Vanderbilt University School of Medicine

Beauchamp, R. Daniel , M.D.
Chair of the Section of Surgical Sciences
Professor of Surgery
Adjunct Professor of Surgery at Meharry Medical College
Professor of Cancer Biology
Professor of Cell and Developmental Biology
John Clinton Foshee Distinguished Chair in Surgery

Lab Url: N/A

Phone Number: 615-322-2363

Email Address:dan.beauchamp@vanderbilt.edu

Beauchamp, R.'s picture

Office Address   Mailing Address

D-4316 MCN

D-4316 MCN 2730


Research Keywords
Transforming growth factor, Gastrointestinal carcinogenesis, Ras oncogene, colon cancer, epithelial to mesenchymal transition, metastasis, mouse models,Cancer,Cell cycle,Gene regulation,Genome,Malignancy,Post-transcriptional modification,Proteomics,Signal transduction,Transformation,Translation

Research Description
R. Daniel Beauchamp, MD, is the John Clinton Foshee Distinguished Professor of Surgery, Chairman of the Section of Surgical Sciences, and Surgeon-in-Chief of Vanderbilt University Hospital and has held these positions since July 2001 and on the faculty at Vanderbilt since December 1994. He holds joint appointments as professor in the departments of Cell and Developmental Biology and Cancer Biology. He also serves as Deputy Director of the Vanderbilt-Ingram Cancer Center. Dr. Beauchamp has two active R01 grants from NIH, and leads one of the main projects in the GI Cancer SPORE. Dr. Beauchamp's primary area of research interest has been in colorectal carcinogenesis, the biology of cancer cell invasion and metastasis, and in the identification of novel molecular biomarkers and therapeutic targets in colorectal and other alimentary tract malignancies. His work applies DNA microarray and proteomic technology to identify novel biomarkers and therapeutic targets in human colorectal cancer samples. He also uses molecular genetics, chemical biology and cell biological approaches to examine mechanistic questions in cancer biology in both cell culture and mouse models. In addition to the basic cancer research Dr. Beauchamp works in collaboration with his Medical Oncology and Radiation Oncology colleagues to accrue cancer patients to approved clinical trials. He has trained and mentored numerous junior faculty members, physician scientist fellows, medical students, graduate students and post-doctoral fellows in his laboratory. He is one of the few surgeon members of the ASCI.

Clinical Research Description
Dr. Beauchamp's clinical practice is primarily in Surgical Oncology. He participates in the multidisciplinary Vanderbilt Breast Center clinic. Dr. Beauchamp's practice includes patients with breast cancers and premalignant breast diseases. He participate in care with a multidisciplinary team along with Radiologists, Medical Oncologists, Pathologists, Radiation Oncologists and the Genetic counseling service to provide the most current and comprehensive diagnostic and therapeutic care available.

Clinical Interests
Dr. Beauchamp's clinical practice is currently focused in the surgical care of breast cancer patients. He has clinic at the Vanderbilt One Hundred Oaks facility in the Vanderbilt Breast Center and performs surgical procedures at Vanderbilt University Hospital.

Publications
Freeman, TJ, Smith, JJ, Chen, X, Washington, MK, Roland, JT, Means, AL, Eschrich, SA, Yeatman, TJ, Deane, NG, Beauchamp, RD. Smad4-mediated signaling inhibits intestinal neoplasia by inhibiting expression of I?-catenin. Gastroenterology, 142(3), 562-571.e2, 2012.

Hanson, AJ, Wallace, HA, Freeman, TJ, Beauchamp, RD, Lee, LA, Lee, E. XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling. Mol Cell, 45(5), 619-28, 2012.

Dhawan, P, Ahmad, R, Chaturvedi, R, Smith, JJ, Midha, R, Mittal, MK, Krishnan, M, Chen, X, Eschrich, S, Yeatman, TJ, Harris, RC, Washington, MK, Wilson, KT, Beauchamp, RD, Singh, AB. Claudin-2 expression increases tumorigenicity of colon cancer cells: role of epidermal growth factor receptor activation. Oncogene, 30(29), 3234-47, 2011. PMCID:3128423

Kauffmann, RM, Landman, MP, Shelton, J, Dmochowski, RR, Bledsoe, SH, Hickson, GB, Beauchamp, RD, Dattilo, JB. The use of a multidisciplinary morbidity and mortality conference to incorporate ACGME general competencies. J Surg Educ, 68(4), 303-8, 2011. PMCID:3128423

Lapierre, LA, Caldwell, CM, Higginbotham, JN, Avant, KM, Hall, J, Beauchamp, RD, Goldenring, JR. Transformation of rat intestinal epithelial cells by overexpression of Rab25 is microtubule dependent. Cytoskeleton (Hoboken), 68(2), 97-111, 2011. PMCID:3128423

