Vanderbilt University School of Medicine

McLean, John
Professor of Chemistry
Stevenson Professor of Chemistry

Lab Url: N/A

Phone Number: (615) 322-119


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Research Keywords
Bioanalytical and Biophysical Chemistry

Research Specialty
Bioanalytical and Biophysical Chemistry

Research Description
Our research focuses on the design, construction, and application of advanced technologies for structural mass spectrometry, in particular, for studies in structural proteomics, systems biology, and biophysics. To identify and structurally characterize biomolecules from complex samples, we perform rapid (A?s-ms) two-dimensional gas-phase separations using ion mobility-mass spectrometry (IM-MS) techniques. IM-MS provides separations on the basis of apparent surface area (ion-neutral collision cross section) and mass-to-charge (m/z), respectively. Biomolecular structural information is interpreted by comparing experimentally obtained collision cross-sections in the context of those obtained via molecular dynamics simulations.


Postdoctoral Position Available

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