Vanderbilt University School of Medicine

Chalkley, Roger , D. Phil.
Senior Associate Dean for Biomedical Research, Education and Training
Professor of Molecular Physiology and Biophysics
Professor of Medical Education and Administration

Lab Url:

Phone Number: 615.343.7251


Chalkley, Roger's picture

Office Address   Mailing Address

340 Light Hall

Biomedical Research Education and Training 340 Light Hall 37232-0301

Chalkley, Roger G. International students at Vanderbilt. Science, 305(5684), 607-9, 2004.

Budhiraja, Rohit, Kayyali, Usamah S, Karamsetty, Mallik, Fogel, Michael, Hill, Nicholas S, Chalkley, Roger, Finlay, Geraldine A, Hassoun, Paul M. Estrogen modulates xanthine dehydrogenase/xanthine oxidase activity by a receptor-independent mechanism. Antioxid Redox Signal, 5(6), 705-11, 2003.

Kayyali, Usamah S, Budhiraja, Rohit, Pennella, Corin M, Cooray, Samantha, Lanzillo, Joe J, Chalkley, Roger, Hassoun, Paul M. Upregulation of xanthine oxidase by tobacco smoke condensate in pulmonary endothelial cells. Toxicol Appl Pharmacol, 188(1), 59-68, 2003.

She, P, Shiota, M, Shelton, K D, Chalkley, R, Postic, C, Magnuson, M A. Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism. Mol Cell Biol, 20(17), 6508-17, 2000. PMCID:86125

Cissell, M A, Chalkley, R. Characterization of a kidney-specific pattern of chromatin structure in the rat phosphoenolpyruvate carboxykinase gene. Biochim Biophys Acta, 1445, 299-313, 1999.

Nagvekar, N, Corlett, L, Jacobson, L W, Matsuo, H, Chalkley, R, Driscoll, P C, Deshpande, S, Spack, E G, Willcox, N. Scanning a DRB3*0101 (DR52a)-restricted epitope cross-presented by DR3: overlapping natural and artificial determinants in the human acetylcholine receptor. J Immunol, 162(7), 4079-87, 1999.

Williams, C P, Postic, C, Robin, D, Robin, P, Parrinello, J, Shelton, K, Printz, R L, Magnuson, M A, Granner, D K, Forest, C, Chalkley, R. Isolation and characterization of the mouse cytosolic phosphoenolpyruvate carboxykinase (GTP) gene: evidence for tissue-specific hypersensitive sites. Mol Cell Endocrinol, 148, 67-77, 1999.

Clark, M P, Chow, C W, Rinaldo, J E, Chalkley, R. Correct usage of multiple transcription initiation sites and C/EBP-dependent transcription activation of the rat XDH/XO TATA-less promoter requires downstream elements located in the coding region of the gene. Nucleic Acids Res, 26, 1801-6, 1998. PMCID:147445

Clark, M P, Chow, C W, Rinaldo, J E, Chalkley, R. Multiple domains for initiator binding proteins TFII-I and YY-1 are present in the initiator and upstream regions of the rat XDH/XO TATA-less promoter. Nucleic Acids Res, 26, 2813-20, 1998. PMCID:147594

Chow, C W, Clark, M P, Rinaldo, J E, Chalkley, R. In vitro transcription in the presence of DNA oligonucleotides can generate strong anomalous initiation sites. Anal Biochem, 235, 82-8, 1996.

Chow, C W, Clark, M P, Rinaldo, J E, Chalkley, R. Multiple initiators and C/EBP binding sites are involved in transcription from the TATA-less rat XDH/XO basal promoter. Nucleic Acids Res, 23, 3132-40, 1995. PMCID:307170

Williams, C P, Granner, D K, Magnuson, M A, Chalkley, R. Cell specific differences in DNase I hypersensitivity between the two promoters of the rat glucokinase gene. Biochem Biophys Res Commun, 215, 272-9, 1995.

