Vanderbilt University School of Medicine

Algood, Holly M. , PhD
Assistant Professor of Medicine
Assistant Professor of Pathology, Microbiology and Immunology

Lab Url: N/A

Phone Number: 343-9242


Algood, Holly's picture

Office Address   Mailing Address

A2210 MCN

AA-2200 MCN 37232

Research Keywords
Helicobacter pylori, inflammation, T lymphocytes, cytokines, bacterial pathogenesis, Th17, bacterial response, oxidative stress, host-pathogen interactions,Immunology,Infectious disease,Microbiology,Pathology

Research Description
Projects in Dr. Algood's lab focus on pathogen - host interactions in chronic infections and during chronic inflammation. Her main model system is Helicobacter pylori infection. Helicobacter pylori is a Gram-negative pathogen which can chronically colonize the human stomach and lead to adverse disease outcomes such as peptic ulcers or gastric cancer. Her projects investigate how T cell cytokines influence gastric epithelial cells responding to infection but also even more broadly how T cell cytokines activate other cells to protect the epithelial cells and the mucosal barrier they maintain. Dr. Algood's research utilizes H. pylori as a model mucosal pathogen, but her long-term research interests lie in understanding the balance between the mucosal immune responses, pathogens, and normal flora. While immune responses may be necessary to control bacterial colonization at the mucosal surfaces, the immune response must also be well controlled to maintain epithelial cell integrity and to control infiltration of other potentially damaging immune cells. Th17-driven immune responses have been implicated in pro-inflammatory activity and induction of chronic inflammation; she would like to better understand how the Th17 response is balanced. Moreover, since the inflammatory/immune response is not sufficient to clear the infection, Dr. Algood's laboratory is beginning studies to investigate how the bacteria persist while combated with the stresses of the immune response.

Carbo, A, Olivares-Villagomez, D, Hontecillas, R, Bassaganya-Riera, J, Chaturvedi, R, Piazuelo, MB, Delgado, A, Washington, MK, Wilson, KT, Algood, HM. Systems modeling of the role of interleukin-21 in the maintenance of effector CD4+ T cell responses during chronic Helicobacter pylori infection. MBio, 5(4), e01243-14, 2014.

Radin, JN, Gonzolez-Rivera, C, Frick-Cheng, AE, Sheng, J, Gaddy, JA, Rubin, DH, Algood, HM, McClain, MS, Cover, TL. Role of connexin 43 in Helicobacter pylori VacA-induced cell death. Infect Immun, 82(1), 423-32, 2014.

Gaddy, JA, Radin, JN, Loh, JT, Zhang, F, Washington, MK, Peek, RM, Algood, HM, Cover, TL. High dietary salt intake exacerbates Helicobacter pylori-induced gastric carcinogenesis. Infect Immun, 81(6), 2258-67, 2013.

Horvath, DJ, Radin, JN, Cho, SH, Washington, MK, Algood, HM. The Interleukin-17 Receptor B subunit ss essential for the Th2 response to Helicobacter pylori, but not for control of bacterial burden. PLoS One, 8(3), e60363, 2013.

Radin, JN, Gaddy, JA, Gonzalez-Rivera, C, Loh, JT, Algood, HM, Cover, TL. Flagellar Localization of a Helicobacter pylori Autotransporter Protein. MBio, 4(2), , 2013.

Gonzalez-Rivera, C, Algood, HM, Radin, JN, McClain, MS, Cover, TL. The intermediate region of Helicobacter pylori VacA is a determinant of toxin potency in a Jurkat T cell assay. Infect Immun, 80(8), 2578-88, 2012.

Horvath, DJ, Washington, MK, Cope, VA, Algood, HM. IL-23 contributes to control of chronic Helicobacter pylori infection and the development of T Helper responses in a mouse model. Front Immunol, 3, 56, 2012.

Goettel, JA, Scott Algood, HM, Olivares-Villagomez, D, Washington, MK, Chaturvedi, R, Wilson, KT, Van Kaer, L, Polk, DB. KSR1 protects from interleukin-10 deficiency-induced colitis in mice by suppressing T-lymphocyte interferon-gamma production. Gastroenterology, 140(1), 265-74, 2011.

Olivares-Villagomez, D, Algood, HM, Singh, K, Parekh, VV, Ryan, KE, Piazuelo, MB, Wilson, KT, Van Kaer, L. Intestinal epithelial cells modulate CD4 T cell responses via the thymus leukemia antigen. J Immunol, 187(8), 4051-60, 2011.

