Vanderbilt University School of Medicine

Crawford, Dana C. , Ph.D.
Associate Professor of Molecular Physiology & Biophysics

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Phone Number: 615-343-7852


Crawford, Dana's picture

Office Address   Mailing Address

515B Light Hall

519 Light Hall 37232

Research Description
My primary research interest is how genetic variation impacts common, complex human phenotypes. The Human Genome Project, the International HapMap Project, the 1000 Genomes Project, and other public/private projects have generated an enormous amount of data for common and rare genetic variation across human populations. Currently, greater than 10 million single nucleotide polymorphisms (SNPs), the most common form of DNA variation, are available in public databases, and advances in technology now make it possible to interrogate a million sites in a single assay. Despite the increasing ease of generating genetic data, we are still faced with the challenge of understanding how these genetic variants affect susceptibility to common disease in the context of environmental exposures.

To meet this challenge, my laboratory is applying genetic variation data to clinical trials, large-scale epidemiological studies, and biobanks linked to quantitative traits and extensive clinical data. As an example, the Centers for Disease Control and Prevention has collected >15,000 DNAs with phenotypic information linked to the samples in a population-based survey known as the National Health and Nutrition Examination Surveys (NHANES). We are using NHANES for candidate gene studies as well as for a recently funded U01 to characterize the genetic architecture of genetics variants identified in genome-wide association studies (GWAS) with an emphasis on African Americans and Mexican Americans. In addition to NHANES, my laboratory also accesses BioVU, the Vanderbilt DNA biobank containing >125,000 DNA samples linked to de-identified electronic medical records. These and other projects in my laboratory cut across various phenotypes and traits and will involve gathering genotyping and sequencing data for various cohorts, as well as developing tools to store, retrieve, and ultimately analyze the combined phenotypic and genetic data. For analysis, traditional (e.g., regressions; haplotype inference) and experimental genetic epidemiological methods will be used to identify SNPs associated with phenotypes, and bioinformatic/genomic tools will be used to make informed decisions to target specific genes/genomic regions and to interpret these associations. Finally, many methodological issues such as adjusting for population stratification and identifying interactions can be explored by mining existing data to aid in the design and analysis of future studies.

Jeff, JM, Donahue, BS, Brown-Gentry, K, Roden, DM, Crawford, DC, Stein, CM, Kurnik, D. Genetic variation in the ??1-adrenergic receptor is associated with the risk of atrial fibrillation after cardiac surgery. Am Heart J, 167(1), 101-108.e1, 2014.

Kocarnik, JM, Park, SL, Han, J, Dumitrescu, L, Cheng, I, Wilkens, LR, Schumacher, FR, Kolonel, L, Carlson, CS, Crawford, DC, Goodloe, RJ, Dilks, H, Baker, P, Richardson, D, Ambite, JL, Song, F, Quresh, AA, Zhang, M, Duggan, D, Hutter, C, Hindorff, LA, Bush, WS, Kooperberg, C, Le Marchand, L, Peters, U. Replication of Associations Between GWAS SNPs and Melanoma Risk in the Population Architecture Using Genomics and Epidemiology (PAGE) Study. J Invest Dermatol, , , 2014.

Malinowski, J, Farber-Eger, E, Crawford, DC. Development of a data-mining algorithm to identify ages at reproductive milestones in electronic medical records. Pac Symp Biocomput, , 376-87, 2014.

Mitchell, SL, Goodloe, R, Brown-Gentry, K, Pendergrass, SA, Murdock, DG, Crawford, DC. Characterization of mitochondrial haplogroups in a large population-based sample from the United States. Hum Genet, , , 2014.

Oetjens, M, Bush, WS, Birdwell, KA, Dilks, HH, Bowton, EA, Denny, JC, Wilke, RA, Roden, DM, Crawford, DC. Utilization of an EMR-biorepository to identify the genetic predictors of calcineurin-inhibitor toxicity in heart transplant recipients. Pac Symp Biocomput, , 253-64, 2014.

Bush, WS, Boston, J, Pendergrass, SA, Dumitrescu, L, Goodloe, R, Brown-Gentry, K, Wilson, S, McClellan, B, Torstenson, E, Basford, MA, Spencer, KL, Ritchie, MD, Crawford, DC. Enabling high-throughput genotype-phenotype associations in the epidemiologic architecture for genes linked to environment (eagle) project as part of the population architecture using genomics and epidemiology (page) study. Pac Symp Biocomput, , 373-84, 2013.