Chow, C W, Clark, M, Rinaldo, J, Chalkley, R. Identification of the rat xanthine dehydrogenase/oxidase promoter. Nucleic Acids Res, 22, 1846-54, 1994. PMCID:308083

Svaren J and Chalkley, R. Binding of Histones and IBF are Mutually Exclusive and DNA Length Dependent: Implications for a Kinetic Window During Chromatin Assembly. J. Biol. Chem., 263, 14044-14052, 1994.

Svaren, J, Klebanow, E, Sealy, L, Chalkley, R. Analysis of the competition between nucleosome formation and transcription factor binding. J Biol Chem, 269, 9335-44, 1994.

Svaren, J, Wineinger, B D, Chalkley, R. Extent of in vivo binding by an upstream activation factor and the role of multiple binding sites in synergistic transcriptional activation. J Biol Chem, 269, 20771-9, 1994.

Svaren, J., Klebanow, E., Sealy, L., and Chalkley, R. Binding of Histones and IBF are mutually exclusive and DNA length dependent: Implications for a Kinetic Window during Chromatin Assembly. J. Biol. Chem. , 269, 9335-9344, 1994.

Wineinger, B., Svaren, J., and Chalkley, R. The Interplay of Chromatin Structure and Transcription Factor Binding in the Synergistic Activation of a Yeast UAS. J. Biol. Chem. , 269, 20771-20779, 1994.

Faber, S, O'Brien, R M, Imai, E, Granner, D K, Chalkley, R. Dynamic aspects of DNA/protein interactions in the transcriptional initiation complex and the hormone-responsive domains of the phosphoenolpyruvate carboxykinase promoter in vivo. J Biol Chem, 268, 24976-85, 1993.

Ozer J., Chalkley, R. and Sealy, L. The Characterization of the Rat CCAAT Transcription Factor EFIA Processed Pseudogenes: Novel Retroposons present clues to the Evolution of the EFIA/dbpB/Yb-1 Gene Family. 124, Gene, 491-498, 1993.

Ozer, J, Chalkley, R, Sealy, L. Isolation of the CCAAT transcription factor subunit EFIA cDNA and a potentially functional EFIA processed pseudogene from Bos taurus: insights into the evolution of the EFIA/dbpB/YB-1 gene family. Gene, 124, 223-30, 1993.

Ozer, J, Chalkley, R, Sealy, L. Characterization of rat pseudogenes for enhancer factor I subunit A: ripping provides clues to the evolution of the EFIA/dbpB/YB-1 multigene family. Gene, 133, 187-95, 1993.

Cheyette, T E, Ip, T, Faber, S, Matsui, Y, Chalkley, R. Characterization of the factors binding to a PEPCK gene upstream hypersensitive site with LCR activity. Nucleic Acids Res, 20, 3427-33, 1992. PMCID:312499

Faber, S, Ip, T, Granner, D, Chalkley, R. The interplay of ubiquitous DNA-binding factors, availability of binding sites in the chromatin, and DNA methylation in the differential regulation of phosphoenolpyruvate carboxykinase gene expression. Nucleic Acids Res, 19, 4681-8, 1991. PMCID:328709

Felts, S J, Weil, P A, Chalkley, R. Transcription factor requirements for in vitro formation of transcriptionally competent 5S rRNA gene chromatin. Mol Cell Biol, 10, 2390-401, 1990. PMCID:360587

Fournier, K. E. and Chalkley, R. Extinction Of PEPCK Gene Expression is associated with Loss of a Specific chromatin-Binding protein from a Far upstream Region. Mol. Cell. Biol., 10, 3782-3787, 1990.

Ip, Y T, Fournier, R E, Chalkley, R. Extinction of phosphoenolpyruvate carboxykinase gene expression is associated with loss of a specific chromatin-binding protein from a far upstream domain. Mol Cell Biol, 10, 3782-7, 1990. PMCID:360833

Ip, Y T, Poon, D, Stone, D, Granner, D K, Chalkley, R. Interaction of a liver-specific factor with an enhancer 4.8 kilobases upstream of the phosphoenolpyruvate carboxykinase gene. Mol Cell Biol, 10, 3770-81, 1990. PMCID:360831

Karnitz, L, Poon, D, Weil, P A, Chalkley, R. Identification and purification of a yeast transcriptional trans-activator. The yeast homolog of the Rous sarcoma virus internal enhancer binding factor. J Biol Chem, 265(11), 6131-8, 1990.

