Vanderbilt University School of Medicine

Wells, K. Sam , Ph.D.
Research Professor of Molecular Physiology and Biophysics

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Phone Number: 322-6687


Wells, K.'s picture

Office Address   Mailing Address

710 Light Hall

702 Light Hall 37232-0615

Sidorova TN, Yermalitskaya LV, Wells KS, Mace LC, Boutaud O, Prinsen JK, Davies SS, Roberts JL, Dikalov SI, Glabe CG, Amarnath V, Barnett JV, Murray KT. Reactive gamma-Ketoaldehydes Promote Protein Misfolding and Preamyloid Oligomer Formation in Rapidly-Activated Atrial Cells. Journal of Molecular and Cellular Cardiology, , , in press.

Exil, V, Ping, L, Yu, Y, Chakraborty, S, Caito, SW, Wells, KS, Karki, P, Lee, E, Aschner, M. Activation of MAPK and FoxO by manganese (Mn) in rat neonatal primary astrocyte cultures. PLoS One, 9(5), e94753, 2014.

Sidorova, TN, Mace, LC, Wells, KS, Yermalitskaya, LV, Su, PF, Shyr, Y, Byrne, JG, Petracek, MR, Greelish, JP, Hoff, SJ, Ball, SK, Glabe, CG, Brown, NJ, Barnett, JV, Murray, KT. Quantitative Imaging of Preamyloid Oligomers, a Novel Structural Abnormality, in Human Atrial Samples. J Histochem Cytochem, 62(7), 479-487, 2014.

Sobolik, T, Su, YJ, Wells, S, Ayers, GD, Cook, RS, Richmond, A. CXCR4 drives the metastatic phenotype in breast cancer through induction of CXCR2 and activation of MEK and PI3K pathways. Mol Biol Cell, 25(5), 566-82, 2014.

Kendall, PL, Case, JB, Sullivan, AM, Holderness, JS, Wells, KS, Liu, E, Thomas, JW. Tolerant anti-insulin B cells are effective APCs. J Immunol, 190(6), 2519-26, 2013.

Schietinger, A, Arina, A, Liu, RB, Wells, S, Huang, J, Engels, B, Bindokas, V, Bartkowiak, T, Lee, D, Herrmann, A, Piston, DW, Pittet, MJ, Lin, PC, Zal, T, Schreiber, H. Longitudinal confocal microscopy imaging of solid tumor destruction following adoptive T cell transfer. Oncoimmunology, 2(11), e26677, 2013.

Hallaq, H, Wang, DW, Kunic, JD, George, AL, Wells, KS, Murray, KT. Activation of protein kinase C alters the intracellular distribution and mobility of cardiac Na+ channels. Am J Physiol Heart Circ Physiol, 302(3), H782-9, 2012.

Chopra, SS, Stroud, DM, Watanabe, H, Bennett, JS, Burns, CG, Wells, KS, Yang, T, Zhong, TP, Roden, DM. Voltage-gated sodium channels are required for heart development in zebrafish. Circ Res, 106(8), 1342-50, 2010.

Zhuang, G, Brantley-Sieders, DM, Vaught, D, Yu, J, Xie, L, Wells, S, Jackson, D, Muraoka-Cook, R, Arteaga, C, Chen, J. Elevation of receptor tyrosine kinase EphA2 mediates resistance to trastuzumab therapy. Cancer Res, 70(1), 299-308, 2010.

Martin, MD, Fingleton, B, Lynch, CC, Wells, S, McIntyre, JO, Piston, DW, Matrisian, LM. Establishment and quantitative imaging of a 3D lung organotypic model of mammary tumor outgrowth. Clin Exp Metastasis, 25(8), 877-85, 2008. PMCID:2588650

Nyman, LR, Wells, KS, Head, WS, McCaughey, M, Ford, E, Brissova, M, Piston, DW, Powers, AC. Real-time, multidimensional in vivo imaging used to investigate blood flow in mouse pancreatic islets. J Clin Invest, 118(11), 3790-7, 2008. PMCID:2564611

Jia, H, King, IN, Chopra, SS, Wan, H, Ni, TT, Jiang, C, Guan, X, Wells, S, Srivastava, D, Zhong, TP. Vertebrate heart growth is regulated by functional antagonism between Gridlock and Gata5. Proc Natl Acad Sci U S A, 104(35), 14008-13, 2007. PMCID:1955785

Hallaq, H, Yang, Z, Viswanathan, PC, Fukuda, K, Shen, W, Wang, DW, Wells, KS, Zhou, J, Yi, J, Murray, KT. Quantitation of protein kinase A-mediated trafficking of cardiac sodium channels in living cells. Cardiovasc Res, 72(2), 250-61, 2006.