Crawford, DC, Goodloe, R, Brown-Gentry, K, Wilson, S, Roberson, J, Gillani, NB, Ritchie, MD, Dilks, HH, Bush, WS. Characterization of the metabochip in diverse populations from the international hapmap project in the epidemiologic architecture for genes linked to environment (eagle) project. Pac Symp Biocomput, , 188-99, 2013.

Duan, Q, Liu, EY, Auer, PL, Zhang, G, Lange, EM, Jun, G, Bizon, C, Jiao, S, Buyske, S, Franceschini, N, Carlson, CS, Hsu, L, Reiner, AP, Peters, U, Haessler, J, Curtis, K, Wassel, CL, Robinson, JG, Martin, LW, Haiman, CA, Le Marchand, L, Matise, TC, Hindorff, LA, Crawford, DC, Assimes, TL, Kang, HM, Heiss, G, Jackson, RD, Kooperberg, C, Wilson, JG, Abecasis, GR, North, KE, Nickerson, DA, Lange, LA, Li, Y. Imputation of coding variants in African Americans: better performance using data from the exome sequencing project. Bioinformatics, 29(21), 2744-9, 2013.

Dumitrescu, L, Carty, CL, Franceschini, N, Hindorff, LA, Cole, SA, Bukova, P, Schumacher, FR, Eaton, CB, Goodloe, RJ, Duggan, DJ, Haessler, J, Cochran, B, Henderson, BE, Cheng, I, Johnson, KC, Carlson, CS, Love, SA, Brown-Gentry, K, Nato, AQ, Quibrera, M, Shohet, RV, Ambite, JL, Wilkens, LR, Le Marchand, L, Haiman, CA, Buyske, S, Kooperberg, C, North, KE, Fornage, M, Crawford, DC. No evidence of interaction between known lipid-associated genetic variants and smoking in the multi-ethnic PAGE population. Hum Genet, , , 2013.

Dumitrescu, L, Carty, CL, Franceschini, N, Hindorff, LA, Cole, SA, Buzkova, P, Schumacher, FR, Eaton, CB, Goodloe, RJ, Duggan, DJ, Haessler, J, Cochran, B, Henderson, BE, Cheng, I, Johnson, KC, Carlson, CS, Love, SA, Brown-Gentry, K, Nato, AQ, Quibrera, M, Anderson, G, Shohet, RV, Ambite, JL, Wilkens, LR, Marchand, LL, Haiman, CA, Buyske, S, Kooperberg, C, North, KE, Fornage, M, Crawford, DC. Post-Genome-Wide Association Study Challenges for Lipid Traits: Describing Age as a Modifier of Gene-Lipid Associations in the Population Architecture Using Genomics and Epidemiology (PAGE) Study. Ann Hum Genet, , , 2013.

Goodloe, R, Brown-Gentry, K, Gillani, NB, Jin, H, Mayo, P, Allen, M, McClellan, B, Boston, J, Sutcliffe, C, Schnetz-Boutaud, N, Dilks, HH, Crawford, DC. Lipid trait-associated genetic variation is associated with gallstone disease in the diverse Third National Health and Nutrition Examination Survey (NHANES III). BMC Med Genet, 14, 120, 2013.

Jeff, JM, Ritchie, MD, Denny, JC, Kho, AN, Ramirez, AH, Crosslin, D, Armstrong, L, Basford, MA, Wolf, WA, Pacheco, JA, Chisholm, RL, Roden, DM, Hayes, MG, Crawford, DC. Generalization of Variants Identified by Genome-Wide Association Studies for Electrocardiographic Traits in African Americans. Ann Hum Genet, , , 2013.

Oetjens, MT, Denny, JC, Ritchie, MD, Gillani, NB, Richardson, DM, Restrepo, NA, Pulley, JM, Dilks, HH, Basford, MA, Bowton, E, Masys, DR, Wilke, RA, Roden, DM, Crawford, DC. Assessment of a pharmacogenomic marker panel in a polypharmacy population identified from electronic medical records. Pharmacogenomics, 14(7), 735-44, 2013.

Ritchie, MD, Denny, JC, Zuvich, RL, Crawford, DC, Schildcrout, JS, Bastarache, L, Ramirez, AH, Mosley, JD, Pulley, JM, Basford, MA, Bradford, Y, Rasmussen, LV, Pathak, J, Chute, CG, Kullo, IJ, McCarty, CA, Chisholm, RL, Kho, AN, Carlson, CS, Larson, EB, Jarvik, GP, Sotoodehnia, N, , , Manolio, TA, Li, R, Masys, DR, Haines, JL, Roden, DM. Genome- and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia risk. Circulation, 127(13), 1377-85, 2013.