Ozer, J, Faber, M, Chalkley, R, Sealy, L. Isolation and characterization of a cDNA clone for the CCAAT transcription factor EFIA reveals a novel structural motif. J Biol Chem, 265, 22143-52, 1990.

Svaren, J, Chalkley, R. The structure and assembly of active chromatin. Trends Genet, 6(2), 52-6, 1990.

Felts, S., Weil, T. and Chalkley, R. Transcription Factor Requirements For Reassembly and Transcription of Yeast 5-S Chromatin Templates In Vitro and In Vivo. Mol. Cell. Biol., 10, 2390-2401, 1989.

Granner, D.K. and Chalkley, R. Hormonal Regulation of PEPCK Gene Expression is Regulated through Modulation of an Already Disrupted Chromatin Structure. Mol. Cell. Biol., 9, 1289-1297 , 1989.

Ip, Y T, Granner, D K, Chalkley, R. Hormonal regulation of phosphoenolpyruvate carboxykinase gene expression is mediated through modulation of an already disrupted chromatin structure. Mol Cell Biol, 9(3), 1289-97, 1989. PMCID:362721

Karnitz, L, Poon, D, Weil, P A, Chalkley, R. Purification and properties of the Rous sarcoma virus internal enhancer binding factor. Mol Cell Biol, 9(5), 1929-39, 1989. PMCID:362984

Sealy, L, Burgess, R R, Cotten, M, Chalkley, R. Purification of Xenopus egg nucleoplasmin and its use in chromatin assembly in vitro. Methods Enzymol, 170, 612-30, 1989.

Ip, Y T, Jackson, V, Meier, J, Chalkley, R. The separation of transcriptionally engaged genes. J Biol Chem, 263(28), 14044-52, 1988.

T.Y., Jackson, V., Meier, J. and Chalkley, R. The Separation of Transcriptionally Engaged Genes. J. Biol. Chem., 263, 14044-14052, 1988.

Chalkley, R., Cotten, M., and Sealy, L. The Role of Phosphorylation in the Activation for Chromatin Assembly of Xenopus Nucleoplasmin. Transcriptional Control of Gene , , 247-258, 1987.

Cotten, M, Chalkley, R. Purification of a novel, nucleoplasmin-like protein from somatic nuclei. EMBO J, 6(13), 3945-54, 1987. PMCID:553873

Felts, S J, Weil, P A, Chalkley, R. Novobiocin inhibits interactions required for yeast TFIIIB sequestration during stable transcription complex formation in vitro. Nucleic Acids Res, 15(4), 1493-506, 1987. PMCID:340563

Karnitz, L, Faber, S, Chalkley, R. Specific nuclear proteins interact with the Rous sarcoma virus internal enhancer and share a common element with the enhancer located in the long terminal repeat of the virus. Nucleic Acids Res, 15(23), 9841-59, 1987. PMCID:306535

Moseley, P L, Chalkley, R. Bleomycin-induced DNA cleavage: studies in vitro and in intact cells. J Lab Clin Med, 110(5), 618-23, 1987.

Sealey, L, Chalkley, R. At least two nuclear proteins bind specifically to the Rous sarcoma virus long terminal repeat enhancer. Mol Cell Biol, 7(2), 787-98, 1987. PMCID:365136

Svaren, J, Inagami, S, Lovegren, E, Chalkley, R. DNA denatures upon drying after ethanol precipitation. Nucleic Acids Res, 15(21), 8739-54, 1987. PMCID:306402

Cotten, M, Bresnahan, D, Thompson, S, Sealy, L, Chalkley, R. Novobiocin precipitates histones at concentrations normally used to inhibit eukaryotic type II topoisomerase. Nucleic Acids Res, 14(9), 3671-86, 1986. PMCID:339807

Cotten, M, Sealy, L, Chalkley, R. Massive phosphorylation distinguishes Xenopus laevis nucleoplasmin isolated from oocytes or unfertilized eggs. Biochemistry, 25(18), 5063-9, 1986.

