Vanderbilt University School of Medicine

Washington, Mary Kay , M.D., Ph.D.
Professor of Pathology, Microbiology and Immunology

Lab Url: N/A

Phone Number: 615 343 5655


Washington, Mary's picture

Office Address   Mailing Address

C-3321 MCN 37232-2561

Research Keywords
Cancer, Knockout, Malignancy, Mouse, Translation,Cancer,Knockout,Malignancy,Mouse,Transplantation

Research Specialty
Histopathology of gastrointestinal and hepatic diseases and mouse models of GI cancer

Research Description
My research focuses on morphology of gastrointestinal and hepatic diseases. I provide expertise in interpretation of histopathologic changes in a variety of animal models of gastrointestinal diseases to basic scientists at Vanderbilt. I also serve as Director for several research biorepositories and shared resources, including the Vanderbilt Digestive Diseases Research Center and the Western Division of the Cooperative Human Tissue Network.

Clinical Research Description
My research focuses on diagnostic aspects of gastrointestinal and hepatic pathology; specific areas of interest include Barrett's esophagus, colorectal neoplasia, inflammatory bowel disease, and gastrointestinal pathology of primary immunodeficiency. I also have an interest in morphology of mouse models of intestinal neoplasia and inflammatory bowel disease.

Barrett, CW, Fingleton, B, Williams, A, Ning, W, Fischer, MA, Washington, MK, Chaturvedi, R, Wilson, KT, Hiebert, SW, Williams, CS. MTGR1 Is Required for Tumorigenesis in the Murine AOM/DSS Colitis-Associated Carcinoma Model. Cancer Res, 17(4), 1302-12, 2011 PMC3150168.

Anjani JA, Barthel JS, Bentrem DJ, DAmico TA, Das P, Denlinger CS, Fuchs CS, Gerdes H, Glasgow RE, Hayman, JA, Hofstetter WL, Ilson DH, Keswani RN, Kleinberg LR, Korn WM, Lockhart AC, Mulcahy MF, Orringer MB, Osarogiagbon RU, Posey JA, Sasson AR, Scott WJ, Shibata S, Strong VE, Varghese TK Jr., Warren G, Washington, MK, Willett C, Wright CD. Esophageal and esophagogastric junction cancers. J Natl Compr Canc Netw, 9(8), 830-87, 2011.

Dhawan, P, Ahmad, R, Chaturvedi, R, Smith, JJ, Midha, R, Mittal, MK, Krishnan, M, Chen, X, Eschrich, S, Yeatman, TJ, Harris, RC, Washington, MK, Wilson, KT, Beauchamp, RD, Singh, AB. Claudin-2 expression increases tumorigenicity of colon cancer cells: role of epidermal growth factor receptor activation. Oncogene, 30(29), 3234-47, 2011. PMCID:3083788

Freeman, TJ, Smith, JJ, Chen, X, Washington, MK, Roland, JT, Means, AL, Eschrich, SA, Yeatman, TJ, Deane, NG, Beauchamp, RD. Smad4-Mediated Signaling Inhibits Intestinal Neoplasia by Inhibiting Expression of I?-Catenin. Gastroenterology, November, e-pub ahead of print, 2011.

Goettel, JA, Scott Algood, HM, Olivares-Villag??mez, D, Washington, MK, Chaturvedi, R, Wilson, KT, Van Kaer, L, Polk, DB. KSR1 protects from interleukin-10 deficiency-induced colitis in mice by suppressing T-lymphocyte interferon-I? production. Gastroenterology, 140(1), 265-74, 2011.

Le Bras, GF, Allison, GL, Richards, NF, Ansari, SS, Washington, MK, Andl, CD. CD44 upregulation in E-cadherin-negative esophageal cancers results in cell invasion. PLoS One, 6(11), e27063, 2011. PMCID:3206075

Moreira RK, Chopp W, Washington. . The concept of hepatic artery-bile duct parallelism in the diagnosis of ductopenia in liver biopsy samples.. Am J Surg Pathol, 35(3), 392-403, 2011.

Nagaraj, NS, Washington, MK, Merchant, NB. Combined Blockade of Src Kinase and Epidermal Growth Factor Receptor with Gemcitabine Overcomes STAT3-Mediated Resistance of Inhibition of Pancreatic Tumor Growth. Clin Cancer Res, 17(3), 483-93, 2011.

Peng, D, Belkhiri, A, Hu, T, Chaturvedi, R, Asim, M, Wilson, KT, Zaika, A, El-Rifai, W. Glutathione peroxidase 7 protects against oxidative DNA damage in oesophageal cells. Gut, December 9 , Epub ahead of print, 2011.

Peng, D, Hu, TL, Jiang, A, Washington, MK, Moskaluk, CA, Schneider-Stock, R, El-Rifai, W. Location-specific epigenetic regulation of the metallothionein 3 gene in esophageal adenocarcinomas. PLoS One, 6(7), e22009, 2011. PMCID:3139601

Ray, KC, Bell, KM, Yan, J, Gu, G, Chung, CH, Washington, MK, Means, AL. Epithelial tissues have varying degrees of susceptibility to Kras(G12D)-initiated tumorigenesis in a mouse model. PLoS One, 6(2), e16786, 2011. PMCID:3032792

Rosen, MJ, Frey, MR, Washington, MK, Chaturvedi, R, Kuhnhein, LA, Matta, P, Revetta, FL, Wilson, KT, Polk, DB. STAT6 activation in ulcerative colitis: A new target for prevention of IL-13-induced colon epithelial cell dysfunction. Inflamm Bowel Dis, , , 2011.

Singh, AB, Sharma, A, Smith, JJ, Krishnan, M, Chen, X, Eschrich, S, Washington, MK, Yeatman, TJ, Beauchamp, RD, Dhawan, P. Claudin-1 Up-regulates the Repressor ZEB-1 to Inhibit E-Cadherin Expression in Colon Cancer Cells. Gastroenterology, 141(6), 2140-53, 2011. PMCID:3195453

Singh, K, Chaturvedi, R, Barry, DP, Coburn, LA, Asim, M, Lewis, ND, Piazuelo, MB, Washington, MK, Vitek, MP, Wilson, KT. The apolipoprotein E-mimetic peptide COG112 inhibits NF-kappaB signaling, proinflammatory cytokine expression, and disease activity in murine models of colitis. J Biol Chem, 286(5), 3839-50, 2011. PMCID:3032792

Smalley-Freed, WG, Efimov, A, Short, SP, Jia, P, Zhao, Z, Washington, MK, Robine, S, Coffey, RJ, Reynolds, AB. Adenoma formation following limited ablation of p120-catenin in the mouse intestine. PLoS One, 6(5), e19880, 2011. PMCID:3096651

Soutto, M, Belkhiri, A, Piazuelo, MB, Schneider, BG, Peng, D, Jiang, A, Washington, MK, Kokoye, Y, Crowe, SE, Zaika, A, Correa, P, Peek, RM, El-Rifai, W. Loss of TFF1 is associated with activation of NF-I?B-mediated inflammation and gastric neoplasia in mice and humans. J Clin Invest, 121(5), 1753-67, 2011. PMCID:3083788

Ueda, Y, Hajri, T, Peng, D, Marks-Shulman, PA, Tamboli, RA, Shukrallah, B, Saliba, J, Jabbour, K, El-Rifai, W, Abumrad, NA, Abumrad, NN. Reduction of 8-iso-prostaglandin F2I? in the first week after Roux-en-Y gastric bypass surgery. Obesity (Silver Spring), 19(8), 1663-8, 2011. PMCID:3176330

Williams, CS, Zhang, B, Smith, JJ, Jayagopal, A, Barrett, CW, Pino, C, Russ, P, Presley, SH, Peng, D, Rosenblatt, DO, Haselton, FR, Yang, JL, Washington, MK, Chen, X, Eschrich, S, Yeatman, TJ, El-Rifai, W, Beauchamp, RD, Chang, MS. BVES regulates EMT in human corneal and colon cancer cells and is silenced via promoter methylation in human colorectal carcinoma. J Clin Invest, 121(10), 4056-69, 2011. PMCID:3195453

Yan, F, Cao, H, Cover, TL, Washington, MK, Shi, Y, Liu, L, Chaturvedi, R, Peek, RM, Wilson, KT, Polk, DB. Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism. J Clin Invest, 121(6), 2242-53, 2011. PMCID:3104743

Zhang, Y, Dub??, PE, Washington, MK, Yan, F, Polk, DB. ErbB2 and ErbB3 regulate recovery from dextran sulfate sodium-induced colitis by promoting mouse colon epithelial cell survival. Lab Invest, , , 2011.

