Vanderbilt University School of
Harrison, David G. , M.D.
Director Division of Clinical Pharmacology
Professor of Medicine
Professor of Molecular Physiology & Biophysics
Professor of Pharmacology
Betty and Jack Bailey Chair in Cardiology
Phone Number: 615-875-3049
536 Robinson Research Building
2200 Pierce Avenue 536 RRB 37232-6602
Inflammation, hypertension, immune activation
Our laboratory has been focused on understanding how inflammation, and in particular, the adaptive immune response contributes to hypertension. Several years ago, we found that T cells are essential for the development of hypertension. We have shown that various hypertensive stimuli, including angiotensin II, norepinephrine and DOCA-salt cause activation of T cells and leads to their accumulation in the perivascular fat and kidneys. Our data indicate that T cell-derived cytokines such as IL-17 and TNF-a enhance vasoconstriction and sodium retention, leading to the hypertensive phenotype. Central signals derived from the circumventricular organs contribute to T cell activation, and manipulation of signals from this region affect T cell activation and the eventual elevation in blood pressure caused by angiotensin II. We are attempting to understand mechanisms involved in T cell activation in response to hypertensive stimuli. We have recently shown that gamma-ketoaldehydes, or isoketals adduct to proteins in hypertensive mice and humans, and that these are immunogenic. These modified proteins seem to act as "auto-antigens" that promote dendritic cell and ultimately T cell activation in hypertension.
Harrison, DG, Guzik, TJ. Studies of the T-cell Angiotensin receptor using cre-lox technology: an unan-T-cellpated result. Circ Res, 110(12), 1543-5, 2012.
Harrison, DG, Marvar, PJ, Titze, JM. Vascular inflammatory cells in hypertension. Front Physiol, 3, 128, 2012. PMCID:3345946
Osgood, MJ, Harrison, DG, Sexton, KW, Hocking, KM, Voskresensky, IV, Komalavilas, P, Cheung-Flynn, J, Guzman, RJ, Brophy, CM. Role of the Renin-Angiotensin System in the Pathogenesis of Intimal Hyperplasia: Therapeutic Potential for Prevention of Vein Graft Failure. Ann Vasc Surg, , , 2012. PMCID:3345946
Chen, W, Li, L, Brod, T, Saeed, O, Thabet, S, Jansen, T, Dikalov, S, Weyand, C, Goronzy, J, Harrison, DG. Role of Increased Guanosine Triphosphate Cyclohydrolase-1 Expression and Tetrahydrobiopterin Levels upon T Cell Activation. J Biol Chem, 286(16), 13846-51, 2011.
Harrison, DG, Guzik, TJ, Lob, HE, Madhur, MS, Marvar, PJ, Thabet, SR, Vinh, A, Weyand, CM. Inflammation, immunity, and hypertension. Hypertension, 57(2), 132-40, 2011.
Lob, HE, Vinh, A, Li, L, Blinder, Y, Offermanns, S, Harrison, DG. Role of vascular extracellular superoxide dismutase in hypertension. Hypertension, 58(2), 232-9, 2011. PMCID:3345946
Madhur, MS, Funt, SA, Li, L, Vinh, A, Chen, W, Lob, HE, Iwakura, Y, Blinder, Y, Rahman, A, Quyyumi, AA, Harrison, DG. Role of Interleukin 17 in Inflammation, Atherosclerosis, and Vascular Function in Apolipoprotein E-Deficient Mice. Arterioscler Thromb Vasc Biol, , , 2011.
McDaniel, MC, Galbraith, EM, Jeroudi, AM, Kashlan, OR, Eshtehardi, P, Suo, J, Dhawan, S, Voeltz, M, Devireddy, C, Oshinski, J, Harrison, DG, Giddens, DP, Samady, H. Localization of culprit lesions in coronary arteries of patients with ST-segment elevation myocardial infarctions: relation to bifurcations and curvatures. Am Heart J, 161(3), 508-15, 2011.