Sealy, L, Cotten, M, Chalkley, R. Xenopus nucleoplasmin: egg vs. oocyte. Biochemistry, 25(10), 3064-72, 1986.

Sealy, L, Cotten, M, Chalkley, R. Novobiocin inhibits passive chromatin assembly in vitro. EMBO J, 5(12), 3305-11, 1986. PMCID:1167327

Strauch, A R, Offord, J D, Chalkley, R, Rubenstein, P A. Characterization of actin mRNA levels during BC3H1 cell differentiation. J Biol Chem, 261(2), 849-55, 1986.

Wright, P S, Dudley, D T, Chalkley, R. Butyrate effects on normal and adapted hepatoma cells: morphological response and implications for vectoral cholesterol transport. Arch Biochem Biophys, 248(1), 243-52, 1986.

Chalkley, R, Shires, A. The isolation of HTC variant cells which can replicate in butyrate. Changes in histone acetylation and tyrosine aminotransferase induction. J Biol Chem, 260(12), 7698-704, 1985.

Cotten, M, Chalkley, R. Hyperacetylated histones facilitate chromatin assembly in vitro. Nucleic Acids Res, 13(2), 401-14, 1985. PMCID:341004

Jackson, V, Chalkley, R. Histone segregation on replicating chromatin. Biochemistry, 24(24), 6930-8, 1985.

Jackson, V, Chalkley, R. Histone synthesis and deposition in the G1 and S phases of hepatoma tissue culture cells. Biochemistry, 24(24), 6921-30, 1985.

Louters, L, Chalkley, R. Exchange of histones H1, H2A, and H2B in vivo. Biochemistry, 24(13), 3080-5, 1985.

Louters, L, Chalkley, R. In vitro exchange of nucleosomal histones H2a and H2b. Biochemistry, 23(3), 547-52, 1984.

Smith, P A, Jackson, V, Chalkley, R. Two-stage maturation process for newly replicated chromatin. Biochemistry, 23(7), 1576-81, 1984.

Plesko, M M, Hargrove, J L, Granner, D K, Chalkley, R. Inhibition by sodium butyrate of enzyme induction by glucocorticoids and dibutyryl cyclic AMP. A role for the rapid form of histone acetylation. J Biol Chem, 258(22), 13738-44, 1983.

Covault, J, Perry, M, Chalkley, R. Effects of histone hyperacetylation and hypoacetylation on RNA synthesis in HTC cells. J Biol Chem, 257(22), 13433-40, 1982.

Covault, J, Sealy, L, Schnell, R, Shires, A, Chalkley, R. Histone hypoacetylation following release of HTC cells from butyrate. J Biol Chem, 257(10), 5809-15, 1982.

Perry, M, Chalkley, R. Histone acetylation increases the solubility of chromatin and occurs sequentially over most of the chromatin. A novel model for the biological role of histone acetylation. J Biol Chem, 257(13), 7336-47, 1982.

Bloxham, D P, Chalkley, R A, Cooper, G. Chloromethyl ketone derivatives of fatty acids. Methods Enzymol, 72, 592-604, 1981.

Brotherton, T W, Covault, J, Shires, A, Chalkley, R. Only a small fraction of avian erythrocyte histone is involved in ongoing acetylation. Nucleic Acids Res, 9(19), 5061-73, 1981. PMCID:327499

Jackson, V, Chalkley, R. Use of whole-cell fixation to visualize replicating and maturing simian virus 40: identification of new viral gene product. Proc Natl Acad Sci U S A, 78(10), 6081-5, 1981. PMCID:348981

Jackson, V, Chalkley, R. A reevaluation of new histone deposition on replicating chromatin. J Biol Chem, 256(10), 5095-103, 1981.

Jackson, V, Chalkley, R. A new method for the isolation of replicative chromatin: selective deposition of histone on both new and old DNA. Cell, 23(1), 121-34, 1981.

Jackson, V, Marshall, S, Chalkley, R. The sites of deposition of newly synthesized histone. Nucleic Acids Res, 9(18), 4563-81, 1981. PMCID:327459

Perry, M, Chalkley, R. The effect of histone hyperacetylation on the nuclease sensitivity and the solubility of chromatin. J Biol Chem, 256(7), 3313-8, 1981.

