Vanderbilt University School of Medicine

Donnelly, Edwin F , M.D., Ph.D.
Associate Professor of Radiology and Radiological Sciences
Associate Professor of Biomedical Engineering

Lab Url: N/A

Phone Number: 615-322-3190


Donnelly, Edwin's picture

Office Address   Mailing Address


1161 21st Avenue South MCN CC 1121 37232-2675

Research Keywords
Phase - Contrast Radiology Power Doppler Ultrasound Anti-angiogenesis treatments for cancer Small animal imaging Computed Tomography,Cancer,Malignancy

Clinical Interests
Thoracic Radiology

Donnelly, EF, Lewis, KG, Wolske, KM, Pickens, DR, Price, RR. Characterization of the phase-contrast radiography edge-enhancement effect in a cabinet x-ray system. Phys Med Biol, 51(1), 21-30, 2006.

Lockhart, AC, Cropp, GF, Berlin, JD, Donnelly, E, Schumaker, RD, Schaaf, LJ, Hande, KR, Fleischer, AC, Hannah, AL, Rothenberg, ML. Phase I/pilot study of SU5416 (semaxinib) in combination with irinotecan/bolus 5-FU/LV (IFL) in patients with metastatic colorectal cancer. Am J Clin Oncol, 29(2), 109-15, 2006.

Cao, C, Shinohara, ET, Niermann, KJ, Donnelly, EF, Chen, X, Hallahan, DE, Lu, B. Murine double minute 2 as a therapeutic target for radiation sensitization of lung cancer. Mol Cancer Ther, 4(8), 1137-45, 2005.

Chen, Y, Donnelly, E, Kobayashi, H, Debusk, LM, Lin, PC. Gene therapy targeting the Tie2 function ameliorates collagen-induced arthritis and protects against bone destruction. Arthritis Rheum, 52(5), 1585-94, 2005.

Donnelly, EF, Price, RR, Pickens, DR. Experimental validation of the Wigner distributions theory of phase-contrast imaging. Med Phys, 32(4), 928-31, 2005.

Lawson, WE, Polosukhin, VV, Stathopoulos, GT, Zoia, O, Han, W, Lane, KB, Li, B, Donnelly, EF, Holburn, GE, Lewis, KG, Collins, RD, Hull, WM, Glasser, SW, Whitsett, JA, Blackwell, TS. Increased and prolonged pulmonary fibrosis in surfactant protein C-deficient mice following intratracheal bleomycin. Am J Pathol, 167(5), 1267-77, 2005. PMCID:1603790

Niermann, KJ, Fleischer, AC, Donnelly, EF, Schueneman, AJ, Geng, L, Hallahan, DE. Sonographic depiction of changes of tumor vascularity in response to various therapies. Ultrasound Q, 21(2), 61-7; quiz 149, 153-4, 2005.

Zhu, Z, Donnelly, E, Dikensoy, O, Misra, H, Bilaceroglu, S, Lane, KB, Light, RW. Efficacy of ultrasound in the diagnosis of pleurodesis in rabbits. Chest, 128(2), 934-9, 2005.

Fleischer, Arthur C, Donnelly, Edwin F, Grippo, Ryan J, Black, Amy S, Hallahan, Dennis E. Quantification of tumor vascularity with contrast-enhanced sonography: correlation with magnetic resonance imaging and fluorodeoxyglucose autoradiography in an implanted tumor. J Ultrasound Med, 23(1), 37-41, 2004.

Fleischer, Arthur C, Niermann, Kenneth J, Donnelly, Edwin F, Yankeelov, Thomas E, Canniff, Kathryn M, Hallahan, Dennis E, Rothenberg, Mace E. Sonographic depiction of microvessel perfusion: principles and potential. J Ultrasound Med, 23(11), 1499-506, 2004.

Lu, Bo, Geng, Ling, Musiek, Amy, Tan, Jiahui, Cao, Carolyn, Donnelly, Edwin, McMahon, Gerald, Choy, Hak, Hallahan, Dennis E. Broad spectrum receptor tyrosine kinase inhibitor, SU6668, sensitizes radiation via targeting survival pathway of vascular endothelium. Int J Radiat Oncol Biol Phys, 58(3), 844-50, 2004.

