Vanderbilt University School of Medicine

Harrison, Fiona E , PhD
Assistant Professor of Medicine

Lab Url:

Phone Number: 615-875-5547


Harrison, Fiona's picture

Office Address   Mailing Address

7445 MRB4

7465 MRBIV 2213 Garland Avenue 37232-0475

Research Specialty
Antioxidants, vitamin C, vitamin E, oxidative stress, animal behavior, learning and memory, Alzheimer's disease, prenatal development, neuroscience

Dixit, S, Bernardo, A, Walker, JM, Kennard, JA, Kim, GY, Kessler, ES, Harrison, FE. Vitamin C deficiency in the brain impairs cognition, increases amyloid accumulation and deposition, and oxidative stress in APP/PSEN1 and normally aging mice. ACS Chem Neurosci, 6(4), 570-81, 2015.

He, XB, Kim, M, Kim, SY, Yi, SH, Rhee, YH, Kim, T, Lee, EH, Park, CH, Dixit, S, Harrison, FE, Lee, SH. Vitamin C facilitates dopamine neuron differentiation in fetal midbrain through TET1- and JMJD3-dependent epigenetic control manner. Stem Cells, 33(4), 1320-32, 2015.

Perez, K, Hailey, CJ, Bauer, FE, Krivonos, RA, Mori, K, Baganoff, FK, Barri??re, NM, Boggs, SE, Christensen, FE, Craig, WW, Grefenstette, BW, Grindlay, JE, Harrison, FA, Hong, J, Madsen, KK, Nynka, M, Stern, D, Tomsick, JA, Wik, DR, Zhang, S, Zhang, WW, Zoglauer, A. Extended hard-X-ray emission in the inner few parsecs of the Galaxy. Nature, 520(7549), 646-9, 2015.

Rao, SK, Ross, JM, Harrison, FE, Bernardo, A, Reiserer, RS, Reiserer, RS, Mobley, JA, McDonald, MP. Differential proteomic and behavioral effects of long-term voluntary exercise in wild-type and APP-overexpressing transgenics. Neurobiol Dis, 78, 45-55, 2015.

Walker, JM, Harrison, FE. Shared Neuropathological Characteristics of Obesity, Type 2 Diabetes and Alzheimer''s Disease: Impacts on Cognitive Decline. Nutrients, 7(9), 7332-57, 2015.

Warner, TA, Kang, JQ, Kennard, JA, Harrison, FE. Low brain ascorbic acid increases susceptibility to seizures in mouse models of decreased brain ascorbic acid transport and Alzheimer''s disease. Epilepsy Res, 110, 20-5, 2015.

Harrison, FE, Bowman, GL, Polidori, MC. Ascorbic acid and the brain: rationale for the use against cognitive decline. Nutrients, 6(4), 1752-81, 2014.

Kennard, JA, Harrison, FE. Intravenous ascorbate improves spatial memory in middle-aged APP/PSEN1 and wild type mice. Behav Brain Res, 264, 34-42, 2014.

Korade, Z, Xu, L, Harrison, FE, Ahsen, R, Hart, SE, Folkes, OM, Mirnics, K, Porter, NA. Antioxidant supplementation ameliorates molecular deficits in Smith-Lemli-Opitz syndrome. Biol Psychiatry, 75(3), 215-22, 2014.

Korade, Z, Folkes, OM, Harrison, FE. Behavioral and serotonergic response changes in the Dhcr7-HET mouse model of Smith-Lemli-Opitz syndrome. Pharmacol Biochem Behav, , , 2013.

May, JM, Harrison, FE. Role of vitamin C in the function of the vascular endothelium. Antioxid Redox Signal, 19(17), 2068-83, 2013.

Pierce, MR, Diasio, DL, Rodrigues, LM, Harrison, FE, May, JM. Combined vitamin C and E deficiency induces motor defects in gulo(-/-)/SVCT2(+/-) mice. Nutr Neurosci, 16(4), 160-73, 2013.

Ward, MS, Lamb, J, May, JM, Harrison, FE. Behavioral and monoamine changes following severe vitamin C deficiency. J Neurochem, 124(3), 363-75, 2013.

Harrison, FE. A critical review of vitamin C for the prevention of age-related cognitive decline and Alzheimer''s disease. J Alzheimers Dis, 29(4), 711-26, 2012.

Harrison, FE, Best, JL, Meredith, ME, Gamlin, CR, Borza, DB, May, JM, May, JM. Increased expression of SVCT2 in a new mouse model raises ascorbic acid in tissues and protects against paraquat-induced oxidative damage in lung. PLoS One, 7(4), e35623, 2012.

