Vanderbilt University School of Medicine

Peebles, R. Stokes , M.D.
Professor of Medicine
Elizabeth and John Murray Chair in Medicine

Lab Url: N/A

Phone Number: 615-322-3412


Peebles, R.'s picture

Office Address   Mailing Address

B-1227 MCN

T-1218 MCN Vanderbilt University Medical Center 37232-2650

Research Keywords
eicosanoid prostaglandin leukotriene lung allergy virus immunology

Research Specialty
Our lab is interested in allergically-mediated and virally-induced lung inflammation. Presently funded projects include how IL-17 and PGI2 mediate inflammatory responses.

Claar, D, Hartert, TV, Peebles, RS. The role of prostaglandins in allergic lung inflammation and asthma. Expert Rev Respir Med, 9(1), 55-72, 2015.

Hotard, AL, Lee, S, Currier, MG, Crowe, JE, Sakamoto, K, Newcomb, DC, Peebles, RS, Plemper, RK, Moore, ML. Identification of residues in the human respiratory syncytial virus fusion protein that modulate fusion activity and pathogenesis. J Virol, 89(1), 512-22, 2015.

Karlin, E, Gebretsadik, T, Peebles, RS, Hartert, TV, Langley, EW, Arnold, DH. Fractional exhaled nitric oxide change in pediatric patients after emergency department care of asthma exacerbations. Ann Allergy Asthma Immunol, 114(2), 149-51, 2015.

Larkin, EK, Gebretsadik, T, Moore, ML, Anderson, LJ, Dupont, WD, Chappell, JD, Minton, PA, Peebles, RS, Moore, PE, Valet, RS, Arnold, DH, Rosas-Salazar, C, Das, SR, Polack, FP, Hartert, TV, , . Objectives, design and enrollment results from the Infant Susceptibility to Pulmonary Infections and Asthma Following RSV Exposure Study (INSPIRE). BMC Pulm Med, 15, 45, 2015.

Newcomb, DC, Cephus, JY, Boswell, MG, Fahrenholz, JM, Langley, EW, Feldman, AS, Zhou, W, Dulek, DE, Goleniewska, K, Woodward, KB, Sevin, CM, Hamilton, RG, Kolls, JK, Peebles, RS. Estrogen and progesterone decrease let-7f microRNA expression and increase IL-23/IL-23 receptor signaling and IL-17A production in patients with severe asthma. J Allergy Clin Immunol, , , 2015.

Peebles, RS. At the bedside: the emergence of group 2 innate lymphoid cells in human disease. J Leukoc Biol, 97(3), 469-75, 2015.

Zaynagetdinov, R, Sherrill, TP, Gleaves, LA, McLoed, AG, Saxon, JA, Habermann, AC, Connelly, L, Dulek, D, Peebles, RS, Fingleton, B, Yull, FE, Stathopoulos, GT, Blackwell, TS. Interleukin-5 facilitates lung metastasis by modulating the immune microenvironment. Cancer Res, 75(8), 1624-34, 2015.

Dulek, DE, Newcomb, DC, Goleniewska, K, Cephus, J, Zhou, W, Reiss, S, Toki, S, Ye, F, Zaynagetdinov, R, Sherrill, TP, Blackwell, TS, Moore, ML, Boyd, KL, Kolls, JK, Peebles, RS. Allergic airway inflammation decreases lung bacterial burden following acute Klebsiella pneumoniae infection in a neutrophil- and CCL8-dependent manner. Infect Immun, 82(9), 3723-39, 2014.

Dulek, DE, Newcomb, DC, Toki, S, Goliniewska, K, Cephus, J, Reiss, S, Bates, JT, Crowe, JE, Boyd, KL, Moore, ML, Zhou, W, Peebles, RS. STAT4 deficiency fails to induce lung Th2 or Th17 immunity following primary or secondary respiratory syncytial virus (RSV) challenge but enhances the lung RSV-specific CD8+ T cell immune response to secondary challenge. J Virol, 88(17), 9655-72, 2014.

Miller, EK, Avila, PC, Khan, YW, Word, CR, Pelz, BJ, Papadopoulos, NG, Peebles, RS, Heymann, PW, , . Wheezing exacerbations in early childhood: evaluation, treatment, and recent advances relevant to the genesis of asthma. J Allergy Clin Immunol Pract, 2(5), 537-43, 2014.

Patel, DA, You, Y, Huang, G, Byers, DE, Kim, HJ, Agapov, E, Moore, ML, Peebles, RS, Castro, M, Sumino, K, Shifren, A, Brody, SL, Holtzman, MJ. Interferon response and respiratory virus control are preserved in bronchial epithelial cells in asthma. J Allergy Clin Immunol, 134(6), 1402-1412.e7, 2014.

