(7), 699-702, 2002.
Sawyer, DB, Zuppinger, C, Miller, TA, Eppenberger, HM, Suter, TM. Modulation of anthracycline-induced myofibrillar disarray in rat ventricular
myocytes by neuregulin-1beta and anti-erbB2: potential mechanism for trastuzumab-induced cardiotoxicity. Circulation, 105(13), 1551-4, 2002.
Xiao, L, Pimentel, DR, Wang, J, Singh, K, Colucci, WS, Sawyer, DB. Role of reactive oxygen species and NAD(P)H oxidase in alpha(1)-adrenoceptor
signaling in adult rat cardiac myocytes. Am J Physiol Cell Physiol, 282(4), C926-34, 2002.
Amin, JK, Xiao, L, Pimental, DR, Pagano, PJ, Singh, K, Sawyer, DB, Colucci, WS. Reactive oxygen species mediate alpha-adrenergic receptor-stimulated hypertrophy
in adult rat ventricular myocytes. J Mol Cell Cardiol, 33(1), 131-9, 2001.
Givertz, MM, Sawyer, DB, Colucci, WS. Antioxidants and myocardial contractility: illuminating the "Dark Side" of
beta-adrenergic receptor activation. Circulation, 103(6), 782-3, 2001.
Jain, M, DerSimonian, H, Brenner, DA, Ngoy, S, Teller, P, Edge, AS, Zawadzka, A, Wetzel, K, Sawyer, DB, Colucci, WS, Apstein, CS, Liao, R. Cell therapy attenuates deleterious ventricular remodeling and improves cardiac
performance after myocardial infarction. Circulation, 103(14), 1920-7, 2001.
Lim, CC, Helmes, MH, Sawyer, DB, Jain, M, Liao, R. High-throughput assessment of calcium sensitivity in skinned cardiac myocytes. Am J Physiol Heart Circ Physiol, 281(2), H969-74, 2001.
Pimentel, DR, Amin, JK, Xiao, L, Miller, T, Viereck, J, Oliver-Krasinski, J, Baliga, R, Wang, J, Siwik, DA, Singh, K, Pagano, P, Colucci, WS, Sawyer, DB. Reactive oxygen species mediate amplitude-dependent hypertrophic and apoptotic
responses to mechanical stretch in cardiac myocytes. Circ Res, 89(5), 453-60, 2001.
Sam, F, Sawyer, DB, Xie, Z, Chang, DL, Ngoy, S, Brenner, DA, Siwik, DA, Singh, K, Apstein, CS, Colucci, WS. Mice lacking inducible nitric oxide synthase have improved left ventricular
contractile function and reduced apoptotic cell death late after myocardial infarction. Circ Res, 89(4), 351-6, 2001.
Singh, K, Xiao, L, Remondino, A, Sawyer, DB, Colucci, WS. Adrenergic regulation of cardiac myocyte apoptosis. J Cell Physiol, 189(3), 257-65, 2001.
Trueblood, NA, Xie, Z, Communal, C, Sam, F, Ngoy, S, Liaw, L, Jenkins, AW, Wang, J, Sawyer, DB, Bing, OH, Apstein, CS, Colucci, WS, Singh, K. Exaggerated left ventricular dilation and reduced collagen deposition after
myocardial infarction in mice lacking osteopontin. Circ Res, 88(10), 1080-7, 2001.
Xiao, L, Pimental, DR, Amin, JK, Singh, K, Sawyer, DB, Colucci, WS. MEK1/2-ERK1/2 mediates alpha1-adrenergic receptor-stimulated hypertrophy in
adult rat ventricular myocytes. J Mol Cell Cardiol, 33(4), 779-87, 2001.
Colucci, WS, Sawyer, DB, Singh, K, Communal, C. Adrenergic overload and apoptosis in heart failure: implications for therapy. J Card Fail, 6(2 Suppl 1), 1-7, 2000.
