Vanderbilt University School of Medicine

Thornton-Wells, Tricia , PhD
Assistant Professor of Molecular Physiology and Biophysics

Lab Url: http://chgr.mc.vanderbilt.edu/page/tricia-a-thornton-wells-ph-d

Phone Number: 615-343-0396

Email Address:t.thornton-wells@vanderbilt.edu

Thornton-Wells, Tricia's picture

Office Address   Mailing Address

515C Light Hall

Center for Human Genetics Research 519 Light Hall 37232


Research Keywords
Human Genetics; Neuropsychiatric disorders; Neurodevelopmental disorders; Neurodegenerative Disorders; Neuroimaging Genetics; Computational & Statistical Genetics; MRI; Alzheimer Disease; Down Syndrome; Williams Syndrome; ,Genetics,Genomics,Human Genetics,Neuroscience

Research Specialty
Neuroimaging Genetics; Statistical & computational genetics; Structural & functional neuroimaging; Neuropsychiatric, Neurodegenerative & Neurodevelopmental disorders; Alzheimer Disease; Down syndrome; Williams syndrome; anxiety; depression; chemotherapy-related cognitive impairment

Research Description
Research in my lab is focused on the genetic and neural bases of neuropsychiatric and neurodevelopmental disorders. We use magnetic resonance imaging (MRI) to derive functional and structural brain-based endophenotypes, and we conduct genetic studies to identify novel associations between genes, endophenotypes, and behavior. We develop and employ statistical and computational methods for the joint analysis of genetic and neuroimaging data (i.e., "imaging genetics").

Clinical Research Description
Research in my lab is focused on the genetic and neural bases of neuropsychiatric and neurodevelopmental disorders. We use magnetic resonance imaging (MRI) to derive functional and structural brain-based endophenotypes, and we conduct genetic studies to identify novel associations between genes, endophenotypes, and behavior. We develop and employ statistical and computational methods for the joint analysis of genetic and neuroimaging data (i.e., "imaging genetics").

Publications
Avery, SN, Thornton-Wells, TA, Anderson, AW, Blackford, JU. White matter integrity deficits in prefrontal-amygdala pathways in Williams syndrome. Neuroimage, 59(2), 887-94, 2012. PMCID:3280212

Han, Z, Thornton-Wells, TA, Dykens, EM, Gore, JC, Dawant, BM. Effect of nonrigid registration algorithms on deformation-based morphometry: a comparative study with control and Williams syndrome subjects. Magn Reson Imaging, 30(6), 774-88, 2012.

Meda, SA, Pryweller, JR, Thornton-Wells, TA. Regional brain differences in cortical thickness, surface area and subcortical volume in individuals with Williams syndrome. PLoS One, 7(2), e31913, 2012. PMCID:3280212

Arlinghaus, LR, Thornton-Wells, TA, Dykens, EM, Anderson, AW. Alterations in diffusion properties of white matter in Williams syndrome. Magn Reson Imaging, 29(9), 1165-1174, 2011.

Tang B, Thornton-Wells TA, Askland K. Comparative linkage meta-analysis reveals regionally-distinct, disparate genetic architectures: application to biopolar disorder and schizophrenia. PLoS ONE, 6(4), e19073, 2011.

Thornton-Wells, TA, Avery, SN, Blackford, JU. Using novel control groups to dissect the amygdala''s role in Williams Syndrome. Dev Cogn Neurosci, 1(3), 295-304, 2011.

Thornton-Wells, TA, Cannistraci, CJ, Anderson, AW, Kim, CY, Eapen, M, Gore, JC, Blake, R, Dykens, EM. Auditory attraction: activation of visual cortex by music and sound in Williams syndrome. Am J Intellect Dev Disabil, 115(2), 172-89, 2010. PMCID:2862007

Thornton-Wells, TA, Moore, JH, Martin, ER, Pericak-Vance, MA, Haines, JL. Confronting complexity in late-onset Alzheimer disease: application of two-stage analysis approach addressing heterogeneity and epistasis. Genet Epidemiol, 32(3), 187-203, 2008.

Bush, WS, Thornton-Wells, TA, Ritchie, MD. Association Rule Discovery Has the Ability to Model Complex Genetic Effects. IEEE Symp Comput Intell Data Min, 2007, 624-629, 2007. PMCID:2954594

Thornton-Wells, TA, Moore, JH, Haines, JL. Dissecting trait heterogeneity: a comparison of three clustering methods applied to genotypic data. BMC Bioinformatics, 7, 204, 2006. PMCID:1525209

Thornton-Wells, TA, Moore, JH, Haines, JL. Genetics, statistics and human disease: analytical retooling for complexity. Trends Genet, 20(12), 640-7, 2004.


Postdoctoral Position Available
No

Postdoctoral Position Details
N/A

Updated Date
02/08/2013



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