Vanderbilt University School of Medicine

Bernard, Gordon R. , M.D.
Associate Vice Chancellor for Clinical and Translational Research
Senior Associate Dean for Clinical Sciences
Professor of Medicine
Melinda Owen Bass Chair in Medicine

Lab Url: N/A

Phone Number: 615-343-0077


Bernard, Gordon's picture

Office Address   Mailing Address

T-1208 MCN Vanderbilt University Medical Center 37232-2650

Research Specialty
Sepsis and Acute Respiratory Distress Syndrome

Byrne, DW, Biaggioni, I, Bernard, GR, Helmer, TT, Boone, LR, Pulley, JM, Edwards, T, Dittus, RS. Clinical and translational research studios: a multidisciplinary internal support program. Acad Med, 87(8), 1052-9, 2012.

Girard, TD, Ware, LB, Bernard, GR, Pandharipande, PP, Thompson, JL, Shintani, AK, Jackson, JC, Dittus, RS, Ely, EW. Associations of markers of inflammation and coagulation with delirium during critical illness. Intensive Care Med, 38(12), 1965-73, 2012.

Pulley, JM, Denny, JC, Peterson, JF, Bernard, GR, Vnencak-Jones, CL, Ramirez, AH, Delaney, JT, Bowton, E, Brothers, K, Johnson, K, Crawford, DC, Schildcrout, J, Masys, DR, Dilks, HH, Wilke, RA, Clayton, EW, Shultz, E, Laposata, M, McPherson, J, Jirjis, JN, Roden, DM. Operational implementation of prospective genotyping for personalized medicine: the design of the Vanderbilt PREDICT project. Clin Pharmacol Ther, 92(1), 87-95, 2012.

Rice, TW, Rubinson, L, Uyeki, TM, Vaughn, FL, John, BB, Miller, RR, Higgs, E, Randolph, AG, Smoot, BE, Thompson, BT, , . Critical illness from 2009 pandemic influenza A virus and bacterial coinfection in the United States. Crit Care Med, 40(5), 1487-98, 2012.

Harris, PA, Swafford, JA, Edwards, TL, Zhang, M, Nigavekar, SS, Yarbrough, TR, Lane, LD, Helmer, T, Lebo, LA, Mayo, G, Masys, DR, Bernard, GR, Pulley, JM. StarBRITE: the Vanderbilt University Biomedical Research Integration, Translation and Education portal. J Biomed Inform, 44(4), 655-62, 2011.

Rice, TW, Mogan, S, Hays, MA, Bernard, GR, Jensen, GL, Wheeler, AP. Randomized trial of initial trophic versus full-energy enteral nutrition in mechanically ventilated patients with acute respiratory failure. Crit Care Med, 39(5), 967-74, 2011.

Rice, TW, Ware, LB, Haponik, EF, Chiles, C, Wheeler, AP, Bernard, GR, Steingrub, JS, Hite, RD, Matthay, MA, Wright, P, Ely, EW, , . Vascular pedicle width in acute lung injury: correlation with intravascular pressures and ability to discriminate fluid status. Crit Care, 15(2), R86, 2011.

Rice, TW, Wheeler, AP, Thompson, BT, deBoisblanc, BP, Steingrub, J, Rock, P, , , , . Enteral omega-3 fatty acid, gamma-linolenic acid, and antioxidant supplementation in acute lung injury. JAMA, 306(14), 1574-81, 2011.

Ware, LB, Koyama, T, Billheimer, D, Landeck, M, Johnson, E, Brady, S, Bernard, GR, Matthay, MA, , . Advancing donor management research: design and implementation of a large, randomized, placebo-controlled trial. Ann Intensive Care, 1(1), 20, 2011.

Bernard, GR. Statins for acutely hospitalized patients: randomized controlled trials are long overdue. Crit Care, 14(2), 141, 2010.

Fremont, RD, Koyama, T, Calfee, CS, Wu, W, Dossett, LA, Bossert, FR, Mitchell, D, Wickersham, N, Bernard, GR, Matthay, MA, May, AK, Ware, LB. Acute lung injury in patients with traumatic injuries: utility of a panel of biomarkers for diagnosis and pathogenesis. J Trauma, 68(5), 1121-7, 2010.

Girard, TD, Jackson, JC, Pandharipande, PP, Pun, BT, Thompson, JL, Shintani, AK, Gordon, SM, Canonico, AE, Dittus, RS, Bernard, GR, Ely, EW. Delirium as a predictor of long-term cognitive impairment in survivors of critical illness. Crit Care Med, 38(7), 1513-20, 2010.

