Vanderbilt University School of Medicine

Atkinson, James B. III, M.D., Ph.D.
Professor of Pathology, Microbiology and Immunology

Lab Url: N/A

Phone Number: 615-343-9576


Atkinson, James's picture

Office Address   Mailing Address

C-3320 Medical Center North

C-3321 MCN 2561

Research Keywords
Heart, Pathology, Transplantation, Vascular Biology, Atherosclerosis, Cardiac function

Research Specialty
Mechanisms of cardiovascular disease (atherosclerosis / cardiovascular pathology / cardiovascular disease / heart transplantation)

Research Description
Research in this laboratory is centered around mechanisms of cardiovascular disease as well as applied cardiovascular pathology. Current projects in atherosclerosis include the role of biogenic amines in human atherogenesis, with emphasis on the developing atherosclerotic lesion in young people.

This laboratory has also developed an animal model for atherosclerosis (the cholesterol-fed heterozygous WHHL rabbit) in which both genetic and nutritional factors are combined to produce vascular disease. This model has been used to study the role of calcium in atherogenesis. These studies have been extended to an animal model for heart transplantation to study the atherosclerosis that develops in transplanted hearts.

Using the heart transplant model, we have explored possible interventions that might suppress graft coronary artery disease, the major factor that currently limits long-term success in cardiac transplantation. Several applied research projects have taken advantage of the unique position of cardiovascular pathology to study the mechanisms of a variety of diseases, including coronary and ischemic heart disease, prosthetic vascular grafts and coronary artery bypass grafts, valvular disease, and the role of calcium regulatory proteins in the pathobiology of cardiomyopathy.

Hill, KD, Atkinson, JB, Doyle, TP, Dodd, D. Routine performance of endomyocardial biopsy decreases the incidence of orthotopic heart transplant for myocarditis. J Heart Lung Transplant, 28(12), 1261-6, 2009.

Pyle, AL, Atkinson, JB, Pozzi, A, Reese, J, Eckes, B, Davidson, JM, Crimmins, DL, Young, PP. Regulation of the atheroma-enriched protein, SPRR3, in vascular smooth muscle cells through cyclic strain is dependent on integrin alpha1beta1/collagen interaction. Am J Pathol, 173(5), 1577-88, 2008. PMCID:2570146

Pyle, AL, Li, B, Maupin, AB, Guzman, RJ, Crimmins, DL, Olson, S, Atkinson, JB, Young, PP. Biomechanical stress induces novel arterial intima-enriched genes: implications for vascular adaptation to stress. Cardiovasc Pathol, 19(2), e13-20, 2008.

Tsiatis, AC, Atkinson, JB, Wright, JK, Cates, JM. Primary hepatic myxoid leiomyosarcoma: a case report and review of the literature. Ultrastruct Pathol, 32(1), 25-8, 2008. PMCID:2570146

Eren, M, Gleaves, LA, Atkinson, JB, King, LE, Declerck, PJ, Vaughan, DE. Reactive site-dependent phenotypic alterations in plasminogen activator inhibitor-1 transgenic mice. J Thromb Haemost, 5(7), 1500-8, 2007. PMCID:2570146

Milam, MR, Atkinson, JB, Currie, JL. Adenosarcoma arising in inguinal endometriosis. Obstet Gynecol, 108(3 Pt 2), 753-5, 2006. PMCID:2570146

Pitchford, CW, Schwartz, HS, Atkinson, JB, Cates, JM. Soft tissue perineurioma in a patient with neurofibromatosis type 2: a tumor not previously associated with the NF2 syndrome. Am J Surg Pathol, 30(12), 1624-9, 2006. PMCID:2570146

Briggs, RC, Atkinson, JB, Miranda, RN. Variable expression of human myeloid specific nuclear antigen MNDA in monocyte lineage cells in atherosclerosis. J Cell Biochem, 95(2), 293-301, 2005. PMCID:2570146

Kagawa, N, Senbonmatsu, TA, Satoh, K, Ichihara, K, Yamagata, N, Hatano, O, Saito, T, Nguyen, VQ, Waterman, MR, Price, E, Atkinson, JB, Inagami, T. Tetracycline protects myocardium against ischemic injury. Front Biosci, 10, 608-19, 2005. PMCID:2570146

Khoo, MS, Kannankeril, PJ, Li, J, Zhang, R, Kupershmidt, S, Zhang, W, Atkinson, JB, Colbran, RJ, Roden, DM, Anderson, ME. Calmodulin kinase II activity is required for normal atrioventricular nodal conduction. Heart Rhythm, 2(6), 634-40, 2005. PMCID:2570146