Zhou, W, Goleniewska, K, Zhang, J, Dulek, DE, Toki, S, Lotz, MT, Newcomb, DC, Boswell, MG, Polosukhin, VV, Milne, GL, Wu, P, Moore, ML, FitzGerald, GA, Peebles, RS. Cyclooxygenase inhibition abrogates aeroallergen-induced immune tolerance by suppressing prostaglandin I2 receptor signaling. J Allergy Clin Immunol, 134(3), 698-705.e5, 2014.

Langley, EW, Gebretsadik, T, Hartert, TV, Peebles, RS, Arnold, DH. Exhaled nitric oxide is associated with severity of pediatric acute asthma exacerbations. J Allergy Clin Immunol Pract, 2(5), 618-20.e1, 2013.

Lotz, MT, Moore, ML, Peebles, RS. Respiratory syncytial virus and reactive airway disease. Curr Top Microbiol Immunol, 372, 105-18, 2013.

Newcomb, DC, Boswell, MG, Reiss, S, Zhou, W, Goleniewska, K, Toki, S, Harintho, MT, Lukacs, NW, Kolls, JK, Peebles, RS. IL-17A inhibits airway reactivity induced by respiratory syncytial virus infection during allergic airway inflammation. Thorax, , , 2013.

Newcomb, DC, Boswell, MG, Sherrill, TP, Polosukhin, VV, Boyd, KL, Goleniewska, K, Brody, SL, Kolls, JK, Adler, KB, Peebles, RS. IL-17A Induces STAT6-Independent Airway Mucous Cell Metaplasia. Am J Respir Cell Mol Biol, , , 2013.

Newcomb, DC, Peebles, RS. Th17-mediated inflammation in asthma. Curr Opin Immunol, 25(6), 755-60, 2013.

Peebles, RS. A new horizon in asthma: inhibiting ILC function. Sci Transl Med, 5(174), 174fs7, 2013.

Rosen, MJ, Chaturvedi, R, Washington, MK, Kuhnhein, LA, Moore, PD, Coggeshall, SS, McDonough, EM, Weitkamp, JH, Singh, AB, Coburn, LA, Williams, CS, Yan, F, Van Kaer, L, Peebles, RS, Wilson, KT. STAT6 Deficiency Ameliorates Severity of Oxazolone Colitis by Decreasing Expression of Claudin-2 and Th2-Inducing Cytokines. J Immunol, 190(4), 1849-58, 2013.

Sevin, CM, Newcomb, DC, Toki, S, Han, W, Sherrill, TP, Boswell, MG, Zhu, Z, Collins, RD, Boyd, KL, Goleniewska, K, Huckabee, MM, Blackwell, TS, Peebles, RS. Deficiency of gp91phox inhibits allergic airway inflammation. Am J Respir Cell Mol Biol, 49(3), 396-402, 2013.

Toki, S, Goleniewska, K, Huckabee, MM, Zhou, W, Newcomb, DC, Fitzgerald, GA, Lawson, WE, Peebles, RS. PGI??? signaling inhibits antigen uptake and increases migration of immature dendritic cells. J Leukoc Biol, 94(1), 77-88, 2013.

Toki, S, Omary, RA, Wilson, K, Gore, JC, Peebles, RS, Pham, W. A comprehensive analysis of transfection-assisted delivery of iron oxide nanoparticles to dendritic cells. Nanomedicine, 9(8), 1235-44, 2013.

Dorris, SL, Peebles, RS. PGI2 as a regulator of inflammatory diseases. Mediators Inflamm, 2012, 926968, 2012.

James, KM, Peebles, RS, Hartert, TV. Response to infections in patients with asthma and atopic disease: an epiphenomenon or reflection of host susceptibility. J Allergy Clin Immunol, 130(2), 343-51, 2012.

Lotz, MT, Peebles, RS. Mechanisms of respiratory syncytial virus modulation of airway immune responses. Curr Allergy Asthma Rep, 12(5), 380-7, 2012.

