Vanderbilt University School of Medicine

Brantley, Milam A. , MD, PhD
Associate Professor of Ophthalmology & Visual Sciences

Lab Url: https://medschool.vanderbilt.edu/ophthalmology/labs/brantley

Phone Number: 615-875-7650

Email Address:milam.brantley@vanderbilt.edu

Brantley, Milam's picture

Office Address   Mailing Address

Langford 11425, MRBIV


Research Specialty
Pharmacogenomics and metabolomics of retinal diseases

Clinical Research Description
Our goal is to develop personalized treatment regimens for patients with degenerative retinal diseases. Our research focuses on genetic and environmental influences on disease development, progression, and response to treatment for age-related macular degeneration (AMD) and diabetic retinopathy.

AMD is influenced by common variations in genes such as complement factor H (CFH) and the ARMS2 locus. It appears that oxidative stress may also play a role in AMD pathogenesis. We have shown that the oxidized thiol cystine may be linked to AMD and its risk factors, such as age and a polymorphism in the CFH gene.

Our laboratory now employs the cutting-edge technique of metabolomics to quantify 3500-7000 metabolites in plasma, yielding comprehensive metabolic profiles for AMD patients and controls. We hypothesize that alterations in oxidative stress-related metabolic pathways influence AMD development, progression, and response to treatment. We aim to identify the specific combination of metabolic and genetic profiles that predicts an individuala??s disease course.

We are currently recruiting patients for a study on the metabolomics of diabetic retinopathy. By comparing the genetic and metabolic profiles of diabetics with and without retinopathy, we aim to isolate the combination of genetic predisposition and metabolic pathways that predict risk of developing diabetic retinopathy.

Clinical Interests
Inherited retinal diseases, genetics of age-related macular degeneration and diabetic retinopathy, ocular pharmacogenomics

Publications
Osborn, MP, Park, Y, Parks, MB, Burgess, LG, Uppal, K, Lee, K, Jones, DP, Brantley, MA. Metabolome-wide association study of neovascular age-related macular degeneration. PLoS One, 8(8), e72737, 2013.

Brantley, MA, Osborn, MP, Sanders, BJ, Rezaei, KA, Lu, P, Li, C, Milne, GL, Cai, J, Sternberg, P. The short-term effects of antioxidant and zinc supplements on oxidative stress biomarker levels in plasma: a pilot investigation. Am J Ophthalmol, 153(6), 1104-9.e2, 2012.

Brantley, MA, Osborn, MP, Sanders, BJ, Rezaei, KA, Lu, P, Li, C, Milne, GL, Cai, J, Sternberg, P. Plasma biomarkers of oxidative stress and genetic variants in age-related macular degeneration. Am J Ophthalmol, 153(3), 460-467.e1, 2012.

Sheybani, A, Brantley, MA, Apte, RS. Pattern electroretinography in age-related macular degeneration. Arch Ophthalmol, 129(5), 580-4, 2011. PMCID:3159552

Yu, Y, Bhangale, TR, Fagerness, J, Ripke, S, Thorleifsson, G, Tan, PL, Souied, EH, Richardson, AJ, Merriam, JE, Buitendijk, GH, Reynolds, R, Raychaudhuri, S, Chin, KA, Sobrin, L, Evangelou, E, Lee, PH, Lee, AY, Leveziel, N, Zack, DJ, Campochiaro, B, Campochiaro, P, Smith, RT, Barile, GR, Guymer, RH, Hogg, R, Chakravarthy, U, Robman, LD, Gustafsson, O, Sigurdsson, H, Ortmann, W, Behrens, TW, Stefansson, K, Uitterlinden, AG, van Duijn, CM, Vingerling, JR, Klaver, CC, Allikmets, R, Brantley, MA, Baird, PN, Katsanis, N, Thorsteinsdottir, U, Ioannidis, JP, Daly, MJ, Graham, RR, Seddon, JM. Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration. Hum Mol Genet, 20(18), 3699-709, 2011. PMCID:3159552

Lee, AY, Kulkarni, M, Fang, AM, Edelstein, S, Osborn, MP, Brantley, MA. The effect of genetic variants in SERPING1 on the risk of neovascular age-related macular degeneration. Br J Ophthalmol, 94(7), 915-7, 2010.

Neale, BM, Fagerness, J, Reynolds, R, Sobrin, L, Parker, M, Raychaudhuri, S, Tan, PL, Oh, EC, Merriam, JE, Souied, E, Bernstein, PS, Li, B, Frederick, JM, Zhang, K, Brantley, MA, Lee, AY, Zack, DJ, Campochiaro, B, Campochiaro, P, Ripke, S, Smith, RT, Barile, GR, Katsanis, N, Allikmets, R, Daly, MJ, Seddon, JM. Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). Proc Natl Acad Sci U S A, 107(16), 7395-400, 2010. PMCID:2867697

Brantley, MA, Edelstein, SL, King, JM, Plotzke, MR, Apte, RS, Kymes, SM, Shiels, A. Association of complement factor H and LOC387715 genotypes with response of exudative age-related macular degeneration to photodynamic therapy. Eye (Lond), 23(3), 626-31, 2009. PMCID:2704905

