Vanderbilt University School of Medicine

Israel, Dawn A. , Ph.D.
Research Assistant Professor of Medicine

Lab Url: N/A

Phone Number: 615-322-5200


Israel, Dawn's picture

Office Address   Mailing Address

1030C MRB IV 37232-2279

Research Keywords
Helicobacter pylori pathogenesis,Bacteria,Cancer,Genomics,Infectious disease,Microbiology

Sitaraman, R, Israel, DA, Romero-Gallo, J, Peek, RM. Cell-associated hemolysis induced by Helicobacter pylori is mediated by phospholipases with mitogen-activated protein kinase-activating properties. J Clin Microbiol, 50(3), 1014-8, 2012.

Yan, F, Wang, L, Shi, Y, Cao, H, Liu, L, Washington, MK, Chaturvedi, R, Israel, DA, Cao, H, Wang, B, Peek, RM, Wilson, KT, Polk, DB. Berberine promotes recovery of colitis and inhibits inflammatory responses in colonic macrophages and epithelial cells in DSS-treated mice. Am J Physiol Gastrointest Liver Physiol, 302(5), G504-14, 2012.

Chaturvedi, R, Asim, M, Romero-Gallo, J, Barry, DP, Hoge, S, de Sablet, T, Delgado, AG, Wroblewski, LE, Piazuelo, MB, Yan, F, Israel, DA, Casero, RA, Correa, P, Gobert, AP, Polk, DB, Peek, RM, Wilson, KT. Spermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagA. Gastroenterology, 141(5), 1696-708.e1-2, 2011.

Nagy, TA, Allen, SS, Wroblewski, LE, Flaherty, DK, Slaughter, JC, Perez-Perez, G, Israel, DA, Peek, RM. Helicobacter pylori induction of eosinophil migration is mediated by the cag pathogenicity island via microbial-epithelial interactions. Am J Pathol, 178(4), 1448-52, 2011.

Nagy, TA, Wroblewski, LE, Wang, D, Piazuelo, MB, Delgado, A, Romero-Gallo, J, Noto, J, Israel, DA, Ogden, SR, Correa, P, Cover, TL, Peek, RM. ??-Catenin and p120 mediate PPAR??-dependent proliferation induced by Helicobacter pylori in human and rodent epithelia. Gastroenterology, 141(2), 553-64, 2011.

de Sablet, T, Piazuelo, MB, Shaffer, CL, Schneider, BG, Asim, M, Chaturvedi, R, Bravo, LE, Sicinschi, LA, Delgado, AG, Mera, RM, Israel, DA, Romero-Gallo, J, Peek, RM, Cover, TL, Correa, P, Wilson, KT. Phylogeographic origin of Helicobacter pylori is a determinant of gastric cancer risk. Gut, 60(9), 1189-95, 2011.

Ogden, SR, Noto, JM, Allen, SS, Patel, DA, Romero-Gallo, J, Washington, MK, Fingleton, B, Israel, DA, Lewis, ND, Wilson, KT, Chaturvedi, R, Zhao, Z, Shyr, Y, Peek, RM. Matrix metalloproteinase-7 and premalignant host responses in Helicobacter pylori-infected mice. Cancer Res, 70(1), 30-5, 2010.

Franco, AT, Friedman, DB, Nagy, TA, Romero-Gallo, J, Krishna, U, Kendall, A, Israel, DA, Tegtmeyer, N, Washington, MK, Peek, RM. Delineation of a carcinogenic Helicobacter pylori proteome. Mol Cell Proteomics, 8(8), 1947-58, 2009.

Gaus, K, Huang, Y, Israel, DA, Pendland, SL, Adeniyi, BA, Mahady, GB. Standardized ginger (Zingiber officinale) extract reduces bacterial load and suppresses acute and chronic inflammation in Mongolian gerbils infected with cagAHelicobacter pylori. Pharm Biol, 47(1), 92-98, 2009.

McClain, MS, Shaffer, CL, Israel, DA, Peek, RM, Cover, TL. Genome sequence analysis of Helicobacter pylori strains associated with gastric ulceration and gastric cancer. BMC Genomics, 10, 3, 2009.

