Vanderbilt University School of Medicine

Rahman, S.M. Jamshedur , Ph.D.
Research Assistant Professor of Medicine

Lab Url: N/A

Phone Number: 615 936-5225


Rahman, S.M. Jamshedur's picture

Office Address   Mailing Address

PRB 642B

PRB 642B 6838

Research Keywords
lung cancer, proteomics, genomics, early detection, biomarker signature, acyl-coA binding protein

Research Specialty
Proteomic and genomic biomarker signatures for the early diagnosis of lung cancer

Research Description
Proteomic and genomic analysis of normal bronchial epithelium and preinvasive bronchial lesion from individuals at risk of lung cancer. The goal is to develop signature for the early diagnosis of lung cancer.

Role of acyl-coA binding protein in lung tumorigenesis

Qian, J, Hassanein, M, Hoeksema, MD, Harris, BK, Zou, Y, Chen, H, Lu, P, Eisenberg, R, Wang, J, Espinosa, A, Ji, X, Harris, FT, Rahman, SM, Massion, PP. The RNA binding protein FXR1 is a new driver in the 3q26-29 amplicon and predicts poor prognosis in human cancers. Proc Natl Acad Sci U S A, 112(11), 3469-74, 2015.

Harris, FT, Rahman, SM, Hassanein, M, Qian, J, Hoeksema, MD, Chen, H, Eisenberg, R, Chaurand, P, Caprioli, RM, Shiota, M, Massion, PP. Acyl-Coenzyme A-Binding Protein Regulates Beta-Oxidation Required for Growth and Survival of Non-Small Cell Lung Cancer. Cancer Prev Res (Phila), , , 2014.

Wang, J, Qian, J, Hoeksema, MD, Zou, Y, Espinosa, AV, Rahman, SM, Zhang, B, Massion, PP. Integrative genomics analysis identifies candidate drivers at 3q26-29 amplicon in squamous cell carcinoma of the lung. Clin Cancer Res, 19(20), 5580-90, 2013.

Kikuchi, T, Hassanein, M, Amann, JM, Liu, Q, Slebos, RJ, Rahman, SM, Kaufman, JM, Zhang, X, Hoeksema, MD, Harris, BK, Li, M, Shyr, Y, Gonzalez, AL, Zimmerman, LJ, Liebler, DC, Massion, PP, Carbone, DP. In-depth proteomic analysis of nonsmall cell lung cancer to discover molecular targets and candidate biomarkers. Mol Cell Proteomics, 11(10), 916-32, 2012.

Hassanein, M, Rahman, JS, Chaurand, P, Massion, PP. Advances in Proteomic Strategies toward the Early Detection of Lung Cancer. Proc Am Thorac Soc, 8(2), 183-8, 2011.

Rahman, SM, Gonzalez, AL, Li, M, Seeley, EH, Zimmerman, LJ, Zhang, XJ, Manier, ML, Olson, SJ, Shah, RN, Miller, AN, Putnam, JB, Miller, YE, Franklin, WA, Blot, WJ, Carbone, DP, Shyr, Y, Caprioli, RM, Massion, PP. Lung Cancer Diagnosis from Proteomic Analysis of Preinvasive Lesions. Cancer Res, 71(8), 3009-3017, 2011.

Zhang, H, Liu, Q, Zimmerman, LJ, Ham, AJ, Slebos, RJ, Rahman, J, Kikuchi, T, Massion, PP, Carbone, DP, Billheimer, D, Liebler, DC. Methods for peptide and protein quantitation by liquid chromatography-multiple reaction monitoring mass spectrometry. Mol Cell Proteomics, , , 2011.

Qian, J, Zou, Y, Rahman, JS, Lu, B, Massion, PP. Synergy between phosphatidylinositol 3-kinase/Akt pathway and Bcl-xL in the control of apoptosis in adenocarcinoma cells of the lung. Mol Cancer Ther, 8(1), 101-9, 2009.

Yildiz, PB, Shyr, Y, Rahman, JS, Wardwell, NR, Zimmerman, LJ, Shakhtour, B, Gray, WH, Chen, S, Li, M, Roder, H, Liebler, DC, Bigbee, WL, Siegfried, JM, Weissfeld, JL, Gonzalez, AL, Ninan, M, Johnson, DH, Carbone, DP, Caprioli, RM, Massion, PP. Diagnostic accuracy of MALDI mass spectrometric analysis of unfractionated serum in lung cancer. J Thorac Oncol, 2(10), 893-901, 2007.

Rahman, SM, Shyr, Y, Yildiz, PB, Gonzalez, AL, Li, H, Zhang, X, Chaurand, P, Yanagisawa, K, Slovis, BS, Miller, RF, Ninan, M, Miller, YE, Franklin, WA, Caprioli, RM, Carbone, DP, Massion, PP. Proteomic patterns of preinvasive bronchial lesions. Am J Respir Crit Care Med, 172(12), 1556-62, 2005. PMCID:2718455

Massion, PP, Taflan, PM, Rahman, SM, Yildiz, P, Shyr, Y, Carbone, DP, Gonzalez, AL. Role of p63 amplification and overexpression in lung cancer development. Chest, 125(5 Suppl), 102S, 2004.

Massion, PP, Taflan, PM, Shyr, Y, Rahman, SM, Yildiz, P, Shakthour, B, Edgerton, ME, Ninan, M, Andersen, JJ, Gonzalez, AL. Early involvement of the phosphatidylinositol 3-kinase/Akt pathway in lung cancer progression. Am J Respir Crit Care Med, 170(10), 1088-94, 2004.