Bhaskara, S, Knutson, SK, Jiang, G, Chandrasekharan, MB, Wilson, AJ, Zheng, S, Yenamandra, A, Locke, K, Yuan, JL, Bonine-Summers, AR, Wells, CE, Kaiser, JF, Washington, MK, Zhao, Z, Wagner, FF, Sun, ZW, Xia, F, Holson, EB, Khabele, D, Hiebert, SW. Hdac3 is essential for the maintenance of chromatin structure and genome stability. Cancer Cell, 18(5), 436-47, 2010.

Blaine, SA, Ray, KC, Anunobi, R, Gannon, MA, Washington, MK, Means, AL. Adult pancreatic acinar cells give rise to ducts but not endocrine cells in response to growth factor signaling. Development, 137(14), 2289-96, 2010.

Miles, S, Piazuelo, MB, Semino-Mora, C, Washington, MK, Dubois, A, Peek, RM, Correa, P, Merrell, DS. Detailed in vivo Analysis of the Role of Helicobacter pylori Fur in Colonization and Disease. Infect Immun, 78(7), 3073-82, 2010.

Mukherjee, K, Peng, D, Brifkani, Z, Belkhiri, A, Pera, M, Koyama, T, Koehler, EA, Revetta, FL, Washington, MK, El-Rifai, W. Dopamine and cAMP regulated phosphoprotein MW 32 kDa is overexpressed in early stages of gastric tumorigenesis. Surgery, 148(2), 354-63, 2010.

Nagaraj, NS, Manning, HC, Revetta, F, Washington, MK, Smith, JJ, Merchant, NB. Oncogenic SRC as a therapeutic target in pancreas cancer. J Surg Res, 158(2), 195-6, 2010.

Nagaraj, NS, Smith, JJ, Revetta, F, Washington, MK, Merchant, NB. Targeted Inhibition of Src Kinase Signaling Attenuates Pancreatic Tumorigenesis. Mol Cancer Ther, 9(8), 2322-32, 2010.

Ogden, SR, Noto, JM, Allen, SS, Patel, DA, Romero-Gallo, J, Washington, MK, Fingleton, B, Israel, DA, Lewis, ND, Wilson, KT, Chaturvedi, R, Zhao, Z, Shyr, Y, Peek, RM. Matrix metalloproteinase-7 and premalignant host responses in Helicobacter pylori-infected mice. Cancer Res, 70(1), 30-5, 2010.

Rich, A, Toro, TZ, Tanksley, J, Fiske, WH, Lind, CD, Ayers, GD, Piessevaux, H, Washington, MK, Coffey, RJ. Distinguishing M??n??trier''s disease from its mimics. Gut, 59(12), 1617-24, 2010.

Schneider, BG, Peng, DF, Camargo, MC, Piazuelo, MB, Sicinschi, LA, Mera, R, Romero-Gallo, J, Delgado, AG, Bravo, LE, Wilson, KT, Peek, RM, Correa, P, El-Rifai, W. Promoter DNA hypermethylation in gastric biopsies from subjects at high and low risk for gastric cancer. Int J Cancer, 127(11), 2588-97, 2010. PMCID:2916942

Smalley-Freed, WG, Efimov, A, Burnett, PE, Short, SP, Davis, MA, Gumucio, DL, Washington, MK, Coffey, RJ, Reynolds, AB. p120-catenin is essential for maintenance of barrier function and intestinal homeostasis in mice. J Clin Invest, 120(6), 1824-35, 2010. PMCID:2877948

Smith, JJ, Deane, NG, Wu, F, Merchant, NB, Zhang, B, Jiang, A, Lu, P, Johnson, JC, Schmidt, C, Edwards, CM, Eschrich, S, Kis, C, Levy, S, Washington, MK, Heslin, MJ, Coffey, RJ, Yeatman, TJ, Shyr, Y, Beauchamp, RD. Experimentally Derived Metastasis Gene Expression Profile Predicts Recurrence and Death in Patients With Colon Cancer. Gastroenterology, 138 (3), 958-68, 2010.

Soutto, M, Peng, D, Razvi, M, Ruemmele, P, Hartmann, A, Roessner, A, Schneider-Stock, R, El-Rifai, W. Epigenetic and genetic silencing of CHFR in esophageal adenocarcinomas. Cancer, 116(17), 4033-42, 2010. PMCID:2930066

Vaezi, MF, Slaughter, JC, Smith, BS, Washington, MK, Jerome, WG, Garrett, CG, Hagaman, D, Goutte, M. Dilated intercellular space in chronic laryngitis and gastro-oesophageal reflux disease: at baseline and post-lansoprazole therapy. Aliment Pharmacol Ther, 32(7), 916-24, 2010.

Vangamudi, B, Peng, DF, Cai, Q, El-Rifai, W, Zheng, W, Belkhiri, A. t-DARPP regulates phosphatidylinositol-3-kinase-dependent cell growth in breast cancer. Mol Cancer, 9, 240, 2010. PMCID:2945963

Vilgelm, AE, Hong, SM, Washington, MK, Wei, J, Chen, H, El-Rifai, W, Zaika, A. Characterization of DeltaNp73 expression and regulation in gastric and esophageal tumors. Oncogene, Advance(online), August, 2010.

Vilgelm, AE, Washington, MK, Wei, J, Chen, H, Prassolov, VS, Zaika, AI. Interactions of the p53 protein family in cellular stress response in gastrointestinal tumors. Mol Cancer Ther, 9(3), 693-705, 2010.

Washington, MK, Berlin, J, Branton, PA, Burgart, LJ, Carter, DK, Compton, CC, Fitzgibbons, PL, Frankel, WL, Jessup, JM, Kakar, S, Minsky, B, Nakhleh, RE, Vauthey, JN, , . Protocol for the examination of specimens from patients with carcinoma of the perihilar bile ducts. Arch Pathol Lab Med, 134(4), e19-24, 2010.

Washington, MK, Berlin, J, Branton, PA, Burgart, LJ, Carter, DK, Compton, CC, Fitzgibbons, PL, Frankel, WL, Jessup, JM, Kakar, S, Minsky, B, Nakhleh, RE, Vauthey, JN, , . Protocol for the examination of specimens from patients with carcinoma of the distal extrahepatic bile ducts. Arch Pathol Lab Med, 134(4), e8-13, 2010.

Washington, MK, Berlin, J, Branton, PA, Burgart, LJ, Carter, DK, Compton, CC, Frankel, WL, Jessup, JM, Kakar, S, Minsky, B, Nakhleh, RE, Vauthey, JN, , . Protocol for the examination of specimens from patients with carcinoma of the intrahepatic bile ducts. Arch Pathol Lab Med, 134(4), e14-8, 2010.

Washington, MK, Tang, LH, Berlin, J, Branton, PA, Burgart, LJ, Carter, DK, Compton, CC, Fitzgibbons, PL, Frankel, WL, Jessup, JM, Kakar, S, Minsky, B, Nakhleh, RE, , . Protocol for the examination of specimens from patients with neuroendocrine tumors (carcinoid tumors) of the appendix. Arch Pathol Lab Med, 134(2), 171-5, 2010.

Washington, MK, Tang, LH, Berlin, J, Branton, PA, Burgart, LJ, Carter, DK, Compton, CC, Fitzgibbons, PL, Frankel, WL, Jessup, JM, Kakar, S, Minsky, B, Nakhleh, RE, , . Protocol for the examination of specimens from patients with neuroendocrine tumors (carcinoid tumors) of the small intestine and ampulla. Arch Pathol Lab Med, 134(2), 181-6, 2010.