Fang, AM, Lee, AY, Kulkarni, M, Osborn, MP, Brantley, MA. Polymorphisms in the VEGFA and VEGFR-2 genes and neovascular age-related macular degeneration. Mol Vis, 15, 2710-9, 2009. PMCID:2793900

Hegedus, B, Hughes, FW, Garbow, JR, Gianino, S, Banerjee, D, Kim, K, Ellisman, MH, Brantley, MA, Gutmann, DH. Optic nerve dysfunction in a mouse model of neurofibromatosis-1 optic glioma. J Neuropathol Exp Neurol, 68(5), 542-51, 2009. PMCID:2746323

Lee, AY, Raya, AK, Kymes, SM, Shiels, A, Brantley, MA. Pharmacogenetics of complement factor H (Y402H) and treatment of exudative age-related macular degeneration with ranibizumab. Br J Ophthalmol, 93(5), 610-3, 2009. PMCID:2746323

Brantley, MA, Jain, S, Barr, EE, Johnson, EM, Milbrandt, J. Neurturin-mediated ret activation is required for retinal function. J Neurosci, 28(16), 4123-35, 2008. PMCID:2704905

Lee, AY, Brantley, MA. CFH and LOC387715/ARMS2 genotypes and antioxidants and zinc therapy for age-related macular degeneration. Pharmacogenomics, 9(10), 1547-50, 2008. PMCID:2746323

Brantley, MA, Edelstein, SL, King, JM, Apte, RS, Kymes, SM, Shiels, A. Clinical phenotypes associated with the complement factor H Y402H variant in age-related macular degeneration. Am J Ophthalmol, 144(3), 404-408, 2007. PMCID:2140051

Brantley, MA, Fang, AM, King, JM, Tewari, A, Kymes, SM, Shiels, A. Association of complement factor H and LOC387715 genotypes with response of exudative age-related macular degeneration to intravitreal bevacizumab. Ophthalmology, 114(12), 2168-73, 2007. PMCID:2704905

Knopf, HL, Carter, K, Council, MD, Brantley, MA. Peripapillary Hemorrhage. Compr Ophthalmol Update, 8(1), 53-4, 2007. PMCID:2140051

Michaelides, M, Chen, LL, Brantley, MA, Andorf, JL, Isaak, EM, Jenkins, SA, Holder, GE, Bird, AC, Stone, EM, Webster, AR. ABCA4 mutations and discordant ABCA4 alleles in patients and siblings with bull''s-eye maculopathy. Br J Ophthalmol, 91(12), 1650-5, 2007. PMCID:2095527

Zhu, Y, Zhang, Y, Ojwang, BA, Brantley, MA, Gidday, JM. Long-term tolerance to retinal ischemia by repetitive hypoxic preconditioning: role of HIF-1alpha and heme oxygenase-1. Invest Ophthalmol Vis Sci, 48(4), 1735-43, 2007. PMCID:2140051

Feiner, L, Barr, EE, Shui, YB, Holekamp, NM, Brantley, MA. Safety of intravitreal injection of bevacizumab in rabbit eyes. Retina, 26(8), 882-8, 2006. PMCID:2140051

Michaelides, M, Jenkins, SA, Brantley, MA, Andrews, RM, Waseem, N, Luong, V, Gregory-Evans, K, Bhattacharya, SS, Fitzke, FW, Webster, AR. Maculopathy due to the R345W substitution in fibulin-3: distinct clinical features, disease variability, and extent of retinal dysfunction. Invest Ophthalmol Vis Sci, 47(7), 3085-97, 2006. PMCID:2140051

Harbour, JW, Brantley, MA, Hollingsworth, H, Gordon, M. Association between posterior uveal melanoma and iris freckles, iris naevi, and choroidal naevi. Br J Ophthalmol, 88(1), 36-8, 2004. PMCID:1771959

Harbour, JW, Brantley, MA, Hollingsworth, H, Gordon, M. Association between choroidal pigmentation and posterior uveal melanoma in a white population. Br J Ophthalmol, 88(1), 39-43, 2004. PMCID:1771924

Mantel, I, Brantley, MA, Bellmann, C, Robson, AG, Holder, GE, Taylor, A, Anderson, G, Moore, AT. Juvenile neuronal ceroid lipofuscinosis (Batten disease) CLN3 mutation (Chrom 16p11.2) with different phenotypes in a sibling pair and low intensity in vivo autofluorescence. Klin Monbl Augenheilkd, 221(5), 427-30, 2004. PMCID:2140051

Joseph, DP, Brantley, MA, Grand, MG. Serpiginouslike choroiditis in a patient with cardiac sarcoidosis. Retina, 23(1), 116-7, 2003. PMCID:1771959

Brantley, MA, Worley, L, Harbour, JW. Altered expression of Rb and p53 in uveal melanomas following plaque radiotherapy. Am J Ophthalmol, 133(2), 242-8, 2002. PMCID:1771959


Postdoctoral Position Available
No

Postdoctoral Position Details
N/A

Updated Date
09/12/2013



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