Girard, TD, Pandharipande, PP, Carson, SS, Schmidt, GA, Wright, PE, Canonico, AE, Pun, BT, Thompson, JL, Shintani, AK, Meltzer, HY, Bernard, GR, Dittus, RS, Ely, EW, , . Feasibility, efficacy, and safety of antipsychotics for intensive care unit delirium: the MIND randomized, placebo-controlled trial. Crit Care Med, 38(2), 428-37, 2010.

Jackson, JC, Girard, TD, Gordon, SM, Thompson, JL, Shintani, AK, Thomason, JW, Pun, BT, Canonico, AE, Dunn, JG, Bernard, GR, Dittus, RS, Ely, EW. Long-term cognitive and psychological outcomes in the awakening and breathing controlled trial. Am J Respir Crit Care Med, 182(2), 183-91, 2010.

Pulley, J, Clayton, E, Bernard, GR, Roden, DM, Masys, DR. Principles of human subjects protections applied in an opt-out, de-identified biobank. Clin Transl Sci, 3(1), 42-8, 2010.

Pulley, J, Hassan, NN, Bernard, GR, Jirjis, JN, Schildcrout, J, Robertson, D, Masys, DR, Harris, P. Identifying unpredicted drug benefit through query of patient experiential knowledge: a proof of concept web-based system. Clin Transl Sci, 3(3), 98-103, 2010.

Pulley, JM, Harris, PA, Yarbrough, T, Swafford, J, Edwards, T, Bernard, GR. An informatics-based tool to assist researchers in initiating research at an academic medical center: Vanderbilt Customized Action Plan. Acad Med, 85(1), 164-8, 2010.

Rice, TW, Wheeler, AP, Bernard, GR, Vincent, JL, Angus, DC, Aikawa, N, Demeyer, I, Sainati, S, Amlot, N, Cao, C, Ii, M, Matsuda, H, Mouri, K, Cohen, J. A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis. Crit Care Med, 38(8), 1685-94, 2010.

Ware, LB, Koyama, T, Billheimer, DD, Wu, W, Bernard, GR, Thompson, BT, Brower, RG, Standiford, TJ, Martin, TR, Matthay, MA, , . Prognostic and pathogenetic value of combining clinical and biochemical indices in patients with acute lung injury. Chest, 137(2), 288-96, 2010.

Pulley, JM, Bernard, GR. Proven processes: The Vanderbilt Institute for clinical and translational research . Clin Transl Sci, 2(3), 180-2, 2009.

Ely, E Wesley, Stephens, Rasheeda K, Jackson, James C, Thomason, Jason W W, Truman, Brenda, Gordon, Sharon, Dittus, Robert S, Bernard, Gordon R. Current opinions regarding the importance, diagnosis, and management of delirium in the intensive care unit: a survey of 912 healthcare professionals. Crit Care Med, 32(1), 106-12, 2004.

Bernard, Gordon R. Drotrecogin alfa (activated) (recombinant human activated protein C) for the treatment of severe sepsis. Crit Care Med, 31(1 Suppl), S85-93, 2003.

Bernard, Gordon R, Macias, William L, Joyce, David E, Williams, Mark D, Bailey, Joan, Vincent, Jean-Louis. Safety assessment of drotrecogin alfa (activated) in the treatment of adult patients with severe sepsis. Crit Care, 7(2), 155-63, 2003. PMCID:270661

Ely, E Wesley, Angus, Derek C, Williams, Mark D, Bates, Becky, Qualy, Rebecca, Bernard, Gordon R. Drotrecogin alfa (activated) treatment of older patients with severe sepsis. Clin Infect Dis, 37(2), 187-95, 2003.

Ely, E Wesley, Laterre, Pierre-Fran??ois, Angus, Derek C, Helterbrand, Jeffrey D, Levy, Howard, Dhainaut, Jean-Fran??ois, Vincent, Jean-Louis, Macias, William L, Bernard, Gordon R, , . Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis. Crit Care Med, 31(1), 12-9, 2003.

Ely, E Wesley, Truman, Brenda, Shintani, Ayumi, Thomason, Jason W W, Wheeler, Arthur P, Gordon, Sharon, Francis, Joseph, Speroff, Theodore, Gautam, Shiva, Margolin, Richard, Sessler, Curtis N, Dittus, Robert S, Bernard, Gordon R. Monitoring sedation status over time in ICU patients: reliability and validity of the Richmond Agitation-Sedation Scale (RASS). JAMA, 289(22), 2983-91, 2003.