Dikalova, AE, Bikineyeva, AT, Budzyn, K, Nazarewicz, RR, McCann, L, Lewis, W, Harrison, DG, Dikalov, SI. Therapeutic targeting of mitochondrial superoxide in hypertension. Circ Res, 107(1), 106-16, 2010.
Dikalova, AE, G??ngora, MC, Harrison, DG, Lambeth, JD, Dikalov, S, Griendling, KK. Upregulation of Nox1 in vascular smooth muscle leads to impaired endothelium-dependent relaxation via eNOS uncoupling. Am J Physiol Heart Circ Physiol, 299(3), H673-9, 2010.
Gongora, MC, Harrison, DG. NO solution for a radical problem: a TAL story. Am J Physiol Renal Physiol, 298(4), F883-4, 2010.
Harrison, DG, Chen, W, Dikalov, S, Li, L. Regulation of endothelial cell tetrahydrobiopterin pathophysiological and therapeutic implications. Adv Pharmacol, 60, 107-32, 2010.
Harrison, DG, Vinh, A, Lob, H, Madhur, MS. Role of the adaptive immune system in hypertension. Curr Opin Pharmacol, 10(2), 203-7, 2010.
Kalogeropoulos, A, Georgiopoulou, V, Psaty, BM, Rodondi, N, Smith, AL, Harrison, DG, Liu, Y, Hoffmann, U, Bauer, DC, Newman, AB, Kritchevsky, SB, Harris, TB, Butler, J, , . Inflammatory markers and incident heart failure risk in older adults: the Health ABC (Health, Aging, and Body Composition) study. J Am Coll Cardiol, 55(19), 2129-37, 2010.
Li, L, Rezvan, A, Salerno, JC, Husain, A, Kwon, K, Jo, H, Harrison, DG, Chen, W. GTP cyclohydrolase I phosphorylation and interaction with GTP cyclohydrolase feedback regulatory protein provide novel regulation of endothelial tetrahydrobiopterin and nitric oxide. Circ Res, 106(2), 328-36, 2010. PMCID:2818799
Lob, HE, Marvar, PJ, Guzik, TJ, Sharma, S, McCann, LA, Weyand, C, Gordon, FJ, Harrison, DG. Induction of hypertension and peripheral inflammation by reduction of extracellular superoxide dismutase in the central nervous system. Hypertension, 55(2), 277-83, 6p following 283, 2010. PMCID:2813894
Madhur, MS, Lob, HE, McCann, LA, Iwakura, Y, Blinder, Y, Guzik, TJ, Harrison, DG. Interleukin 17 promotes angiotensin II-induced hypertension and vascular dysfunction. Hypertension, 55(2), 500-7, 2010. PMCID:2819301
Marvar, PJ, Lob, H, Vinh, A, Zarreen, F, Harrison, DG. The central nervous system and inflammation in hypertension. Curr Opin Pharmacol, , , 2010.
Marvar, PJ, Thabet, SR, Guzik, TJ, Lob, HE, McCann, LA, Weyand, C, Gordon, FJ, Harrison, DG. Central and peripheral mechanisms of T-lymphocyte activation and vascular inflammation produced by angiotensin II-induced hypertension. Circ Res, 107(2), 263-70, 2010.
Nam, D, Ni, CW, Rezvan, A, Suo, J, Budzyn, K, Llanos, A, Harrison, DG, Giddens, DP, Jo, H. A model of disturbed flow-induced atherosclerosis in mouse carotid artery by partial ligation and a simple method of RNA isolation from carotid endothelium. J Vis Exp, (40), , 2010.
Oshiro, H, Iwai, T, Hirota, M, Mitsudo, K, Tohnai, I, Minamimoto, R, Omura-Minamisawa, M, Nagashima, Y, Yamanaka, S, Fukui, T, Kanazawa, M, Sagawa, H, Mita, K, Nakayama, T, Inayama, Y. Primary sebaceous carcinoma of the tongue. Med Mol Morphol, 43(4), 246-52, 2010. PMCID:3078539
Schneider, MP, Sullivan, JC, Wach, PF, Boesen, EI, Yamamoto, T, Fukai, T, Harrison, DG, Pollock, DM, Pollock, JS. Protective role of extracellular superoxide dismutase in renal ischemia/reperfusion injury. Kidney Int, 78(4), 374-81, 2010.