Washington, MK, Tang, LH, Berlin, J, Branton, PA, Burgart, LJ, Carter, DK, Compton, CC, Fitzgibbons, PL, Frankel, WL, Jessup, JM, Kakar, S, Minsky, B, Nakhleh, RE, , . Protocol for the examination of specimens from patients with neuroendocrine tumors (carcinoid tumors) of the stomach. Arch Pathol Lab Med, 134(2), 187-91, 2010.

Washington, MK, Tang, LH, Berlin, J, Branton, PA, Burgart, LJ, Carter, DK, Compton, CC, Fitzgibbons, PL, Frankel, WL, Jessup, JM, Kakar, S, Minsky, B, Nakhleh, RE, , . Protocol for the examination of specimens from patients with neuroendocrine tumors (carcinoid tumors) of the colon and rectum. Arch Pathol Lab Med, 134(2), 176-80, 2010.

Wei, J, Nagy, TA, Vilgelm, A, Zaika, E, Ogden, SR, Romero-Gallo, J, Piazuelo, MB, Correa, P, Washington, MK, El-Rifai, W, Peek, RM, Zaika, A. Regulation of p53 Tumor Suppressor by Helicobacter pylori in Gastric Epithelial Cells. Gastroenterology, ahead of print(Pub ), Jun 12, 2010.

Algood, HM, Allen, SS, Washington, MK, Peek, RM, Miller, GG, Cover, TL. Regulation of gastric B cell recruitment is dependent on IL-17 receptor A signaling in a model of chronic bacterial infection. J Immunol, 183(9), 5837-46, 2009.

Boomershine, CS, Chamberlain, A, Kendall, P, Afshar-Sharif, AR, Huang, H, Washington, MK, Lawson, WE, Thomas, JW, Blackwell, TS, Bhowmick, NA. Autoimmune pancreatitis results from loss of TGFbeta signalling in S100A4-positive dendritic cells. Gut, 58(9), 1267-74, 2009. PMCID:2719085

Fiske, WH, Tanksley, J, Nam, KT, Goldenring, JR, Slebos, RJ, Liebler, DC, Abtahi, AM, La Fleur, B, Ayers, GD, Lind, CD, Washington, MK, Coffey, RJ. Efficacy of cetuximab in the treatment of Menetrier''s disease. Sci Transl Med, 1(8), 8ra18, 2009.

Franco, AT, Friedman, DB, Nagy, TA, Romero-Gallo, J, Krishna, U, Kendall, A, Israel, DA, Tegtmeyer, N, Washington, MK, Peek, RM. Delineation of a carcinogenic Helicobacter pylori proteome. Mol Cell Proteomics, 8(8), 1947-58, 2009. PMCID:2719085

Johnson, EM, Doyle, JD, Wetzel, JD, McClung, RP, Katunuma, N, Chappell, JD, Washington, MK, Dermody, TS. Genetic and pharmacologic alteration of cathepsin expression influences reovirus pathogenesis. J Virol, 83(19), 9630-40, 2009.

Peng, DF, Razvi, M, Chen, H, Washington, K, Roessner, A, Schneider-Stock, R, El-Rifai, W. DNA hypermethylation regulates the expression of members of the Mu-class glutathione S-transferases and glutathione peroxidases in Barrett''s adenocarcinoma. Gut, 58(1), 5-15, 2009.

Ray, KC, Blaine, SA, Washington, MK, Braun, AH, Singh, AB, Harris, RC, Harding, PA, Coffey, RJ, Means, AL. Transmembrane and soluble isoforms of heparin-binding epidermal growth factor-like growth factor regulate distinct processes in the pancreas. Gastroenterology, 137(5), 1785-94, 2009.

Sparks, EE, Huppert, KA, Brown, MA, Washington, MK, Huppert, SS. Notch signaling regulates formation of the three-dimensional architecture of intrahepatic bile ducts in mice. Hepatology, 51(4), 1391-400, 2009.

Sprung, RW, Brock, JW, Tanksley, JP, Li, M, Washington, MK, Slebos, RJ, Liebler, DC. Equivalence of protein inventories obtained from formalin-fixed paraffin-embedded and frozen tissue in multidimensional liquid chromatography-tandem mass spectrometry shotgun proteomic analysis. Mol Cell Proteomics, 8(8), 1988-98, 2009. PMCID:2722776

Trobridge, P, Knoblaugh, S, Washington, MK, Munoz, NM, Tsuchiya, KD, Rojas, A, Song, X, Ulrich, CM, Sasazuki, T, Shirasawa, S, Grady, WM. TGF-beta Receptor Inactivation and Mutant Kras Induce Intestinal Neoplasms in Mice via a beta-Catenin-Independent Pathway. Gastroenterology, Epub 2009 Feb 4. 136(5), 1680-8, 2009.

VanSaun, MN, Lee, IK, Washington, MK, Matrisian, L, Gorden, DL. High fat diet induced hepatic steatosis establishes a permissive microenvironment for colorectal metastases and promotes primary dysplasia in a murine model. Am J Pathol, 175(1), 355-64, 2009. PMCID:2719085

Washington, MK, Berlin, J, Branton, P, Burgart, LJ, Carter, DK, Fitzgibbons, PL, Halling, K, Frankel, W, Jessup, J, Kakar, S, Minsky, B, Nakhleh, R, Compton, CC, , . Protocol for the examination of specimens from patients with primary carcinoma of the colon and rectum. Arch Pathol Lab Med, 133(10), 1539-51, 2009.

Xu, BJ, Li, J, Beauchamp, RD, Shyr, Y, Li, M, Washington, MK, Yeatman, TJ, Whitehead, RH, Coffey, RJ, Caprioli, RM. Identification of early intestinal neoplasia protein biomarkers using laser capture microdissection and MALDI MS. Mol Cell Proteomics, Epub 2009 Jan 21. 8(5), 936-45, 2009. PMCID:2689774

Yan, F, Cao, H, Chaturvedi, R, Krishna, U, Hobbs, SS, Dempsey, PJ, Peek, RM, Cover, TL, Washington, MK, Wilson, KT, Polk, DB. Epidermal Growth Factor Receptor Activation Protects Gastric Epithelial Cells From Helicobacter pylori-Induced Apoptosis. Gastroenterology, 136(4), 1297-1307, 2009.

Zhang, H, Ables, ET, Pope, CF, Washington, MK, Hipkens, S, Means, AL, Path, G, Seufert, J, Costa, RH, Leiter, AB, Magnuson, MA, Gannon, M. Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation. Mech Dev, 126(11-12), 958-73, 2009.

Ajani, JA, Barthel, JS, Bekaii-Saab, T, Bentrem, DJ, D'Amico, TA, Fuchs, CS, Gerdes, H, Hayman, JA, Hazard, L, Ilson, DH, Kleinberg, LR, McAleer, MF, Meropol, NJ, Mulcahy, MF, Orringer, MB, Osarogiagbon, RU, Posey, JA, Sasson, AR, Scott, WJ, Shibata, S, Strong, VE, Swisher, SG, Washington, MK, Willett, C, Wood, DE, Wright, CD, Yang, G . Esophageal cancer. J Natl Compr Canc Netw, 6(9), 818-49, 2008.

Belkhiri, A, Dar, AA, Peng, DF, Razvi, MH, Rinehart, C, Arteaga, CL, El-Rifai, W. Expression of t-DARPP mediates trastuzumab resistance in breast cancer cells. Clin Cancer Res, 14(14), 4564-71, 2008. PMCID:2842884

Cates, JM, Byrd, RH, Fohn, LE, Tatsas, AD, Washington, MK, Black, CC. Epithelial-Mesenchymal Transition Markers in Pancreatic Ductal Adenocarcinoma. Pancreas, 38(1), e1-6, 2008.

Dar, AA, Zaika, A, Piazuelo, MB, Correa, P, Koyama, T, Belkhiri, A, Washington, K, Castells, A, Pera, M, El-Rifai, W. Frequent overexpression of Aurora Kinase A in upper gastrointestinal adenocarcinomas correlates with potent antiapoptotic functions. Cancer, 112(8), 1688-98, 2008.