Asim, M, Chaturvedi, R, Hoge, S, Lewis, ND, Singh, K, Barry, DP, Algood, HS, de Sablet, T, Gobert, AP, Wilson, KT. Helicobacter pylori induces ERK-dependent formation of a phospho-c-Fos c-Jun activator protein-1 complex that causes apoptosis in macrophages. J Biol Chem, 285(26), 20343-57, 2010.

Ivie, SE, McClain, MS, Algood, HM, Lacy, DB, Cover, TL. Analysis of a beta-helical region in the p55 domain of Helicobacter pylori vacuolating toxin. BMC Microbiol, 10, 60, 2010. PMCID:2836311

Algood, HM, Allen, SS, Washington, MK, Peek, RM, Miller, GG, Cover, TL. Regulation of gastric B cell recruitment is dependent on IL-17 receptor A signaling in a model of chronic bacterial infection. J Immunol, 183(9), 5837-46, 2009. PMCID:2834183

Ivie, SE, McClain, MS, Torres, VJ, Algood, HM, Lacy, DB, Yang, R, Blanke, SR, Cover, TL. Helicobacter pylori VacA subdomain required for intracellular toxin activity and assembly of functional oligomeric complexes. Infect Immun, 76(7), 2843-51, 2008. PMCID:2446698

Loh, JT, Torres, VJ, Algood, HM, McClain, MS, Cover, TL. Helicobacter pylori HopQ outer membrane protein attenuates bacterial adherence to gastric epithelial cells. FEMS Microbiol Lett, 289(1), 53-8, 2008. PMCID:2651568

Algood, HM, Gallo-Romero, J, Wilson, KT, Peek, RM, Cover, TL. Host response to Helicobacter pylori infection before initiation of the adaptive immune response. FEMS Immunol Med Microbiol, 51(3), 577-86, 2007. PMCID:2446698

Algood, HM, Torres, VJ, Unutmaz, D, Cover, TL. Resistance of primary murine CD4+ T cells to Helicobacter pylori vacuolating cytotoxin. Infect Immun, 75(1), 334-41, 2007. PMCID:1828377

Chaturvedi, R, Asim, M, Lewis, ND, Algood, HM, Cover, TL, Kim, PY, Wilson, KT. L-arginine availability regulates inducible nitric oxide synthase-dependent host defense against Helicobacter pylori. Infect Immun, 75(9), 4305-15, 2007. PMCID:1951193

Algood, HM, Cover, TL. Helicobacter pylori persistence: an overview of interactions between H. pylori and host immune defenses. Clin Microbiol Rev, 19(4), 597-613, 2006. PMCID:1592695

Algood, HM, Lin, PL, Flynn, JL. Tumor necrosis factor and chemokine interactions in the formation and maintenance of granulomas in tuberculosis. Clin Infect Dis, 41 Suppl 3, S189-93, 2005. PMCID:1592695

Algood, HM, Flynn, JL. CCR5-deficient mice control Mycobacterium tuberculosis infection despite increased pulmonary lymphocytic infiltration. J Immunol, 173(5), 3287-96, 2004. PMCID:1592695

Algood, HM, Lin, PL, Yankura, D, Jones, A, Chan, J, Flynn, JL. TNF influences chemokine expression of macrophages in vitro and that of CD11b+ cells in vivo during Mycobacterium tuberculosis infection. J Immunol, 172(11), 6846-57, 2004. PMCID:1592695

Algood, HM, Chan, J, Flynn, JL. Chemokines and tuberculosis. Cytokine Growth Factor Rev, 14(6), 467-77, 2003. PMCID:1592695

Scott, HM, Flynn, JL. Mycobacterium tuberculosis in chemokine receptor 2-deficient mice: influence of dose on disease progression. Infect Immun, 70(11), 5946-54, 2002.

Mohan, VP, Scanga, CA, Yu, K, Scott, HM, Tanaka, KE, Tsang, E, Tsai, MM, Flynn, JL, Chan, J. Effects of tumor necrosis factor alpha on host immune response in chronic persistent tuberculosis: possible role for limiting pathology. Infect Immun, 69(3), 1847-55, 2001.

Peters, W, Scott, HM, Chambers, HF, Flynn, JL, Charo, IF, Ernst, JD. Chemokine receptor 2 serves an early and essential role in resistance to Mycobacterium tuberculosis

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