Silberman, GA, Fan, TH, Liu, H, Jiao, Z, Xiao, HD, Lovelock, JD, Boulden, BM, Widder, J, Fredd, S, Bernstein, KE, Wolska, BM, Dikalov, S, Harrison, DG, Dudley, SC. Uncoupled cardiac nitric oxide synthase mediates diastolic dysfunction. Circulation, 121(4), 519-28, 2010. PMCID:2819317
Vinh, A, Chen, W, Blinder, Y, Weiss, D, Taylor, WR, Goronzy, JJ, Weyand, CM, Harrison, DG, Guzik, TJ. Inhibition and genetic ablation of the B7/CD28 T-cell costimulation axis prevents experimental hypertension. Circulation, 122(24), 2529-37, 2010.
Harrison, DG, Gongora, MC. Oxidative stress and hypertension. Med Clin North Am, 93(3), 621-35, 2009. PMCID:2818799
Hoch, NE, Guzik, TJ, Chen, W, Deans, T, Maalouf, SA, Gratze, P, Weyand, C, Harrison, DG. Regulation of T-cell function by endogenously produced angiotensin II. Am J Physiol Regul Integr Comp Physiol, 296(2), R208-16, 2009. PMCID:2643984
Jones, R, Baker, MB, Weber, M, Harrison, DG, Bao, G, Searles, CD. Molecular beacons can assess changes in expression and 3''-polyadenylation of human eNOS mRNA. Am J Physiol Cell Physiol, 296(3), C498-504, 2009. PMCID:2660266
Guzik, TJ, Chen, W, Gongora, MC, Guzik, B, Lob, HE, Mangalat, D, Hoch, N, Dikalov, S, Rudzinski, P, Kapelak, B, Sadowski, J, Harrison, DG. Calcium-dependent NOX5 nicotinamide adenine dinucleotide phosphate oxidase contributes to vascular oxidative stress in human coronary artery disease. J Am Coll Cardiol, 52(22), 1803-9, 2008. PMCID:2593790
Inoue, N, Ohara, Y, Fukai, T, Harrison, DG, Nishida, K. Probucol improves endothelial-dependent relaxation and decreases vascular superoxide production in cholesterol-fed rabbits. Am J Med Sci, 315(4), 242-7, 1998.
Harrison, DG, Sayegh, H, Ohara, Y, Inoue, N, Venema, RC. Regulation of expression of the endothelial cell nitric oxide synthase. Clin Exp Pharmacol Physiol, 23(3), 251-5, 1996.
Venema, RC, Sayegh, HS, Kent, JD, Harrison, DG. Identification, characterization, and comparison of the calmodulin-binding domains of the endothelial and inducible nitric oxide synthases. J Biol Chem, 271(11), 6435-40, 1996.
Harrison, DG, Venema, RC, Arnal, JF, Inoue, N, Ohara, Y, Sayegh, H, Murphy, TJ. The endothelial cell nitric oxide synthase: is it really constitutively expressed. Agents Actions Suppl, 45, 107-17, 1995. PMCID:295938
Inoue, N, Venema, RC, Sayegh, HS, Ohara, Y, Murphy, TJ, Harrison, DG. Molecular regulation of the bovine endothelial cell nitric oxide synthase by transforming growth factor-beta 1. Arterioscler Thromb Vasc Biol, 15(8), 1255-61, 1995.
James, NL, Harrison, DG, Nerem, RM. Effects of shear on endothelial cell calcium in the presence and absence of ATP. FASEB J, 9(10), 968-73, 1995.
