Vanderbilt University School of Medicine

Young, Jamey D. , Ph.D.
Assistant Professor of Chemical and Biomolecular Engineering
Assistant Professor of Molecular Physiology & Biophysics

Lab Url: http://www.vanderbilt.edu/younglab

Phone Number: 615-343-4253

Email Address:j.d.young@vanderbilt.edu

Young, Jamey's picture

Office Address   Mailing Address

212B Olin Hall

VU Station B #351604 2400 Highland Ave; 107 Olin Hall 37235-1304


Research Specialty
Metabolic engineering and systems biology

Research Description
The central theme of our research is the application of engineering, biochemistry, and molecular biology to quantitatively analyze and redirect cellular metabolism. In particular, we use an approach called metabolic flux analysis (MFA) to quantify the rates, or "fluxes", of intracellular metabolic pathways in a variety of cell models of relevance to medicine and biotechnology. In addition to tool-oriented research aimed at Enhancing MFA Methodologies, we are actively pursuing research in four specific application areas: Diabetes & Obesity, Cancer Metabolism, Cell Culture Engineering, and Photosynthesis Research. Although diverse in their biological scope, all projects rely on our lab's core expertise to integrate numerous metabolic measurements into a quantitative map of cell metabolism using rigorous mathematical models, with the ultimate goal of deciphering how metabolic networks are natively regulated and how they can be further engineered to achieve a desired outcome.

Publications
Murphy, TA, Dang, CV, Young, J. Isotopically nonstationary (13)C flux analysis of Myc-induced metabolic reprogramming in B-cells. Metab Eng, , , 2012.

Strand, DW, Jiang, M, Murphy, TA, Yi, Y, Konvinse, KC, Franco, OE, Wang, Y, Young, JD, Hayward, SW. PPARI? isoforms differentially regulate metabolic networks to mediate mouse prostatic epithelial differentiation. Cell Death Dis, 3, e361, 2012.

Young, JL, Martin, PR. Treatment of opioid dependence in the setting of pregnancy. Psychiatr Clin North Am, 35(2), 441-60, 2012.

Noguchi, Y, Young, JD, Aleman, JO, Hansen, ME, Kelleher, JK, Stephanopoulos, G. Tracking cellular metabolomics in lipoapoptosis- and steatosis-developing liver cells. Mol Biosyst, 7(5), 1409-19, 2011.

Srour, O, Young, JD, Eldar, YC. Fluxomers: a new approach for 13C metabolic flux analysis. BMC Syst Biol, 5, 129, 2011.

Young, JD, Shastri, AA, Stephanopoulos, G, Morgan, JA. Mapping photoautotrophic metabolism with isotopically nonstationary (13)C flux analysis. Metab Eng, 13(6), 656-65, 2011.

Deming, SL, Egbuji, A, Smith, J, Gociu, A, Young, J, Carter, C, Barnes, F, Oduma, J, Kimende, K, Onayade, A, Durosinmi, M, Lawal, OO, Adegoke, OJ, Marshall, DR. Challenges unique to the design of a comprehensive questionnaire assessing breast cancer risk factors among women in sub-Saharan Africa. J Health Care Poor Underserved, 21(1 Suppl), 11-6, 2010.

Noguchi, Y, Nishikata, N, Shikata, N, Kimura, Y, Aleman, JO, Young, JD, Koyama, N, Kelleher, JK, Takahashi, M, Stephanopoulos, G. Ketogenic essential amino acids modulate lipid synthetic pathways and prevent hepatic steatosis in mice. PLoS One, 5(8), e12057, 2010. PMCID:2919399

Reed, JL, Senger, RS, Antoniewicz, MR, Young, JD. Computational approaches in metabolic engineering. J Biomed Biotechnol, 2010, 207414, 2010. PMCID:3092504

Wanna, G, Young, JA, Swanson, E, Haynes, D. Spontaneous otogenic posterior fossa pneumocephalus. Otolaryngol Head Neck Surg, 143(4), 593-4, 2010.

Haynes, DS, Young, JA, Wanna, GB, Glasscock, ME. Middle ear implantable hearing devices: an overview. Trends Amplif, 13(3), 206-14, 2009.