Singh, AB, Sharma, A, Smith, JJ, Krishnan, M, Chen, X, Eschrich, S, Washington, MK, Yeatman, TJ, Beauchamp, RD, Dhawan, P. Claudin-1 up-regulates the repressor ZEB-1 to inhibit E-cadherin expression in colon cancer cells. Gastroenterology, 141(6), 2140-53, 2011. PMCID:3195453

Stoops, SL, Pearson, AS, Weaver, C, Waterson, AG, Days, E, Farmer, C, Brady, S, Weaver, CD, Beauchamp, RD, Lindsley, CW. Identification and optimization of small molecules that restore E-cadherin expression and reduce invasion in colorectal carcinoma cells. ACS Chem Biol, 6(5), 452-65, 2011. PMCID:3128423

Williams, CS, Zhang, B, Smith, JJ, Jayagopal, A, Barrett, CW, Pino, C, Russ, P, Presley, SH, Peng, D, Rosenblatt, DO, Haselton, FR, Yang, JL, Washington, MK, Chen, X, Eschrich, S, Yeatman, TJ, El-Rifai, W, Beauchamp, RD, Chang, MS. BVES regulates EMT in human corneal and colon cancer cells and is silenced via promoter methylation in human colorectal carcinoma. J Clin Invest, 121(10), 4056-69, 2011. PMCID:3195453

Krishnan, M, Singh, AB, Smith, JJ, Sharma, A, Chen, X, Eschrich, S, Yeatman, TJ, Beauchamp, RD, Dhawan, P. HDAC inhibitors regulate claudin-1 expression in colon cancer cells through modulation of mRNA stability. Oncogene, 29(2), 305-12, 2010. PMCID:2827957

Nam, KT, Lee, HJ, Smith, JJ, Lapierre, LA, Kamath, VP, Chen, X, Aronow, BJ, Yeatman, TJ, Bhartur, SG, Calhoun, BC, Condie, B, Manley, NR, Beauchamp, RD, Coffey, RJ, Goldenring, JR. Loss of Rab25 promotes the development of intestinal neoplasia in mice and is associated with human colorectal adenocarcinomas. J Clin Invest, 120(3), 840-9, 2010. PMCID:2827957

Smith, JJ, Deane, NG, Wu, F, Merchant, NB, Zhang, B, Jiang, A, Lu, P, Johnson, JC, Schmidt, C, Bailey, CE, Eschrich, S, Kis, C, Levy, S, Washington, MK, Heslin, MJ, Coffey, RJ, Yeatman, TJ, Shyr, Y, Beauchamp, RD. Experimentally derived metastasis gene expression profile predicts recurrence and death in patients with colon cancer. Gastroenterology, 138(3), 958-68, 2010. PMCID:2827957

Xu, BJ, Li, J, Beauchamp, RD, Shyr, Y, Li, M, Washington, MK, Yeatman, TJ, Whitehead, RH, Coffey, RJ, Caprioli, RM. Identification of early intestinal neoplasia protein biomarkers using laser capture microdissection and MALDI MS. Mol Cell Proteomics, 8(5), 936-45, 2009. PMCID:2689774

Kanies, CL, Smith, JJ, Kis, C, Schmidt, C, Levy, S, Khabar, KS, Morrow, J, Deane, N, Dixon, DA, Beauchamp, RD. Oncogenic Ras and transforming growth factor-beta synergistically regulate AU-rich element-containing mRNAs during epithelial to mesenchymal transition. Mol Cancer Res, 6(7), 1124-36, 2008. PMCID:2572152

Smith, JJ, Deane, NG, Dhawan, P, Beauchamp, RD. Regulation of metastasis in colorectal adenocarcinoma: a collision between development and tumor biology. Surgery, 144(3), 353-66, 2008. PMCID:2594010

Kim, DW, Blanke, CD, Wu, H, Shyr, Y, Berlin, J, Beauchamp, RD, Chakravarthy, B. Phase II study of preoperative paclitaxel/cisplatin with radiotherapy in locally advanced esophageal cancer. Int J Radiat Oncol Biol Phys, 67(2), 397-404, 2007.

Li, JQ, Xu, BJ, Shakhtour, B, Deane, N, Merchant, N, Heslin, MJ, Washington, K, Coffey, RJ, Beauchamp, RD, Shyr, Y, Billheimer, D. Variability of in situ proteomic profiling and implications for study design in colorectal tumors. Int J Oncol, 31(1), 103-11, 2007.

Shiou, SR, Singh, AB, Moorthy, K, Datta, PK, Washington, MK, Beauchamp, RD, Dhawan, P. Smad4 regulates claudin-1 expression in a transforming growth factor-beta-independent manner in colon cancer cells. Cancer Res, 67(4), 1571-9, 2007.