Nagy, TA, Frey, MR, Yan, F, Israel, DA, Polk, DB, Peek, RM. Helicobacter pylori regulates cellular migration and apoptosis by activation of phosphatidylinositol 3-kinase signaling. J Infect Dis, 199(5), 641-51, 2009.

Schneider, N, Krishna, U, Romero-Gallo, J, Israel, DA, Piazuelo, MB, Camargo, MC, Sicinschi, LA, Schneider, BG, Correa, P, Peek, RM. Role of Helicobacter pylori CagA molecular variations in induction of host phenotypes with carcinogenic potential. J Infect Dis, 199(8), 1218-21, 2009.

Wroblewski, LE, Shen, L, Ogden, S, Romero-Gallo, J, Lapierre, LA, Israel, DA, Turner, JR, Peek, RM. Helicobacter pylori dysregulation of gastric epithelial tight junctions by urease-mediated myosin II activation. Gastroenterology, 136(1), 236-46, 2009.

Franco, AT, Johnston, E, Krishna, U, Yamaoka, Y, Israel, DA, Nagy, TA, Wroblewski, LE, Piazuelo, MB, Correa, P, Peek, RM. Regulation of gastric carcinogenesis by Helicobacter pylori virulence factors. Cancer Res, 68(2), 379-87, 2008.

O''Brien, DP, Romero-Gallo, J, Schneider, BG, Chaturvedi, R, Delgado, A, Harris, EJ, Krishna, U, Ogden, SR, Israel, DA, Wilson, KT, Peek, RM. Regulation of the Helicobacter pylori cellular receptor decay-accelerating factor. J Biol Chem, 283(35), 23922-30, 2008.

Ogden, SR, Wroblewski, LE, Weydig, C, Romero-Gallo, J, O''Brien, DP, Israel, DA, Krishna, US, Fingleton, B, Reynolds, AB, Wessler, S, Peek, RM. p120 and Kaiso regulate Helicobacter pylori-induced expression of matrix metalloproteinase-7. Mol Biol Cell, 19(10), 4110-21, 2008.

Israel, DA, Peek, RM. The role of persistence in Helicobacter pylori pathogenesis. Curr Opin Gastroenterol, 22(1), 3-7, 2006.

O''Brien, DP, Israel, DA, Krishna, U, Romero-Gallo, J, Nedrud, J, Medof, ME, Lin, F, Redline, R, Lublin, DM, Nowicki, BJ, Franco, AT, Ogden, S, Williams, AD, Polk, DB, Peek, RM. The role of decay-accelerating factor as a receptor for Helicobacter pylori and a mediator of gastric inflammation. J Biol Chem, 281(19), 13317-23, 2006.

Franco, AT, Israel, DA, Washington, MK, Krishna, U, Fox, JG, Rogers, AB, Neish, AS, Collier-Hyams, L, Perez-Perez, GI, Hatakeyama, M, Whitehead, R, Gaus, K, O''Brien, DP, Romero-Gallo, J, Peek, RM. Activation of beta-catenin by carcinogenic Helicobacter pylori. Proc Natl Acad Sci U S A, 102(30), 10646-51, 2005.

Popescu, A, Karpay, A, Israel, DA, Peek, RM, Krezel, AM. Helicobacter pylori protein HP0222 belongs to Arc/MetJ family of transcriptional regulators. Proteins, 59(2), 303-11, 2005.

Cover, Timothy L, Krishna, Uma S, Israel, Dawn A, Peek, Richard M. Induction of gastric epithelial cell apoptosis by Helicobacter pylori vacuolating cytotoxin. Cancer Res, 63(5), 951-7, 2003.

Crawford, Howard C, Krishna, Uma S, Israel, Dawn A, Matrisian, Lynn M, Washington, M Kay, Peek, Richard M. Helicobacter pylori strain-selective induction of matrix metalloproteinase-7 in vitro and within gastric mucosa. Gastroenterology, 125(4), 1125-36, 2003.

Fox, James G, Wang, Timothy C, Rogers, Arlin B, Poutahidis, Theofilos, Ge, Zhongming, Taylor, Nancy, Dangler, Charles A, Israel, Dawn A, Krishna, Uma, Gaus, Kristen, Peek, Richard M. Host and microbial constituents influence Helicobacter pylori-induced cancer in a murine model of hypergastrinemia. Gastroenterology, 124(7), 1879-90, 2003.

