Vanderbilt University School of Medicine

Patel, Sachin , MD PhD
Assistant Professor of Psychiatry
Assistant Professor of Molecular Physiology and Biophysics

Lab Url: http://www.mc.vanderbilt.edu/patellab

Phone Number: 936 7768

Email Address:sachin.patel@vanderbilt.edu

Patel, Sachin's picture

Office Address   Mailing Address

724B Robinson Research Building

a?? 702 Robinson Research Building


Research Keywords
neuroscience, stress, depression, anxiety, cannabinoid, endocannabinoid, amygdala, electrophysiology,Kinase,Mouse,Neuroscience,Physiology

Research Specialty
Our research program focuses on the role of endocannabinoids in stress-induced neuroadaptation.

Research Description
Psychosocial stress is a key trigger for the development and exacerbation of a variety of psychiatric disorders including depression, addiction, schizophrenia, and post-traumatic stress disorder. By understanding the molecular, structural, and physiological adaptations in endocannabinoid signaling that occur in response to stress, we hope uncover novel bio-markers and pharmacological targets for drug development. In addition, we hope these investigations will provide insight into the pathophysiology of stress-related neuropsychiatric disorders. We use a variety of techniques including electrophysiology, mass spectrometry, protein biochemistry, genetic models, and functional anatomical studies, to understand the role of endocannabinoids in the brain's response to stress.

Publications
Ho, WS, Patel, S, Thompson, JR, Roberts, CJ, Stuhr, KL, Hillard, CJ. Endocannabinoid modulation of hyperaemia evoked by physiologically relevant stimuli in the rat primary somatosensory cortex. Br J Pharmacol, 160(3), 736-46, 2010.

McElligott, ZA, Klug, JR, Nobis, WP, Patel, S, Grueter, BA, Kash, TL, Winder, DG. Distinct forms of Gq-receptor-dependent plasticity of excitatory transmission in the BNST are differentially affected by stress. Proc Natl Acad Sci U S A, 107(5), 2271-6, 2010.

Hill, MN, Hillard, CJ, Bambico, FR, Patel, S, Gorzalka, BB, Gobbi, G. The therapeutic potential of the endocannabinoid system for the development of a novel class of antidepressants. Trends Pharmacol Sci, 30(9), 484-93, 2009.

Patel, S, Kingsley, PJ, Mackie, K, Marnett, LJ, Winder, DG. Repeated homotypic stress elevates 2-arachidonoylglycerol levels and enhances short-term endocannabinoid signaling at inhibitory synapses in basolateral amygdala. Neuropsychopharmacology, 34(13), 2699-709, 2009. PMCID:2881681

Hill, MN, Carrier, EJ, Ho, WS, Shi, L, Patel, S, Gorzalka, BB, Hillard, CJ. Prolonged glucocorticoid treatment decreases cannabinoid CB1 receptor density in the hippocampus. Hippocampus, 18(2), 221-6, 2008. PMCID:2593941

Patel, S, Hillard, CJ. Adaptations in endocannabinoid signaling in response to repeated homotypic stress: a novel mechanism for stress habituation. Eur J Neurosci, 27(11), 2821-9, 2008. PMCID:2593941

Patel, S, Hillard, CJ. Pharmacological evaluation of cannabinoid receptor ligands in a mouse model of anxiety: further evidence for an anxiolytic role for endogenous cannabinoid signaling. J Pharmacol Exp Ther, 318(1), 304-11, 2006. PMCID:2593941

Carrier, EJ, Patel, S, Hillard, CJ. Endocannabinoids in neuroimmunology and stress. Curr Drug Targets CNS Neurol Disord, 4(6), 657-65, 2005. PMCID:2593941

Hill, MN, Patel, S, Carrier, EJ, Rademacher, DJ, Ormerod, BK, Hillard, CJ, Gorzalka, BB. Downregulation of endocannabinoid signaling in the hippocampus following chronic unpredictable stress. Neuropsychopharmacology, 30(3), 508-15, 2005. PMCID:2593941

Patel, S, Carrier, EJ, Ho, WS, Rademacher, DJ, Cunningham, S, Reddy, DS, Falck, JR, Cravatt, BF, Hillard, CJ. The postmortal accumulation of brain N-arachidonylethanolamine (anandamide) is dependent upon fatty acid amide hydrolase activity. J Lipid Res, 46(2), 342-9, 2005. PMCID:2593941