Chakravarthy, AB, Kelley, MC, McLaren, B, Truica, CI, Billheimer, D, Mayer, IA, Grau, AM, Johnson, DH, Simpson, JF, Beauchamp, RD, Jones, C, Pietenpol, JA. Neoadjuvant concurrent paclitaxel and radiation in stage II/III breast cancer. Clin Cancer Res, 12(5), 1570-6, 2006.

Halder, SK, Anumanthan, G, Maddula, R, Mann, J, Chytil, A, Gonzalez, AL, Washington, MK, Moses, HL, Beauchamp, RD, Datta, PK. Oncogenic Function of a Novel WD-Domain Protein, STRAP, in Human Carcinogenesis. Cancer Res, 66(12), 6156-66, 2006.

Johnson, JC, Schmidt, CR, Shrubsole, MJ, Billheimer, DD, Joshi, PR, Morrow, JD, Heslin, MJ, Washington, MK, Ness, RM, Zheng, W, Schwartz, DA, Coffey, RJ, Beauchamp, RD, Merchant, NB. Urine PGE-M: A metabolite of prostaglandin E2 as a potential biomarker of advanced colorectal neoplasia. Clin Gastroenterol Hepatol, 4(11), 1358-65, 2006.

Shiou, SR, Datta, PK, Dhawan, P, Law, BK, Yingling, JM, Dixon, DA, Beauchamp, RD. Smad4-dependent regulation of urokinase plasminogen activator secretion and RNA stability associated with invasiveness by autocrine and paracrine transforming growth factor-beta. J Biol Chem, 281(45), 33971-81, 2006.

Beauchamp, RD. The changing roles of a surgical department chair: adapting to a changing environment. Arch Surg, 140(3), 258-63, 2005.

Deane, NG, Parker, MA, Beauchamp, RD. Cell proliferation: a matter of time and place. Surgery, 138(1), 1-7, 2005.

Dhawan, P, Singh, AB, Deane, NG, No, Y, Shiou, SR, Schmidt, C, Neff, J, Washington, MK, Beauchamp, RD. Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer. J Clin Invest, 115(7), 1765-76, 2005. PMCID:1150288

Halder, SK, Beauchamp, RD, Datta, PK. A specific inhibitor of TGF-beta receptor kinase, SB-431542, as a potent antitumor agent for human cancers. Neoplasia, 7(5), 509-21, 2005. PMCID:1501161

Halder, SK, Beauchamp, RD, Datta, PK. Smad7 induces tumorigenicity by blocking TGF-beta-induced growth inhibition and apoptosis. Exp Cell Res, 307(1), 231-46, 2005.

Poulose, BK, Ray, WA, Arbogast, PG, Needleman, J, Buerhaus, PI, Griffin, MR, Abumrad, NN, Beauchamp, RD, Holzman, MD. Resident work hour limits and patient safety. Ann Surg, 241(6), 847-56; discussion 856-60, 2005. PMCID:1357165

Tedesco, KL, Berlin, J, Blanke, CD, Teng, M, Choy, H, Roberts, J, Beauchamp, RD, Leach, S, Wyman, K, Tarpley, J, Shyr, Y, Caillouette, C, Chakravarthy, B. Phase I trial of Orzel (UFT plus leucovorin), cisplatin, and radiotherapy in the treatment of potentially resectable esophageal cancer. Int J Radiat Oncol Biol Phys, 61(5), 1364-70, 2005.

Beauchamp, RD. Department of Surgery, Vanderbilt University Medical Center, Nashville, Tenn. Arch Surg, 139(8), 814-5, 2004.

Deane, Natasha G, Lee, Haakil, Hamaamen, Jalal, Ruley, Anna, Washington, M Kay, LaFleur, Bonnie, Thorgeirsson, Snorri S, Price, Ronald, Beauchamp, R Daniel. Enhanced tumor formation in cyclin D1 x transforming growth factor beta1 double transgenic mice with characterization by magnetic resonance imaging. Cancer Res, 64(4), 1315-22, 2004.

Lawson, LL, Sandler, M, Martin, W, Beauchamp, RD, Kelley, MC. Preoperative lymphoscintigraphy and internal mammary sentinel lymph node biopsy do not enhance the accuracy of lymphatic mapping for breast cancer. Am Surg, 70(12), 1050-5; discussion 1055-6, 2004.

Li, JQ, Wu, F, Masaki, T, Kubo, A, Fujita, J, Dixon, DA, Beauchamp, RD, Ishida, T, Kuriyama, S, Imaida, K. Correlation of Skp2 with carcinogenesis, invasion, metastasis, and prognosis in colorectal tumors. Int J Oncol, 25(1), 87-95, 2004.

Mithani, SK, Balch, GC, Shiou, SR, Whitehead, RH, Datta, PK, Beauchamp, RD. Smad3 has a critical role in TGF-beta-mediated growth inhibition and apoptosis in colonic epithelial cells. J Surg Res, 117(2), 296-305, 2004.