D'Haese, P, Niermann, K J, Cmelak, A J, Donnelly, E F, Duay, V, Li, R, Dawant, B. Neuroanatomical automatic segmentation in brain cancer patients. Int J Radiat Oncol Biol Phys, 57(2 Suppl), S205, 2003.

D'Haese, PF, Duay V, Li R, du Bois d'Aische, A, Merchant, TE, Cmelak, AJ, Donnelly, EF, Niermann, KJ, Macq, B, Dawant, BM. Automatic segmentation of brain structures for radiation therapy planning. in Proceedings of SPIE: Medical Imaging 2003: Image Processing. Ed by: Milan Sonka, J. Michael Fitzpatrick.. , 5032, 517-526, 2003.

Donnelly, Edwin F, Price, Ronald R, Pickens, David R. Dual focal-spot imaging for phase extraction in phase-contrast radiography. Med Phys, 30(9), 2292-6, 2003.

Donnelly, Edwin F, Price, Ronald R, Pickens, David R. Quantification of the effect of system and object parameters on edge enhancement in phase-contrast radiography. Med Phys, 30(11), 2888-96, 2003.

Hallahan, Dennis, Geng, Ling, Qu, Shimian, Scarfone, Christopher, Giorgio, Todd, Donnelly, Edwin, Gao, Xiang, Clanton, Jeff. Integrin-mediated targeting of drug delivery to irradiated tumor blood vessels. Cancer Cell, 3(1), 63-74, 2003.

Schueneman, A, Himmelfarb, E, Geng, L, Donnelly, E, McMahon, G, Laird, D, Choy, H, Hallahan, D. Tyrosine kinase inhibition prevents tumor regrowth following fractionated irradiation of murine tumor models. Int J Radiat Oncol Biol Phys, 57(2 Suppl), S296, 2003.

Schueneman, Aaron J, Himmelfarb, Eric, Geng, Ling, Tan, Jiahua, Donnelly, Edwin, Mendel, Dirk, McMahon, Gerald, Hallahan, Dennis E. SU11248 maintenance therapy prevents tumor regrowth after fractionated irradiation of murine tumor models. Cancer Res, 63(14), 4009-16, 2003.

Donnelly, Edwin F, Price, Ronald R. Quantification of the effect of kvp on edge-enhancement index in phase-contrast radiography. Med Phys, 29(6), 999-1002, 2002.

Edwards, Eric, Geng, Ling, Tan, J, Onishko, Halina, Donnelly, Edwin, Hallahan, Dennis E. Phosphatidylinositol 3-kinase/Akt signaling in the response of vascular endothelium to ionizing radiation. Cancer Res, 62(16), 4671-7, 2002.

Muniz, C Joseph, Fleischer, Arthur C, Donnelly, Edwin F, Mazer, Murray J. Three-dimensional color Doppler sonography and uterine artery arteriography of fibroids: assessment of changes in vascularity before and after embolization. J Ultrasound Med, 21(2), 129-33, 2002.

Donnelly, E F, Geng, L, Wojcicki, W E, Fleischer, A C, Hallahan, D E. Quantified power Doppler US of tumor blood flow correlates with microscopic quantification of tumor blood vessels. Radiology, 219(1), 166-70, 2001.

Geng, L, Donnelly, E, McMahon, G, Lin, P C, Sierra-Rivera, E, Oshinka, H, Hallahan, D E. Inhibition of vascular endothelial growth factor receptor signaling leads to reversal of tumor resistance to radiotherapy. Cancer Res, 61(6), 2413-9, 2001.

Fleischer, A C, Donnelly, E F, Campbell, M G, Mazer, M J, Grippo, D, Lipsitz, N L. Three-dimensional color Doppler sonography before and after fibroid embolization. J Ultrasound Med, 19(10), 701-5, 2000.

Donnelly, E F. The Hawkins sign. Radiology, 210(1), 195-6, 1999.

Fleischer, A C, Wojcicki, W E, Donnelly, E F, Pickens, D R, Thirsk, G, Thurman, G B, Hellerqvist, C G. Quantified color Doppler sonography of tumor vascularity in an animal model. J Ultrasound Med, 18(8), 547-51, 1999.

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