Sealy, L, Hartley, J, Donelson, J, Chalkley, R, Hutchison, N, Hamkalo, B. Characterization of a highly repetitive sequence DNA family in rat. J Mol Biol, 145(2), 291-318, 1981.

Covault, J, Chalkley, R. The identification of distinct populations of acetylated histone. J Biol Chem, 255(19), 9110-6, 1980.

Nelson, D, Covault, J, Chalkley, R. Segregation of rapidly acetylated histones into a chromatin fraction released from intact nuclei by the action of micrococcal nuclease. Nucleic Acids Res, 8(8), 1745-63, 1980. PMCID:324033

Shoemaker, C B, Chalkley, R. H3-specific nucleohistone kinase of bovine thymus chromatin. Purification, characterization, and specificity for threonine residue 3. J Biol Chem, 255(22), 11048-55, 1980.

Gaubatz, J, Ellis, M, Chalkley, R. Nuclease digestion studies of mouse chromatin as a function of age. J Gerontol, 34(5), 672-9, 1979.

Gaubatz, J, Ellis, M, Chalkley, R. The structural organization of mouse chromatin as a function of age. Fed Proc, 38(6), 1973-8, 1979.

Moore, M, Jackson, V, Sealy, L, Chalkley, R. Comparative studies on highly metabolically active histone acetylation. Biochim Biophys Acta, 561(1), 248-60, 1979.

Nelson, D, Perry, M E, Chalkley, R. A correlation between nucleosome spacer region susceptibility to DNase I and histone acetylation. Nucleic Acids Res, 6(2), 561-74, 1979. PMCID:327713

Perry, M, Nelson, D, Moore, M, Chalkley, R. Histone deacetylation in nuclei isolated from hepatoma tissue culture cells. Inhibition by sodium butyrate. Biochim Biophys Acta, 561(2), 517-25, 1979.

Rubenstein, P, Sealy, L, Marshall, S, Chalkley, R. Cellular protein synthesis and inhibition of cell division are independent of butyrate-induced histone hyperacetylation. Nature, 280(5724), 692-3, 1979.

Sealy, L, Chalkley, R. Modification of histones immediately following synthesis. Arch Biochem Biophys, 197(1), 78-82, 1979.

Bloxham, D P, Chalkley, R A, Coghlin, S J, Salam, W. Synthesis of chloromethyl ketone derivatives of fatty acids. Their use as specific inhibitors of acetoacetyl-coenzyme A thiolase, cholesterol biosynthesis and fatty acid synthesis. Biochem J, 175(3), 999-1011, 1978. PMCID:1186163

Gaubatz, J, Hardison, R, Murphy, J, Eichner, M E, Chalkley, R. The role of H1 in the structure of chromatin. Cold Spring Harb Symp Quant Biol, 42 Pt 1, 265-71, 1978.

Hardison, R, Chalkley, R. Polyacrylamide gel electrophoretic fractionation of histones. Methods Cell Biol, 17, 235-51, 1978.

Hoffmann, P, Chalkley, R. Procedures for minimizing protease activity during isolation of nuclei, chromatin, and the histones. Methods Cell Biol, 17, 1-12, 1978.

Nadeau, P, Oliver, D R, Chalkley, R. Effect of inhibition of DNA synthesis on histone synthesis and deposition. Biochemistry, 17(23), 4885-93, 1978.

Nelson, D A, Perry, M, Sealy, L, Chalkley, R. DNAse I preferentially digests chromatin containing hyperacetylated histones. Biochem Biophys Res Commun, 82(4), 1346-53, 1978.

Nelson, D A, Perry, W M, Chalkley, R. Sensitivity of regions of chromatin containing hyperacetylated histones to DNAse I. Biochem Biophys Res Commun, 82(1), 365-63, 1978.

Sealy, L, Chalkley, R. DNA associated with hyperacetylated histone is preferentially digested by DNase I. Nucleic Acids Res, 5(6), 1863-76, 1978. PMCID:342130

Sealy, L, Chalkley, R. The effect of sodium butyrate on histone modification. Cell, 14(1), 115-21, 1978.