Newcomb, DC, Boswell, MG, Huckabee, MM, Goleniewska, K, Dulek, DE, Reiss, S, Lukacs, NW, Kolls, JK, Peebles, RS. IL-13 regulates Th17 secretion of IL-17A in an IL-10-dependent manner. J Immunol, 188(3), 1027-35, 2012. PMCID:3349674

Zhou, W, Dowell, DR, Huckabee, MM, Newcomb, DC, Boswell, MG, Goleniewska, K, Lotz, MT, Toki, S, Yin, H, Yao, S, Natarajan, C, Wu, P, Sriram, S, Breyer, RM, Fitzgerald, GA, Peebles, RS. Prostaglandin i(2) signaling drives th17 differentiation and exacerbates experimental autoimmune encephalomyelitis. PLoS One, 7(5), e33518, 2012. PMCID:3349674

Boswell, MG, Zhou, W, Newcomb, DC, Peebles, RS. PGI2 as a regulator of CD4+ subset differentiation and function. Prostaglandins Other Lipid Mediat, 96(1-4), 21-6, 2011. PMCID:3349674

Dulek, DE, Peebles, RS. Bacteria and asthma: more there than we thought. Expert Rev Respir Med, 5(3), 329-32, 2011. PMCID:3349674

Dulek, DE, Peebles, RS. Viruses and asthma. Biochim Biophys Acta, 1810(11), 1080-90, 2011. PMCID:3349674

Newcomb, DC, Boswell, MG, Zhou, W, Huckabee, MM, Goleniewska, K, Sevin, CM, Hershey, GK, Kolls, JK, Peebles, RS. Human TH17 cells express a functional IL-13 receptor and IL-13 attenuates IL-17A production. J Allergy Clin Immunol, 127(4), 1006-13.e1-4, 2011. PMCID:3349674

Zaynagetdinov, R, Stathopoulos, GT, Sherrill, TP, Cheng, DS, McLoed, AG, Ausborn, JA, Polosukhin, VV, Connelly, L, Zhou, W, Fingleton, B, Peebles, RS, Prince, LS, Yull, FE, Blackwell, TS. Epithelial nuclear factor-I?B signaling promotes lung carcinogenesis via recruitment of regulatory T lymphocytes. Oncogene, , , 2011. PMCID:3349674

Zhou, W, Dowell, DR, Geraci, MW, Blackwell, TS, Collins, RD, Polosukhin, VV, Lawson, WE, Wu, P, Sussan, T, Biswal, S, Goleniewska, K, O''Neal, J, Newcomb, DC, Toki, S, Morrow, JD, Peebles, RS. PGI synthase overexpression protects against bleomycin-induced mortality and is associated with increased Nqo 1 expression. Am J Physiol Lung Cell Mol Physiol, 301(4), L615-22, 2011. PMCID:3349674

Hartert, TV, Carroll, K, Gebretsadik, T, Woodward, K, Minton, P, , . The Tennessee Children''s Respiratory Initiative: Objectives, design and recruitment results of a prospective cohort study investigating infant viral respiratory illness and the development of asthma and allergic diseases. Respirology, 15(4), 691-9, 2010. PMCID:2992986

Sevin, CM, Peebles, RS. Infections and asthma: new insights into old ideas. Clin Exp Allergy, 40(8), 1142-54, 2010. PMCID:2966842

Stathopoulos, GT, Sherrill, TP, Karabela, SP, Goleniewska, K, Kalomenidis, I, Roussos, C, Fingleton, B, Yull, FE, Peebles, RS, Blackwell, TS. Host-derived interleukin-5 promotes adenocarcinoma-induced malignant pleural effusion. Am J Respir Crit Care Med, 182(10), 1273-81, 2010. PMCID:3001265

Westerly, BD, Peebles, RS. Respiratory syncytial virus infections in the adult asthmatic--mechanisms of host susceptibility and viral subversion. Immunol Allergy Clin North Am, 30(4), 523-39, vi-vii, 2010. PMCID:2966842

Zaynagetdinov, R, Ryzhov, S, Goldstein, AE, Yin, H, Novitskiy, SV, Goleniewska, K, Polosukhin, VV, Newcomb, DC, Mitchell, D, Morschl, E, Zhou, Y, Blackburn, MR, Peebles, RS, Biaggioni, I, Feoktistov, I. Attenuation of chronic pulmonary inflammation in A2B adenosine receptor knockout mice. Am J Respir Cell Mol Biol, 42(5), 564-71, 2010. PMCID:2874442

Huckabee, MM, Peebles, RS. Novel concepts in virally induced asthma. Clin Mol Allergy, 7, 2, 2009. PMCID:2651109

Moore, ML, Chi, MH, Luongo, C, Lukacs, NW, Polosukhin, VV, Huckabee, MM, Newcomb, DC, Buchholz, UJ, Crowe, JE, Goleniewska, K, Williams, JV, Collins, PL, Peebles, RS. A chimeric A2 strain of respiratory syncytial virus (RSV) with the fusion protein of RSV strain line 19 exhibits enhanced viral load, mucus, and airway dysfunction. J Virol, 83(9), 4185-94, 2009. PMCID:2668460