Edelblum, KL, Washington, MK, Koyama, T, Robine, S, Baccarini, M, Polk, DB. Raf protects against colitis by promoting mouse colon epithelial cell survival through NF-kappaB. Gastroenterology, 135(2), 539-51, 2008. PMCID:2640938

Edgerton, ME, Morrison, C, Livolsi, VA, Moskaluk, CA, Qualman, SJ, Washington, MK, Grizzle, WE. A Standards based Ontological Approach to Information Handling for use by Organizations Providing Human Tissue for Research. Cancer Inform, 6, 127-37, 2008. PMCID:2623300

Farmer, TE, Williams, CS, Washington, MK, Hiebert, SW. Inactivation of the p19(ARF) tumor suppressor affects intestinal epithelial cell proliferation and integrity. J Cell Biochem, 104(6), 2228-40, 2008.

Grady, WM, Parkin, RK, Mitchell, PS, Lee, JH, Kim, YH, Tsuchiya, KD, Washington, MK, Paraskeva, C, Willson, JK, Kaz, AM, Kroh, EM, Allen, A, Fritz, BR, Markowitz, SD, Tewari, M. Epigenetic silencing of the intronic microRNA hsa-miR-342 and its host gene EVL in colorectal cancer. Oncogene, 27(27), 3880-8, 2008.

Harris, EI, Lewin, DN, Wang, HL, Lauwers, GY, Srivastava, A, Shyr, Y, Shakhtour, B, Revetta, F, Washington, MK. Lymphovascular Invasion in Colorectal Cancer: An Interobserver Variability Study. Am J Surg Pathol, 32(12), 1816-21, 2008. PMCID:2605104

Lee, W, Belkhiri, A, Lockhart, AC, Merchant, N, Glaeser, H, Harris, EI, Washington, MK, Brunt, EM, Zaika, A, Kim, RB, El-Rifai, W. Overexpression of OATP1B3 confers apoptotic resistance in colon cancer. Cancer Res, 68(24), 10315-23, 2008. PMCID:2605661

Manning, HC, Merchant, NB, Foutch, AC, Virostko, JM, Wyatt, SK, Shah, C, McKinley, ET, Xie, J, Mutic, NJ, Washington, MK, LaFleur, B, Tantawy, MN, Peterson, TE, Ansari, MS, Baldwin, RM, Rothenberg, ML, Bornhop, DJ, Gore, JC, Coffey, RJ. Molecular imaging of therapeutic response to epidermal growth factor receptor blockade in colorectal cancer. Clin Cancer Res, 14(22), 7413-22, 2008. PMCID:2657180

Marcellin, P, Heathcote, EJ, Buti, M, Gane, E, de Man, RA, Krastev, Z, Germanidis, G, Lee, SS, Flisiak, R, Kaita, K, Manns, M, Kotzev, I, Tchernev, K, Buggisch, P, Weilert, F, Kurdas, OO, Shiffman, ML, Trinh, H, Washington, MK, Sorbel, J, Anderson, J, Snow-Lampart, A, Mondou, E, Quinn, J, Rousseau, F. Tenofovir disoproxil fumarate versus adefovir dipivoxil for chronic hepatitis B. N Engl J Med, 359(23), 2442-55, 2008.

Merchant, NB, Voskresensky, I, Rogers, CM, Lafleur, B, Dempsey, PJ, Graves-Deal, R, Revetta, F, Foutch, AC, Rothenberg, ML, Washington, MK, Coffey, RJ. TACE/ADAM-17: a component of the epidermal growth factor receptor axis and a promising therapeutic target in colorectal cancer. Clin Cancer Res, 14(4), 1182-91, 2008.

Peng, D, Sheta, EA, Powell, SM, Moskaluk, CA, Washington, K, Goldknopf, IL, El-Rifai, W. Alterations in Barrett''s-related adenocarcinomas: a proteomic approach. Int J Cancer, 122(6), 1303-10, 2008.

Rojas, A, Meherem, S, Kim, YH, Washington, MK, Willis, JE, Markowitz, SD, Grady, WM. The aberrant methylation of TSP1 suppresses TGF-beta1 activation in colorectal cancer. Int J Cancer, 123(1), 14-21, 2008.

Romero-Gallo, J, Harris, EJ, Krishna, U, Washington, MK, Perez-Perez, GI, Peek, RM. Effect of Helicobacter pylori eradication on gastric carcinogenesis. Lab Invest, 88(3), 328-36, 2008.

Thompson, BJ, Washington, MK, Kurre, U, Singh, M, Rula, EY, Emeson, RB. Protective roles of alpha-calcitonin and beta-calcitonin gene-related peptide in spontaneous and experimentally induced colitis. Dig Dis Sci, 53(1), 229-41, 2008.

Vilgelm, A, Wei, JX, Piazuelo, MB, Washington, MK, Prassolov, V, El-Rifai, W, Zaika, A. DeltaNp73alpha regulates MDR1 expression by inhibiting p53 function. Oncogene, 27(15), 2170-6, 2008.

Washington, MK. Colorectal carcinoma: selected issues in pathologic examination and staging and determination of prognostic factors. Arch Pathol Lab Med, 132(10), 1600-7, 2008.

Washington, MK, Berlin, J, Branton, PA, Burgart, LJ, Carter, DK, Fitzgibbons, PL, Frankel, WL, Jessup, JM, Kakar, S, Minsky, B, Nakhleh, RE, Compton, CC . Protocol for the examination of specimens from patients with primary carcinomas of the colon and rectum. Arch Pathol Lab Med, 132(7), 1182-93, 2008.

Wei, J, O''Brien, D, Vilgelm, A, Piazuelo, MB, Correa, P, Washington, MK, El-Rifai, W, Peek, RM, Zaika, A. Interaction of Helicobacter pylori with gastric epithelial cells is mediated by the p53 protein family. Gastroenterology, 134(5), 1412-23, 2008. PMCID:2430883

Bamborough, P, Angell, RM, Bhamra, I, Brown, D, Bull, J, Christopher, JA, Cooper, AW, Fazal, LH, Giordano, I, Hind, L, Patel, VK, Ranshaw, LE, Sims, MJ, Skone, PA, Smith, KJ, Vickerstaff, E, Washington, M. N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: indazoles as phenol isosteres with improved pharmacokinetics. Bioorg Med Chem Lett, 17(15), 4363-8, 2007.

Barnes, SL, Lyshchik, A, Washington, MK, Gore, JC, Miga, MI. Development of a mechanical testing assay for fibrotic murine liver. Med Phys, 34(11), 4439-50, 2007. PMCID:2442892

Coffey, RJ, Washington, MK, Corless, CL, Heinrich, MC. Menetrier disease and gastrointestinal stromal tumors: hyperproliferative disorders of the stomach. J Clin Invest, 117(1), 70-80, 2007. PMCID:1716220

Deane, NG, Manning, HC, Foutch, AC, Washington, MK, Aronow, BJ, Aronow, BA, Bornhop, DJ, Coffey, RJ. Targeted imaging of colonic tumors in smad3-/- mice discriminates cancer and inflammation. Mol Cancer Res, 5(4), 341-9, 2007.

Felts, AS, Ji, C, Stafford, JB, Crews, BC, Kingsley, PJ, Rouzer, CA, Washington, MK, Subbaramaiah, K, Siegel, BS, Young, SM, Dannenberg, AJ, Marnett, LJ. Desmethyl derivatives of indomethacin and sulindac as probes for cyclooxygenase-dependent biology. ACS Chem Biol, 2(7), 479-83, 2007.

Finegold, MJ, Lopez-Terrada, DH, Bowen, J, Washington, MK, Qualman, SJ. Protocol for the examination of specimens from pediatric patients with hepatoblastoma. Arch Pathol Lab Med, 131(4), 520-9, 2007.

Li, JQ, Xu, BJ, Shakhtour, B, Deane, N, Merchant, N, Heslin, MJ, Washington, K, Coffey, RJ, Beauchamp, RD, Shyr, Y, Billheimer, D. Variability of in situ proteomic profiling and implications for study design in colorectal tumors. Int J Oncol, 31(1), 103-11, 2007.