Temple, J, Frias, P, Rottman, J, Yang, T, Wu, Y, Verheijck, EE, Zhang, W, Siprachanh, C, Kanki, H, Atkinson, JB, King, P, Anderson, ME, Kupershmidt, S, Roden, DM. Atrial fibrillation in KCNE1-null mice. Circ Res, 97(1), 62-9, 2005. PMCID:2570146

Zhang, R, Khoo, MS, Wu, Y, Yang, Y, Grueter, CE, Ni, G, Price, EE, Thiel, W, Guatimosim, S, Song, LS, Madu, EC, Shah, AN, Vishnivetskaya, TA, Atkinson, JB, Gurevich, VV, Salama, G, Lederer, WJ, Colbran, RJ, Anderson, ME. Calmodulin kinase II inhibition protects against structural heart disease. Nat Med, 11(4), 409-17, 2005. PMCID:2570146

Eren, M, Painter, C A, Gleaves, L A, Schoenhard, J A, Atkinson, J B, Brown, N J, Vaughan, D E. Tissue- and agonist-specific regulation of human and murine plasminogen activator inhibitor-1 promoters in transgenic mice. J Thromb Haemost, 1(11), 2389-96, 2003.

Fan, Xuemo, Semchyshyn, Terry M, Mawn, Louise A, Atkinson, James B, Anderson, James C, Toms, Steven A, Johnson, Mahlon D. July 2002: 66-year-old female with a one-year history of progressive left proptosis. Brain Pathol, 13(1), 111-2, 117, 2003.

Schr??der, Carsten, Azimzadeh, Agnes M, Wu, Guosheng, Price, James O, Atkinson, James B, Pierson, Richard N. Anti-CD20 treatment depletes B-cells in blood and lymphatic tissue of cynomolgus monkeys. Transpl Immunol, 12(1), 19-28, 2003.

Eren, Mesut, Painter, Corrie A, Atkinson, James B, Declerck, Paul J, Vaughan, Douglas E. Age-dependent spontaneous coronary arterial thrombosis in transgenic mice that express a stable form of human plasminogen activator inhibitor-1. Circulation, 106(4), 491-6, 2002.

Atkinson, J B, Hill, K E, Burk, R F. Centrilobular endothelial cell injury by diquat in the selenium-deficient rat liver. Lab Invest, 81(2), 193-200, 2001.

Parker, K K, Taylor, L K, Atkinson, J B, Hansen, D E, Wikswo, J P, Atkinson, B. The effects of tubulin-binding agents on stretch-induced ventricular arrhythmias. Eur J Pharmacol, 417(1-2), 131-40, 2001.

R Virmani, A Burke, A Farb, JB Atkinson. Cardiovascular Pathology. , , , 2001.

Chapman, W C, Debelak, J P, Wright Pinson, C, Washington, M K, Atkinson, J B, Venkatakrishnan, A, Blackwell, T S, Christman, J W. Hepatic cryoablation, but not radiofrequency ablation, results in lung inflammation. Ann Surg, 231(5), 752-61, 2000. PMCID:1421063

Gobbi, H, Atkinson, J B, Kardos, T F, Simpson, J F, Page, D L. Inflammatory myofibroblastic tumour of the breast: report of a case with giant vacuolated cells. Breast, 8(3), 135-8, 1999.

Miller, G G, Davis, S F, Atkinson, J B, Chomsky, D B, Pedroso, P, Reddy, V S, Drinkwater, D C, Zhao, X M, Pierson, R N. Longitudinal analysis of fibroblast growth factor expression after transplantation and association with severity of cardiac allograft vasculopathy. Circulation, 100(24), 2396-9, 1999.

Pierson, R N, Chang, A C, Blum, M G, Blair, K S, Scott, M A, Atkinson, J B, Collins, B J, Zhang, J P, Thomas, D W, Burkly, L C, Miller, G G. Prolongation of primate cardiac allograft survival by treatment with ANTI-CD40 ligand (CD154) antibody. Transplantation, 68(11), 1800-5, 1999.

Scoggins, C R, Vitola, J V, Sandler, M P, Atkinson, J B, Frexes-Steed, M. Occult breast carcinoma presenting as an axillary mass. Am Surg, 65(1), 1-5, 1999.

Singer, R J, Clough, J, Johnson, M, Atkinson, J B, Copeland, M. Pigmented schwannoma of the ventral spinal cord. South Med J, 92(5), 532-4, 1999.

Atkinson J.B. Accelerated arteriosclerosis after transplantation: the possible role of calcium channel blockers. Int. J. Cardiol., 2, 5125-5134, 1998.

Atkinson, J B. Accelerated arteriosclerosis after transplantation: the possible role of calcium channel blockers. Int J Cardiol, 62 Suppl 2, S125-34, 1997.