Moore, ML, Newcomb, DC, Parekh, VV, Van Kaer, L, Collins, RD, Zhou, W, Goleniewska, K, Chi, MH, Mitchell, D, Boyce, JA, Durbin, JE, Sturkie, C, Peebles, RS. STAT1 negatively regulates lung basophil IL-4 expression induced by respiratory syncytial virus infection. J Immunol, 183(3), 2016-26, 2009. PMCID:2992986

Newcomb, DC, Peebles, RS. Bugs and asthma: a different disease. Proc Am Thorac Soc, 6(3), 266-71, 2009. PMCID:2677401

Newcomb, DC, Zhou, W, Moore, ML, Goleniewska, K, Hershey, GK, Kolls, JK, Peebles, RS. A functional IL-13 receptor is expressed on polarized murine CD4+ Th17 cells and IL-13 signaling attenuates Th17 cytokine production. J Immunol, 182(9), 5317-21, 2009.

Sheller, JR, Polosukhin, VV, Mitchell, D, Cheng, DS, Peebles, RS, Blackwell, TS. Nuclear factor kappa B induction in airway epithelium increases lung inflammation in allergen-challenged mice. Exp Lung Res, 35(10), 883-95, 2009. PMCID:2992986

Yin, H, Liu, W, Goleniewsk, K, Porter, NA, Morrow, JD, Peebles, RS. Dietary Supplementation of omega-3 Fatty Acid - Containing Fish Oil Suppresses F(2)-Isoprostanes But Enhances Inflammatory Cytokine Response in a Mouse Model of Ovalbumin-Induced Allergic Lung Inflammation. Free Radic Biol Med, , , 2009. PMCID:2716436

Hashimoto, K, Ishibashi, K, Gebretsadik, T, Hartert, TV, Yamamoto, A, Nakayama, T, Ohashi, K, Sakata, H, Kawasaki, Y, Katayose, M, Sakuma, H, Suzuki, H, Hosoya, M, Peebles, RS, Suzutani, T. Functional polymorphism of the promoter region of the prostacyclin synthase gene and severity of RSV infection in hospitalized children. J Med Virol, 80(11), 2015-22, 2008.

Moore, ML, Chi, MH, Goleniewska, K, Durbin, JE, Peebles, RS. Differential regulation of GM1 and asialo-GM1 expression by T cells and natural killer (NK) cells in respiratory syncytial virus infection. Viral Immunol, 21(3), 327-39, 2008.

Temi??o, VM, Peebles, RS. The spectrum and treatment of angioedema. Am J Med, 121(4), 282-6, 2008.

Zhou, W, Newcomb, DC, Moore, ML, Goleniewska, K, O''Neal, JF, Peebles, RS. Cyclooxygenase inhibition during allergic sensitization increases STAT6-independent primary and memory Th2 responses. J Immunol, 181(8), 5360-7, 2008.

Moore, ML, Chi, MH, Zhou, W, Goleniewska, K, O''Neal, JF, Higginbotham, JN, Peebles, RS. Cutting Edge: Oseltamivir decreases T cell GM1 expression and inhibits clearance of respiratory syncytial virus: potential role of endogenous sialidase in antiviral immunity. J Immunol, 178(5), 2651-4, 2007.

Peebles, RS, Moore, ML. A mechanistic advance in understanding RSV pathogenesis, but still a long way from therapy. Am J Respir Cell Mol Biol, 37(4), 375-7, 2007.

Rudd, BD, Luker, GD, Luker, KE, Peebles, RS, Lukacs, NW. Type I interferon regulates respiratory virus infected dendritic cell maturation and cytokine production. Viral Immunol, 20(4), 531-40, 2007.

Sadikot, RT, Zeng, H, Azim, AC, Joo, M, Dey, SK, Breyer, RM, Peebles, RS, Blackwell, TS, Christman, JW. Bacterial clearance of Pseudomonas aeruginosa is enhanced by the inhibition of COX-2. Eur J Immunol, 37(4), 1001-9, 2007.

Zhou, W, Blackwell, TS, Goleniewska, K, O'neal, JF, Fitzgerald, GA, Lucitt, M, Breyer, RM, Peebles, RS. Prostaglandin I2 analogs inhibit Th1 and Th2 effector cytokine production by CD4 T cells. J Leukoc Biol, 81(3), 809-817, 2007.