M??nzel, T, Giaid, A, Kurz, S, Stewart, DJ, Harrison, DG. Evidence for a role of endothelin 1 and protein kinase C in nitroglycerin tolerance. Proc Natl Acad Sci U S A, 92(11), 5244-8, 1995. PMCID:41885
M??nzel, T, Sayegh, H, Freeman, BA, Tarpey, MM, Harrison, DG. Evidence for enhanced vascular superoxide anion production in nitrate tolerance. A novel mechanism underlying tolerance and cross-tolerance. J Clin Invest, 95(1), 187-94, 1995. PMCID:295403
Ohara, Y, Peterson, TE, Sayegh, HS, Subramanian, RR, Wilcox, JN, Harrison, DG. Dietary correction of hypercholesterolemia in the rabbit normalizes endothelial superoxide anion production. Circulation, 92(4), 898-903, 1995.
Ohara, Y, Sayegh, HS, Yamin, JJ, Harrison, DG. Regulation of endothelial constitutive nitric oxide synthase by protein kinase C. Hypertension, 25(3), 415-20, 1995.
Supari, F, Ungerer, T, Harrison, DG, Williams, JK. Fish oil treatment decreases superoxide anions in the myocardium and coronary arteries of atherosclerotic monkeys. Circulation, 91(4), 1123-8, 1995.
Uematsu, M, Ohara, Y, Navas, JP, Nishida, K, Murphy, TJ, Alexander, RW, Nerem, RM, Harrison, DG. Regulation of endothelial cell nitric oxide synthase mRNA expression by shear stress. Am J Physiol, 269(6 Pt 1), C1371-8, 1995.
Venema, RC, Sayegh, HS, Arnal, JF, Harrison, DG. Role of the enzyme calmodulin-binding domain in membrane association and phospholipid inhibition of endothelial nitric oxide synthase. J Biol Chem, 270(24), 14705-11, 1995.
Arnal, JF, Yamin, J, Dockery, S, Harrison, DG. Regulation of endothelial nitric oxide synthase mRNA, protein, and activity during cell growth. Am J Physiol, 267(5 Pt 1), C1381-8, 1994.
Lamping, KG, Bloom, EN, Harrison, DG. Regulation of native collateral vessel dilation after coronary occlusion in the dog. Am J Physiol, 266(2 Pt 2), H769-78, 1994.
Ohara, Y, Peterson, TE, Zheng, B, Kuo, JF, Harrison, DG. Lysophosphatidylcholine increases vascular superoxide anion production via protein kinase C activation. Arterioscler Thromb, 14(6), 1007-13, 1994.
Venema, RC, Nishida, K, Alexander, RW, Harrison, DG, Murphy, TJ. Organization of the bovine gene encoding the endothelial nitric oxide synthase. Biochim Biophys Acta, 1218(3), 413-20, 1994.
Wheatley, RM, Dockery, SP, Kurz, MA, Sayegh, HS, Harrison, DG. Interactions of nitroglycerin and sulfhydryl-donating compounds in coronary microvessels. Am J Physiol, 266(1 Pt 2), H291-7, 1994.
Delafontaine, P, Lou, H, Harrison, DG, Bernstein, KE. Sequence of a cDNA encoding dog insulin-like growth factor I. Gene, 130(2), 305-6, 1993. PMCID:507072
Harrison, DG, Bates, JN. The nitrovasodilators. New ideas about old drugs. Circulation, 87(5), 1461-7, 1993.
Kurz, MA, Boyer, TD, Whalen, R, Peterson, TE, Harrison, DG. Nitroglycerin metabolism in vascular tissue: role of glutathione S-transferases and relationship between NO. and NO2- formation. Biochem J, 292 ( Pt 2), 545-50, 1993. PMCID:1134244
Ohara, Y, Peterson, TE, Harrison, DG. Hypercholesterolemia increases endothelial superoxide anion production. J Clin Invest, 91(6), 2546-51, 1993. PMCID:443316
Harrison, DG, Kurz, MA, Quillen, JE, Sellke, FW, M??gge, A. Normal and pathophysiologic considerations of endothelial regulation of vascular tone and their relevance to nitrate therapy. Am J Cardiol, 70(8), 11B-17B, 1992.