Schmidt, CR, Gi, YJ, Coffey, RJ, Beauchamp, RD, Pearson, AS. Oncogenic Ras dominates overexpression of E-cadherin in malignant transformation of intestinal epithelial cells. Surgery, 136(2), 303-9, 2004.

Ahmed, Atique, Thompson, Jill, Emiliusen, Lisa, Murphy, Stephen, Beauchamp, R Daniel, Suzuki, Kaori, Alemany, Ramon, Harrington, Kevin, Vile, Richard G, . A conditionally replicating adenovirus targeted to tumor cells through activated RAS/P-MAPK-selective mRNA stabilization.. Nat Biotechnol, 21, 771-7, 2003.

Balch, Glen C, Mithani, Suhail K, Richards, Ken R, Beauchamp, R Daniel, Kelley, Mark C, . Lymphatic mapping and sentinel lymphadenectomy after preoperative therapy for stage II and III breast cancer.. Ann Surg Oncol, 10, 616-21, 2003.

Berger, David, O'mahony, Christine, Sheng, Hongmiao, Shao, Jinyi, Albo, Daniel, Dubois, Raymond, Beauchamp, R. Intestinal transformation results in transforming growth factor-beta-dependent alteration in tumor cell-cell matrix interactions. Surgery, 133(5), 568-579, 2003.

Dixon, Dan A, Balch, Glen C, Kedersha, Nancy, Anderson, Paul, Zimmerman, Guy A, Beauchamp, R Daniel, Prescott, Stephen M, . Regulation of cyclooxygenase-2 expression by the translational silencer TIA-1.. J Exp Med, 198, 475-81, 2003. PMCID:2194089

Parker, M A, Deane, N G, Thompson, E A, Whitehead, R H, Mithani, S K, Washington, M K, Datta, P K, Dixon, D A, Beauchamp, R D. Over-expression of cyclin D1 regulates Cdk4 protein synthesis. Cell Prolif, 36(6), 347-60, 2003.

Schmidt, Carl R, Washington, M Kay, Gi, Y J, Coffey, Robert J, Beauchamp, R Daniel, Pearson, A Scott. Dysregulation of E-cadherin by oncogenic Ras in intestinal epithelial cells is blocked by inhibiting MAP kinase. Am J Surg, 186(5), 426-30, 2003.

Berger, David H, Feng, Xin-Hua, Yao, Jun, Saha, Debabrata, Beauchamp, R Daniel, Lin, Xia, . Resistance to transforming growth factor-beta occurs in the presence of normal Smad activation.. Surgery, 132, 310-6, 2002.

Fujimoto, Koji, Beauchamp, R Daniel, Whitehead, Robert H. Identification and isolation of candidate human colonic clonogenic cells based on cell surface integrin expression. Gastroenterology, 123(6), 1941-8, 2002.

Roman, Christopher D, Choy, Hak, Nanney, Lillian, Riordan, Colin, Parman, Kelly, Johnson, David, Beauchamp, R Daniel. Vascular endothelial growth factor-mediated angiogenesis inhibition and postoperative wound healing in rats. J Surg Res, 105(1), 43-7, 2002.

Roman, Christopher D, Hanley, Greg A, Beauchamp, R Daniel. Operative technique for safe pulmonary lobectomy in Sprague-Dawley rats. Contemp Top Lab Anim Sci, 41(2), 28-30, 2002.

Roman, Christopher D, Morrow, Jason, Whitehead, Robert, Beauchamp, R Daniel. Induction of cyclooxygenase-2 and invasiveness by transforming growth factor-beta(1) in immortalized mouse colonocytes expressing oncogenic Ras. J Gastrointest Surg, 6(3), 304-9, 2002.

Saha, Debabrata, Roman, Christopher, Beauchamp, R Daniel. New strategies for colorectal cancer prevention and treatment. World J Surg, 26(7), 762-6, 2002.

Deane, N G, Parker, M A, Aramandla, R, Diehl, L, Lee, W J, Washington, M K, Nanney, L B, Shyr, Y, Beauchamp, R D. Hepatocellular carcinoma results from chronic cyclin D1 overexpression in transgenic mice. Cancer Res, 61(14), 5389-95, 2001.

Fujimoto, K, Sheng, H, Shao, J, Beauchamp, R D. Transforming growth factor-beta1 promotes invasiveness after cellular transformation with activated Ras in intestinal epithelial cells. Exp Cell Res, 266(2), 239-49, 2001.

Saha, D, Datta, P K, Beauchamp, R D. Oncogenic ras represses transforming growth factor-beta /Smad signaling by degrading tumor suppressor Smad4. J Biol Chem, 276(31), 29531-7, 2001.