Buyske, S, Wu, Y, Carty, CL, Cheng, I, Assimes, TL, Dumitrescu, L, Hindorff, LA, Mitchell, S, Ambite, JL, Boerwinkle, E, Buzkova, P, Carlson, CS, Cochran, B, Duggan, D, Eaton, CB, Fesinmeyer, MD, Franceschini, N, Haessler, J, Jenny, N, Kang, HM, Kooperberg, C, Lin, Y, Le Marchand, L, Matise, TC, Robinson, JG, Rodriguez, C, Schumacher, FR, Voight, BF, Young, A, Manolio, TA, Mohlke, KL, Haiman, CA, Peters, U, Crawford, DC, North, KE. Evaluation of the metabochip genotyping array in African Americans and implications for fine mapping of GWAS-identified loci: the PAGE study. PLoS One, 7(4), e35651, 2012. PMCID:3335090

Crosslin, DR, McDavid, A, Weston, N, Nelson, SC, Zheng, X, Hart, E, de Andrade, M, Kullo, IJ, McCarty, CA, Doheny, KF, Pugh, E, Kho, A, Hayes, MG, Pretel, S, Saip, A, Ritchie, MD, Crawford, DC, Crane, PK, Newton, K, Li, R, Mirel, DB, Crenshaw, A, Larson, EB, Carlson, CS, Jarvik, GP, The eMERGE Network . Genetic variants associated with the white blood cell count in 13,923 subjects in the eMERGE Network. Hum Genet, 131(4), 639-652, 2012.

Delaney, JT, Jeff, JM, Brown, NJ, Pretorius, M, Okafor, HE, Darbar, D, Roden, DM, Crawford, DC. Characterization of genome-wide association-identified variants for atrial fibrillation in african americans. PLoS One, 7(2), e32338, 2012. PMCID:3285683

Delaney, JT, Ramirez, AH, Bowton, E, Pulley, JM, Basford, MA, Schildcrout, JS, Shi, Y, Zink, R, Oetjens, M, Xu, H, Cleator, JH, Jahangir, E, Ritchie, MD, Masys, DR, Roden, DM, Crawford, DC, Denny, JC. Predicting clopidogrel response using DNA samples linked to an electronic health record. Clin Pharmacol Ther, 91(2), 257-63, 2012. PMCID:3326353

Dumitrescu, L, Goodloe, R, Brown-Gentry, K, Mayo, P, Allen, M, Jin, H, Gillani, NB, Schnetz-Boutaud, N, Dilks, HH, Crawford, DC. Serum vitamins A and E as modifiers of lipid trait genetics in the National Health and Nutrition Examination Surveys as part of the Population Architecture using Genomics and Epidemiology (PAGE) study. Hum Genet, 131(11), 1699-708, 2012.

Fesinmeyer, MD, North, KE, Ritchie, MD, Lim, U, Franceschini, N, Wilkens, LR, Gross, MD, Buzkova, P, Glenn, K, Quibrera, PM, Fern?!ndez-Rhodes, L, Li, Q, Fowke, JH, Li, R, Carlson, CS, Prentice, RL, Kuller, LH, Manson, JE, Matise, TC, Cole, SA, Chen, CT, Howard, BV, Kolonel, LN, Henderson, BE, Monroe, KR, Crawford, DC, Hindorff, LA, Buyske, S, Haiman, CA, Le Marchand, L, Peters, U. Genetic Risk Factors for BMI and Obesity in an Ethnically Diverse Population: Results From the Population Architecture Using Genomics and Epidemiology (PAGE) Study. Obesity (Silver Spring), , , 2012. PMCID:3410659

Fullerton, SM, Wolf, WA, Brothers, KB, Clayton, EW, Crawford, DC, Denny, JC, Greenland, P, Koenig, BA, Leppig, KA, Lindor, NM, McCarty, CA, McGuire, AL, McPeek Hinz, ER, Mirel, DB, Ramos, EM, Ritchie, MD, Smith, ME, Waudby, CJ, Burke, W, Jarvik, GP. Return of individual research results from genome-wide association studies: experience of the Electronic Medical Records and Genomics (eMERGE) Network. Genet Med, 14(4), 424-31, 2012. PMCID:3285683

Haiman, CA, Fesinmeyer, MD, Spencer, KL, Buzkov?!, P, Voruganti, VS, Wan, P, Haessler, J, Franceschini, N, Monroe, KR, Howard, BV, Jackson, RD, Florez, JC, Kolonel, LN, Buyske, S, Goodloe, RJ, Liu, S, Manson, JE, Meigs, JB, Waters, K, Mukamal, KJ, Pendergrass, SA, Shrader, P, Wilkens, LR, Hindorff, LA, Ambite, JL, North, KE, Peters, U, Crawford, DC, Le Marchand, L, Pankow, JS. Consistent directions of effect for established type 2 diabetes risk variants across populations: the population architecture using Genomics and Epidemiology (PAGE) Consortium. Diabetes, 61(6), 1642-7, 2012. PMCID:3335090

