Vanderbilt University School of Medicine

Shi, Chanjuan , MD, PhD
Associate Professor of Pathology, Microbiology and Immunology

Lab Url: N/A

Phone Number: 615-936-8342


Shi, Chanjuan's picture

Office Address   Mailing Address

C2318A MCN

Vanderbilt University School of Medicine Pathology, Microbiology, and Immunology - 3rd Fl C3321 MCN 37232-2561

Clinical Research Description
Early detection and biomarkers in pancreatic cancer. Histopathology and molecular biology of gastroenteropancreatic neuroendocrine neoplasms.

Clinical Interests
Gastrointestinal, hepatic and pancreatic diseases and malignancies

Ayers, K, Shi, C, Washington, K, Yachimski, P. Expert pathology review and endoscopic mucosal resection alters the diagnosis of patients referred to undergo therapy for Barrett''s esophagus. Surg Endosc, 27(8), 2836-40, 2013.

Ellison, TA, Wolfgang, CL, Shi, C, Cameron, JL, Murakami, P, Mun, LJ, Singhi, AD, Cornish, TC, Olino, K, Meriden, Z, Choti, M, Diaz, LA, Pawlik, TM, Schulick, RD, Hruban, RH, Edil, BH. A Single Institution''s 26-Year Experience With Nonfunctional Pancreatic Neuroendocrine Tumors: A Validation of Current Staging Systems and a New Prognostic Nomogram. Ann Surg, , , 2013.

Kawamoto, S, Johnson, PT, Shi, C, Singhi, AD, Hruban, RH, Wolfgang, CL, Edil, BH, Fishman, EK. Pancreatic neuroendocrine tumor with cystlike changes: evaluation with MDCT. AJR Am J Roentgenol, 200(3), W283-90, 2013.

O''Neal, RL, Nam, KT, LaFleur, BJ, Barlow, B, Nozaki, K, Lee, HJ, Kim, WH, Yang, HK, Shi, C, Maitra, A, Montgomery, E, Washington, MK, El Rifai, W, Drapkin, RI, Goldenring, JR. Human epididymis protein 4 is up-regulated in gastric and pancreatic adenocarcinomas. Hum Pathol, 44(5), 734-42, 2013.

Deery, S, Yates, R, Hata, J, Shi, C, Parikh, AA. Gastric adenocarcinoma associated with gastritis cystica profunda in an unoperated stomach. Am Surg, 78(8), E379-80, 2012.

McCall, CM, Shi, C, Klein, AP, Konukiewitz, B, Edil, BH, Ellison, TA, Wolfgang, CL, Schulick, RD, Kl??ppel, G, Hruban, RH. Serotonin expression in pancreatic neuroendocrine tumors correlates with a trabecular histologic pattern and large duct involvement. Hum Pathol, 43(8), 1169-76, 2012.

Shi, C, Hruban, RH. Intraductal papillary mucinous neoplasm. Hum Pathol, 43(1), 1-16, 2012.

Shi, C, Washington, K. Molecular testing in colorectal cancer: diagnosis of Lynch syndrome and personalized cancer medicine. Am J Clin Pathol, 137(6), 847-59, 2012.

Singhi, AD, Chu, LC, Tatsas, AD, Shi, C, Ellison, TA, Fishman, EK, Kawamoto, S, Schulick, RD, Wolfgang, CL, Hruban, RH, Edil, BH. Cystic pancreatic neuroendocrine tumors: a clinicopathologic study. Am J Surg Pathol, 36(11), 1666-73, 2012.

Wentz, SC, Zhao, ZG, Shyr, Y, Shi, CJ, Merchant, NB, Washington, K, Xia, F, Chakravarthy, AB. Lymph node ratio and preoperative CA 19-9 levels predict overall survival and recurrence-free survival in patients with resected pancreatic adenocarcinoma. World J Gastrointest Oncol, 4(10), 207-15, 2012.

Yachida, S, Vakiani, E, White, CM, Zhong, Y, Saunders, T, Morgan, R, de Wilde, RF, Maitra, A, Hicks, J, Demarzo, AM, Shi, C, Sharma, R, Laheru, D, Edil, BH, Wolfgang, CL, Schulick, RD, Hruban, RH, Tang, LH, Klimstra, DS, Iacobuzio-Donahue, CA. Small Cell and Large Cell Neuroendocrine Carcinomas of the Pancreas are Genetically Similar and Distinct From Well-differentiated Pancreatic Neuroendocrine Tumors. Am J Surg Pathol, 36(2), 173-84, 2012. PMCID:3261427

Kawamoto S, Shi C, Hruban RH, Choti MA, Schulick RD, Fishman EK, Siegelman SS. Small serotonin-producing neuroendocrine tumor of the pancreas associated with pancreatic duct obstruction. AJR Am J Roentgenol, 197(3), W482-8, 2011 PMID:21862776.