Zhang, Z, Sheng, H, Shao, J, Beauchamp, R D, DuBois, R N. Posttranscriptional regulation of cyclooxygenase-2 in rat intestinal epithelial cells. Neoplasia, 2(6), 523-30, 2001. PMCID:1508084

Beauchamp, R D. Presidential address: evolution. Surgery, 128(2), 123-32, 2000.

Bulus N., Sheng H-M., Sizemore N., Oldham S.M., Barnett J.V., Coffey R.J., Beauchamp R.D. and Barnard J.A. Ras-mediated suppression of TFGRII expression in intestinal pedithelial cells involves a Raf-independent signaling. Neoplasia , 2(4), 357-364, 2000.

Fujimoto, K, Hosotani, R, Miyamoto, Y, Doi, R, Koshiba, T, Otaka, A, Fujii, N, Beauchamp, R D, Imamura, M. Inhibition of pRb phosphorylation and cell cycle progression by an antennapedia-p16(INK4A) fusion peptide in pancreatic cancer cells. Cancer Lett, 159(2), 151-8, 2000.

Jo, H, Zhang, R, Zhang, H, McKinsey, T A, Shao, J, Beauchamp, R D, Ballard, D W, Liang, P. NF-kappa B is required for H-ras oncogene induced abnormal cell proliferation and tumorigenesis. Oncogene, 19(7), 841-9, 2000.

Shao, J, Sheng, H, DuBois, R N, Beauchamp, R D. Oncogenic Ras-mediated cell growth arrest and apoptosis are associated with increased ubiquitin-dependent cyclin D1 degradation. J Biol Chem, 275(30), 22916-24, 2000.

Shao, J., Sheng, H.M., Dubois, R.N., and Beauchamp, R.D. Oncogenic Ras-mediated cell growth arrest and apoptosis is associated with increased ubiquitin-dependent cyclin D1 degradation. Journal of Biological Chemistry , 275, 22916-22924, 2000.

Sheng, H, Shao, J, Dixon, D A, Williams, C S, Prescott, S M, DuBois, R N, Beauchamp, R D. Transforming growth factor-beta1 enhances Ha-ras-induced expression of cyclooxygenase-2 in intestinal epithelial cells via stabilization of mRNA. J Biol Chem, 275(9), 6628-35, 2000.

Sheng, H., Shao, J., Williams, C.S., Prescott, S.M., Dubois, R.N., and Beauchamp, R.D. TGF-1 enhances Ha-Ras-induced expression of cyclooxygenase-2 in intestinal epithelial cells via stabilization of mRNA. Journal of Biological Chemistry , 275, 6628-6635, 2000.

Delbeke, D, Rose, D M, Chapman, W C, Pinson, C W, Wright, J K, Beauchamp, R D, Shyr, Y, Leach, S D. Optimal interpretation of FDG PET in the diagnosis, staging and management of pancreatic carcinoma. J Nucl Med, 40(11), 1784-91, 1999.

Rose, D M, Delbeke, D, Beauchamp, R D, Chapman, W C, Sandler, M P, Sharp, K W, Richards, W O, Wright, J K, Frexes, M E, Pinson, C W, Leach, S D. 18Fluorodeoxyglucose-positron emission tomography in the management of patients with suspected pancreatic cancer. Ann Surg, 229(5), 729-37; discussion 737-8, 1999. PMCID:1420818

Saha, D, Datta, P K, Sheng, H, Morrow, J D, Wada, M, Moses, H L, Beauchamp, R D. Synergistic induction of cyclooxygenase-2 by transforming growth factor-beta1 and epidermal growth factor inhibits apoptosis in epithelial cells. Neoplasia, 1(6), 508-17, 1999. PMCID:1508120

Scoggins, C R, Meszoely, I M, Blanke, C D, Beauchamp, R D, Leach, S D. Nonoperative management of primary colorectal cancer in patients with stage IV disease. Ann Surg Oncol, 6(7), 651-7, 1999.

Shao, J, Sheng, H, Aramandla, R, Pereira, M A, Lubet, R A, Hawk, E, Grogan, L, Kirsch, I R, Washington, M K, Beauchamp, R D, DuBois, R N. Coordinate regulation of cyclooxygenase-2 and TGF-beta1 in replication error-positive colon cancer and azoxymethane-induced rat colonic tumors. Carcinogenesis, 20(2), 185-91, 1999.

Shao, J., Sheng, H.M., Aramandla, R., Pereira, M.A., Lubet, R.A., Hawk, E., Grogan, L., Kirshc, I.R., Washington, M.K., Beauchamp, R.D. and Dubois, R.N. Coordinate regulation of cyclooxygenase-2 and TGF-1 in replication error-positive colon cancer and azoxymethane-induced rat colonic tumors. Carcinogenesis , 20(2), 185-191, 1999.