Jiang, Keyuan, Higgins, Stanley B, Swindell, Bridget B, Bernard, Gordon R. CommLog: a communication log system for clinical trials. IEEE Trans Inf Technol Biomed, 7(4), 378-83, 2003.

Ely, E Wesley, Wheeler, Arthur P, Thompson, B Taylor, Ancukiewicz, Marek, Steinberg, Kenneth P, Bernard, Gordon R. Recovery rate and prognosis in older persons who develop acute lung injury and the acute respiratory distress syndrome. Ann Intern Med, 136(1), 25-36, 2002.

Bernard, G R, Ely, E W, Wright, T J, Fraiz, J, Stasek, J E, Russell, J A, Mayers, I, Rosenfeld, B A, Morris, P E, Yan, S B, Helterbrand, J D. Safety and dose relationship of recombinant human activated protein C for coagulopathy in severe sepsis. Crit Care Med, 29(11), 2051-9, 2001.

Bernard, G R, Vincent, J L, Laterre, P F, LaRosa, S P, Dhainaut, J F, Lopez-Rodriguez, A, Steingrub, J S, Garber, G E, Helterbrand, J D, Ely, E W, Fisher, C J, , . Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med, 344(10), 699-709, 2001.

Ely, E W, Inouye, S K, Bernard, G R, Gordon, S, Francis, J, May, L, Truman, B, Speroff, T, Gautam, S, Margolin, R, Hart, R P, Dittus, R. Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU). JAMA, 286(21), 2703-10, 2001.

Ely, E W, Margolin, R, Francis, J, May, L, Truman, B, Dittus, R, Speroff, T, Gautam, S, Bernard, G R, Inouye , S K. Evaluation of delirium in critically ill patients: validation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). Crit Care Med, 29(7), 1370-9, 2001.

Martin, G S, Bernard, G R, , . Airway and lung in sepsis. Intensive Care Med, 27 Suppl 1, S63-79, 2001.

Bernard, G R, Sopko, G, Cerra, F, Demling, R, Edmunds, H, Kaplan, S, Kessler, L, Masur, H, Parsons, P, Shure, D, Webb, C, Weidemann, H, Weinmann, G, Williams, D. Pulmonary artery catheterization and clinical outcomes: National Heart, Lung, and Blood Institute and Food and Drug Administration Workshop Report. Consensus Statement. JAMA, 283(19), 2568-72, 2000.

Conner, B D, Bernard, G R. Acute respiratory distress syndrome. Potential pharmacologic interventions. Clin Chest Med, 21(3), 563-87, 2000.

Mangialardi, R J, Martin, G S, Bernard, G R, Wheeler, A P, Christman, B W, Dupont, W D, Higgins, S B, Swindell, B B. Hypoproteinemia predicts acute respiratory distress syndrome development, weight gain, and death in patients with sepsis. Ibuprofen in Sepsis Study Group. Crit Care Med, 28(9), 3137-45, 2000.

Arons, M M, Wheeler, A P, Bernard, G R, Christman, B W, Russell, J A, Schein, R, Summer, W R, Steinberg, K P, Fulkerson, W, Wright, P, Dupont, W D, Swindell, B B. Effects of ibuprofen on the physiology and survival of hypothermic sepsis. Ibuprofen in Sepsis Study Group. Crit Care Med, 27(4), 699-707, 1999.

Bernard, G R. Research in sepsis and acute respiratory distress syndrome: are we changing course. Crit Care Med, 27(2), 434-6, 1999.

Wheeler, A P, Bernard, G R. Treating patients with severe sepsis. N Engl J Med, 340(3), 207-14, 1999.

Price, B J, Bernard, G R, Drew, K, Foss, J, Wheeler, A P. Impact of a critical care pathway for unstable mechanically ventilated patients. Crit Care Nurs Clin North Am, 10(1), 75-85, 1998.

Bernard, G R, Wheeler, A P, Arons, M M, Morris, P E, Paz, H L, Russell, J A, Wright, P E. A trial of antioxidants N-acetylcysteine and procysteine in ARDS. The Antioxidant in ARDS Study Group. Chest, 112(1), 164-72, 1997.