Fazio, S, Babaev, V R, Murray, A B, Hasty, A H, Carter, K J, Gleaves, L A, Atkinson, J B, Linton, M F. Increased atherosclerosis in mice reconstituted with apolipoprotein E null macrophages. Proc Natl Acad Sci U S A, 94(9), 4647-52, 1997. PMCID:20778

Foster, M T, Atkinson, J B, Yeoh, T K, Fischell, T A. Histopathology of restenosis after stenting of narrowed coronary arteries after cardiac transplantation during the teenage years. Am J Cardiol, 80(3), 389-93, 1997.

Vitola, J V, Forman, M B, Holsinger, J P, Atkinson, J B, Murray, J J. Reduction of myocardial infarct size in rabbits and inhibition of activation of rabbit and human neutrophils by lidocaine. Am Heart J, 133(3), 315-22, 1997.

Dawood, M M, Gutpa, D K, Southern, J, Walia, A, Atkinson, J B, Eagle, K A. Pathology of fatal perioperative myocardial infarction: implications regarding pathophysiology and prevention. Int J Cardiol, 57(1), 37-44, 1996.

Vitola, J V, Forman, M B, Holsinger, J P, Kawana, M, Atkinson, J B, Quertermous, T, Jackson, E K, Murray, J J. Role of endothelin in a rabbit model of acute myocardial infarction: effects of receptor antagonists. J Cardiovasc Pharmacol, 28(6), 774-83, 1996.

Linton, M F, Atkinson, J B, Fazio, S. Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation. Science, 267(5200), 1034-7, 1995.

Linton, M.F., Atkinson, J.B., Fazio, S. Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation. Science , 267, 1034-1037, 1995.

Zhao, X M, Citrin, B S, Miller, G G, Frist, W H, Merrill, W H, Fischell, T A, Atkinson, J B, Yeoh, T K. Association of acidic fibroblast growth factor and untreated low grade rejection with cardiac allograft vasculopathy. Transplantation, 59(7), 1005-10, 1995.

Atkinson, J B, Harlan, C W, Harlan, G C, Virmani, R. The association of mast cells and atherosclerosis: a morphologic study of early atherosclerotic lesions in young people. Hum Pathol, 25(2), 154-9, 1994.

Atkinson, J.B., Harlan, C.W., Harlan, G.C., Virmani, R. The association of mast cells and atherosclerosis: a morphologic study of early atherosclerotic lesions in young people. Hum. Pathol. , 25, 154-159, 1994.

Velasco, C E, Turner, M, Inagami, T, Atkinson, J B, Virmani, R, Jackson, E K, Murray, J J, Forman, M B. Reperfusion enhances the local release of endothelin after regional myocardial ischemia. Am Heart J, 128(3), 441-51, 1994.

Atkinson, J B, Wudel, J H, Hoff, S J, Stewart, J R, Frist, W H. Amlodipine reduces graft coronary artery disease in rat heterotopic cardiac allografts. J Heart Lung Transplant, 12(6 Pt 1), 1036-43, 1993.

Delbeke, D, Lorenz, C H, Votaw, J R, Silveira, S T, Frist, W H, Atkinson, J B, Kessler, R M, Sandler, M P. Estimation of left ventricular mass and infarct size from nitrogen-13-ammonia PET images based on pathological examination of explanted human hearts. J Nucl Med, 34(5), 826-33, 1993.

Dodd, D A, Atkinson, J B, Olson, R D, Buck, S, Cusack, B J, Fleischer, S, Boucek, R J. Doxorubicin cardiomyopathy is associated with a decrease in calcium release channel of the sarcoplasmic reticulum in a chronic rabbit model. J Clin Invest, 91(4), 1697-705, 1993. PMCID:288149

Hoff, S J, Stewart, J R, Frist, W H, Atkinson, J B, Kronenberg, M W, Votaw, J, Kessler, R M, Sandler, M P. Noninvasive detection of acute rejection in a new experimental model of heart transplantation. Ann Thorac Surg, 56(5), 1074-7, 1993.

Ware, D L, Atkinson, J B, Brooks, M J, Echt, D S. Ventricular defibrillation in canines with chronic infarction, and effects of lidocaine and procainamide. Pacing Clin Electrophysiol, 16(2), 337-46, 1993.

Abou Mrad, J, Yakubu, F, Lin, D, Peters, J C, Atkinson, J B, Hill, J O. Skeletal muscle composition in dietary obesity-susceptible and dietary obesity-resistant rats. Am J Physiol, 262(4 Pt 2), R684-8, 1992.