Myers, PR, Guerra, R, Harrison, DG. Release of multiple endothelium-derived relaxing factors from porcine coronary arteries. J Cardiovasc Pharmacol, 20(3), 392-400, 1992.
M??nzel, T, M??lsch, A, Holtz, J, Just, H, Harrison, DG, Bassenge, E. Mechanisms of interaction between the sulfhydryl precursor L-methionine and glyceryl trinitrate. Circulation, 86(3), 995-1003, 1992.
Nishida, K, Harrison, DG, Navas, JP, Fisher, AA, Dockery, SP, Uematsu, M, Nerem, RM, Alexander, RW, Murphy, TJ. Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase. J Clin Invest, 90(5), 2092-6, 1992. PMCID:443276
Quillen, JE, Harrison, DG. Vasomotor properties of porcine endocardial and epicardial microvessels. Am J Physiol, 262(4 Pt 2), H1143-8, 1992.
Bates, JN, Baker, MT, Guerra, R, Harrison, DG. Nitric oxide generation from nitroprusside by vascular tissue. Evidence that reduction of the nitroprusside anion and cyanide loss are required. Biochem Pharmacol, 42 Suppl, S157-65, 1991.
Bates, JN, Harrison, DG, Myers, PR, Minor, RL. EDRF: nitrosylated compound or authentic nitric oxide. Basic Res Cardiol, 86 Suppl 2, 17-26, 1991.
Harrison, DG, Marcus, ML, Dellsperger, KC, Lamping, KG, Tomanek, RJ. Pathophysiology of myocardial perfusion in hypertension. Circulation, 83(5 Suppl), III14-8, 1991.
Harrison, DG, Simonetti, I. Neurohumoral regulation of collateral perfusion. Circulation, 83(5 Suppl), III62-7, 1991.
Harrison, DG, Treasure, CB, M??gge, A, Dellsperger, KC, Lamping, KG. Hypertension and the coronary circulation. With special attention to endothelial regulation. Am J Hypertens, 4(7 Pt 2), 454S-459S, 1991.
Komaru, T, Lamping, KG, Eastham, CL, Harrison, DG, Marcus, ML, Dellsperger, KC. Effect of an arginine analogue on acetylcholine-induced coronary microvascular dilatation in dogs. Am J Physiol, 261(6 Pt 2), H2001-7, 1991.
Kurz, MA, Lamping, KG, Bates, JN, Eastham, CL, Marcus, ML, Harrison, DG. Mechanisms responsible for the heterogeneous coronary microvascular response to nitroglycerin. Circ Res, 68(3), 847-55, 1991.
Myers, PR, Banitt, PF, Guerra, R, Harrison, DG. Role of the endothelium in modulation of the acetylcholine vasoconstrictor response in porcine coronary microvessels. Cardiovasc Res, 25(2), 129-37, 1991.
M??gge, A, Elwell, JH, Peterson, TE, Harrison, DG. Release of intact endothelium-derived relaxing factor depends on endothelial superoxide dismutase activity. Am J Physiol, 260(2 Pt 1), C219-25, 1991. PMCID:1886078
M??gge, A, Elwell, JH, Peterson, TE, Hofmeyer, TG, Heistad, DD, Harrison, DG. Chronic treatment with polyethylene-glycolated superoxide dismutase partially restores endothelium-dependent vascular relaxations in cholesterol-fed rabbits. Circ Res, 69(5), 1293-300, 1991.
M??gge, A, Harrison, DG. L-arginine does not restore endothelial dysfunction in atherosclerotic rabbit aorta in vitro. Blood Vessels, 28(5), 354-7, 1991.
M??gge, A, Peterson, T, Harrison, DG. Release of nitrogen oxides from cultured bovine aortic endothelial cells is not impaired by calcium channel antagonists. Circulation, 83(4), 1404-9, 1991.