Sheng, H, Shao, J, O'Mahony, C A, Lamps, L, Albo, D, Isakson, P C, Berger, D H, DuBois, R N, Beauchamp, R D. Transformation of intestinal epithelial cells by chronic TGF-beta1 treatment results in downregulation of the type II TGF-beta receptor and induction of cyclooxygenase-2. Oncogene, 18(4), 855-67, 1999.

Sheng, H., Shao, J., O'Mahony, C.A., Lamps, L., Albo, D., Isakson, P.C., Berger, D.H., DuBois, R.N., and Beauchamp, R.D. Transformation of intestinal epithelial cells by chronic TGF-b1 treatment results in downregulation of the type II TGF-b receptor and induction of cyclooxygenase-2. Oncogene, 18, 855-867, 1999.

Chinery, R, Beauchamp, R D, Shyr, Y, Kirkland, S C, Coffey, R J, Morrow, J D. Antioxidants reduce cyclooxygenase-2 expression, prostaglandin production, and proliferation in colorectal cancer cells. Cancer Res, 58(11), 2323-7, 1998.

Chinery, R., Beauchamp, R.D., Shyr, Y., Kirkland, S.C., Coffey, R.J., and Morrow, J.D. Antioxidants reduce cyclooxygenase -2 expression, prostaglandin production and proliferation in colorectal cancer cells. Cancer Research , 58, 2323-2327, 1998.

Ko, T.C., Yu, W., Sakai, T., Sheng, H., Shao, J., Beauchamp, R.D and Thompson, E.A. TGF-b1 effects on proliferation of rat intestinal epithelial cells are due to inhibition of cyclin D1 expression. Oncogene , 16, 3445-3454, 1998.

Sheng, H, Shao, J, Morrow, J D, Beauchamp, R D, DuBois, R N. Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells. Cancer Res, 58(2), 362-6, 1998.

Sheng, H, Shao, J, Williams, C S, Pereira, M A, Taketo, M M, Oshima, M, Reynolds, A B, Washington, M K, DuBois, R N, Beauchamp, R D. Nuclear translocation of beta-catenin in hereditary and carcinogen-induced intestinal adenomas. Carcinogenesis, 19(4), 543-9, 1998.

Sheng, H, Williams, C S, Shao, J, Liang, P, DuBois, R N, Beauchamp, R D. Induction of cyclooxygenase-2 by activated Ha-ras oncogene in Rat-1 fibroblasts and the role of mitogen-activated protein kinase pathway. J Biol Chem, 273(34), 22120-7, 1998.

Sheng, H., Shao, J., Morrow, J., Beauchamp, R., DuBois, R. Modulation of Apoptosis and Bcl-2 Expression by Prostaglandin E2 in Human Colon Cancer Cells. Cancer Research , 58, 362-366, 1998.

Sheng, H., Shao,J., Williams, C.S., Pereira, M.A., Taketo, M.M., Oshima, M., Reynolds, A.B., Washington, M.W., DuBois, R.N and Beauchamp, R.D. Nuclear translocation of b-catenin in hereditary and carcinogen- induced intestinal adenomas. Carcinogenesis , 19, 543-549, 1998.

Sheng, H., Williams, C.S., Shao, J., Liang, P., DuBois, R.N., and Beauchamp, R.D. Induction of cyclooxygenase-2 by activated Ha-ras oncogene in Rat-1 fibroblasts and the role of mitogen-activated protein kinase pathway. Journal of Biological Chemistry, , 22120-22127, 1998.

Washington, K., Chiappori, A., Hamilton, K., Yu, S., Blanke, C., johnson, D., Sawyers, J., and Beauchamp, R.D. Expression of -catenin, -catenin, and E-cadherin in Barrett?s esophagus and esophageal adenocarcinomas. Modern Pathology , 11(9), 805-813, 1998.

Chinery, R, Brockman, J A, Peeler, M O, Shyr, Y, Beauchamp, R D, Coffey, R J. Antioxidants enhance the cytotoxicity of chemotherapeutic agents in colorectal cancer: a p53-independent induction of p21WAF1/CIP1 via C/EBPbeta. Nat Med, 3(11), 1233-41, 1997.

Chinery, R., Brockman, J.A., Peeler, M.O., Shyr, Y., Beauchamp, R.D., and Coffey, R.J. Antioxidants enhance the cytotoxicity of chemotherapeutic agents in colorectal cancer: A p53-independent induction of p21Waf1/Cip1 via C/EBP. Nature Medicine , 3, 1-9, 1997.

Sheng, G G, Shao, J, Sheng, H, Hooton, E B, Isakson, P C, Morrow, J D, Coffey, R J, DuBois, R N, Beauchamp, R D. A selective cyclooxygenase 2 inhibitor suppresses the growth of H-ras-transformed rat intestinal epithelial cells. Gastroenterology, 113(6), 1883-91, 1997.