Zhou, W, Hashimoto, K, Goleniewska, K, O''Neal, JF, Ji, S, Blackwell, TS, Fitzgerald, GA, Egan, KM, Geraci, MW, Peebles, RS. Prostaglandin I2 analogs inhibit proinflammatory cytokine production and T cell stimulatory function of dendritic cells. J Immunol, 178(2), 702-10, 2007.

Lukacs, NW, Moore, ML, Rudd, BD, Berlin, AA, Collins, RD, Olson, SJ, Ho, SB, Peebles, RS. Differential immune responses and pulmonary pathophysiology are induced by two different strains of respiratory syncytial virus. Am J Pathol, 169(3), 977-86, 2006. PMCID:1698832

Moore, ML, Peebles, RS. Respiratory syncytial virus disease mechanisms implicated by human, animal model, and in vitro data facilitate vaccine strategies and new therapeutics. Pharmacol Ther, 112(2), 405-24, 2006.

Moore, ML, Peebles, RS. Update on the role of prostaglandins in allergic lung inflammation: separating friends from foes, harder than you might think. J Allergy Clin Immunol, 117(5), 1036-9, 2006.

Moore, PE, Cunningham, G, Calder, MM, DeMatteo, AD, Peeples, ME, Summar, ML, Peebles, RS. Respiratory syncytial virus infection reduces beta2-adrenergic responses in human airway smooth muscle. Am J Respir Cell Mol Biol, 35(5), 559-64, 2006. PMCID:2643275

Hashimoto, K, Durbin, JE, Zhou, W, Collins, RD, Ho, SB, Kolls, JK, Dubin, PJ, Sheller, JR, Goleniewska, K, O''Neal, JF, Olson, SJ, Mitchell, D, Graham, BS, Peebles, RS. Respiratory syncytial virus infection in the absence of STAT 1 results in airway dysfunction, airway mucus, and augmented IL-17 levels. J Allergy Clin Immunol, 116(3), 550-7, 2005.

Hashimoto, K, Sheller, JR, Morrow, JD, Collins, RD, Goleniewska, K, O''Neal, J, Zhou, W, Ji, S, Mitchell, DB, Graham, BS, Peebles, RS. Cyclooxygenase inhibition augments allergic inflammation through CD4-dependent, STAT6-independent mechanisms. J Immunol, 174(1), 525-32, 2005.

Kalomenidis, I, Guo, Y, Peebles, RS, Lane, KB, Papiris, S, Elias, J, Light, RW. Pneumothorax-associated pleural eosinophilia in mice is interleukin-5 but not interleukin-13 dependent. Chest, 128(4), 2978-83, 2005.

Peebles, RS, Hashimoto, K, Sheller, JR, Moore, ML, Morrow, JD, Ji, S, Elias, JA, Goleniewska, K, O''neal, J, Mitchell, DB, Graham, BS, Zhou, W. Allergen-induced airway hyperresponsiveness mediated by cyclooxygenase inhibition is not dependent on 5-lipoxygenase or IL-5, but is IL-13 dependent. J Immunol, 175(12), 8253-9, 2005.

Zhou, W, Hashimoto, K, Moore, ML, Elias, JA, Zhu, Z, Durbin, J, Colasurdo, G, Rutigliano, JA, Chiappetta, CL, Goleniewska, K, O''Neal, JF, Graham, BS, Peebles, RS. IL-13 is associated with reduced illness and replication in primary respiratory syncytial virus infection in the mouse. Microbes Infect, 8(14-15), 2880-9, 2005. PMCID:1811125

Hashimoto, K, Graham, BS, Geraci, MW, FitzGerald, GA, Egan, K, Zhou, W, Goleniewska, K, O''Neal, JF, Morrow, JD, Durbin, RK, Wright, PF, Collins, RD, Suzutani, T, Peebles, RS. Signaling through the prostaglandin I2 receptor IP protects against respiratory syncytial virus-induced illness. J Virol, 78(19), 10303-9, 2004. PMCID:516432

Hashimoto, K, Graham, BS, Ho, SB, Adler, KB, Collins, RD, Olson, SJ, Zhou, W, Suzutani, T, Jones, PW, Goleniewska, K, O''Neal, JF, Peebles, RS. Respiratory syncytial virus in allergic lung inflammation increases Muc5ac and gob-5. Am J Respir Crit Care Med, 170(3), 306-12, 2004.

Postdoctoral Position Available

Postdoctoral Position Details
Post-doctoral research fellow position will be open in Sepetmber 2009. Funding will be provided by the Peebles lab; however, the expectation is that the candidate will be eligible for an NIH F32 or T32 grant. Our lab has a strong track record in obtaining these grants for post-doctoral fellows.

Updated Date

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