Vanderbilt University School of Medicine

Benninger, Richard K.P. , PhD

Lab Url:

Phone Number: 615 322 9710


Benninger, Richard's picture

Office Address   Mailing Address

747 Light Hall, Vanderbilt University Medical Center 37232

Research Keywords
Fluorescence microscopy, Computer modeling, Insulin secretion, Gap junctions

Research Specialty
Multi-cellular interactions and dynamics underlying insulin secretion

Benninger, RKP, Remedi, MS, Head, WS, Ustione, A, Piston, DW, Nichols, CG. Defects in beta cell Ca(2+) signalling, glucose metabolism and insulin secretion in a murine model of K(ATP) channel-induced neonatal diabetes mellitus. Diabetologia, , , 2011.

Meyer-Hermann M, Benninger RKP. . A mathematical model of I?-cells in an islet of Langerhans sensing a glucose gradient. . HFSP J, 4(2), 61-71, 2010.

Zhao, A, Ohara-Imaizumi, M, Brissova, M, Benninger, RKP, Xu, Y, Hao, Y, Abramowitz, J, Boulay, G, Powers, AC, Piston, D, Jiang, M, Nagamatsu, S, Birnbaumer, L, Gu, G. GI?o represses insulin secretion by reducing vesicular docking in pancreatic beta-cells. Diabetes, 59(10), 2522-9, 2010.

Benninger, RKP, Piston, DW. Recent Advances in Single-photon-counting Detection Technology in Fluorescence Microscopy. Laser Focus World, June, 59-63, 2009.

Benninger, RKP, Vanherberghen, B, Young, S, Taner, SB, Culley, FJ, Schnyder, T, Neil, MAA, W??stner, D, French, PMW, Davis, DM, Onfelt, B. Live cell linear dichroism imaging reveals extensive membrane ruffling within the docking structure of natural killer cell immune synapses. Biophys J, 96(2), L13-5, 2009. PMCID:2716478

Easley, CJ, Benninger, RKP, Shaver, JH, Steven Head, W, Piston, DW. Rapid and inexpensive fabrication of polymeric microfluidic devices via toner transfer masking. Lab Chip, 9(8), 1119-27, 2009. PMCID:2752280

Gunawardana, SC, Benninger, RKP, Piston, DW. Subcutaneous transplantation of embryonic pancreas for correction of type 1 diabetes. Am J Physiol Endocrinol Metab, 296(2), E323-32, 2009. PMCID:2645017

Pound, LD, Sarkar, SA, Benninger, RKP, Wang, Y, Suwanichkul, A, Shadoan, MK, Printz, RL, Oeser, JK, Lee, CE, Piston, DW, McGuinness, OP, Hutton, JC, Powell, DR, O'Brien, RM. Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion. Biochem J, 421(3), 371-6, 2009.

Benninger, RKP, Ashby, WJ, Ring, EA, Piston, DW. Single-photon-counting detector for increased sensitivity in two-photon laser scanning microscopy. Opt Lett, 33(24), 2895-7, 2008. PMCID:2749309

Benninger, RKP, Hao, M, Piston, DW. Multi-photon excitation imaging of dynamic processes in living cells and tissues. Rev Physiol Biochem Pharmacol, 160, 71-92, 2008.

Benninger, RKP, Zhang, M, Head, WS, Satin, LS, Piston, DW. Gap junction coupling and calcium waves in the pancreatic islet. Biophys J, 95(11), 5048-61, 2008. PMCID:2586567

Mao, S, Benninger, RKP, Yan, Y, Petchprayoon, C, Jackson, D, Easley, CJ, Piston, DW, Marriott, G. Optical lock-in detection of FRET using synthetic and genetically encoded optical switches. Biophys J, 94(11), 4515-24, 2008. PMCID:2480664

Benninger, RKP, Hofmann, O, Onfelt, B, Munro, I, Dunsby, C, Davis, DM, Neil, MAA, French, PMW, de Mello, AJ. Fluorescence-lifetime imaging of DNA-dye interactions within continuous-flow microfluidic systems. Angew Chem Int Ed Engl, 46(13), 2228-31, 2007.

De Beule, P, Owen, DM, Manning, HB, Talbot, CB, Requejo-Isidro, J, Dunsby, C, McGinty, J, Benninger, RKP, Elson, DS, Munro, I, John Lever, M, Anand, P, Neil, MAA, French, PMW. Rapid hyperspectral fluorescence lifetime imaging. Microsc Res Tech, 70(5), 481-4, 2007.

Kumar, S, Dunsby, C, De Beule, PA, Owen, DM, Anand, U, Lanigan, PMP, Benninger, RKP, Davis, DM, Neil, MAA, Anand, P, Benham, C, Naylor, A, French, PMW. Multifocal multiphoton excitation and time correlated single photon counting detection for 3-D fluorescence lifetime imaging. Opt Express, 15(20), 12548-61, 2007.

Benninger, RKP, Ko??, Y, Hofmann, O, Requejo-Isidro, J, Neil, MAA, French, PMW, DeMello, AJ. Quantitative 3D mapping of fluidic temperatures within microchannel networks using fluorescence lifetime imaging. Anal Chem, 78(7), 2272-8, 2006.

Onfelt, B, Nedvetzki, S, Benninger, RKP, Purbhoo, MA, Sowinski, S, Hume, AN, Seabra, MC, Neil, MAA, French, PMW, Davis, DM. Structurally distinct membrane nanotubes between human macrophages support long-distance vesicular traffic or surfing of bacteria. J Immunol, 177(12), 8476-83, 2006.

Benninger RKP, Hofmann O, McGinty J, Requejo-Isidro J, Munro I, Neil MAA, deMello AJ, French PMW . Time-resolved fluorescence imaging of solvent interactions in microfluidic devices . Optics Express, 13(16), 6275-6285, 2005.

Benninger, RKP, Onfelt, B, Neil, MAA, Davis, DM, French, PMW. Fluorescence imaging of two-photon linear dichroism: cholesterol depletion disrupts molecular orientation in cell membranes. Biophys J, 88(1), 609-22, 2005. PMCID:1305038

Daniel Elson, Jose Requejo-Isidro, Ian Munro, Fred Reavell, Jan Siegel, Klaus Suhling, Paul Tadrous, Richard Benninger, Peter Lanigan, James McGinty, Clifford Talbot, Bebhinn Treanor, Stephen Webb, Anne Sandison, Andrew Wallace, Daniel Davis, John Lever, Mark Neil, David Phillips, Gordon Stamp, Paul French. A Perspective: Time-domain fluorescence lifetime imaging applied to biological tissue. Photochemical Photobiological Sciences , 3, 795-801, 2004.

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