Xu, M, Wells, KS, Emeson, RB. Substrate-dependent contribution of double-stranded RNA-binding motifs to ADAR2 function. Mol Biol Cell, 17(7), 3211-20, 2006. PMCID:1552048

Boczko, EM, Cooper, TG, Gedeon, T, Mischaikow, K, Murdock, DG, Pratap, S, Wells, KS. Structure theorems and the dynamics of nitrogen catabolite repression in yeast. Proc Natl Acad Sci U S A, 102(16), 5647-52, 2005. PMCID:556013

Bundy, L, Wells, S, Sealy, L. C/EBPbeta-2 confers EGF-independent growth and disrupts the normal acinar architecture of human mammary epithelial cells. Mol Cancer, 4, 43, 2005. PMCID:1360092

Kanki, H, Kupershmidt, S, Yang, T, Wells, S, Roden, DM. A structural requirement for processing the cardiac K+ channel KCNQ1. J Biol Chem, 279(32), 33976-83, 2004.

Manza LL, Codreanu SG, Stamer SL, Smith DL, Wells KS, Roberts RL, Liebler DC.. Global shifts in protein sumoylation in response to electrophile and oxidative stress.. Chem Res Toxicol., 12(Dec; 17), 1706-15, 2004.

McIntyre, J Oliver, Fingleton, Barbara, Wells, K Sam, Piston, David W, Lynch, Conor C, Gautam, Shiva, Matrisian, Lynn M. Development of a novel fluorogenic proteolytic beacon for in vivo detection and imaging of tumour-associated matrix metalloproteinase-7 activity. Biochem J, 377(Pt 3), 617-28, 2004. PMCID:1223892

Sheng, J, Organ, EL, Hao, C, Wells, KS, Ruley, HE, Rubin, DH. Mutations in the IGF-II pathway that confer resistance to lytic reovirus infection. BMC Cell Biol, 5(1), 32, 2004. PMCID:517494

Campbell, M, Qu, S, Wells, S, Sugandha, H, Jensen, RA. An adenoviral vector containing an arg-gly-asp (RGD) motif in the fiber knob enhances protein product levels from transgenes refractory to expression. Cancer Gene Ther, 10(7), 559-70, 2003.

Sansam, Christopher L, Wells, K Sam, Emeson, Ronald B. Modulation of RNA editing by functional nucleolar sequestration of ADAR2. Proc Natl Acad Sci U S A, 100(24), 14018-23, 2003. PMCID:283538

Kupershmidt, Sabina, Yang, Iris C-H, Sutherland, Margaret, Wells, K Sam, Yang, Tao, Yang, Ping, Balser, Jeffrey R, Roden, Dan M. Cardiac-enriched LIM domain protein fhl2 is required to generate I(Ks) in a heterologous system. Cardiovasc Res, 56, 93-103, 2002.

Gurrieri, S, Wells, K S, Johnson, I D, Bustamante, C. Direct visualization of individual DNA molecules by fluorescence microscopy: characterization of the factors affecting signal/background and optimization of imaging conditions using YOYO. Anal Biochem, 249, 44-53, 1997.

Gurrieri, S, Smith, S B, Wells, K S, Johnson, I D, Bustamante, C. Real-time imaging of the reorientation mechanisms of YOYO-labelled DNA molecules during 90 degrees and 120 degrees pulsed field gel electrophoresis. Nucleic Acids Res, 24, 4759-67, 1996. PMCID:146294

Poot, M, Zhang, Y Z, Kramer, J A, Wells, K S, Jones, L J, Hanzel, D K, Lugade, A G, Singer, V L, Haugland, R P. Analysis of mitochondrial morphology and function with novel fixable fluorescent stains. J Histochem Cytochem, 44, 1363-72, 1996.

Larison, K D, BreMiller, R, Wells, K S, Clements, I, Haugland, R P. Use of a new fluorogenic phosphatase substrate in immunohistochemical applications. J Histochem Cytochem, 43, 77-83, 1995.