Jagasia, M, Clark, WB, Brown-Gentry, KD, Crawford, DC, Fan, KH, Chen, H, Kassim, A, Greer, JP, Engelhardt, BG, Savani, BN. Genetic Variation in Donor CTLA-4 Regulatory Region is a Strong Predictor of Outcome after Allogeneic Hematopoietic Cell Transplantation for Hematologic Malignancies. Biol Blood Marrow Transplant, 18(7), 1069-1075, 2012.

Jeff, JM, Brown-Gentry, K, Crawford, DC. Replication and characterisation of genetic variants in the fibrinogen gene cluster with plasma fibrinogen levels and haematological traits in the Third National Health and Nutrition Examination Survey. Thromb Haemost, 107(3), 458-67, 2012. PMCID:3285683

Liu, EY, Buyske, S, Aragaki, AK, Peters, U, Boerwinkle, E, Carlson, C, Carty, C, Crawford, DC, Haessler, J, Hindorff, LA, Marchand, LL, Manolio, TA, Matise, T, Wang, W, Kooperberg, C, North, KE, Li, Y. Genotype Imputation of MetabochipSNPs Using a Study-Specific Reference Panel of a??4,000 Haplotypes in African Americans From the Women''s Health Initiative. Genet Epidemiol, 36(2), 107-17, 2012. PMCID:3410659

Mitchell, S, Welch-Burke, T, Dumitrescu, L, Lomenick, JP, Murdock, DG, Crawford, DC, Summar, M. Peptide tyrosine tyrosine levels are increased in patients with urea cycle disorders. Mol Genet Metab, 106(1), 39-42, 2012.

Pendergrass, SA, Dudek, S, Crawford, DC, Ritchie, MD. Visually integrating and exploring high throughput Phenome-Wide Association (PheWAS) results using PheWAS-View. BioData Min, 5(1), 5, 2012. PMCID:3410659

Pulley, JM, Denny, JC, Peterson, JF, Bernard, GR, Vnencak-Jones, CL, Ramirez, AH, Delaney, JT, Bowton, E, Brothers, K, Johnson, K, Crawford, DC, Schildcrout, J, Masys, DR, Dilks, HH, Wilke, RA, Clayton, EW, Shultz, E, Laposata, M, McPherson, J, Jirjis, JN, Roden, DM. Operational Implementation of Prospective Genotyping for Personalized Medicine: The Design of the Vanderbilt PREDICT Project. Clin Pharmacol Ther, 92(1), 87-95, 2012.

Ramirez, AH, Shi, Y, Schildcrout, JS, Delaney, JT, Xu, H, Oetjens, MT, Zuvich, RL, Basford, MA, Bowton, E, Jiang, M, Speltz, P, Zink, R, Cowan, J, Pulley, JM, Ritchie, MD, Masys, DR, Roden, DM, Crawford, DC, Denny, JC. Predicting warfarin dosage in European-Americans and African-Americans using DNA samples linked to an electronic health record. Pharmacogenomics, 13(4), 407-18, 2012. PMCID:3285683

Rasmussen-Torvik, LJ, Pacheco, JA, Wilke, RA, Thompson, WK, Ritchie, MD, Kho, AN, Muthalagu, A, Hayes, MG, Armstrong, LL, Scheftner, DA, Wilkins, JT, Zuvich, RL, Crosslin, D, Roden, DM, Denny, JC, Jarvik, GP, Carlson, CS, Kullo, IJ, Bielinski, SJ, McCarty, CA, Li, R, Manolio, TA, Crawford, DC, Chisholm, RL. High density GWAS for LDL cholesterol in African Americans using electronic medical records reveals a strong protective variant in APOE. Clin Transl Sci, 5(5), 394-9, 2012.

Schildcrout, JS, Denny, JC, Bowton, E, Gregg, W, Pulley, JM, Basford, MA, Cowan, JD, Xu, H, Ramirez, AH, Crawford, DC, Ritchie, MD, Peterson, JF, Masys, DR, Wilke, RA, Roden, DM. Optimizing drug outcomes through pharmacogenetics: a case for preemptive genotyping. Clin Pharmacol Ther, 92(2), 235-42, 2012.

