Vanderbilt University School of Medicine

Page-McCaw, Andrea , PhD
Associate Professor of Cell and Developmental Biology
Associate Professor of Cancer Biology

Lab Url: N/A

Phone Number: 615-875-5841

Email Address:andrea.page-mccaw@vanderbilt.edu

Page-McCaw, Andrea's picture

Office Address   Mailing Address

Learned Lab/MRBIII, rm U4206

4206 MRB III, 465 21st Avenue South, Nashville, TN 37232-8240


Research Keywords
Matrix metalloproteinases (MMPs), tissue remodeling, wound healing, basement membrane, extracellular matrix, developmental biology, Drosophila, genetics, signaling.

Research Description
During embryogenesis, animals develop complex structures, but they often have to modify their morphology to meet the demands of continuing growth or environmental challenge. This is known as tissue remodeling. Tissue remodeling is also required for animals to heal wounds, and it goes awry during cancer when tumors usurp tissue remodeling functions to promote metastasis. The matrix metalloproteinase (MMP) family of extracellular proteases is required for tissue remodeling events throughout the animal kingdom. These proteases are also upregulated in cancer and many inflammatory conditions such as arthritis. Understanding how MMPs promote tissue remodeling, both in normal and pathological circumstances, is a central question in my laboratory.

Drosophila melanogaster (the common fruitfly) has been an important model organism for understanding cell and developmental biology because of their advanced genetics and beautiful cytology. Although mammals have about 24 MMPs with overlapping substrate specificity and functional redundancy, Drosophila has only two MMPs, greatly simplifying genetic analysis of MMP function. We have found MMPs to be absolutley required for developmental tissue remodeling and epidermal wound healing in our system. We are currently investigating how basement membrane is modified and expanded in coordination with tissue growth during development.


Publications
Saito-Diaz, K, Chen, TW, Wang, X, Thorne, CA, Wallace, HA, Page-McCaw, A, Lee, E. The way Wnt works: components and mechanism. Growth Factors, 31(1), 1-31, 2013.

Broderick, S, Wang, X, Simms, N, Page-McCaw, A. Drosophila Ninjurin A induces nonapoptotic cell death. PLoS One, 7(9), e44567, 2012.

Stevens, LJ, Page-McCaw, A. A secreted MMP is required for reepithelialization during wound healing. Mol Biol Cell, 23(6), 1068-79, 2012.

Miller, CM, Liu, N, Page-McCaw, A, Broihier, HT. Drosophila mmp2 regulates the matrix molecule faulty attraction (frac) to promote motor axon targeting in Drosophila. J Neurosci, 31(14), 5335-47, 2011.

Glasheen, BM, Robbins, RM, Piette, C, Beitel, GJ, Page-McCaw, A. A matrix metalloproteinase mediates airway remodeling in Drosophila. Dev Biol, 344(2), 772-83, 2010.

Glasheen, BM, Kabra, AT, Page-McCaw, A. Distinct functions for the catalytic and hemopexin domains of a Drosophila matrix metalloproteinase. Proc Natl Acad Sci U S A, 106(8), 2659-64, 2009. PMCID:2636737

Miller, CM, Page-McCaw, A, Broihier, HT. Matrix metalloproteinases promote motor axon fasciculation in the Drosophila embryo. Development, 135(1), 95-109, 2008. PMCID:2636737

Page-McCaw, A. Remodeling the model organism: matrix metalloproteinase functions in invertebrates. Semin Cell Dev Biol, 19(1), 14-23, 2008. PMCID:2248213

Beaucher, M, Hersperger, E, Page-McCaw, A, Shearn, A. Metastatic ability of Drosophila tumors depends on MMP activity. Dev Biol, 303(2), 625-34, 2007. PMCID:2760082

Page-McCaw, A, Ewald, AJ, Werb, Z. Matrix metalloproteinases and the regulation of tissue remodelling. Nat Rev Mol Cell Biol, 8(3), 221-33, 2007. PMCID:2760082

Zhang, S, Dailey, GM, Kwan, E, Glasheen, BM, Sroga, GE, Page-McCaw, A. An MMP liberates the Ninjurin A ectodomain to signal a loss of cell adhesion. Genes Dev, 20(14), 1899-910, 2006. PMCID:1522090

Myllykangas, L, Tyynel, J, Page-McCaw, A, Rubin, GM, Haltia, MJ, Feany, MB. Cathepsin D-deficient Drosophila recapitulate the key features of neuronal ceroid lipofuscinoses. Neurobiol Dis, 19(1-2), 194-9, 2004.

Page-McCaw, A, Serano, J, Sante, JM, Rubin, GM. Drosophila matrix metalloproteinases are required for tissue remodeling, but not embryonic development. Dev Cell, 4(1), 95-106, 2003. PMCID:1522090


Postdoctoral Position Available
No

Postdoctoral Position Details
N/A

Updated Date
08/08/2013



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