Jiang, H, Harrison, FE, Jain, K, Benjamin, S, May, JM, Graves, JP, Zeldin, DC, Falck, JR, Hammock, BD, McGiff, JC. Vitamin C activation of the biosynthesis of epoxyeicosatrienoic acids. Adv Biosci Biotechnol, 3(3), 204-218, 2012.

Davies, SS, Bodine, C, Matafonova, E, Pantazides, BG, Bernoud-Hubac, N, Harrison, FE, Olson, SJ, Montine, TJ, Amarnath, V, Roberts, LJ. Treatment with a I?-ketoaldehyde scavenger prevents working memory deficits in hApoE4 mice. J Alzheimers Dis, 27(1), 49-59, 2011. PMCID:3289064

Harrison, F, Hailey, CJ. X-ray vision. Sci Am, 304(2), 78-9, 2011.

Meredith, ME, Harrison, FE, May, JM. Differential regulation of the ascorbic acid transporter SVCT2 during development and in response to ascorbic acid depletion. Biochem Biophys Res Commun, 414(4), 737-42, 2011.

Harrison, FE, Dawes, SM, Meredith, ME, Babaev, VR, Li, L, May, JM. Low vitamin C and increased oxidative stress cell death in mice that lack the sodium-dependent vitamin C transporter SVCT2. Free Radic Biol Med, , , 2010.

Harrison, FE, Green, RJ, Dawes, SM, May, JM. Vitamin C distribution and retention in the mouse brain. Brain Res, , , 2010.

Harrison, FE, Meredith, ME, Dawes, SM, Saskowski, JL, May, JM. Low ascorbic acid and increased oxidative stress in gulo(-/-) mice during development. Brain Res, , , 2010.

Harrison, FE, Allard, J, Bixler, R, Usoh, C, Li, L, May, JM, McDonald, MP. Antioxidants and cognitive training interact to affect oxidative stress and memory in APP/PSEN1 mice. Nutr Neurosci, 12(5), 203-18, 2009.

Harrison, FE, Hosseini, AH, Dawes, SM, Weaver, S, May, JM. Ascorbic acid attenuates scopolamine-induced spatial learning deficits in the water maze. Behav Brain Res, , , 2009.

Harrison, FE, Hosseini, AH, McDonald, MP. Endogenous anxiety and stress responses in water maze and Barnes maze spatial memory tasks. Behav Brain Res, 198(1), 247-51, 2009. PMCID:2663577

Harrison, FE, Hosseini, AH, McDonald, MP, May, JM. Vitamin C reduces spatial learning deficits in middle-aged and very old APP/PSEN1 transgenic and wild-type mice. Pharmacol Biochem Behav, , , 2009. PMCID:2725435

Harrison, FE, May, JM. Vitamin C function in the brain: vital role of the ascorbate transporter SVCT2. Free Radic Biol Med, 46(6), 719-30, 2009. PMCID:2649700

Harrison, FE, May, JM, McDonald, MP. Vitamin C deficiency increases basal exploratory activity but decreases scopolamine-induced activity in APP/PSEN1 transgenic mice. Pharmacol Biochem Behav, , , 2009.

Bernardo, A, Harrison, FE, McCord, M, Zhao, J, Bruchey, A, Davies, SS, Jackson Roberts, L, Mathews, PM, Matsuoka, Y, Ariga, T, Yu, RK, Thompson, R, McDonald, MP. Elimination of GD3 synthase improves memory and reduces amyloid-beta plaque load in transgenic mice. Neurobiol Aging, , , 2008.

Harrison, FE, Yu, SS, Van Den Bossche, KL, Li, L, May, JM, McDonald, MP. Elevated oxidative stress and sensorimotor deficits but normal cognition in mice that cannot synthesize ascorbic acid. J Neurochem, 106(3), 1198-208, 2008. PMCID:2575028

Reiserer, RS, Harrison, FE, Syverud, DC, McDonald, MP. Impaired spatial learning in the APPSwe + PSEN1DeltaE9 bigenic mouse model of Alzheimer''s disease. Genes Brain Behav, 6(1), 54-65, 2007.

Harrison, FE, Reiserer, RS, Tomarken, AJ, McDonald, MP. Spatial and nonspatial escape strategies in the Barnes maze. Learn Mem, 13(6), 809-19, 2006. PMCID:1783636

Postdoctoral Position Available

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