Spencer, KL, Glenn, K, Brown-Gentry, K, Haines, JL, Crawford, DC. Population differences in genetic risk for age-related macular degeneration and implications for genetic testing. Arch Ophthalmol, 130(1), 116-7, 2012. PMCID:3326353

Wassel, CL, Lamina, C, Nambi, V, Coassin, S, Mukamal, KJ, Ganesh, SK, Jacobs, DR, Franceschini, N, Papanicolaou, GJ, Gibson, Q, Yanek, LR, van der Harst, P, Ferguson, JF, Crawford, DC, Waite, LL, Allison, MA, Criqui, MH, McDermott, MM, Mehra, R, Cupples, LA, Hwang, SJ, Redline, S, Kaplan, RC, Heiss, G, Rotter, JI, Boerwinkle, E, Taylor, HA, Eraso, LH, Haun, M, Li, M, Meisinger, C, O''Connell, JR, Shuldiner, AR, Tybj?|rg-Hansen, A, Frikke-Schmidt, R, Kollerits, B, Rantner, B, Dieplinger, B, Stadler, M, Mueller, T, Haltmayer, M, Klein-Weigel, P, Summerer, M, Wichmann, HE, Asselbergs, FW, Navis, G, Leach, IM, Brown-Gentry, K, Goodloe, R, Assimes, TL, Becker, DM, Cooke, JP, Absher, DM, Olin, JW, Mitchell, BD, Reilly, MP, Mohler, ER, North, KE, Reiner, AP, Kronenberg, F, Murabito, JM. Genetic determinants of the ankle-brachial index: a meta-analysis of a cardiovascular candidate gene 50K SNP panel in the candidate gene association resource (CARe) consortium. Atherosclerosis, 222(1), 138-47, 2012. PMCID:3285683

Clark, WB, Brown-Gentry, KD, Crawford, DC, Fan, KH, Snavely, J, Chen, H, Savani, BN, Kassim, A, Greer, JP, Schuening, FG, Engelhardt, BG, Jagasia, MH. Genetic variation in recipient B-cell activating factor (BAFF) modulates phenotype of graft-versus-host disease. Blood, 118(4), 1140-1144, 2011.

Crawford, DC, Dilks, HH. Strategies for genotyping. Curr Protoc Hum Genet, Chapter 1, Unit1.3, 2011. PMCID:3030597

Denny, JC, Crawford, DC, Ritchie, MD, Bielinski, SJ, Basford, MA, Bradford, Y, Chai, HS, Bastarache, L, Zuvich, R, Peissig, P, Carrell, D, Ramirez, AH, Pathak, J, Wilke, RA, Rasmussen, L, Wang, X, Pacheco, JA, Kho, AN, Hayes, MG, Weston, N, Matsumoto, M, Kopp, PA, Newton, KM, Jarvik, GP, Li, R, Manolio, TA, Kullo, IJ, Chute, CG, Chisholm, RL, Larson, EB, McCarty, CA, Masys, DR, Roden, DM, de Andrade, M. Variants near FOXE1 are associated with hypothyroidism and other thyroid conditions: using electronic medical records for genome- and phenome-wide studies. Am J Hum Genet, 89(4), 529-42, 2011. PMCID:3188836

Dumitrescu, L, Brown-Gentry, K, Goodloe, R, Glenn, K, Yang, W, Kornegay, N, Pui, CH, Relling, MV, Crawford, DC. Evidence for age as a modifier of genetic associations for lipid levels. Ann Hum Genet, 75(5), 589-97, 2011. PMCID:3188836

Dumitrescu, L, Carty, CL, Taylor, K, Schumacher, FR, Hindorff, LA, Ambite, JL, Anderson, G, Best, LG, Brown-Gentry, K, B????kov?!, P, Carlson, CS, Cochran, B, Cole, SA, Devereux, RB, Duggan, D, Eaton, CB, Fornage, M, Franceschini, N, Haessler, J, Howard, BV, Johnson, KC, Laston, S, Kolonel, LN, Lee, ET, MacCluer, JW, Manolio, TA, Pendergrass, SA, Quibrera, M, Shohet, RV, Wilkens, LR, Haiman, CA, Le Marchand, L, Buyske, S, Kooperberg, C, North, KE, Crawford, DC. Genetic determinants of lipid traits in diverse populations from the population architecture using genomics and epidemiology (PAGE) study. PLoS Genet, 7(6), e1002138, 2011. PMCID:3128106

Dumitrescu, L, Glenn, K, Brown-Gentry, K, Shephard, C, Wong, M, Rieder, MJ, Smith, JD, Nickerson, DA, Crawford, DC. Variation in LPA Is Associated with Lp(a) Levels in Three Populations from the Third National Health and Nutrition Examination Survey. PLoS One, 6(1), e16604, 2011. PMCID:3030597