Meriden Z, Shi C, Edil BH, Ellison T, Wolfgang CL, Cornish TC, Schulick RD, Hruban RH. . Hyaline globules in neuroendocrine and solid-pseudopapillary neoplasms of the pancreas: a clue to the diagnosis. Am J Surg Pathol, 35(7), 981-8, 2011 PMID: 21677537.

Heaphy CM, de Wilde RF, Jiao Y, Klein AP, Edil BH, Shi C, Bettegowda C, Rodriguez FJ, Eberhart CG, Hebbar S, Offerhaus GJ, McLendon R, Rasheed BA, He Y, Yan H, Bigner DD, Oba-Shinjo SM, Marie SK, Riggins GJ, Kinzler KW, Vogelstein B, Hruban RH, Maitra A, Papadopoulos N, Meeker AK. Altered telomeres in tumors with ATRX and DAXX mutations. Science, 333(6041 Epub), 425, 2011 PMC3174141.

Hong, SM, Heaphy, CM, Shi, C, Eo, SH, Cho, H, Meeker, AK, Eshleman, JR, Hruban, RH, Goggins, M. Telomeres are shortened in acinar-to-ductal metaplasia lesions associated with pancreatic intraepithelial neoplasia but not in isolated acinar-to-ductal metaplasias. Mod Pathol, 24(2), 256-66, 2011. PMCID:3166222

Jiao, Y, Shi, C, Edil, BH, de Wilde, RF, Klimstra, DS, Maitra, A, Schulick, RD, Tang, LH, Wolfgang, CL, Choti, MA, Velculescu, VE, Diaz, LA, Vogelstein, B, Kinzler, KW, Hruban, RH, Papadopoulos, N. DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors. Science, 331(6021), 1199-203, 2011. PMCID:3144496

Kern, SE, Shi, C, Hruban, RH. The complexity of pancreatic ductal cancers and multidimensional strategies for therapeutic targeting. J Pathol, 223(2), 295-306, 2011.

Xiong, W, Shi, C. Images in clinical medicine. Malignant pericardial effusion. N Engl J Med, 364(9), e18, 2011.

Gold, DV, Goggins, M, Modrak, DE, Newsome, G, Liu, M, Shi, C, Hruban, RH, Goldenberg, DM. Detection of early-stage pancreatic adenocarcinoma. Cancer Epidemiol Biomarkers Prev, 19(11), 2786-94, 2010. PMCID:2976815

Kamiyama, H, Kamiyama, M, Hong, SM, Karikari, CA, Lin, MT, Borges, MW, Griffith, M, Young, A, Norris-Kirby, A, Lubek, C, Mizuma, M, Feldmann, G, Shi, C, Liang, H, Goggins, MG, Maitra, A, Hruban, RH, Eshleman, JR. In vivo and in vitro propagation of intraductal papillary mucinous neoplasms. Lab Invest, 90(5), 665-73, 2010. PMCID:2885280

Lam-Himlin, D, Park, JY, Cornish, TC, Shi, C, Montgomery, E. Morphologic characterization of syndromic gastric polyps. Am J Surg Pathol, 34(11), 1656-62, 2010.

Park, JY, Cornish, TC, Lam-Himlin, D, Shi, C, Montgomery, E. Gastric lesions in patients with autoimmune metaplastic atrophic gastritis (AMAG) in a tertiary care setting. Am J Surg Pathol, 34(11), 1591-8, 2010.

Scudiere, JR, Shi, C, Hruban, RH, Herman, JM, Fishman, EK, Schulick, RD, Wolfgang, CL, Makary, MA, Thornton, K, Montgomery, E, Horton, KM. Sclerosing mesenteritis involving the pancreas: a mimicker of pancreatic cancer. Am J Surg Pathol, 34(4), 447-53, 2010. PMCID:2861335

Shi, C, Scudiere, JR, Cornish, TC, Lam-Himlin, D, Park, JY, Fox, MR, Montgomery, EA. Clear cell change in colonic tubular adenoma and corresponding colonic clear cell adenocarcinoma is associated with an altered mucin core protein profile. Am J Surg Pathol, 34(9), 1344-50, 2010.