Shoemaker, C B, Chalkley, R. An H3 histone-specific kinase isolated from bovine thymus chromatin. J Biol Chem, 253(16), 5802-7, 1978.

Gaubatz, J W, Chalkley, R. Distribution of H1 histone in chromatin digested by micrococcal nuclease. Nucleic Acids Res, 4(10), 3281-301, 1977. PMCID:342654

Hardison, R C, Zeitler, D P, Murphy, J M, Chalkley, R. Histone neighbors in nuclei and extended chromatin. Cell, 12(2), 417-27, 1977.

Bloxham, D P, Chalkley, R A. Selective modification of rabbit muscle pyruvate kinase by 5-chloro-4-oxopentanoic acid. Biochem J, 159(2), 201-11, 1976. PMCID:1164107

Chalkley, R A, Bloxham, D P. Identification of cysteine as the reactive group in pyruvate kinase alkylated by 5-chloro-4-oxopentanoic acid. Biochem J, 159(2), 213-9, 1976. PMCID:1164108

Chalkley, R A, Bloxham, D P. Improved alkylation of acetoacetyl-coenzyme A thiolase by extension of chain length in chloromethyl ketone fatty acids. Biochem Soc Trans, 4(2), 279-81, 1976.

Hoffmann, P J, Chalkley, R. A neutral pH acrylamide gel electrophoretic system for histones and other basic proteins. Anal Biochem, 76(2), 539-46, 1976.

Jackson, V, Granner, D, Chalkley, R. Deposition of histone onto the replicating chromosome: newly synthesized histone is not found near the replication fork. Proc Natl Acad Sci U S A, 73(7), 2266-9, 1976. PMCID:430523

Jackson, V, Shires, A, Tanphaichitr, N, Chalkley, R. Modifications to histones immediately after synthesis. J Mol Biol, 104(2), 471-83, 1976.

Shires, A, Carpenter, M P, Chalkley, R. A cysteine-containing H2B-like histone found in mature mammalian testis. J Biol Chem, 251(13), 4155-8, 1976.

Tanphaichitr, N, Chalkley, R. Production of high levels of phosphorylated F1 histone by zinc chloride. Biochemistry, 15(8), 1610-4, 1976.

Tanphaichitr, N, Moore, K C, Granner, D K, Chalkley, R. Relationship between chromosome condensation and metaphase lysine-rich histone phosphorylation. J Cell Biol, 69(1), 43-50, 1976. PMCID:2110976

Balhorn, R, Chalkley, R. Methods for the assessment of selective histone phosphorylation. Methods Enzymol, 40, 138-44, 1975.

Barnett, J E, Holman, G D, Chalkley, R A, Munday, K A. Evidence for two asymmetric conformational states in the human erythrocyte sugar-transport system. Biochem J, 145(3), 417-29, 1975. PMCID:1165241

Chalkley, R. Histone propinquity using imidoesters. Biochem Biophys Res Commun, 64(2), 587-94, 1975.

Chalkley, R, Hunter, C. Histone-histone propinquity by aldehyde fixation of chromatin. Proc Natl Acad Sci U S A, 72(4), 1304-8, 1975. PMCID:432521

Hardison, R C, Eichner, M E, Chalkley, R. An approach to histone nearest neighbours in extended chromatin. Nucleic Acids Res, 2(10), 1751-70, 1975. PMCID:343543

Jackson, V, Chalkley, R. The effect of urea on staphylococcal nuclease digestion of chromatin. Biochem Biophys Res Commun, 67(4), 1391-400, 1975.

Jackson, V, Granner, D K, Chalkley, R. Deposition of histones onto replicating chromosomes. Proc Natl Acad Sci U S A, 72(11), 4440-4, 1975. PMCID:388737

Jackson, V, Shires, A, Chalkley, R, Granner, D K. Studies on highly metabolically active acetylation and phosphorylation of histones. J Biol Chem, 250(13), 4856-63, 1975.

Sherod, D, Johnson, G, Balhorn, R, Jackson, V, Chalkley, R, Granner, D. The phosphorylation region of lysine-rich histone in dividing cells. Biochim Biophys Acta, 381(2), 337-47, 1975.