Massion, PP, Taflan, PM, Jamshedur Rahman, SM, Yildiz, P, Shyr, Y, Edgerton, ME, Westfall, MD, Roberts, JR, Pietenpol, JA, Carbone, DP, Gonzalez, AL. Significance of p63 amplification and overexpression in lung cancer development and prognosis. Cancer Res, 63(21), 7113-21, 2003. PMCID:314397

Petro, JB, Rahman, SM, Ballard, DW, Khan, WN. Bruton''s tyrosine kinase is required for activation of IkappaB kinase and nuclear factor kappaB in response to B cell receptor engagement. J Exp Med, 191(10), 1745-54, 2000. PMCID:2193161

Resta, R, Hooker, SW, Laurent, AB, Jamshedur Rahman, SM, Franklin, M, Knudsen, TB, Nadon, NL, Thompson, LF. Insights into thymic purine metabolism and adenosine deaminase deficiency revealed by transgenic mice overexpressing ecto-5''-nucleotidase (CD73). J Clin Invest, 99(4), 676-83, 1997. PMCID:507850

Rahman, SM, Pu, MY, Yi, H, Ohkusu, K, Kato, M, Isobe, K, Taguchi, R, Ikezawa, H, Nakashima, I. Promotion of cytotoxic T-cell generation in mixed leukocyte culture by phosphatidylinositol-specific phospholipase C from Bacillus thuringiensis. Infect Immun, 63(1), 259-63, 1995. PMCID:172986

Nakashima, I, Pu, MY, Nishizaki, A, Rosila, I, Ma, L, Katano, Y, Ohkusu, K, Rahman, SM, Isobe, K, Hamaguchi, M. Redox mechanism as alternative to ligand binding for receptor activation delivering disregulated cellular signals. J Immunol, 152(3), 1064-71, 1994.

Nakashima, I, Pu, MY, Hamaguchi, M, Iwamoto, T, Rahman, SM, Zhang, YH, Kato, M, Ohkusu, K, Katano, Y, Yoshida, T. Pathway of signal delivery to murine thymocytes triggered by co-crosslinking CD3 and Thy-1 for cellular DNA fragmentation and growth inhibition. J Immunol, 151(7), 3511-20, 1993.

Rahman, SM, Pu, MY, Hamaguchi, M, Iwamoto, T, Isobe, K, Nakashima, I. Redox-linked ligand-independent cell surface triggering for extensive protein tyrosine phosphorylation. FEBS Lett, 317(1-2), 35-8, 1993.

Jamshedur Rahman, SM, Pu, MV, Zhang, YH, Hamaguchi, M, Iwamoto, T, Taguchi, R, Ikezawa, H, Isobe, K, Yoshida, T, Nakashima, I. Delivery of an accessory signal for cell activation by exogenous phosphatidylinositol-specific phospholipase C. FEBS Lett, 303(2-3), 193-6, 1992.

Ding, LN, Yoshida, T, Isobe, K, Rahman, SM, Nagase, F, Yokochi, T, Kawashima, K, Nakashima, I. Characterization of the individual and cross-reactive antigens involved in the anti-tumor immunity induced by use of an H-2K-erbB recombinant gene transfectant. Jpn J Cancer Res, 82(7), 841-7, 1991.

Nakamura, M, Yoshida, T, Isobe, K, Iwamoto, T, Jamshedur Rahman, SM, Zhang, YH, Hasegawa, T, Ichihara, M, Nakashima, I. Modulation of the secondary antibody response of murine lymphocytes to sheep red blood cells in vitro by neuraminidase and exoglycosidases. Immunol Lett, 29(3), 235-40, 1991.

Nakashima, I, Zhang, YH, Rahman, SM, Yoshida, T, Isobe, K, Ding, LN, Iwamoto, T, Hamaguchi, M, Ikezawa, H, Taguchi, R. Evidence of synergy between Thy-1 and CD3/TCR complex in signal delivery to murine thymocytes for cell death. J Immunol, 147(4), 1153-62, 1991.

Zhang, YH, Yoshida, T, Isobe, K, Rahman, SM, Nagase, F, Ding, L, Nakashima, I. Modulation by glycyrrhizin of the cell-surface expression of H-2 class I antigens on murine tumour cell lines and normal cell populations. Immunology, 70(3), 405-10, 1990. PMCID:1384173

Mizoguchi, K, Isobe, K, Yoshida, T, Iwamoto, T, Hasegawa, T, Ding, L, Rahman, SM, Miyata, T, Nagase, F, Shimokata, K. Further evidence for H-2-unrestricted induction of minor histocompatibility antigens-specific T cell immunity in vivo. Immunol Lett, 19(1), 41-7, 1988.

Rahman, SM, Kawashima, K, Nakashima, I, Nagase, F. Induction of high-grade tumor-specific immunity in a host using a cytotoxic T-lymphocyte clone specific for a stable tumor antigen on murine leukemia L1210. Cancer Res, 48(22), 6450-4, 1988.

Nagase, F, Rahman, SM, Yokochi, T, Kawashima, K, Isobe, K, Yoshida, T, Nagura, E, Nakashima, I. Dynamics of generation of antigen loss variants from L1210 murine leukemia clones detected by a tumor-specific T-cell clone. Cancer Res, 47(24 Pt 1), 6494-9, 1987.

Nagase, F, Ueda, K, Kawashima, K, Jamshedur Rahman, SM, Isobe, K, Yoshida, T, Hasegawa, Y, Ando, K, Iwamoto, T, Nagura, E. Development of host-dependent high-grade tumor-specific immunity through a novel mechanism triggered by the Lyt-2+ tumor-specific T cell clone (K7L) that induces temporal growth of L1210 leukemia-K7L-variant. J Immunol, 138(7), 2359-65, 1987.

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