Shi, C, Siegelman, SS, Kawamoto, S, Wolfgang, CL, Schulick, RD, Maitra, A, Hruban, RH. Pancreatic duct stenosis secondary to small endocrine neoplasms: a manifestation of serotonin production. Radiology, 257(1), 107-14, 2010. PMCID:2941724

Xiong, W, Shi, C. Images in cardiovascular medicine: Concomitant persistent left superior vena cava and agenesis of right superior vena cava: a rare congenital anomaly. Circulation, 121(21), 2329-30, 2010.

Shi C and Argani P. Synchronous primary perianal Pageta??s disease and rectal adenocarcinoma: Report of a hitherto unreported phenomenon. Int J of Surg Pathol, 17(1), 42-5, 2009 PMID:18499687.

Koorstra, JB, Hong, SM, Shi, C, Meeker, AK, Ryu, JK, Offerhaus, GJ, Goggins, MG, Hruban, RH, Maitra, A. Widespread activation of the DNA damage response in human pancreatic intraepithelial neoplasia. Mod Pathol, 22(11), 1439-45, 2009. PMCID:2784029

Shi, C, Chandrasekaran, A, Thuluvath, PJ, Karikari, C, Argani, P, Goggins, M, Maitra, A, Eshleman, JR. Ultrasensitive detection of KRAS2 mutations in bile and serum from patients with biliary tract carcinoma using LigAmp technology. J Mol Diagn, 11(6), 583-9, 2009. PMCID:2765758

Shi, C, Hong, SM, Lim, P, Kamiyama, H, Khan, M, Anders, RA, Goggins, M, Hruban, RH, Eshleman, JR. KRAS2 mutations in human pancreatic acinar-ductal metaplastic lesions are limited to those with PanIN: implications for the human pancreatic cancer cell of origin. Mol Cancer Res, 7(2), 230-6, 2009. PMCID:2708114

Shi, C, Hruban, RH, Klein, AP. Familial pancreatic cancer. Arch Pathol Lab Med, 133(3), 365-74, 2009.

Shi, C, Klein, AP, Goggins, M, Maitra, A, Canto, M, Ali, S, Schulick, R, Palmisano, E, Hruban, RH. Increased Prevalence of Precursor Lesions in Familial Pancreatic Cancer Patients. Clin Cancer Res, 15(24), 7737-7743, 2009. PMCID:2795080

Taube, JM, Begum, S, Shi, C, Eshleman, JR, Westra, WH. Benign nodal nevi frequently harbor the activating V600E BRAF mutation. Am J Surg Pathol, 33(4), 568-71, 2009.

Shi, C, Daniels, JA, Hruban, RH. Molecular characterization of pancreatic neoplasms. Adv Anat Pathol, 15(4), 185-95, 2008.

Shi, C, Fukushima, N, Abe, T, Bian, Y, Hua, L, Wendelburg, BJ, Yeo, CJ, Hruban, RH, Goggins, MG, Eshleman, JR. Sensitive and quantitative detection of KRAS2 gene mutations in pancreatic duct juice differentiates patients with pancreatic cancer from chronic pancreatitis, potential for early detection. Cancer Biol Ther, 7(3), 353-360, 2008.

Shi, C, Parker, AR, Hua, L, Morrell, CN, Lee, SC, Bandaru, V, Dumler, JS, Wu, TC, Eshleman, JR. Anti-gene padlocks eliminate Escherichia coli based on their genotype. J Antimicrob Chemother, 61(2), 262-72, 2008.

Bertolesi, GE, Walia Da Silva, R, Jollimore, CA, Shi, C, Barnes, S, Kelly, ME. Ca(v)3.1 splice variant expression during neuronal differentiation of Y-79 retinoblastoma cells. Neuroscience, 141(1), 259-68, 2006.

Church, JD, Jones, D, Flys, T, Hoover, D, Marlowe, N, Chen, S, Shi, C, Eshleman, JR, Guay, LA, Jackson, JB, Kumwenda, N, Taha, TE, Eshleman, SH. Sensitivity of the ViroSeq HIV-1 genotyping system for detection of the K103N resistance mutation in HIV-1 subtypes A, C, and D. J Mol Diagn, 8(4), 430-2; quiz 527, 2006. PMCID:1867617

Rogers, CD, Fukushima, N, Sato, N, Shi, C, Prasad, N, Hustinx, SR, Matsubayashi, H, Canto, M, Eshleman, JR, Hruban, RH, Goggins, M. Differentiating pancreatic lesions by microarray and QPCR analysis of pancreatic juice RNAs. Cancer Biol Ther, 5(10), 1383-9, 2006.