Quillen, JE, Sellke, FW, Armstrong, ML, Harrison, DG. Long-term cholesterol feeding alters the reactivity of primate coronary microvessels to platelet products. Arterioscler Thromb, 11(3), 639-44, 1991.
Sellke, FW, Tomanek, RJ, Harrison, DG. L-cysteine selectively potentiates nitroglycerin-induced dilation of small coronary microvessels. J Pharmacol Exp Ther, 258(1), 365-9, 1991.
Tomanek, RJ, Wessel, TJ, Harrison, DG. Capillary growth and geometry during long-term hypertension and myocardial hypertrophy in dogs. Am J Physiol, 261(4 Pt 2), H1011-8, 1991.
Armstrong, ML, Heistad, DD, Megan, MB, Lopez, JA, Harrison, DG. Reversibility of atherosclerosis. Cardiovasc Clin, 20(3), 113-26, 1990.
Cappelli-Bigazzi, M, Lamping, KG, Nuno, DW, Harrison, DG. Leukocyte and platelet-derived factors augment canine coronary constriction to serotonin. Am J Physiol, 259(4 Pt 2), H1161-70, 1990. PMCID:1860715
Harrison, DG, Sellke, FW, Quillen, JE. Neurohumoral regulation of coronary collateral vasomotor tone. Basic Res Cardiol, 85 Suppl 1, 121-9, 1990.
Minor, RL, Myers, PR, Guerra, R, Bates, JN, Harrison, DG. Diet-induced atherosclerosis increases the release of nitrogen oxides from rabbit aorta. J Clin Invest, 86(6), 2109-16, 1990. PMCID:329851
Murphy, S, Minor, RL, Welk, G, Harrison, DG. Evidence for an astrocyte-derived vasorelaxing factor with properties similar to nitric oxide. J Neurochem, 55(1), 349-51, 1990.
Myers, PR, Minor, RL, Guerra, R, Bates, JN, Harrison, DG. Vasorelaxant properties of the endothelium-derived relaxing factor more closely resemble S-nitrosocysteine than nitric oxide. Nature, 345(6271), 161-3, 1990. PMCID:329851
Quillen, JE, Sellke, FW, Brooks, LA, Harrison, DG. Ischemia-reperfusion impairs endothelium-dependent relaxation of coronary microvessels but does not affect large arteries. Circulation, 82(2), 586-94, 1990.
Sellke, FW, Armstrong, ML, Harrison, DG. Endothelium-dependent vascular relaxation is abnormal in the coronary microcirculation of atherosclerotic primates. Circulation, 81(5), 1586-93, 1990.
Sellke, FW, Myers, PR, Bates, JN, Harrison, DG. Influence of vessel size on the sensitivity of porcine coronary microvessels to nitroglycerin. Am J Physiol, 258(2 Pt 2), H515-20, 1990.
Sellke, FW, Quillen, JE, Brooks, LA, Harrison, DG. Endothelial modulation of the coronary vasculature in vessels perfused via mature collaterals. Circulation, 81(6), 1938-47, 1990.
Feldman, RD, Christy, JP, Paul, ST, Harrison, DG. Beta-adrenergic receptors on canine coronary collateral vessels: characterization and function. Am J Physiol, 257(5 Pt 2), H1634-9, 1989.
Guerra, R, Brotherton, AF, Goodwin, PJ, Clark, CR, Armstrong, ML, Harrison, DG. Mechanisms of abnormal endothelium-dependent vascular relaxation in atherosclerosis: implications for altered autocrine and paracrine functions of EDRF. Blood Vessels, 26(5), 300-14, 1989.
Lopez, JA, Armstrong, ML, Harrison, DG, Piegors, DJ, Heistad, DD. Vascular responses to leukocyte products in atherosclerotic primates. Circ Res, 65(4), 1078-86, 1989.