Sam, F, Sawyer, DB, Chang, DL, Eberli, FR, Ngoy, S, Jain, M, Amin, J, Apstein, CS, Colucci, WS. Progressive left ventricular remodeling and apoptosis late after myocardial
infarction in mouse heart. Am J Physiol Heart Circ Physiol, 279(1), H422-8, 2000.
Sawyer, DB, Colucci, WS. Mitochondrial oxidative stress in heart failure: "oxygen wastage" revisited. Circ Res, 86(2), 119-20, 2000.
Singh, K, Communal, C, Sawyer, DB, Colucci, WS. Adrenergic regulation of myocardial apoptosis. Cardiovasc Res, 45(3), 713-9, 2000.
Arstall, MA, Sawyer, DB, Fukazawa, R, Kelly, RA. Cytokine-mediated apoptosis in cardiac myocytes: the role of inducible nitric
oxide synthase induction and peroxynitrite generation. Circ Res, 85(9), 829-40, 1999.
Baliga, RR, Pimental, DR, Zhao, YY, Simmons, WW, Marchionni, MA, Sawyer, DB, Kelly, RA. NRG-1-induced cardiomyocyte hypertrophy. Role of PI-3-kinase, p70(S6K), and
MEK-MAPK-RSK. Am J Physiol, 277(5 Pt 2), H2026-37, 1999.
Communal, C, Singh, K, Sawyer, DB, Colucci, WS. Opposing effects of beta(1)- and beta(2)-adrenergic receptors on cardiac myocyte
apoptosis : role of a pertussis toxin-sensitive G protein. Circulation, 100(22), 2210-2, 1999.
Sawyer, DB, Fukazawa, R, Arstall, MA, Kelly, RA. Daunorubicin-induced apoptosis in rat cardiac myocytes is inhibited by dexrazoxane. Circ Res, 84(3), 257-65, 1999.
Siwik, DA, Tzortzis, JD, Pimental, DR, Chang, DL, Pagano, PJ, Singh, K, Sawyer, DB, Colucci, WS. Inhibition of copper-zinc superoxide dismutase induces cell growth, hypertrophic
phenotype, and apoptosis in neonatal rat cardiac myocytes in vitro. Circ Res, 85(2), 147-53, 1999.
Sawyer, DB, Colucci, WS. Nitric oxide in the failing myocardium. Cardiol Clin, 16(4), 657-64, viii, 1998.
Wright, SA, Sawyer, DB, Sacks, DB, Chyu, S, Goldhaber, SZ. Elevation of troponin I levels in patients without evidence of myocardial injury. JAMA, 278(24), 2144, 1998.
Sawyer, DB, Koeppe, RE, Andersen, OS. Gramicidin single-channel properties show no solvent-history dependence. Biophys J, 57(3), 515-23, 1990. PMCID:1280745
Sawyer, DB, Williams, LP, Whaley, WL, Koeppe, RE, Andersen, OS. Gramicidins A, B, and C form structurally equivalent ion channels. Biophys J, 58(5), 1207-12, 1990. PMCID:1281065
Sawyer, DB, Andersen, OS. Platelet-activating factor is a general membrane perturbant. Biochim Biophys Acta, 987(1), 129-32, 1989.
Sawyer, DB, Koeppe, RE, Andersen, OS. Induction of conductance heterogeneity in gramicidin channels. Biochemistry, 28(16), 6571-83, 1989.
Cliff, WH, Sawyer, DB, Beyenbach, KW. Renal proximal tubule of flounder II. Transepithelial Mg secretion. Am J Physiol, 250(4 Pt 2), R616-24, 1986.
Sawyer, DB, Beyenbach, KW. Mechanism of fluid secretion in isolated shark renal proximal tubules. Am J Physiol, 249(6 Pt 2), F884-90, 1985.
Sawyer, DB, Beyenbach, KW. Dibutyryl-cAMP increases basolateral sodium conductance of mosquito Malpighian
tubules. Am J Physiol, 248(3 Pt 2), R339-45, 1985.
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