Hung, AM, Ikizler, TA, Griffin, MR, Glenn, K, Greevy, RA, Grijalva, CG, Siew, ED, Crawford, DC. CRP polymorphisms and chronic kidney disease in the third national health and nutrition examination survey. BMC Med Genet, 12, 65, 2011. PMCID:3092760

Lingappa, JR, Dumitrescu, L, Zimmer, SM, Lynfield, R, McNicholl, JM, Messonnier, NE, Whitney, CG, Crawford, DC. Identifying host genetic risk factors in the context of public health surveillance for invasive pneumococcal disease. PLoS One, 6(8), e23413, 2011. PMCID:3156135

Matise, TC, Ambite, JL, Buyske, S, Carlson, CS, Cole, SA, Crawford, DC, Haiman, CA, Heiss, G, Kooperberg, C, Marchand, LL, Manolio, TA, North, KE, Peters, U, Ritchie, MD, Hindorff, LA, Haines, JL, , . The Next PAGE in Understanding Complex Traits: Design for the Analysis of Population Architecture Using Genetics and Epidemiology (PAGE) Study. Am J Epidemiol, 174(7), 849-859, 2011. PMCID:3156135

Miller, EK, Dumitrescu, L, Cupp, C, Dorris, S, Taylor, S, Sparks, R, Fawkes, D, Frontiero, V, Rezendes, AM, Marchant, C, Edwards, KM, Crawford, DC. Atopy history and the genomics of wheezing after influenza vaccination in children 6-59 months of age. Vaccine, 29(18), 3431-7, 2011. PMCID:3334304

Pendergrass, SA, Brown-Gentry, K, Dudek, SM, Torstenson, ES, Ambite, JL, Avery, CL, Buyske, S, Cai, C, Fesinmeyer, MD, Haiman, C, Heiss, G, Hindorff, LA, Hsu, CN, Jackson, RD, Kooperberg, C, Le Marchand, L, Lin, Y, Matise, TC, Moreland, L, Monroe, K, Reiner, AP, Wallace, R, Wilkens, LR, Crawford, DC, Ritchie, MD. The use of phenome-wide association studies (PheWAS) for exploration of novel genotype-phenotype relationships and pleiotropy discovery. Genet Epidemiol, 35(5), 410-22, 2011. PMCID:3116446

Turner, S, Armstrong, LL, Bradford, Y, Carlson, CS, Crawford, DC, Crenshaw, AT, de Andrade, M, Doheny, KF, Haines, JL, Hayes, G, Jarvik, G, Jiang, L, Kullo, IJ, Li, R, Ling, H, Manolio, TA, Matsumoto, M, McCarty, CA, McDavid, AN, Mirel, DB, Paschall, JE, Pugh, EW, Rasmussen, LV, Wilke, RA, Zuvich, RL, Ritchie, MD. Quality control procedures for genome-wide association studies. Curr Protoc Hum Genet, Chapter 1, Unit1.19, 2011. PMCID:3030597

Turner, SD, Berg, RL, Linneman, JG, Peissig, PL, Crawford, DC, Denny, JC, Roden, DM, McCarty, CA, Ritchie, MD, Wilke, RA. Knowledge-Driven Multi-Locus Analysis Reveals Gene-Gene Interactions Influencing HDL Cholesterol Level in Two Independent EMR-Linked Biobanks. PLoS One, 6(5), e19586, 2011. PMCID:3092760

Xu, H, Jiang, M, Oetjens, M, Bowton, EA, Ramirez, AH, Jeff, JM, Basford, MA, Pulley, JM, Cowan, JD, Wang, X, Ritchie, MD, Masys, DR, Roden, DM, Crawford, DC, Denny, JC. Facilitating pharmacogenetic studies using electronic health records and natural-language processing: a case study of warfarin. J Am Med Inform Assoc, 18(4), 387-91, 2011. PMCID:3128409

Zuvich, RL, Armstrong, LL, Bielinski, SJ, Bradford, Y, Carlson, CS, Crawford, DC, Crenshaw, AT, de Andrade, M, Doheny, KF, Haines, JL, Hayes, MG, Jarvik, GP, Jiang, L, Kullo, IJ, Li, R, Ling, H, Manolio, TA, Matsumoto, ME, McCarty, CA, McDavid, AN, Mirel, DB, Olson, LM, Paschall, JE, Pugh, EW, Rasmussen, LV, Rasmussen-Torvik, LJ, Turner, SD, Wilke, RA, Ritchie, MD. Pitfalls of merging GWAS data: lessons learned in the eMERGE network and quality control procedures to maintain high data quality. Genet Epidemiol, 35(8), 887-98, 2011. PMCID:3326353