Shires, A, Carpenter, M P, Chalkley, R. New histones found in mature mammalian testes. Proc Natl Acad Sci U S A, 72(7), 2714-8, 1975. PMCID:432841

Jackson, V, Chalkley, R. The cytoplasmic estradiol receptors of bovine uterus. Their occurrence, interconversion, and binding properties. J Biol Chem, 249(5), 1627-36, 1974.

Jackson, V, Chalkley, R. The binding of estradiol-17 beta to the bovine endometrial nuclear membrane. J Biol Chem, 249(5), 1615-26, 1974.

Jackson, V, Chalkley, R. Separation of newly synthesized nucleohistone by equilibrium centrifugation in cesium chloride. Biochemistry, 13(19), 3952-6, 1974.

Oliver, D, Chalkley, R. Asymmetric distribution of histone on DNA: a model for nucleohistone primary structure. Biochemistry, 13(25), 5093-8, 1974.

Oliver, D, Granner, D, Chalkley, R. Identification of a distinction between cytoplasmic histone synthesis and subsequent histone deposition within the nucleus. Biochemistry, 13(4), 746-9, 1974.

Sherod, D, Johnson, G, Chalkley, R. Studies on the hetrogeneity of lysine-rich histones in dividing cells. J Biol Chem, 249(12), 3923-31, 1974.

Sommer, K R, Chalkley, R. A new method for fractionating histones for physical and chemical studies. Biochemistry, 13(5), 1022-7, 1974.

Tanphaichitr, N, Balhorn, R, Granner, D, Chalkley, R. Further studies of histone phosphorylation in the presence of inhibitors of DNA synthesis. Biochemistry, 13(21), 4249-54, 1974.

Balhorn, R, Tanphaichitr, N, Chalkley, R, Granner, D K. The effect of inhibition of deoxyribonucleic acid synthesis on histone phosphorylation. Biochemistry, 12(25), 5146-50, 1973.

Bartley, J, Chalkley, R. An approach to the structure of native nucleohistone. Biochemistry, 12(3), 468-74, 1973.

Hooper, J A, Smith, E L, Sommer, K R, Chalkley, R. Histone 3. IV. Amino acid sequence of histone 3 of the testes of the carp, Letiobus bubalus. J Biol Chem, 248(9), 3275-9, 1973.

Balhorn, R, Balhorn, M, Chalkley, R. Lysine-rach histone phosphorylation and hyperplasia in the developing rat. Dev Biol, 29(2), 199-203, 1972.

Balhorn, R, Balhorn, M, Morris, H P, Chalkley, R. Comparative high-resolution electrophoresis of tumor histones: variation in phosphorylation as a function of cell replication rate. Cancer Res, 32(8), 1775-84, 1972.

Balhorn, R, Bordwell, J, Sellers, L, Granner, D, Chalkley, R. Histone phosphorylation and DNA synthesis are linked in synchronous cultures of HTC cells. Biochem Biophys Res Commun, 46(3), 1326-33, 1972.

Balhorn, R, Chalkley, R, Granner, D. Lysine-rich histone phosphorylation. A positive correlation with cell replication. Biochemistry, 11(6), 1094-8, 1972.

Balhorn, R, Oliver, D, Hohmann, P, Chalkley, R, Granner, D. Turnover of deoxyribonucleic acid, histones, and lysine-rich histone phosphate in hepatoma tissue culture cells. Biochemistry, 11(21), 3915-21, 1972.

Bartley, J A, Chalkley, R. The binding of deoxyribonucleic acid and histone in native nucleohistone. J Biol Chem, 247(11), 3647-55, 1972.

Chattoraj, D K, Bull, H B, Chalkley, R. Binding of histone to DNA. Arch Biochem Biophys, 152(2), 778-85, 1972.

Easton, D, Chalkley, R. High-resolution electrophoretic analysis of the histones from embryos and sperm of Arbacia punctulata. Exp Cell Res, 72(2), 502-8, 1972.

Oliver, D R, Chalkley, R. An electrophoretic analysis of Drosophila histones. II. Comparison of larval and adult histone patterns in two species of Drosophila. Exp Cell Res, 73(2), 303-10, 1972.