Noguchi, Y, Young, JD, Aleman, JO, Hansen, ME, Kelleher, JK, Stephanopoulos, G. Effect of anaplerotic fluxes and amino acid availability on hepatic lipoapoptosis. J Biol Chem, 284(48), 33425-36, 2009. PMCID:2785187

Young, JD, Henne, KL, Morgan, JA, Konopka, AE, Ramkrishna, D. Integrating cybernetic modeling with pathway analysis provides a dynamic, systems-level description of metabolic control. Biotechnol Bioeng, 100(3), 542-59, 2008. PMCID:2785187

Young, JD, Walther, JL, Antoniewicz, MR, Yoo, H, Stephanopoulos, G. An elementary metabolite unit (EMU) based method of isotopically nonstationary flux analysis. Biotechnol Bioeng, 99(3), 686-99, 2008. PMCID:2785187

Young, JD, Ramkrishna, D. On the matching and proportional laws of cybernetic models. Biotechnol Prog, 23(1), 83-99, 2007. PMCID:2785187

Butler, J, Young, JB, Abraham, WT, Bourge, RC, Adams, KF, Clare, R, O''Connor, C, , . Beta-blocker use and outcomes among hospitalized heart failure patients. J Am Coll Cardiol, 47(12), 2462-9, 2006.

Voehler, MW, Collier, G, Young, JK, Stone, MP, Germann, MW. Performance of cryogenic probes as a function of ionic strength and sample tube geometry. J Magn Reson, 183(1), 102-9, 2006.

Butler, J, Emerman, C, Peacock, WF, Mathur, VS, Young, JB, , . The efficacy and safety of B-type natriuretic peptide (nesiritide) in patients with renal insufficiency and acutely decompensated congestive heart failure. Nephrol Dial Transplant, 19(2), 391-9, 2004.

Butler, J, Forman, DE, Abraham, WT, Gottlieb, SS, Loh, E, Massie, BM, O''Connor, CM, Rich, MW, Stevenson, LW, Wang, Y, Young, JB, Krumholz, HM. Relationship between heart failure treatment and development of worsening renal function among hospitalized patients. Am Heart J, 147(2), 331-8, 2004.

J. D. Young, K. L. Henne, J. A. Morgan, A. E. Konopka and D. Ramkrishna. . Cybernetic modeling of metabolism: towards a framework for rational design of recombinant organisms.. Chemical Engineering Science , 59, 5041-9, 2004.

Eastridge, CE, Fields, ML, Young, JM. Cushing''s syndrome associated with bronchial adenoma. Am J Surg, 133(2), 236-9, 1977.


Postdoctoral Position Available
Yes

Postdoctoral Position Details
PROJECT TITLE: Pathways of redox regulation in LKB1-deficient NSCLC cells

DEGREE AND EXPERIENCE REQUIREMENTS
a?? Ph.D. in Engineering (e.g., Chemical, Biomedical) or Biological Sciences (e.g., Biochemistry, Molecular/Cell Biology, Cancer Biology, Physiology, Biophysics).
a?? Experience with mammalian cell culture required.
a?? Experience with molecular/cell biology is desirable, especially methods for analysis and manipulation of protein expression or cell signaling.
a?? Experience with mass spectrometry and gas or liquid chromatography is a plus.
a?? Experience or desire to learn quantitative approaches for analysis of metabolic pathways, especially metabolic flux analysis.
a?? Strong oral and written communication skills. Ability to organize material for journal publications and grant submissions.
a?? Ability to train and supervise graduate and undergraduate students.
a?? Good publication record as first author in major journals.
a?? US citizens or residents interested in academic careers and/or desiring to apply for an individual NIH postdoctoral fellowship will be given special attention and priority.

DESCRIPTION OF PROJECT
LKB1 is a master kinase that is mutated or underexpressed in 20-30% of non-small cell lung cancer (NSCLC) patient tumors. Because wild-type LKB1 normally functions as a sensor of energetic or oxidative stress, the response to metabolic insults becomes dysregulated in LKB1-deficient cells. The overall objective of this project is to apply metabolic flux analysis and quantitative biochemical profiling to identify critical pathways that maintain redox homeostasis in LKB1-deficient NSCLC cells, and to test their potential as targets for cancer therapeutics.

PI BIOGRAPHICAL SKETCH
The central theme of the Young lab is the application of engineering, biochemistry, and molecular biology to quantitatively analyze and redirect cellular metabolism. We are currently applying 13C flux analysis to assess metabolic phenotypes in a variety of cell models of relevance to human disease, including cancer and type-2 diabetes.
More information is available at http://www.vanderbilt.edu/younglab

CONTACT
Send CV (including current list of publications) and contact information of 3 references to:
Dr. Jamey D. Young
PMB 351604
2301 Vanderbilt Place
Nashville, TN 37235-1604
Phone: 615-343-4253
Fax: 615-343-7951
Email: j.d.young@vanderbilt.edu (Use the subject line: a??Postdoctoral position in Young Laba??)

Updated Date
04/07/2012



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