Crawford, DC, Brown-Gentry, K, Rieder, MJ. VKORC1 common variation and bone mineral density in the Third National Health and Nutrition Examination Survey. PLoS One, 5(12), e15088, 2010. PMCID:3001474

Denny, JC, Ritchie, MD, Basford, MA, Pulley, JM, Bastarache, L, Brown-Gentry, K, Wang, D, Masys, DR, Roden, DM, Crawford, DC. PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations. Bioinformatics, 26(9), 1205-10, 2010. PMCID:2859132

Heike CL, Starr JR, Rieder MJ, Cunningham ML, Edwards KL, Stanaway I, Crawford DC. Single nucleotide polymorphism discovery in TBX1 in individuals with and without 22q11.2 deletion syndrome. Birth Defects Research Part A: Clinical and Molecular Teratology , 88(1), 54-63, 2010.

Hung, AM, Crawford, DC, Griffin, MR, Brown-Gentry, K, Lipkowitz, MS, Siew, ED, Cavanaugh, K, Lewis, JB, Ikizler, TA, , . CRP polymorphisms and progression of chronic kidney disease in African Americans. Clin J Am Soc Nephrol, 5(1), 24-33, 2010. PMCID:2801650

Pendergrass, SA, Dudek, SM, Crawford, DC, Ritchie, MD. Synthesis-View: visualization and interpretation of SNP association results for multi-cohort, multi-phenotype data and meta-analysis. BioData Min, 3, 10, 2010. PMCID:3012023

Ritchie, MD, Denny, JC, Crawford, DC, Ramirez, AH, Weiner, JB, Pulley, JM, Basford, MA, Brown-Gentry, K, Balser, JR, Masys, DR, Haines, JL, Roden, DM. Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record. Am J Hum Genet, 86(4), 560-72, 2010. PMCID:2850440

Bush, WS, Crawford, DC, Alexander, C, George, AL, Roden, DM, Ritchie, MD. Genetic variation in the rhythmonome: ethnic variation and haplotype structure in candidate genes for arrhythmias. Pharmacogenomics, 10(6), 1043-53, 2009. PMCID:2746955

Crawford, DC, Zheng, N, Speelmon, EC, Stanaway, I, Rieder, MJ, Nickerson, DA, McElrath, MJ, Lingappa, J. An excess of rare genetic variation in ABCE1 among Yorubans and African-American individuals with HIV-1. Genes Immun, 10(8), 715-21, 2009. PMCID:2829431

Turner, SD, Crawford, DC, Ritchie, MD. Methods for optimizing statistical analyses in pharmacogenomics research. Expert Rev Clin Pharmacol, 2(5), 559-570, 2009. PMCID:2835152

Crawford, DC, Nord, AS, Badzioch, MD, Ranchalis, J, McKinstry, LA, Ahearn, M, Bertucci, C, Shephard, C, Wong, M, Rieder, MJ, Schellenberg, GD, Nickerson, DA, Heagerty, PJ, Wijsman, EM, Jarvik, GP. A common VLDLR polymorphism interacts with APOE genotype in the prediction of carotid artery disease risk. J Lipid Res, 49(3), 588-96, 2008.

Crawford, DC, Peng, Z, Cheng, JF, Boffelli, D, Ahearn, M, Nguyen, D, Shaffer, T, Yi, Q, Livingston, RJ, Rieder, MJ, Nickerson, DA. LPA and PLG sequence variation and kringle IV-2 copy number in two populations. Hum Hered, 66(4), 199-209, 2008. PMCID:2861532

Crawford, DC, Zimmer, SM, Morin, CA, Messonnier, NE, Lynfield, R, Yi, Q, Shephard, C, Wong, M, Rieder, MJ, Livingston, RJ, Nickerson, DA, Whitney, CG, Lingappa, J. Integrating host genomics with surveillance for invasive bacterial diseases. Emerg Infect Dis, 14(7), 1138-40, 2008. PMCID:2600343

Crawford, DC, Yi, Q, Smith, JD, Shephard, C, Wong, M, Witrak, L, Livingston, RJ, Rieder, MJ, Nickerson, DA. Allelic spectrum of the natural variation in CRP. Hum Genet, 119(5), 496-504, 2006. PMCID:1449912

Crawford, DC, Akey, DT, Nickerson, DA. The patterns of natural variation in human genes. Annu Rev Genomics Hum Genet, 6, 287-312, 2005.

Crawford, DC, Nickerson, DA. Definition and clinical importance of haplotypes. Annu Rev Med, 56, 303-20, 2005.