Bernard, G R, Wheeler, A P, Russell, J A, Schein, R, Summer, W R, Steinberg, K P, Fulkerson, W J, Wright, P E, Christman, B W, Dupont, W D, Higgins, S B, Swindell, B B. The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. N Engl J Med, 336(13), 912-8, 1997.

Carmichael, L C, Dorinsky, P M, Higgins, S B, Bernard, G R, Dupont, W D, Swindell, B, Wheeler, A P. Diagnosis and therapy of acute respiratory distress syndrome in adults: an international survey. J Crit Care, 11(1), 9-18, 1996.

Weikert, L F, Bernard, G R. Pharmacotherapy of sepsis. Clin Chest Med, 17(2), 289-305, 1996.

Wheeler, A P, Bernard, G R. Applications of molecular biology and biotechnology: antibody therapy of sepsis. J Crit Care, 11(2), 77-94, 1996.

Bernard, G R. Sepsis trials. Intersection of investigation, regulation, funding, and practice. Am J Respir Crit Care Med, 152(1), 4-10, 1995.

Bernard, G R, Pou, N A, Coggeshall, J W, Carroll, F E, Snapper, J R. Comparison of the pulmonary dysfunction caused by cardiogenic and noncardiogenic pulmonary edema. Chest, 108(3), 798-803, 1995.

Higgins, S B, Jiang, K, Plummer, W D, Edens, T R, Stroud, M J, Swindell, B B, Wheeler, A P, Bernard, G R. Pivot/Remote: a distributed database for remote data entry in multi-center clinical trials. Medinfo, 8 Pt 2, 1097, 1995.

Bernard, G R, Artigas, A, Brigham, K L, Carlet, J, Falke, K, Hudson, L, Lamy, M, LeGall, J R, Morris, A, Spragg, R. Report of the American-European consensus conference on ARDS: definitions, mechanisms, relevant outcomes and clinical trial coordination. The Consensus Committee. Intensive Care Med, 20(3), 225-32, 1994.

Bernard, G R, Artigas, A, Brigham, K L, Carlet, J, Falke, K, Hudson, L, Lamy, M, Legall, J R, Morris, A, Spragg, R. The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med, 149(3 Pt 1), 818-24, 1994.

Morris, P E, Bernard, G R. Significance of glutathione in lung disease and implications for therapy. Am J Med Sci, 307(2), 119-27, 1994.

Wright, P E, Carmichael, L C, Bernard, G R. Effect of bronchodilators on lung mechanics in the acute respiratory distress syndrome (ARDS). Chest, 106(5), 1517-23, 1994.

Christman, B W, Bernard, G R. Antilipid mediator and antioxidant therapy in adult respiratory distress syndrome. New Horiz, 1(4), 623-30, 1993.

Wheeler, A P, Carroll, F E, Bernard, G R. Radiographic issues in adult respiratory distress syndrome. New Horiz, 1(4), 471-7, 1993.

Christman, B W, McPherson, C D, Newman, J H, King, G A, Bernard, G R, Groves, B M, Loyd, J E. An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension. N Engl J Med, 327(2), 70-5, 1992.

Hardie, W D, Wheeler, A P, Wright, P W, Swindell, B B, Bernard, G R. Effect of cyclooxygenase inhibition on amphotericin B-induced lung injury in awake sheep. J Infect Dis, 166(1), 134-8, 1992.

Schriver, E E, Davidson, J M, Sutcliffe, M C, Swindell, B B, Bernard, G R. Comparison of elastin peptide concentrations in body fluids from healthy volunteers, smokers, and patients with chronic obstructive pulmonary disease. Am Rev Respir Dis, 145(4 Pt 1), 762-6, 1992.

Wheeler, A P, Hardie, W D, Bernard, G R. The role of cyclooxygenase products in lung injury induced by tumor necrosis factor in sheep. Am Rev Respir Dis, 145(3), 632-9, 1992.

Bernard, G R. N-acetylcysteine in experimental and clinical acute lung injury. Am J Med, 91(3C), 54S-59S, 1991.

Bernard, G R, Korley, V, Chee, P, Swindell, B, Ford-Hutchinson, A W, Tagari, P. Persistent generation of peptido leukotrienes in patients with the adult respiratory distress syndrome. Am Rev Respir Dis, 144(2), 263-7, 1991.