M''Koma, AE, Wise, PE, Muldoon, RL, Schwartz, DA, Washington, MK, Herline, AJ. Evolution of the restorative proctocolectomy and its effects on gastrointestinal hormones. Int J Colorectal Dis, 22(10), 1143-63, 2007.

Razvi, MH, Peng, D, Dar, AA, Powell, SM, Frierson, HF, Moskaluk, CA, Washington, K, El-Rifai, W. Transcriptional oncogenomic hot spots in Barrett''s adenocarcinomas: serial analysis of gene expression. Genes Chromosomes Cancer, 46(10), 914-28, 2007.

Shao, J, Washington, MK, Saxena, R, Sheng, H. Heterozygous disruption of the PTEN promotes intestinal neoplasia in APCmin/+ mouse: roles of osteopontin. Carcinogenesis, 28(12), 2476-83, 2007.

Shiou, SR, Singh, AB, Moorthy, K, Datta, PK, Washington, MK, Beauchamp, RD, Dhawan, P. Smad4 regulates claudin-1 expression in a transforming growth factor-beta-independent manner in colon cancer cells. Cancer Res, 67(4), 1571-9, 2007.

Washington, MK. Autoimmune liver disease: overlap and outliers. Mod Pathol, 20 Suppl 1, S15-30, 2007.

Yan, F, Cao, H, Cover, TL, Whitehead, R, Washington, MK, Polk, DB. Soluble proteins produced by probiotic bacteria regulate intestinal epithelial cell survival and growth. Gastroenterology, 132(2), 562-75, 2007.

Gray, KD, Ballard, BR, Washington, MK, Belue, R, Grady, WM, Chapman, WC, Stain, SC. Do adverse histopathologic findings in colorectal cancer patients explain disparate outcomes. J Natl Med Assoc, 98(3), 348-51, 2006. PMCID:2576115

Halder, SK, Anumanthan, G, Maddula, R, Mann, J, Chytil, A, Gonzalez, AL, Washington, MK, Moses, HL, Beauchamp, RD, Datta, PK. Oncogenic function of a novel WD-domain protein, STRAP, in human carcinogenesis. Cancer Res, 66(12), 6156-66, 2006.

Johnson, JC, Schmidt, CR, Shrubsole, MJ, Billheimer, DD, Joshi, PR, Morrow, JD, Heslin, MJ, Washington, MK, Ness, RM, Zheng, W, Schwartz, DA, Coffey, RJ, Beauchamp, RD, Merchant, NB. Urine PGE-M: A metabolite of prostaglandin E2 as a potential biomarker of advanced colorectal neoplasia. Clin Gastroenterol Hepatol, 4(11), 1358-65, 2006.

Kim, YH, Petko, Z, Dzieciatkowski, S, Lin, L, Ghiassi, M, Stain, S, Chapman, WC, Washington, MK, Willis, J, Markowitz, SD, Grady, WM. CpG island methylation of genes accumulates during the adenoma progression step of the multistep pathogenesis of colorectal cancer. Genes Chromosomes Cancer, 45(8), 781-9, 2006.

Lee, OJ, Hong, SM, Razvi, MH, Peng, D, Powell, SM, Smoklin, M, Moskaluk, CA, El-Rifai, W. Expression of calcium-binding proteins S100A2 and S100A4 in Barrett''s adenocarcinomas. Neoplasia, 8(10), 843-50, 2006. PMCID:1715926

Leys, CM, Nomura, S, Rudzinski, E, Kaminishi, M, Montgomery, E, Washington, MK, Goldenring, JR. Expression of Pdx-1 in human gastric metaplasia and gastric adenocarcinoma. Hum Pathol, 37(9), 1162-8, 2006.

Lim, SG, Ng, TM, Kung, N, Krastev, Z, Volfova, M, Husa, P, Lee, SS, Chan, S, Shiffman, ML, Washington, MK, Rigney, A, Anderson, J, Mondou, E, Snow, A, Sorbel, J, Guan, R, Rousseau, F . A double-blind placebo-controlled study of emtricitabine in chronic hepatitis B. Arch Intern Med, 166(1), 49-56, 2006.

Martinez, JA, Williams, CS, Amann, JM, Ellis, TC, Moreno-Miralles, I, Washington, MK, Gregoli, P, Hiebert, SW. Deletion of Mtgr1 sensitizes the colonic epithelium to dextran sodium sulfate-induced colitis. Gastroenterology, 131(2), 579-88, 2006.

Munoz, NM, Upton, M, Rojas, A, Washington, MK, Lin, L, Chytil, A, Sozmen, EG, Madison, BB, Pozzi, A, Moon, RT, Moses, HL, Grady, WM. Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation. Cancer Res, 66(20), 9837-44, 2006.

Shulman, HM, Kleiner, D, Lee, SJ, Morton, T, Pavletic, SZ, Farmer, E, Moresi, JM, Greenson, J, Janin, A, Martin, PJ, McDonald, G, Flowers, ME, Turner, M, Atkinson, J, Lefkowitch, J, Washington, MK, Prieto, VG, Kim, SK, Argenyi, Z, Diwan, AH, Rashid, A, Hiatt, K, Couriel, D, Schultz, K, Hymes, S, Vogelsang, GB. Histopathologic diagnosis of chronic graft-versus-host disease: National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: II. Pathology Working Group Report. Biol Blood Marrow Transplant, 12(1), 31-47, 2006.

Smith, LH, Dixon, JD, Stringham, JR, Eren, M, Elokdah, H, Crandall, DL, Washington, K, Vaughan, DE. Pivotal role of PAI-1 in a murine model of hepatic vein thrombosis. Blood, 107(1), 132-4, 2006. PMCID:1895352

Su, Y, Shrubsole, MJ, Ness, RM, Cai, Q, Kataoka, N, Washington, K, Zheng, W. Immunohistochemical expressions of Ki-67, cyclin D1, beta-catenin, cyclooxygenase-2, and epidermal growth factor receptor in human colorectal adenoma: a validation study of tissue microarrays. Cancer Epidemiol Biomarkers Prev, 15(9), 1719-26, 2006.

Washington K. Hepatic iron deposition: new observations in non-HFE hemochromatosis. Advances in Anatomic Pathology, 13(6), 341-2, 2006.

Welch, DC, Wirth, PS, Goldenring, JR, Ness, E, Jagasia, M, Washington, K. Gastric graft-versus-host disease revisited: does proton pump inhibitor therapy affect endoscopic gastric biopsy interpretation. Am J Surg Pathol, 30(4), 444-9, 2006.

Ye, C, Shrubsole, MJ, Cai, Q, Ness, R, Grady, WM, Smalley, W, Cai, H, Washington, K, Zheng, W. Promoter methylation status of the MGMT, hMLH1, and CDKN2A/p16 genes in non-neoplastic mucosa of patients with and without colorectal adenomas. Oncol Rep, 16(2), 429-35, 2006.

Amann, JM, Chyla, BJ, Ellis, TC, Martinez, A, Moore, AC, Franklin, JL, McGhee, L, Meyers, S, Ohm, JE, Luce, KS, Ouelette, AJ, Washington, MK, Thompson, MA, King, D, Gautam, S, Coffey, RJ, Whitehead, RH, Hiebert, SW. Mtgr1 is a transcriptional corepressor that is required for maintenance of the secretory cell lineage in the small intestine. Mol Cell Biol, 25(21), 9576-85, 2005. PMCID:1265807

Bao, P, Welch, DC, Washington, MK, Herline, AJ. Resection of mesenteric inflammatory veno-occlusive disease causing ischemic colitis. J Gastrointest Surg, 9(6), 812-7, 2005.