Sheng, G., Shao, J., Sheng, H., Hooton, E., Isakson, P., Morrow, J., Coffey, R., DuBois, R., Beauchamp, R. A Selective Cyclooxygenase 2 Inhibitor Suppresses the Growth of H-ras-Transformed Rat Intestinal Epithelial Cells. Gastroenterology , 113, 1883-1891, 1997.

Sheng, H, Shao, J, Hooton, E B, Tsujii, M, DuBois, R N, Beauchamp, R D. Cyclooxygenase-2 induction and transforming growth factor beta growth inhibition in rat intestinal epithelial cells. Cell Growth Differ, 8(4), 463-70, 1997.

Sheng, H, Shao, J, Kirkland, S C, Isakson, P, Coffey, R J, Morrow, J, Beauchamp, R D, DuBois, R N. Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2. J Clin Invest, 99(9), 2254-9, 1997. PMCID:508057

Sheng, H., Shao, J., Hooton, E.B., Masahiko, T., DuBois, R.N., Beauchamp, R.D. Cyclooxygenase-2 induction and transforming growth factor (TGF)-b growth inhibition in rat intestinal epithelial cells. Cell Growth and Differentiation , 8, 463-470, 1997.

Sheng, H., Shao, J., Kirkland, S.C., Isakson, P., Coffey, R.J., Morrow, J., Beauchamp, R.D., DuBois R.N. Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2. The Journal of Clinical Investigation, 99, 2254-2259, 1997.

Zhang, T, Nanney, L B, Luongo, C, Lamps, L, Heppner, K J, DuBois, R N, Beauchamp, R D. Concurrent overexpression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple intestinal neoplasia (Min) mice and human familial adenomatous polyposis patients. Cancer Res, 57(1), 169-75, 1997.

Zhang, T, Nanney, L B, Peeler, M O, Williams, C S, Lamps, L, Heppner, K J, DuBois, R N, Beauchamp, R D. Decreased transforming growth factor beta type II receptor expression in intestinal adenomas from Min/+ mice is associated with increased cyclin D1 and cyclin-dependent kinase 4 expression. Cancer Res, 57(9), 1638-43, 1997.

Zhang, T., Nanney, L.B., Luongo, C., Lamps, L., Heppner, K.J., DuBois, R.N., and Beauchamp, R.D. Concurrent overexpression of cyclin D1 and Cdk4 in intestinal adenomas from min mice and human familial adenomatous polyposis patients. Cancer Research , 57, 169-175, 1997.

Zhang, T., Nanney, L.B., Peeler, M.O., Williams, C.S., Lamps, L., Heppner, K.J., DuBois, R.N., and Beauchamp, R.D. Decreased TFG- type II receptor expression in intestinal adenomas from Min/+ Mice is associated with increased cyclin D1 and Cdk4 expression. Cancer Research, 57, 1638-1643, 1997.

Beauchamp, R D, Sheng, H M, Shao, J Y, Thompson, E A, Ko, T C. Intestinal cell cycle regulations. Interactions of cyclin D1, Cdk4, and p21Cip1. Ann Surg, 223(5), 620-7; discussion 627-8, 1996. PMCID:1235195

DuBois, R N, Shao, J, Tsujii, M, Sheng, H, Beauchamp, R D. G1 delay in cells overexpressing prostaglandin endoperoxide synthase-2. Cancer Res, 56(4), 733-7, 1996.

DuBois, R. N., Shao, J., Masahiko, T., Sheng, H-M., Beauchamp, R.D. G1 delay in cells overexpressing prostaglandin endoperoxide synthase-21. Cancer Research , 56, 733-737, 1996.

Williams, C S, Luongo, C, Radhika, A, Zhang, T, Lamps, L W, Nanney, L B, Beauchamp, R D, DuBois, R N. Elevated cyclooxygenase-2 levels in Min mouse adenomas. Gastroenterology, 111(4), 1134-40, 1996.

Williams, C.S., Luongo, C., Radhika, A., Zhang, R., Lamps, L.W., Nanney, L.B., Beauchamp, R.D., Dubois, R.N. Elevated cyclooxygenase-2 levels in min mouse adenomas. Gastroenterology , 111, 1134-1140, 1996.

Barnard, J A, Beauchamp, R D, Russell, W E, Dubois, R N, Coffey, R J. Epidermal growth factor-related peptides and their relevance to gastrointestinal pathophysiology. Gastroenterology, 108(2), 564-80, 1995.

Barnard, J.A., Beauchamp, R.D., Russell, W.E., DuBois, R.N., Coffey, R.J. Epidermal growth factor-related peptides and their relevance to gastrointestinal pathophysiology. Gastroenterology , 108, 564-580, 1995.