Bernard, G R, Reines, H D, Halushka, P V, Higgins, S B, Metz, C A, Swindell, B B, Wright, P E, Watts, F L, Vrbanac, J J. Prostacyclin and thromboxane A2 formation is increased in human sepsis syndrome. Effects of cyclooxygenase inhibition. Am Rev Respir Dis, 144(5), 1095-101, 1991.

Hardie, W D, Wright, P E, Bernard, G R. Effects of intravenous amphotericin B infusion on hemodynamics and airway mechanics in awake sheep. Chest, 99(2), 457-62, 1991.

Higgins, S B, Jiang, K, Swindell, B B, Bernard, G R. A graphical ICU workstation. Proc Annu Symp Comput Appl Med Care, , 783-7, 1991. PMCID:2247637

Morris, P, Bernard, G R. Adult respiratory distress syndrome. Strategies to provide support and enhance oxygen delivery. Postgrad Med, 90(8), 163-6, 169-70, 172, 1991.

Onrot, J, Bernard, G R, Biaggioni, I, Hollister, A S, Robertson, D. Direct vasodilator effect of hyperventilation-induced hypocarbia in autonomic failure patients. Am J Med Sci, 301(5), 305-9, 1991.

Watts, F L, Bernard, G R. Effects of ritodrine infusion on hemodynamics and lung lymph in awake sheep. Pulm Pharmacol, 4(1), 32-6, 1991.

Bernard, G R. Potential of N-acetylcysteine as treatment for the adult respiratory distress syndrome. Eur Respir J Suppl, 11, 496s-498s, 1990.

Cowan, H B, Bernard, G R. The adult respiratory distress syndrome. Compr Ther, 16(10), 66-71, 1990.

Harris, T R, Bernard, G R, Brigham, K L, Higgins, S B, Rinaldo, J E, Borovetz, H S, Sibbald, W J, Kariman, K, Sprung, C L. Lung microvascular transport properties measured by multiple indicator dilution methods in patients with adult respiratory distress syndrome. A comparison between patients reversing respiratory failure and those failing to reverse. Am Rev Respir Dis, 141(2), 272-80, 1990.

Wheeler, A P, Bernard, G R. Minimal positive end expiratory pressure (PEEP): a safe, effective, defensible practice. Clin Intensive Care, 1(4), 175-9, 1990.

Taylor, R F, Bernard, G R. Airway complications from free-basing cocaine. Chest, 95(2), 476-7, 1989.

Wright, P E, Bernard, G R. The role of airflow resistance in patients with the adult respiratory distress syndrome. Am Rev Respir Dis, 139(5), 1169-74, 1989.

Wright, P E, Bernard, G R. Mechanisms of late hemodynamic and airway dynamic responses to endotoxin in awake sheep. Am Rev Respir Dis, 140(3), 672-8, 1989.

Wright, P E, Marini, J J, Bernard, G R. In vitro versus in vivo comparison of endotracheal tube airflow resistance. Am Rev Respir Dis, 140(1), 10-6, 1989.

Lucht, W D, Bernard, G R, Butka, B, Brigham, K L. Corticosteroids inhibit endotoxin-induced lung lymph neutrophil stimulating activity in sheep. Am J Med Sci, 296(2), 98-102, 1988.

Wright, P, Ishihara, Y, Bernard, G R. Effects of nitroprusside on lung mechanics and hemodynamics after endotoxemia in awake sheep. J Appl Physiol, 64(5), 2026-32, 1988.

Bernard, G R, Luce, J M, Sprung, C L, Rinaldo, J E, Tate, R M, Sibbald, W J, Kariman, K, Higgins, S, Bradley, R, Metz, C A. High-dose corticosteroids in patients with the adult respiratory distress syndrome. N Engl J Med, 317(25), 1565-70, 1987.

Coggeshall, J W, Lefferts, P L, Butterfield, M J, Bernard, G R, Carroll, F E, Pou, N A, Snapper, J R. Perilla ketone: a model of increased pulmonary microvascular permeability pulmonary edema in sheep. Am Rev Respir Dis, 136(6), 1453-8, 1987.

Lucht, W D, English, D K, Bernard, G R, Serafin, W E, Brigham, K L. Prevention of release of granulocyte aggregants into sheep lung lymph following endotoxemia by N-acetylcysteine. Am J Med Sci, 294(3), 161-7, 1987.

May, D G, Stratton, C W, Denney, W D, Watts, F L, Bernard, G R, Branch, R A. Vancomycin entry into lung lymph in sheep. Antimicrob Agents Chemother, 31(11), 1689-91, 1987. PMCID:175021

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