Crawford, DC, Bhangale, T, Li, N, Hellenthal, G, Rieder, MJ, Nickerson, DA, Stephens, M. Evidence for substantial fine-scale variation in recombination rates across the human genome. Nat Genet, 36(7), 700-6, 2004.

Crawford, DC, Carlson, CS, Rieder, MJ, Carrington, DP, Yi, Q, Smith, JD, Eberle, MA, Kruglyak, L, Nickerson, DA. Haplotype diversity across 100 candidate genes for inflammation, lipid metabolism, and blood pressure regulation in two populations. Am J Hum Genet, 74(4), 610-22, 2004. PMCID:1181939

Livingston, RJ, von Niederhausern, A, Jegga, AG, Crawford, DC, Carlson, CS, Rieder, MJ, Gowrisankar, S, Aronow, BJ, Weiss, RB, Nickerson, DA. Pattern of sequence variation across 213 environmental response genes. Genome Res, 14(10A), 1821-31, 2004. PMCID:524406

Crawford, DC, Caggana, M, Harris, KB, Lorey, F, Nash, C, Pass, KA, Tempelis, C, Olney, RS. Characterization of beta-globin haplotypes using blood spots from a population-based cohort of newborns with homozygous HbS. Genet Med, 4(5), 328-35, 2002.

Crawford, DC, Meadows, KL, Newman, JL, Taft, LF, Scott, E, Leslie, M, Shubek, L, Holmgreen, P, Yeargin-Allsopp, M, Boyle, C, Sherman, SL. Prevalence of the fragile X syndrome in African-Americans. Am J Med Genet, 110(3), 226-33, 2002.

Sullivan, AK, Crawford, DC, Scott, EH, Leslie, ML, Sherman, SL. Paternally transmitted FMR1 alleles are less stable than maternally transmitted alleles in the common and intermediate size range. Am J Hum Genet, 70(6), 1532-44, 2002. PMCID:379140

Tan, CG, Sandhu, HS, Crawford, DC, Redd, SC, Beach, MJ, Buehler, JW, Bresnitz, EA, Pinner, RW, Bell, BP, , , , . Surveillance for anthrax cases associated with contaminated letters, New Jersey, Delaware, and Pennsylvania, 2001. Emerg Infect Dis, 8(10), 1073-7, 2002. PMCID:2730289

Crawford, DC, Acu??a, JM, Sherman, SL. FMR1 and the fragile X syndrome: human genome epidemiology review. Genet Med, 3(5), 359-71, 2001.

Crawford, DC, Schwartz, CE, Meadows, KL, Newman, JL, Taft, LF, Gunter, C, Brown, WT, Carpenter, NJ, Howard-Peebles, PN, Monaghan, KG, Nolin, SL, Reiss, AL, Feldman, GL, Rohlfs, EM, Warren, ST, Sherman, SL. Survey of the fragile X syndrome CGG repeat and the short-tandem-repeat and single-nucleotide-polymorphism haplotypes in an African American population. Am J Hum Genet, 66(2), 480-93, 2000. PMCID:1288101

Crawford, DC, Wilson, B, Sherman, SL. Factors involved in the initial mutation of the fragile X CGG repeat as determined by sperm small pool PCR. Hum Mol Genet, 9(19), 2909-18, 2000.

Crawford, DC, Zhang, F, Wilson, B, Warren, ST, Sherman, SL. Fragile X CGG repeat structures among African-Americans: identification of a novel factor responsible for repeat instability. Hum Mol Genet, 9(12), 1759-69, 2000.

Crawford, DC, Meadows, KL, Newman, JL, Taft, LF, Pettay, DL, Gold, LB, Hersey, SJ, Hinkle, EF, Stanfield, ML, Holmgreen, P, Yeargin-Allsopp, M, Boyle, C, Sherman, SL. Prevalence and phenotype consequence of FRAXA and FRAXE alleles in a large, ethnically diverse, special education-needs population. Am J Hum Genet, 64(2), 495-507, 1999. PMCID:1377758

Gunter, C, Paradee, W, Crawford, DC, Meadows, KA, Newman, J, Kunst, CB, Nelson, DL, Schwartz, C, Murray, A, Macpherson, JN, Sherman, SL, Warren, ST. Re-examination of factors associated with expansion of CGG repeats using a single nucleotide polymorphism in FMR1. Hum Mol Genet, 7(12), 1935-46, 1998.

Savage, A, Sun, F, Crawford, DC, Ashley, AE, Yang, Q, Sherman, SL. Sequential sib-pair and association studies to detect genes in quantitative traits. Genet Epidemiol, 14(6), 885-90, 1997.

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