Dhawan, P, Singh, AB, Deane, NG, No, Y, Shiou, SR, Schmidt, C, Neff, J, Washington, MK, Beauchamp, RD. Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer. J Clin Invest, 115(7), 1765-76, 2005. PMCID:1150288

Franco, AT, Israel, DA, Washington, MK, Krishna, U, Fox, JG, Rogers, AB, Neish, AS, Collier-Hyams, L, Perez-Perez, GI, Hatakeyama, M, Whitehead, R, Gaus, K, O''Brien, DP, Romero-Gallo, J, Peek, RM. Activation of beta-catenin by carcinogenic Helicobacter pylori. Proc Natl Acad Sci U S A, 102(30), 10646-51, 2005. PMCID:1180811

Hansel, DE, Dhara, S, Huang, RC, Ashfaq, R, Deasel, M, Shimada, Y, Bernstein, HS, Harmon, J, Brock, M, Forastiere, A, Washington, MK, Maitra, A, Montgomery, E. CDC2/CDK1 expression in esophageal adenocarcinoma and precursor lesions serves as a diagnostic and cancer progression marker and potential novel drug target. Am J Surg Pathol, 29(3), 390-9, 2005.

Huang, W, Zhang, J, Washington, M, Liu, J, Parant, JM, Lozano, G, Moore, DD. Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor. Mol Endocrinol, 19(6), 1646-53, 2005.

Park, YK, Franklin, JL, Settle, SH, Levy, SE, Chung, E, Jeyakumar, LH, Shyr, Y, Washington, MK, Whitehead, RH, Aronow, BJ, Coffey, RJ. Gene expression profile analysis of mouse colon embryonic development. Genesis, 41(1), 1-12, 2005.

Petko, Z, Ghiassi, M, Shuber, A, Gorham, J, Smalley, W, Washington, MK, Schultenover, S, Gautam, S, Markowitz, SD, Grady, WM. Aberrantly methylated CDKN2A, MGMT, and MLH1 in colon polyps and in fecal DNA from patients with colorectal polyps. Clin Cancer Res, 11(3), 1203-9, 2005.

Robert, ME, Washington, MK, Lee, JR, Goldenring, JR, Bronner, MP, Goldblum, JR, Greenson, JK, Haber, MM, Hart, JA, Lamps, LW, Lauwers, GY, Lewin, D, Lazenby, AJ, Montgomery, E, Crawford, JM. Rab11a immunohistochemical analysis does not distinguish indefinite, low-, and high-grade dysplasia in Barrett esophagus. Am J Clin Pathol, 124(4), 519-27, 2005.

Rothenberg, ML, LaFleur, B, Levy, DE, Washington, MK, Morgan-Meadows, SL, Ramanathan, RK, Berlin, JD, Benson, AB, Coffey, RJ. Randomized phase II trial of the clinical and biological effects of two dose levels of gefitinib in patients with recurrent colorectal adenocarcinoma. J Clin Oncol, 23(36), 9265-74, 2005.

Settle, SH, Washington, K, Lind, C, Itzkowitz, S, Fiske, WH, Burdick, JS, Jerome, WG, Ray, M, Weinstein, W, Coffey, RJ. Chronic treatment of M??n??trier''s disease with Erbitux: clinical efficacy and insight into pathophysiology. Clin Gastroenterol Hepatol, 3(7), 654-9, 2005.

Thliveris, AT, Halberg, RB, Clipson, L, Dove, WF, Sullivan, R, Washington, MK, Stanhope, S, Newton, MA. Polyclonality of familial murine adenomas: analyses of mouse chimeras with low tumor multiplicity suggest short-range interactions. Proc Natl Acad Sci U S A, 102(19), 6960-5, 2005. PMCID:1100801

Thomas, KT, Welch, D, Trueblood, A, Sulur, P, Wise, P, Gorden, DL, Chari, RS, Wright, JK, Washington, K, Pinson, CW. Effective treatment of biliary cystadenoma. Ann Surg, 241(5), 769-73; discussion 773-5, 2005. PMCID:1357131

Washington, K. Update on post-liver transplantation infections, malignancies, and surgical complications. Adv Anat Pathol, 12(4), 221-6, 2005.

Anderson, CD, Lin, WC, Buttemere, CR, Washington, MK, Mahadevan-Jansen, A, Pierce, J, Nicoud, IB, Pinson, CW, Chari, RS. Real-time spectroscopic assessment of thermal damage: implications for radiofrequency ablation. J Gastrointest Surg, 8(6), 660-9, 2004.

Bhowmick, NA, Chytil, A, Plieth, D, Gorska, AE, Dumont, N, Shappell, S, Washington, MK, Neilson, EG, Moses, HL. TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia. Science, 303(5659), 848-51, 2004.

Biswas, S, Chytil, A, Washington, K, Romero-Gallo, J, Gorska, AE, Wirth, PS, Gautam, S, Moses, HL, Grady, WM. Transforming growth factor beta receptor type II inactivation promotes the establishment and progression of colon cancer. Cancer Res, 64(14), 4687-92, 2004.

Buttemere, CR, Chari, RS, Anderson, CD, Washington, MK, Mahadevan-Jansen, A, Lin, WC. In vivo assessment of thermal damage in the liver using optical spectroscopy. J Biomed Opt, 9(5), 1018-27, 2004.

Deane, NG, Lee, H, Hamaamen, J, Ruley, A, Washington, MK, LaFleur, B, Thorgeirsson, SS, Price, R, Beauchamp, RD. Enhanced tumor formation in cyclin D1 x transforming growth factor beta1 double transgenic mice with characterization by magnetic resonance imaging. Cancer Res, 64(4), 1315-22, 2004.

Qualman, SJ, France, M, Grizzle, WE, LiVolsi, VA, Moskaluk, CA, Ramirez, NC, Washington, MK. Establishing a tumour bank: banking, informatics and ethics. Br J Cancer, 90(6), 1115-9, 2004. PMCID:2409638

Scoggins, C, Moore, D, Washington, K, Wright, J, Chari, R. Supra-elevated CA 19-9 in a benign hepatic cyst adenoma. HPB (Oxford), 6(1), 43-4, 2004. PMCID:2020653

Stack, E, Washington, K, Avant, GR, Eisen, GM. Cytomegalovirus enteritis in common variable immunodeficiency. South Med J, 97(1), 96-101, 2004.

Yan, F, John, SK, Wilson, G, Jones, DS, Washington, MK, Polk, DB. Kinase suppressor of Ras-1 protects intestinal epithelium from cytokine-mediated apoptosis during inflammation. J Clin Invest, 114(9), 1272-80, 2004. PMCID:524224

Barton, ES, Youree, BE, Ebert, DH, Forrest, JC, Connolly, JL, Valyi-Nagy, T, Washington, K, Wetzel, JD, Dermody, TS. Utilization of sialic acid as a coreceptor is required for reovirus-induced biliary disease. J Clin Invest, 111(12), 1823-33, 2003. PMCID:161418

Crawford, HC, Krishna, US, Israel, DA, Matrisian, LM, Washington, MK, Peek, RM. Helicobacter pylori strain-selective induction of matrix metalloproteinase-7 in vitro and within gastric mucosa. Gastroenterology, 125(4), 1125-36, 2003.

Gray, KD, Simovic, MO, Chapman, WC, Blackwell, TS, Christman, JW, Washington, MK, Yull, FE, Jaffal, N, Jansen, ED, Gautman, S, Stain, SC. Systemic nf-kappaB activation in a transgenic mouse model of acute pancreatitis. J Surg Res, 110(1), 310-4, 2003.

Limitations of histopathology in distinguishing high grade dysplasia and early adenocarcinoma in Barretts esophagus: an interobserver agreement study. Washington K. Evidence Based Gastroenterology , 4, 37-38, 2003.

Means, AL, Ray, KC, Singh, AB, Washington, MK, Whitehead, RH, Harris, RC, Wright, CV, Coffey, RJ, Leach, SD. Overexpression of heparin-binding EGF-like growth factor in mouse pancreas results in fibrosis and epithelial metaplasia. Gastroenterology, 124(4), 1020-36, 2003.

Parker, MA, Deane, NG, Thompson, EA, Whitehead, RH, Mithani, SK, Washington, MK, Datta, PK, Dixon, DA, Beauchamp, RD. Over-expression of cyclin D1 regulates Cdk4 protein synthesis. Cell Prolif, 36(6), 347-60, 2003.