Ko, T.C., Sheng, H.M.,,Reisman, D., Thompson, E.A., Beauchamp, R.D. Transforming growth factor- inhibits cyclin D1 Expression of intestinal epithelial clls. Oncongene , 10, 177-184, 1995.

Beauchamp, R.D., Papaconstantinou, J., Henderson, A.M., Sheng, H-M., Townsend, C.M. Jr.,Thompson, J.C. Activation of hepatic proliferation-associated transcription factors by lipopolysaccharide. Surgery , 116, 367-377, 1994.

Ko, T.C., Beauchamp, R.D., Townsend, C.M. Jr., Thompson, E.A., Thompson, J.C. Transforming growth factor beta inhibits rat intestinal cell growth by regulating cell cycle specific gene expression. American Journal of Surgery , 167, 14-20, 1994.

Parekh, D., Ishizuka, J., Townsend, C.M. Jr., Haber, B., Beauchamp, R.D., Karp, G., Kim, S.W., Rajaraman, S., Greeley, G.H. Jr., Thompson, J.C. Characterization of a human pancreatic carcinoid in vitro: morphology, amine and peptide storage and secretion. Pancreas , 9, 83-90, 1994.

Sumi, S., Beauchamp, R.D., Townsend, C.M. Jr., Pour, P.M., Ishizuka, J., Thompson, J.C. Lovastatin inhibits pancreatic cancer growth regardless of ras mutation. Pancreas , 90, 657-661, 1994.

Guo, Y-S., Beauchamp, RD., Jin, G-F., Townsend, C.M. Jr., Thompson, J.C. Insulinlike growth factor-binding protein modulates the growth response to insulinlike growth factor 1 by human gastric cancer cells. Gastroenterology , 104, 1595-1604, 1993.

Ishizuka, J., Beauchamp, R.D., Sato, K., Townsend, C.M. Jr., Thompson, J.C. Novel action of transforming growth factor  1 in functioning human pancreatic carcinoid cells. Journal of Cellular Physiology , 156, 112-118, 1993.

Ko, T.C., Beauchamp, R.D., Townsend, C.M. Jr., Thompson, J.C. Glutamine is essential for epidermal growth factor-stimulated intestinal cell proliferation. Surgery , 114, 147-154, 1993.

Beauchamp, R.D., Sheng, H-M., Alam, T., Townsend, C.M. Jr., Papaconstantinou, J. Posttranscriptional regulation of albumin and -fetoprotein messenger RNA by transforming growth factor- 1 requires de novo RNA and protein synthesis. Molecular Endocrinology , 6, 1789-1796, 1992.

Beauchamp, R.D., Sheng, H-M., Ishizuka, J., Townsend, C.M. Jr., Thompson, J.C. Transforming growth factor (TGF)- stimulates hepatic jun-B and fos-B proto-oncogenes and decreases albumin mRNA. Annals of Surgery , 216, 300-308, 1992.

Chung, D.H., Evers, B.M., Beauchamp, R.D., Upp, J.R. Jr., Rajaraman, S., Townsend, C.M. Jr., Thompson, J.C. Bombesin stimulates growth of human gastrinoma. Surgery , 112, 1059-1065, 1992.

Ishizuka, J., Beauchamp, R.D., Evers, B.M., Townsend, C.M. Jr., Thompson, J.C. Unexpected growth-stimulatory effect of somatostatin analogue on cultured human pancreatic carcinoid cells. Biochemical and Biophysical Research Communications , 185, 577-581, 1992.

Polk, W H, Dempsey, P J, Russell, W E, Brown, P I, Beauchamp, R D, Barnard, J A, Coffey, R J. Increased production of transforming growth factor alpha following acute gastric injury. Gastroenterology, 102(5), 1467-74, 1992.

Sumi, S., Beauchamp, R.D., Townsend, C.M. Jr., Uchida, T., Murakami, M., Rajaraman, S., Ishizuka, J., Thompson, J.C. Inhibition of pancreatic adenocarcinoma cell growth by lovastatin. Gastroenterology , 103, 982-9, 1992.

Beauchamp, R D, Lyons, R M, Yang, E Y, Coffey, R J, Moses, H L. Expression of and response to growth regulatory peptides by two human pancreatic carcinoma cell lines. Pancreas, 5(4), 369-80, 1990.

Barnard, J A, Beauchamp, R D, Coffey, R J, Moses, H L. Regulation of intestinal epithelial cell growth by transforming growth factor type beta. Proc Natl Acad Sci U S A, 86(5), 1578-82, 1989. PMCID:286741

Beauchamp, R D, Barnard, J A, McCutchen, C M, Cherner, J A, Coffey, R J. Localization of transforming growth factor alpha and its receptor in gastric mucosal cells. Implications for a regulatory role in acid secretion and mucosal renewal. J Clin Invest, 84(3), 1017-23, 1989. PMCID:329750


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Updated Date
08/22/2013



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