Haugland, R P, You, W, Paragas, V B, Wells, K S, DuBose, D A, . Simultaneous visualization of G- and F-actin in endothelial cells.. J Histochem Cytochem, 42, 345-50, 1994.

Sandison DR, Williams RM, Wells KS, Strickler J, Webb WW. Quantitative Fluorescence Confocal Laser Scanning Microscopy (CLSM). Handbook of Confocal Microscopy, Pawley, J., Ed.(2nd Edition), Plenum, 1994.

Singer, V L, Paragas, V B, Larison, K D, Wells, K S, Fox, C J, Haugland, R P, . Fluorescence-based signal amplification technology.. Am Biotechnol Lab, 12, 55-58, 1994.

Wells, K.S. and Johnson, I.D.. Fluorescent Labels for Confocal Microscopy. In: Three Dimensional Confocal Microscopy: Volume Investigation of Biological Specimens, Stevens, J., Mills, L.R. and Trogadis, J., Eds,(Acadedmic Press), 101-129, 1994.

Kwon YH, Wells KS, Hoch HC. Fluorescence Confocal Microscopy: Applications in Fungal Cytology. Mycologia, 85(5), 721-733, 1993.

Webb WW, Wells KS, Sandison DR Strickler J. Criteria for Quantitative Dynamical Confocal Fluorescence Imaging. In: An International Conference on Digitized Video Microscopy, , Alan R. Liss, Inc., 1990.

Wells KS, Sandison DR, Strickler J, Webb, WW. Quantitative Fluorescence Imaging in Laser Scanning Confocal Microscopy. Handbook of Biological Confocal Microscopy, Pawley, J. Ed.(Plenum), 27-39, 1990.

Beach, D A, Bustamante, C, Wells, K S, Foucar, K M, . Differential polarization imaging. III. Theory confirmation. Patterns of polymerization of hemoglobin S in red blood sickle cells.. Biophys J, 53, 449-56, 1988. PMCID:1330212

Garab G, Wells S, Finzi L, Bustamante C. Helically Organized Macroaggregates of Pigment Protein Complexes in Chloroplasts: Evidence from Circular Intensity Differential Scattering. Biochemistry, 27(16), 5839-43, 1988.

Spada GP, Gotterelli G, Samori B, Bustamante CJ, Wells KS. A Study of some Lyotropic Cholesteric Mesophases by Circular and Linear Dichroism and by Circular Intensity Differential Scattering. Liquid Crystals 3, 3(1), 101-113, 1988.

Beach DA, Wells KS, Husher F, Bustamante C. Differential Polarization Microscope Using an Image Dissector Camera and Phase Lock Detection. Rev. Sci. Instr., 58(Nov), 1987-1995, 1987.

Beach, D A, Bustamante, C, Wells, K S, Foucar, K M, . Differential polarization imaging. III. Theory confirmation. Patterns of polymerization of hemoglobin S in red blood sickle cells.. Biophys J, 52, 947-54, 1987. PMCID:1330093

Bustamante, C, Maestre, M F, Wells, K S. Recent advances in polarization spectroscopy: perspectives of the extension to the soft X-ray region. Photochem Photobiol, 44(3), 331-41, 1986.

Wells KS, Beach DA, Keller D, Bustamante C. An analysis of circular intensity differential scattering measurements: studies on the sperm cell of Eledone cirrhosa. Biopolymers, 25(11), 2043-64, 1986.

Hall K, Wells KS, Keller D, Samori B, Maestre MF, Tinoco Jr. I, Bustamante C. Circular Intensity Differential Scattering of Planar and Focal Conic Orientations of Cholesteric Liquid Crystals. Applications of Circularly Polarized Radiation, Allen FS, Bustamante C, Eds.(Springer), , 1985.

Bustamante, C., Wells, K.S., Keller, D., Samori, B., Maestre, M.F. and Tinoco, I.,Jr. The Circular Intensity Differential Scattering (CIDS) of Cholesteric and Blue Mesophases. Molecular Crystals and Liquid Crystals, 111(1), 79-102, 1984.

Katz JE, Wells S, Ussery D, Bustamante C, Maestre MF. Design and Construction of a Circular Intensity Differential Scattering Instrument. Rev. Sci. Instrum., 55(Oct), 1574-1579, 1984.

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