Atkinson, J B, Swift, L L, Virmani, R. Watanabe heritable hyperlipidemic rabbits. Familial hypercholesterolemia. Am J Pathol, 140(3), 749-53, 1992. PMCID:1886168

Fogo, A, Superdock, K R, Atkinson, J B. Severe arteriosclerosis in the kidney of a cocaine addict. Am J Kidney Dis, 20(5), 513-5, 1992.

Hoff, S J, Stewart, J R, Frist, W H, Kessler, R M, Sandler, M P, Atkinson, J B, Votaw, J, Carey, J A, Ansari, M S, Merrill, W H. Noninvasive detection of heart transplant rejection with positron emission scintigraphy. Ann Thorac Surg, 53(4), 572-7, 1992.

Hernanz-Schulman, M, Stein, S M, Neblett, W W, Atkinson, J B, Kirchner, S G, Heller, R M, Merrill, W H, Fleischer, A C. Pulmonary sequestration: diagnosis with color Doppler sonography and a new theory of associated hydrothorax. Radiology, 180(3), 817-21, 1991.

Atkinson, J B, Swift, L L. Nifedipine reduces atherogenesis in cholesterol-fed heterozygous WHHL rabbits. Atherosclerosis, 84(2-3), 195-201, 1990.

Frist, W H, Gerhardt, E B, Merrill, W H, Atkinson, J B, Eastburn, T E, Stewart, J R, Hammon, J W, Bender, H W. Therapy of refractory, recurrent heart rejection with multiple courses of OKT3. J Heart Transplant, 9(6), 724-6, 1990.

Frist, W H, Merrill, W H, Eastburn, T E, Atkinson, J B, Stewart, J R, Hammon, J W, Bender, J W. Unique antithymocyte serum versus OKT3 for induction immunotherapy after heart transplantation. J Heart Transplant, 9(5), 489-94, 1990.

Mackey, E S, Sandler, M P, Campbell, R M, Graham, T P, Atkinson, J B, Price, R, Moreau, G A. Right ventricular myocardial mass quantification with magnetic resonance imaging. Am J Cardiol, 65(7), 529-32, 1990.

Nifedipine Suppresses Atherogenesis in Cholesterol-fed Heterozygous WHHL rabbits. Atkinson J.B. and Swift L.L. Atherosclerosis, 84, 195-201, 1990.

Atkinson, J B, Hoover, R L, Berry, K K, Swift, L L. Cholesterol-fed heterozygous Watanabe heritable hyperlipidemic rabbits: a new model for atherosclerosis. Atherosclerosis, 78(2-3), 123-36, 1989.

Atkinson, J B, Virmani, R. Congestive heart failure due to coronary artery disease without myocardial infarction: clinicopathologic description of an unusual cardiomyopathy. Hum Pathol, 20(12), 1155-62, 1989.

Frist, W H, Winterland, A W, Gerhardt, E B, Merrill, W H, Atkinson, J B, Eastburn, T E, Stewart, J R, Eisert, D R. Total lymphoid irradiation in heart transplantation: adjunctive treatment for recurrent rejection. Ann Thorac Surg, 48(6), 863-4, 1989.

McGee, G S, Shuman, T A, Atkinson, J B, Weaver, F A, Edwards, W H. Long-term assessment of a damp-stored, albumin-coated, knitted vascular graft. Am Surg, 55(3), 174-6, 1989.

Atkinson, J B, Rybicka, K, Huddleston, C B, Starnes, V A, Prager, R L, Virmani, R. The effect of verapamil cardioplegia on myocardial ultrastructure. Am J Cardiovasc Pathol, 2(1), 69-77, 1988.

Loyd, J E, Atkinson, J B, Pietra, G G, Virmani, R, Newman, J H. Heterogeneity of pathologic lesions in familial primary pulmonary hypertension. Am Rev Respir Dis, 138(4), 952-7, 1988.

Loyd, J E, Tillman, B F, Atkinson, J B, Des Prez, R M. Mediastinal fibrosis complicating histoplasmosis. Medicine (Baltimore), 67(5), 295-310, 1988.

Shelton, M E, Forman, M B, Virmani, R, Bajaj, A, Stoney, W S, Atkinson, J B. A comparison of morphologic and angiographic findings in long-term internal mammary artery and saphenous vein bypass grafts. J Am Coll Cardiol, 11(2), 297-307, 1988.

Koury, M J, Bondurant, M C, Atkinson, J B. Erythropoietin control of terminal erythroid differentiation: maintenance of cell viability, production of hemoglobin, and development of the erythrocyte membrane. Blood Cells, 13(1-2), 217-26, 1987.

McGee, G S, Shuman, T A, Atkinson, J B, Weaver, F A, Edwards, W H. Experimental evaluation of a new albumin-impregnated knitted dacron prosthesis. Am Surg, 53(12), 695-701, 1987.

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