Myers, PR, Banitt, PF, Guerra, R, Harrison, DG. Characteristics of canine coronary resistance arteries: importance of endothelium. Am J Physiol, 257(2 Pt 2), H603-10, 1989. PMCID:329851
Myers, PR, Guerra, R, Harrison, DG. Release of NO and EDRF from cultured bovine aortic endothelial cells. Am J Physiol, 256(4 Pt 2), H1030-7, 1989. PMCID:329851
Peters, KG, Marcus, ML, Harrison, DG. Vasopressin and the mature coronary collateral circulation. Circulation, 79(6), 1324-31, 1989.
Tomanek, RJ, Schalk, KA, Marcus, ML, Harrison, DG. Coronary angiogenesis during long-term hypertension and left ventricular hypertrophy in dogs. Circ Res, 65(2), 352-9, 1989.
Gumm, DC, Cooper, SM, Thompson, SB, Marcus, ML, Harrison, DG. Influence of risk area size and location on native collateral resistance and ischemic zone perfusion. Am J Physiol, 254(3 Pt 2), H473-80, 1988.
Harrison, DG, Florentine, MS, Brooks, LA, Cooper, SM, Marcus, ML. The effect of hypertension and left ventricular hypertrophy on the lower range of coronary autoregulation. Circulation, 77(5), 1108-15, 1988.
Lopez, JA, Armstrong, ML, Harrison, DG, Piegors, DJ, Heistad, DD. Responsiveness of iliac collateral vessels to constrictor stimuli in atherosclerotic primates. Circ Res, 63(6), 1020-8, 1988.
Marcus, ML, Harrison, DG, White, CW, McPherson, DD, Wilson, RF, Kerber, RE. Assessing the physiologic significance of coronary obstructions in patients: importance of diffuse undetected atherosclerosis. Prog Cardiovasc Dis, 31(1), 39-56, 1988.
Marcus, ML, Skorton, DJ, Johnson, MR, Collins, SM, Harrison, DG, Kerber, RE. Visual estimates of percent diameter coronary stenosis: "a battered gold standard". J Am Coll Cardiol, 11(4), 882-5, 1988.
Harrison, DG, Armstrong, ML, Freiman, PC, Heistad, DD. Restoration of endothelium-dependent relaxation by dietary treatment of atherosclerosis. J Clin Invest, 80(6), 1808-11, 1987. PMCID:442458
Harrison, DG, Freiman, PC, Armstrong, ML, Marcus, ML, Heistad, DD. Alterations of vascular reactivity in atherosclerosis. Circ Res, 61(5 Pt 2), II74-80, 1987.
Heistad, DD, Harrison, DG, Armstrong, ML. Serotonin and experimental vascular disease. Int J Cardiol, 14(2), 205-12, 1987. PMCID:442458
Inou, T, Lamberth, WC, Koyanagi, S, Harrison, DG, Eastham, CL, Marcus, ML. Relative importance of hypertension after coronary occlusion in chronic hypertensive dogs with LVH. Am J Physiol, 253(5 Pt 2), H1148-58, 1987.
Marcus, ML, Harrison, DG, Chilian, WM, Koyanagi, S, Inou, T, Tomanek, RJ, Martins, JB, Eastham, CL, Hiratzka, LF. Alterations in the coronary circulation in hypertrophied ventricles. Circulation, 75(1 Pt 2), I19-25, 1987.
Chilian, WM, Harrison, DG, Haws, CW, Snyder, WD, Marcus, ML. Adrenergic coronary tone during submaximal exercise in the dog is produced by circulating catecholamines. Evidence for adrenergic denervation supersensitivity in the myocardium but not in coronary vessels. Circ Res, 58(1), 68-82, 1986.
Freiman, PC, Mitchell, GG, Heistad, DD, Armstrong, ML, Harrison, DG. Atherosclerosis impairs endothelium-dependent vascular relaxation to acetylcholine and thrombin in primates. Circ Res, 58(6), 783-9, 1986.
Harrison, DG, Chapman, MP, Christy, JP, Marcus, ML. Studies of functional site of origin of native coronary collaterals. Am J Physiol, 251(6 Pt 2), H1217-24, 1986.