Rice, PL, Washington, M, Schleman, S, Beard, KS, Driggers, LJ, Ahnen, DJ. Sulindac sulfide inhibits epidermal growth factor-induced phosphorylation of extracellular-regulated kinase 1/2 and Bad in human colon cancer cells. Cancer Res, 63(3), 616-20, 2003.

Schmidt, CR, Washington, MK, Gi, YJ, Coffey, RJ, Beauchamp, RD, Pearson, AS. Dysregulation of E-cadherin by oncogenic Ras in intestinal epithelial cells is blocked by inhibiting MAP kinase. Am J Surg, 186(5), 426-30, 2003.

Sotomayor, RE, Washington, M, Nguyen, L, Nyang''anyi, R, Hinton, DM, Chou, M. Effects of intermittent exposure to aflatoxin B1 on DNA and RNA adduct formation in rat liver: dose-response and temporal patterns. Toxicol Sci, 73(2), 329-38, 2003.

Wudel, LJ, Allos, TM, Washington, MK, Sheller, JR, Chapman, WC. Multi-organ inflammation after hepatic cryoablation in BALB/c mice. J Surg Res, 112(2), 131-7, 2003.

Wudel, LJ, Delbeke, D, Morris, D, Rice, M, Washington, MK, Shyr, Y, Pinson, CW, Chapman, WC. The role of [18F]fluorodeoxyglucose positron emission tomography imaging in the evaluation of hepatocellular carcinoma. Am Surg, 69(2), 117-24; discussion 124-6, 2003.

Crawford, HC, Scoggins, CR, Washington, MK, Matrisian, LM, Leach, SD. Matrix metalloproteinase-7 is expressed by pancreatic cancer precursors and regulates acinar-to-ductal metaplasia in exocrine pancreas. J Clin Invest, 109(11), 1437-44, 2002. PMCID:150998

Koay, MA, Gao, X, Washington, MK, Parman, KS, Sadikot, RT, Blackwell, TS, Christman, JW. Macrophages are necessary for maximal nuclear factor-kappa B activation in response to endotoxin. Am J Respir Cell Mol Biol, 26(5), 572-8, 2002.

Roberts, RB, Min, L, Washington, MK, Olsen, SJ, Settle, SH, Coffey, RJ, Threadgill, DW. Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesis. Proc Natl Acad Sci U S A, 99(3), 1521-6, 2002. PMCID:122223

Washington K. Solid-pseudopapillary tumor of the pancreas: challenges presented by an unusual pancreatic neoplasm. Annals Surg Oncol, 9, 3-4, 2002.

Washington K. Autoimmune cholangitis: not just AMA-negative primary biliary cirrhosis. Commentary on Autoimmune cholangitis within the spectrum of autoimmune liver disease. Czaja A.J., Carpenter H.A., Santrach P.J., Moore S.B., Hepatology, 2000, 31: 1231-1238. Advances in Anatomic Pathology, 9(6), 244-250, 2002.

Washington, K. Autoimmune cholangitis: not just AMA-negative primary biliary cirrhosis. Adv Anat Pathol, 9(4), 244-50, 2002.

Washington, K, Greenson, JK, Montgomery, E, Shyr, Y, Crissinger, KD, Polk, DB, Barnard, J, Lauwers, GY. Histopathology of ulcerative colitis in initial rectal biopsy in children. Am J Surg Pathol, 26(11), 1441-9, 2002.

Wise, PE, Wudel, LJ, Belous, AE, Allos, TM, Kuhn, SJ, Feurer, ID, Washington, MK, Pinson, CW, Chapman, WC. Biliary reconstruction is enhanced with a collagen-polyethylene glycol sealant. Am Surg, 68(6), 553-61; discussion 561-2, 2002.

Lamps LW, Washington K. "Pediatric gastrointestinal and liver pathology." Pediatric Hematopathology, Collins RC, ed. Philadelphia: Churchill Livingstone, 2001.

Deane, NG, Parker, MA, Aramandla, R, Diehl, L, Lee, WJ, Washington, MK, Nanney, LB, Shyr, Y, Beauchamp, RD. Hepatocellular carcinoma results from chronic cyclin D1 overexpression in transgenic mice. Cancer Res, 61(14), 5389-95, 2001.

Kong, FM, Anscher, MS, Sporn, TA, Washington, MK, Clough, R, Barcellos-Hoff, MH, Jirtle, RL. Loss of heterozygosity at the mannose 6-phosphate insulin-like growth factor 2 receptor (M6P/IGF2R) locus predisposes patients to radiation-induced lung injury. Int J Radiat Oncol Biol Phys, 49(1), 35-41, 2001.

Sheng, H, Shao, J, Washington, MK, DuBois, RN. Prostaglandin E2 increases growth and motility of colorectal carcinoma cells. J Biol Chem, 276(21), 18075-81, 2001.

Washington, K, Debelak, JP, Gobbell, C, Sztipanovits, DR, Shyr, Y, Olson, S, Chapman, WC. Hepatic cryoablation-induced acute lung injury: histopathologic findings. J Surg Res, 95(1), 1-7, 2001.

Williams, CS, Sheng, H, Brockman, JA, Armandla, R, Shao, J, Washington, MK, Elkahloun, AG, DuBois, RN. A cyclooxygenase-2 inhibitor (SC-58125) blocks growth of established human colon cancer xenografts. Neoplasia, 3(5), 428-36, 2001. PMCID:1506203

Wise, PE, Shi, YY, Washington, MK, Chapman, WC, Wright, JK, Sharp, KW, Pinson, CW. Radical resection improves survival for patients with pT2 gallbladder carcinoma. Am Surg, 67(11), 1041-7, 2001.

Wolfe, SG, Chey, WY, Washington, MK, Harding, J, Heath, AT, McSorley, DJ, Dukes, GE, Hunt, CM. Tolerability and safety of alosetron during long-term administration in female and male irritable bowel syndrome patients. Am J Gastroenterol, 96(3), 803-11, 2001.

Chapman, WC, Debelak, JP, Wright Pinson, C, Washington, MK, Atkinson, JB, Venkatakrishnan, A, Blackwell, TS, Christman, JW. Hepatic cryoablation, but not radiofrequency ablation, results in lung inflammation. Ann Surg, 231(5), 752-61, 2000. PMCID:1421063

Kong, FM, Anscher, MS, Washington, MK, Killian, JK, Jirtle, RL. M6P/IGF2R is mutated in squamous cell carcinoma of the lung. Oncogene, 19(12), 1572-8, 2000.

Lamps, LW, Gray, GF, Dilday, BR, Washington, MK. The coexistence of low-grade mucinous neoplasms of the appendix and appendiceal diverticula: a possible role in the pathogenesis of pseudomyxoma peritonei. Mod Pathol, 13(5), 495-501, 2000.

Shattuck-Brandt, RL, Varilek, GW, Radhika, A, Yang, F, Washington, MK, DuBois, RN. Cyclooxygenase 2 expression is increased in the stroma of colon carcinomas from IL-10(-/-) mice. Gastroenterology, 118(2), 337-45, 2000.

Washington, K, Wright, K, Shyr, Y, Hunter, EB, Olson, S, Raiford, DS. Hepatic stellate cell activation in nonalcoholic steatohepatitis and fatty liver. Hum Pathol, 31(7), 822-8, 2000.

Blackwell, TS, Debelak, JP, Venkatakrishnan, A, Schot, DJ, Harley, DH, Pinson, CW, Williams, P, Washington, K, Christman, JW, Chapman, WC. Acute lung injury after hepatic cryoablation: correlation with NF-kappa B activation and cytokine production. Surgery, 126(3), 518-26, 1999.

Lamps, LW, Carson, K, Bradley, AL, Pinson, CW, Johnson, JE, Coogan, AC, Hunter, EB, Clavien, PA, Washington, MK. Pulmonary vascular morphological changes in cirrhotic patients undergoing liver transplantation. Liver Transpl Surg, 5(1), 57-64, 1999.