Oliver, D, Balhorn, R, Granner, D, Chalkley, R. Molecular nature of F 1 histone phosphorylation in cultured hepatoma cells. Biochemistry, 11(21), 3921-5, 1972.

Oliver, D, Chalkley, R. An electrophoretic analysis of Drosophila histones. I. Isolation and identification. Exp Cell Res, 73(2), 295-302, 1972.

Oliver, D, Sommer, K R, Panyim, S, Spiker, S, Chalkley, R. A modified procedure for fractionating histones. Biochem J, 129(2), 349-53, 1972. PMCID:1174084

Balhorn, R, Rieke, W O, Chalkley, R. Rapid electrophoretic analysis for histone phosphorylation. A reinvestigation of phosphorylation of lysine-rich histone during rat liver regeneration. Biochemistry, 10(21), 3952-9, 1971.

Granner, D K, Belhorn, R, Chalkley, R. Histone phosphorylation and cell division. J Lab Clin Med, 78(6), 992-3, 1971.

Oliver, D, Chalkley, R. An improved photographic system for polyacrylamide gels. Anal Biochem, 44(2), 540-2, 1971.

Panyim, S, Bilek, D, Chalkley, R. An electrophoretic comparison of vertebrate histones. J Biol Chem, 246(13), 4206-15, 1971.

Panyim, S, Chalkley, R. The molecular weights of vertebrate histones exploiting a modified sodium dodecyl sulfate electrophoretic method. J Biol Chem, 246(24), 7557-60, 1971.

Panyim, S, Sommer, K R, Chalkley, R. Oxidation of the cysteine-containing histone F3. Detection of an evolutionary mutation in a conservative histone. Biochemistry, 10(21), 3911-7, 1971.

Stegink, L D, Meyer, P D, Chalkley, R. Acrylamide gel electrophoresis of hemoglobin polypeptide chains. Anal Biochem, 41(2), 351-9, 1971.

Bartley, J, Chalkley, R. Further studies of a thymus nucleohistone-associated protease. J Biol Chem, 245(17), 4286-92, 1970.

Panyim, S, Chalkley, R, Spiker, S, Oliver, D. Constant electrophoretic mobility of the cysteine-containing histone in plants and animals. Biochim Biophys Acta, 214(1), 216-21, 1970.

Sherod, D, Johnson, G, Chalkley, R. Phosphorylation of mouse ascites tumor cell lysine-rich histone. Biochemistry, 9(23), 4611-5, 1970.

Panyim, S, Chalkley, R. A new histone found only in mammalian tissues with little cell division. Biochem Biophys Res Commun, 37(6), 1042-9, 1969.

Panyim, S, Chalkley, R. The heterogeneity of histones. I. A quantitative analysis of calf histones in very long polyacrylamide gels. Biochemistry, 8(10), 3972-9, 1969.

Panyim, S, Chalkley, R. High resolution acrylamide gel electrophoresis of histones. Arch Biochem Biophys, 130(1), 337-46, 1969.

Bartley, J A, Chalkley, R. The viscosity of nucleohistone in urea. Biochim Biophys Acta, 160(2), 224-8, 1968.

Chalkley, R, Jensen, R H. A study of the structure of isolated chromatin. Biochemistry, 7(12), 4380-8, 1968.

Jackson, V, Earnhardt, J, Chalkley, R. A DNA-lipid protein containing material isolated from calf thymus nuclear chromatin. Biochem Biophys Res Commun, 33(2), 253-9, 1968.

Jensen, R H, Chalkley, R. The physical state of nucleohistone under physiological ionic strength. The effect of interaction with free nucleic acids. Biochemistry, 7(12), 4388-95, 1968.

Panyim, S, Jensen, R H, Chalkley, R. Proteolytic contamination of calf thymus nucleohistone and its inhibition. Biochim Biophys Acta, 160(2), 252-5, 1968.

Chalkley, R. Histones in relation to control in living systems. NASA CR-673. NASA Contract Rep NASA CR, , 131-47, 1967.

Postdoctoral Position Available

Postdoctoral Position Details

Updated Date