Harrison, DG, Chilian, WM, Marcus, ML. Absence of functioning alpha-adrenergic receptors in mature canine coronary collaterals. Circ Res, 59(2), 133-42, 1986.
Johnson, MR, Brayden, GP, Ericksen, EE, Collins, SM, Skorton, DJ, Harrison, DG, Marcus, ML, White, CW. Changes in cross-sectional area of the coronary lumen in the six months after angioplasty: a quantitative analysis of the variable response to percutaneous transluminal angioplasty. Circulation, 73(3), 467-75, 1986.
Marcus, ML, Harrison, DG, White, CW, Hiratzka, LF. Assessing the physiological significance of coronary obstruction in man. Can J Cardiol, Suppl A, 195A-199A, 1986.
Marcus, ML, Hiratzka, LF, Doty, DB, Wright, CB, Harrison, DG, White, CW. Coronary obstructive lesions: assessing their physiological significance in humans. Ann Thorac Surg, 42(6 Suppl), S5-8, 1986.
Marcus, ML, Hiratzka, LF, White, CW, Harrison, DG, Eastham, CL, Kerber, RE. Application of Doppler technology to studies of the coronary circulation. Cardiovasc Clin, 17(1), 33-43, 1986.
Harrison, DG, Barnes, DH, Hiratzka, LF, Eastham, CL, Kerber, RE, Marcus, ML. The effect of cardiac hypertrophy on the coronary collateral circulation. Circulation, 71(6), 1135-45, 1985.
Roberts, N, Harrison, DG, Reimer, KA, Crain, BS, Wagner, GS. Right ventricular infarction with shock but without significant left ventricular infarction: a new clinical syndrome. Am Heart J, 110(5), 1047-53, 1985.
Harrison, DG, Ferguson, DW, Collins, SM, Skorton, DJ, Ericksen, EE, Kioschos, JM, Marcus, ML, White, CW. Rethrombosis after reperfusion with streptokinase: importance of geometry of residual lesions. Circulation, 69(5), 991-9, 1984.
Harrison, DG, White, CW, Hiratzka, LF, Doty, DB, Barnes, DH, Eastham, CL, Marcus, ML. The value of lesion cross-sectional area determined by quantitative coronary angiography in assessing the physiologic significance of proximal left anterior descending coronary arterial stenoses. Circulation, 69(6), 1111-9, 1984.
White, CW, Wright, CB, Doty, DB, Hiratza, LF, Eastham, CL, Harrison, DG, Marcus, ML. Does visual interpretation of the coronary arteriogram predict the physiologic importance of a coronary stenosis. N Engl J Med, 310(13), 819-24, 1984.
Anderson, CI, Harrison, DG, Stack, NC, Hindman, NB, Ideker, RE, Palmeri, ST, Selvester, RH, Wagner, GS. Evaluation of serial QRS changes during acute inferior myocardial infarction using a QRS scoring system. Am J Cardiol, 52(3), 252-6, 1983.
Baker, JT, Bramlet, DA, Lester, RM, Harrison, DG, Roe, CR, Cobb, FR. Myocardial infarct extension: incidence and relationship to survival. Circulation, 65(5), 918-23, 1982.
Koyanagi, S, Eastham, CL, Harrison, DG, Marcus, ML. Transmural variation in the relationship between myocardial infarct size and risk area. Am J Physiol, 242(5), H867-74, 1982.
Koyanagi, S, Eastham, CL, Harrison, DG, Marcus, ML. Increased size of myocardial infarction in dogs with chronic hypertension and left ventricular hypertrophy. Circ Res, 50(1), 55-62, 1982.
Palmeri, ST, Harrison, DG, Cobb, FR, Morris, KG, Harrell, FE, Ideker, RE, Selvester, RH, Wagner, GS. A QRS scoring system for assessing left ventricular function after myocardial infarction. N Engl J Med, 306(1), 4-9, 1982.
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