Shao, J, Sheng, H, Aramandla, R, Pereira, MA, Lubet, RA, Hawk, E, Grogan, L, Kirsch, IR, Washington, MK, Beauchamp, RD, DuBois, RN. Coordinate regulation of cyclooxygenase-2 and TGF-beta1 in replication error-positive colon cancer and azoxymethane-induced rat colonic tumors. Carcinogenesis, 20(2), 185-91, 1999.

Song, SY, Gannon, M, Washington, MK, Scoggins, CR, Meszoely, IM, Goldenring, JR, Marino, CR, Sandgren, EP, Coffey, RJ, Wright, CV, Leach, SD. Expansion of Pdx1-expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor alpha. Gastroenterology, 117(6), 1416-26, 1999.

Stutts, JT, Washington, K, Barnard, JA. Cholestatic jaundice with skin desquamation in a 12-year-old girl. J Pediatr, 134(5), 649-53, 1999.

Chapman, WC, Fisk, J, Schot, D, Debelak, JP, Washington, MK, Bluth, RF, Pierce, D, Williams, LF. Establishment and characterization of primary gallbladder epithelial cell cultures in the prairie dog. J Surg Res, 80(1), 35-43, 1998.

Lamps, LW, Hunt, CM, Green, A, Gray, GF, Washington, K. Alterations in colonic mucosal vessels in patients with cirrhosis and noncirrhotic portal hypertension. Hum Pathol, 29(5), 527-35, 1998.

Lamps, LW, Pinson, CW, Raiford, DS, Shyr, Y, Scott, MA, Washington, MK. The significance of microabscesses in liver transplant biopsies: a clinicopathological study. Hepatology, 28(6), 1532-7, 1998.

Roselli, HT, Su, M, Washington, K, Kerins, DM, Vaughan, DE, Russell, WE. Liver regeneration is transiently impaired in urokinase-deficient mice. Am J Physiol, 275(6 Pt 1), G1472-9, 1998.

Sheng, H, Shao, J, Williams, CS, Pereira, MA, Taketo, MM, Oshima, M, Reynolds, AB, Washington, MK, DuBois, RN, Beauchamp, RD. Nuclear translocation of beta-catenin in hereditary and carcinogen-induced intestinal adenomas. Carcinogenesis, 19(4), 543-9, 1998.

Taga, SA, Washington, MK, Terrault, N, Wright, TL, Somberg, KA, Ferrell, LD. Cholestatic hepatitis C in liver allografts. Liver Transpl Surg, 4(4), 304-10, 1998.

Washington, K, Chiappori, A, Hamilton, K, Shyr, Y, Blanke, C, Johnson, D, Sawyers, J, Beauchamp, D. Expression of beta-catenin, alpha-catenin, and E-cadherin in Barrett''s esophagus and esophageal adenocarcinomas. Mod Pathol, 11(9), 805-13, 1998.

Yan, HP, Carter, CE, Wang, EZ, Page, DL, Washington, K, Wamil, BD, Yakes, FM, Thurman, GB, Hellerqvist, CG. Functional studies on the anti-pathoangiogenic properties of CM101. Angiogenesis, 2(3), 219-33, 1998.

Carson, K, Washington, MK, Treem, WR, Clavien, PA, Hunt, CM. Recurrence of nonalcoholic steatohepatitis in a liver transplant recipient. Liver Transpl Surg, 3(2), 174-6, 1997.

Gao, W, Washington, MK, Bentley, RC, Clavien, PA. Antiangiogenic agents protect liver sinusoidal lining cells from cold preservation injury in rat liver transplantation. Gastroenterology, 113(5), 1692-700, 1997.

McCauley, J, Irish, W, Thompson, L, Stevenson, J, Lockett, R, Bussard, R, Washington, M. Factors determining the rate of referral, transplantation, and survival on dialysis in women with ESRD. Am J Kidney Dis, 30(6), 739-48, 1997.

Mergener, K, Washington, MK, Pappas, TN, Sharara, AI. Benign gastric ulcer masquerading as a submucosal tumor. Endoscopy, 29(4), 331, 1997.

Washington, K, Bentley, RC, Green, A, Olson, J, Treem, WR, Krigman, HR. Gastric graft-versus-host disease: a blinded histologic study. Am J Surg Pathol, 21(9), 1037-46, 1997.

Washington, K, Clavien, PA, Killenberg, P. Peribiliary vascular plexus in primary sclerosing cholangitis and primary biliary cirrhosis. Hum Pathol, 28(7), 791-5, 1997.

Bodily, K, Perfect, JR, Procop, G, Washington, MK, Affronti, J. Small intestinal histoplasmosis: successful treatment with itraconazole in an immunocompetent host. Gastrointest Endosc, 43(5), 518-21, 1996.

Camargo, CA, Washington, MK, Fitz, JG, Clavien, PA. Adult presentation of diffuse bile duct stenosis: therapy with liver transplantation. Liver Transpl Surg, 2(3), 235-7, 1996.

Clavien, PA, Camargo, CA, Cameron, R, Washington, MK, Phillips, MJ, Greig, PD, Levy, GA. Kupffer cell erythrophagocytosis and graft-versus-host hemolysis in liver transplantation. Gastroenterology, 110(6), 1891-6, 1996.

Clavien, PA, Camargo, CA, Gorczynski, R, Washington, MK, Levy, GA, Langer, B, Greig, PD. Acute reactant cytokines and neutrophil adhesion after warm ischemia in cirrhotic and noncirrhotic human livers. Hepatology, 23(6), 1456-63, 1996.

Kong, FM, Washington, MK, Jirtle, RL, Anscher, MS. Plasma transforming growth factor-beta 1 reflects disease status in patients with lung cancer after radiotherapy: a possible tumor marker. Lung Cancer, 16(1), 47-59, 1996.

Mantyh, CR, Pappas, TN, Lapp, JA, Washington, MK, Neville, LM, Ghilardi, JR, Rogers, SD, Mantyh, PW, Vigna, SR. Substance P activation of enteric neurons in response to intraluminal Clostridium difficile toxin A in the rat ileum. Gastroenterology, 111(5), 1272-80, 1996.

Procop, GW, Harrell, LJ, Washington, MK, Owen, CH, Pappas, TN. Pericolic abscess due to Streptococcus pyogenes: report of a case that clinically mimicked acute cholecystitis. Clin Infect Dis, 23(1), 182-3, 1996.

Telen, MJ, Udani, M, Washington, MK, Levesque, MC, Lloyd, E, Rao, N. A blood group-related polymorphism of CD44 abolishes a hyaluronan-binding consensus sequence without preventing hyaluronan binding. J Biol Chem, 271(12), 7147-53, 1996.

Caniza, MA, Granger, DL, Wilson, KH, Washington, MK, Kordick, DL, Frush, DP, Blitchington, RB. Bartonella henselae: etiology of pulmonary nodules in a patient with depressed cell-mediated immunity. Clin Infect Dis, 20(6), 1505-11, 1995.

De Souza, AT, Hankins, GR, Washington, MK, Fine, RL, Orton, TC, Jirtle, RL. Frequent loss of heterozygosity on 6q at the mannose 6-phosphate/insulin-like growth factor II receptor locus in human hepatocellular tumors. Oncogene, 10(9), 1725-9, 1995.

De Souza, AT, Hankins, GR, Washington, MK, Orton, TC, Jirtle, RL. M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity. Nat Genet, 11(4), 447-9, 1995.

Boockvar, KS, Granger, DL, Poston, RM, Maybodi, M, Washington, MK, Hibbs, JB, Kurlander, RL. Nitric oxide produced during murine listeriosis is protective. Infect Immun, 62(3), 1089-100, 1994. PMCID:186228

Eisen, GM, Schutz, SM, Washington, MK, Burton, CS, Sidhu-Malik, N, Wilson, JA. Atypical presentation of inflammatory bowel disease in the elderly. Am J Gastroenterol, 88(12), 2098-101, 1993.

Sarasua, MM, Faught, KR, Steedman, SL, Gordin, MD, Washington, MK. A comparison of ethanol partitioning in biological and model membranes: nonideal partitioning is enhanced in synaptosomal membranes. Alcohol Clin Exp Res, 13(5), 698-705, 1989.

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