Donahue, John P, Israel, Dawn A, Torres, Victor J, Necheva, Antoaneta S, Miller, Geraldine G. Inactivation of a Helicobacter pylori DNA methyltransferase alters dnaK operon expression following host-cell adherence. FEMS Microbiol Lett, 208(2), 295-301, 2002.

Takeuchi, Hiroaki, Israel, Dawn A, Miller, Geraldine G, Donahue, John P, Krishna, Uma, Gaus, Kristin, Peek, Richard M. Characterization of expression of a functionally conserved Helicobacter pylori methyltransferase-encoding gene within inflamed mucosa and during in vitro growth. J Infect Dis, 186(8), 1186-9, 2002.

Gupta, R A, Polk, D B, Krishna, U, Israel, D A, Yan, F, DuBois, R N, Peek, R M. Activation of peroxisome proliferator-activated receptor gamma suppresses nuclear factor kappa B-mediated apoptosis induced by Helicobacter pylori in gastric epithelial cells. J Biol Chem, 276(33), 31059-66, 2001.

Israel, D A, Peek, R M. pathogenesis of Helicobacter pylori-induced gastric inflammation. Aliment Pharmacol Ther, 15(9), 1271-90, 2001.

Israel, D A, Salama, N, Arnold, C N, Moss, S F, Ando, T, Wirth, H P, Tham, K T, Camorlinga, M, Blaser, M J, Falkow, S, Peek, R M. Helicobacter pylori strain-specific differences in genetic content, identified by microarray, influence host inflammatory responses. J Clin Invest, 107(5), 611-20, 2001. PMCID:199426

Israel, D A, Salama, N, Krishna, U, Rieger, U M, Atherton, J C, Falkow, S, Peek, R M. Helicobacter pylori genetic diversity within the gastric niche of a single human host. Proc Natl Acad Sci U S A, 98(25), 14625-30, 2001. PMCID:64732

Kidd, M, Peek, R M, Lastovica, A J, Israel, D A, Kummer, A F, Louw, J A. Analysis of iceA genotypes in South African Helicobacter pylori strains and relationship to clinically significant disease. Gut, 49(5), 629-35, 2001. PMCID:1728508

Ando, T, Xu, Q, Torres, M, Kusugami, K, Israel, D A, Blaser, M J. Restriction-modification system differences in Helicobacter pylori are a barrier to interstrain plasmid transfer. Mol Microbiol, 37(5), 1052-65, 2000.

Donahue, J P, Israel, D A, Peek, R M, Blaser, M J, Miller, G G. Overcoming the restriction barrier to plasmid transformation of Helicobacter pylori. Mol Microbiol, 37(5), 1066-74, 2000.

Israel, D A, Lou, A S, Blaser, M J. Characteristics of Helicobacter pylori natural transformation. FEMS Microbiol Lett, 186(2), 275-80, 2000.

Kuipers, E J, Israel, D A, Kusters, J G, Gerrits, M M, Weel, J, van Der Ende, A, van Der Hulst, R W, Wirth, H P, H????k-Nikanne, J, Thompson, S A, Blaser, M J. Quasispecies development of Helicobacter pylori observed in paired isolates obtained years apart from the same host. J Infect Dis, 181(1), 273-82, 2000.

P??rez-P??rez, G I, Israel, D A. Role of iron in Helicobacter pylori: its influence in outer membrane protein expression and in pathogenicity. Eur J Gastroenterol Hepatol, 12(12), 1263-5, 2000.

Ando, T, Israel, D A, Kusugami, K, Blaser, M J. HP0333, a member of the dprA family, is involved in natural transformation in Helicobacter pylori. J Bacteriol, 181(18), 5572-80, 1999. PMCID:94075

Kuipers, E J, Israel, D A, Kusters, J G, Blaser, M J. Evidence for a conjugation-like mechanism of DNA transfer in Helicobacter pylori. J Bacteriol, 180(11), 2901-5, 1998. PMCID:107256

Postdoctoral Position Available

Postdoctoral Position Details

Updated Date

Vanderbilt University is committed to principles of equal opportunity and affirmative action.
Copyright 2008 Vanderbilt University School of Medicine
The office of Biomedical Research Education & Training All rights reserved.
For questions or problems concerning this page, please submit a help ticket.