Patel, S, Cravatt, BF, Hillard, CJ. Synergistic interactions between cannabinoids and environmental stress in the activation of the central amygdala. Neuropsychopharmacology, 30(3), 497-507, 2005. PMCID:2593941

Patel, S, Roelke, CT, Rademacher, DJ, Hillard, CJ. Inhibition of restraint stress-induced neural and behavioural activation by endogenous cannabinoid signalling. Eur J Neurosci, 21(4), 1057-69, 2005. PMCID:2593941

Rademacher, DJ, Patel, S, Ho, WS, Savoie, AM, Rusch, NJ, Gauthier, KM, Hillard, CJ. U-46619 but not serotonin increases endocannabinoid content in middle cerebral artery: evidence for functional relevance. Am J Physiol Heart Circ Physiol, 288(6), H2694-701, 2005. PMCID:2593941

Lu, H, Patel, S, Luo, F, Li, SJ, Hillard, CJ, Ward, BD, Hyde, JS. Spatial correlations of laminar BOLD and CBV responses to rat whisker stimulation with neuronal activity localized by Fos expression. Magn Reson Med, 52(5), 1060-8, 2004. PMCID:2593941

Patel, S, Roelke, CT, Rademacher, DJ, Cullinan, WE, Hillard, CJ. Endocannabinoid signaling negatively modulates stress-induced activation of the hypothalamic-pituitary-adrenal axis. Endocrinology, 145(12), 5431-8, 2004. PMCID:2593941

Rademacher, DJ, Kearn, CS, Carrier, EJ, Patel, S, Delgado, MA, Barkmeier, A, Klick, DE, Breese, NM, Pfister, SL, Nithipatikom, K, Campbell, WB, Hillard, CJ. Production of hydroxyeicosatetraenoic acids and prostaglandins by a novel rat microglial cell line. J Neuroimmunol, 149(1-2), 130-41, 2004. PMCID:2593941

Seagard, JL, Dean, C, Patel, S, Rademacher, DJ, Hopp, FA, Schmeling, WT, Hillard, CJ. Anandamide content and interaction of endocannabinoid/GABA modulatory effects in the NTS on baroreflex-evoked sympathoinhibition. Am J Physiol Heart Circ Physiol, 286(3), H992-1000, 2004. PMCID:2593941

Patel, S, Hillard, CJ. Cannabinoid-induced Fos expression within A10 dopaminergic neurons. Brain Res, 963(1-2), 15-25, 2003. PMCID:1573928

Patel, S, Rademacher, DJ, Hillard, CJ. Differential regulation of the endocannabinoids anandamide and 2-arachidonylglycerol within the limbic forebrain by dopamine receptor activity. J Pharmacol Exp Ther, 306(3), 880-8, 2003. PMCID:1573928

Patel, S, Wohlfeil, ER, Rademacher, DJ, Carrier, EJ, Perry, LJ, Kundu, A, Falck, JR, Nithipatikom, K, Campbell, WB, Hillard, CJ. The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase. Br J Pharmacol, 139(5), 1005-13, 2003. PMCID:1573928

Rademacher, DJ, Patel, S, Hopp, FA, Dean, C, Hillard, CJ, Seagard, JL. Microinjection of a cannabinoid receptor antagonist into the NTS increases baroreflex duration in dogs. Am J Physiol Heart Circ Physiol, 284(5), H1570-6, 2003. PMCID:1573928

Patel, S, Gerrits, R, Muthian, S, Greene, AS, Hillard, CJ. The CB1 receptor antagonist SR141716 enhances stimulus-induced activation of the primary somatosensory cortex of the rat. Neurosci Lett, 335(2), 95-8, 2002. PMCID:1573928

Scruggs, JL, Patel, S, Bubser, M, Deutch, AY. DOI-Induced activation of the cortex: dependence on 5-HT2A heteroceptors on thalamocortical glutamatergic neurons. J Neurosci, 20(23), 8846-52, 2000. PMCID:2593941


Postdoctoral Position Available
Yes

Postdoctoral Position Details
Positions in electrophysiology are available

Updated Date
08/04/2010



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