Rubio-Viqueira, B, Jimeno, A, Cusatis, G, Zhang, X, Iacobuzio-Donahue, C, Karikari, C, Shi, C, Danenberg, K, Danenberg, PV, Kuramochi, H, Tanaka, K, Singh, S, Salimi-Moosavi, H, Bouraoud, N, Amador, ML, Altiok, S, Kulesza, P, Yeo, C, Messersmith, W, Eshleman, J, Hruban, RH, Maitra, A, Hidalgo, M. An in vivo platform for translational drug development in pancreatic cancer. Clin Cancer Res, 12(15), 4652-61, 2006.

Flys, T, Nissley, DV, Claasen, CW, Jones, D, Shi, C, Guay, LA, Musoke, P, Mmiro, F, Strathern, JN, Jackson, JB, Eshleman, JR, Eshleman, SH. Sensitive drug-resistance assays reveal long-term persistence of HIV-1 variants with the K103N nevirapine (NVP) resistance mutation in some women and infants after the administration of single-dose NVP: HIVNET 012. J Infect Dis, 192(1), 24-9, 2005.

Parker, AR, Sieber, OM, Shi, C, Hua, L, Takao, M, Tomlinson, IP, Eshleman, JR. Cells with pathogenic biallelic mutations in the human MUTYH gene are defective in DNA damage binding and repair. Carcinogenesis, 26(11), 2010-8, 2005.

Shi, C, Eshleman, SH, Jones, D, Fukushima, N, Hua, L, Parker, AR, Yeo, CJ, Hruban, RH, Goggins, MG, Eshleman, JR. LigAmp for sensitive detection of single-nucleotide differences. Nat Methods, 1(2), 141-7, 2004.

Vessey, JP, Shi, C, Jollimore, CA, Stevens, KT, Coca-Prados, M, Barnes, S, Kelly, ME. Hyposmotic activation of ICl,swell in rabbit nonpigmented ciliary epithelial cells involves increased ClC-3 trafficking to the plasma membrane. Biochem Cell Biol, 82(6), 708-18, 2004.

Bertolesi, GE, Jollimore, CA, Shi, C, Elbaum, L, Denovan-Wright, EM, Barnes, S, Kelly, ME. Regulation of alpha1G T-type calcium channel gene (CACNA1G) expression during neuronal differentiation. Eur J Neurosci, 17(9), 1802-10, 2003.

Shi, C, Szczesniak, A, Mao, L, Jollimore, C, Coca-Prados, M, Hung, O, Kelly, ME. A3 adenosine and CB1 receptors activate a PKC-sensitive Cl- current in human nonpigmented ciliary epithelial cells via a G beta gamma-coupled MAPK signaling pathway. Br J Pharmacol, 139(3), 475-86, 2003. PMCID:1573867

Bertolesi, GE, Shi, C, Elbaum, L, Jollimore, C, Rozenberg, G, Barnes, S, Kelly, ME. The Ca(2+) channel antagonists mibefradil and pimozide inhibit cell growth via different cytotoxic mechanisms. Mol Pharmacol, 62(2), 210-9, 2002.

Shi, C, Barnes, S, Coca-Prados, M, Kelly, ME. Protein tyrosine kinase and protein phosphatase signaling pathways regulate volume-sensitive chloride currents in a nonpigmented ciliary epithelial cell line. Invest Ophthalmol Vis Sci, 43(5), 1525-32, 2002.

Thoreson, WB, Ryan, JS, Shi, C, Kelly, ME, Bryson, EJ, Toews, ML, Ediger, TL, Chacko, DM. Lysophosphatidic acid receptor signaling in mammalian retinal pigment epithelial cells. Invest Ophthalmol Vis Sci, 43(7), 2450-61, 2002.

Ryan, JS, Shi, C, Kelly, ME. Patch-clamp recording methods for examining adrenergic regulation of potassium currents in ocular epithelial cells. Methods Mol Biol, 126, 391-407, 2000.

Shi, C, Ryan, JS, French, AS, Coca-Prados, M, Kelly, ME. Hyposmotically activated chloride channels in cultured rabbit non-pigmented ciliary epithelial cells. J Physiol, 521 Pt 1, 57-67, 1999. PMCID:2269649

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